GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMSETA 2238 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human mRNA for secreted epithelial tumour mucin antigen
ACCESSION X52228
KEYWORDS secreted protein; tumor antigen.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2238)
AUTHORS Wreschner,D.H.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 2238)
AUTHORS Wreschener,D.H., Hareuveni,M., Tsarfaty,I., Smorodinsky,N.,
Horov,J., Zaretsky,J., Kotkes,P., Weiss,M., Lathe,R., Dion,A.S. and
Keydar,I.
TITLE Human epithelial tumor antigen cDNA sequences. Differential
splicing may generate multiple protein forms.
JOURNAL Eur. J. Biochem. 189, 463-473 (1990)
STANDARD full automatic
REFERENCE 3 (sites)
AUTHORS Hareuveni,M., Tsarfaty,I., Zaretsky,J., Kotkes,P., Horev,J.,
Zrihan,S., Weiss,M., Green,S., Lathe,R., Keydar,I. and
Wreschner,D.H.
TITLE A transcribed gene, containing a variable number of tandem repeats,
codes for a human epithelial tumor antigen. cDNA cloning,
expression of the transfected gene and over- expression in breast
cancer tissue.
JOURNAL Eur. J. Biochem. 189, 475-486 (1990)
STANDARD full staff_review
COMMENT SWISS-PROT; P17626; SETA$HUMAN.
*source: cell line=T47D breast tumour; library=lambda gt11; **map:
chromosome=1q21-24; See <X52229> for transmembrane tumour antigen.
From EMBL entry HSSETA; dated 21-JUN-1990.
FEATURES Location/Qualifiers
CDS 58..1098
/note="precursor polypeptide (AA -21 to 326)"
/codon_start=58
CDS 58..120
/note="signal peptide (AA -21 to -1)"
/codon_start=58
CDS 121..1098
/note="secreted tumor mucin antigen (AA 1 to 326)"
/codon_start=121
BASE COUNT 439 a 755 c 585 g 459 t
ORIGIN
1 gaattccctg gctgcttgaa tctgttctgc cccctcccca cccatttcac caccaccatg
61 acaccgggca cccagtctcc tttcttcctg ctgctgctcc tcacagtgct tacagttgtt
121 acaggttctg gtcatgcaag ctctacccca ggtggagaaa aggagacttc ggctacccag
181 agaagttcag tgcccagctc tactgagaag aatgctgtga gtatgaccag cagcgtactc
241 tccagccaca gccccggttc aggctcctcc accactcagg gacaggatgt cactctggcc
301 ccggccacgg aaccagcttc aggttcagct gccacctggg gacaggatgt cacctcggtc
361 ccagtcacca ggccagccct gggctccacc accccgccag cccacgatgt cacctcagcc
421 ccggacaaca agccagcccc gggctccacc gcccccccag cccacggtgt cacctcggcc
481 ccggacacca ggccgccccc gggctccacc gcccccccag cccacggtgt cacctcggcc
541 ccggacacca ggccgccccc gggctccacc gcgcccgcag cccacggtgt cacctcggcc
601 ccggacacca ggccggcccc gggctccacc gcccccccag cccatggtgt cacctcggcc
661 ccggacaaca ggcccgcctt gggctccacc gcccctccag tccacaatgt cacctcggcc
721 tcaggctctg catcaggctc agcttctact ctggtgcaca acggcacctc tgccagggct
781 accacaaccc cagccagcaa gagcactcca ttctcaattc ccagccacca ctctgatact
841 cctaccaccc ttgccagcca tagcaccaag actgatgcca gtagcactca ccatagcacg
901 gtacctcctc tcacctcctc caatcacagc acttctcccc agttgtctac tggggtctct
961 ttctttttcc tgtcttttca catttcaaac ctccagttta attcctctct ggaagatccc
1021 agcaccgact actaccaaga gctgcagaga gacatttctg aaatggtgag tatcggcctt
1081 tccttcccca tgctcccctg aagcagccat cagaactgtc cacacccttt gcatcaagcc
1141 tgagtccttt ccctctcacc ccagtttttg cagatttata aacaaggggg ttttctgggc
1201 ctctccaata ttaagttcag gtacagttct gggtgtggac ccagtgtggt ggttggaggg
1261 ttgggtggtg gtcatgaccg taggagggac tggtcgcact taaggttggg ggaagagtcg
1321 tgagccagag ctgggacccg tggctgaagt gcccatttcc ctgtgaccag gccaggatct
1381 gtggtggtac aattgactct ggccttccga gaaggtacca tcaatgtcca cgacgtggag
1441 acacagttca atcagtataa aacggaagca gcctctcgat ataacctgac gatctcagac
1501 gtcagcggtg aggctacttc cctggctgca gcccagcacc atgccggggc cctctccttc
1561 cagtgcctgg gtccccgctc tttccttagt gctggcagcg ggaggggcgc ctcctctggg
1621 agactgccct gaccactgct tttcctttta gtgagtgatg tgccatttcc tttctctgcc
1681 cagtctgggg ctggggtgcc aggctggggc atcgcgctgc tggtgctggt ctgtgttctg
1741 gttgcgctgg ccattgtcta tctcattgcc ttggtgagtg cagtccctgg ccctgatcag
1801 agccccccgg tagaaggcac tccatggcct gccataacct cctatctccc caggctgtct
1861 gtcagtgccg ccgaaagaac tacgggcagc tggacatctt tccagcccgg gatacctacc
1921 atcctatgag cgagtacccc acctaccaca cccatgggcg ctatgtgccc cctagcagta
1981 ccgatcgtag cccctatgag aaggtgagat tggccccaca ggccagggga agcagagggt
2041 ttggctgggc aaggattctg aagggggtac ttggaaaacc caaagagctt ggaagaggtg
2101 agaagtggcg tgaagtgagc aggggagggc ctggaaagga tgaggggcag aggtcagagg
2161 agttttgggg gacaggcctg ggaggagact atggaagaaa ggggccctca aaagggagtg
2221 gccccactgc cagaattc
//