GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMTRGV3S 598 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human rearranged gene for T-cell receptor gamma chain TRGV3-J2
previously designated V(b)-J(2)
ACCESSION X03437
KEYWORDS N-region; T-cell receptor; T-cell receptor gamma; joining region;
variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 598)
AUTHORS Lefranc,M.-P., Forster,A. and Rabbitts,T.H.
TITLE Rearrangement of two distinct T-cell gamma-chain variable-region
genes in human DNA
JOURNAL Nature 319, 420-422 (1986)
STANDARD full automatic
COMMENT *source: cell line=SUPT1; clone=lambda S12, lambda S1
Data kindly reviewed (06-JUL-1988) by Lefranc J.-M.
From EMBL entry HSTRGV3S; dated 22-MAR-1990.
FEATURES Location/Qualifiers
mRNA <1..51
/note="T-cell receptor gamma chain TRGV3-J2 exon 1"
misc_feature 9..51
/note="variable region V3"
CDS 9..51
/note="T-cell gamma chain precursor (51 is 1st base in
codon)"
/codon_start=9
CDS 9..51
/note="signal peptide (AA -16 to -3)"
/codon_start=9
intron 52..165
/note="intron"
mRNA 166..525
/note="T-cell receptor gamma chain TRGV3-J2 exon 2"
misc_feature 166..470
/note="variable region V3"
CDS 166..525
/note="T-cell gamma precursor (166 is 2nd base in codon)
(525 is 1 st base in codon)"
/codon_start=166
CDS 166..170
/note="signal peptide (AA -2 to -1)"
/codon_start=166
CDS 171..525
/note="mat. T-cell gamma chain (AA 1-118)"
/codon_start=171
misc_feature 471..476
/note="N region"
misc_feature 477..525
/note="joining region J2"
intron 526..>598
/note="intron"
BASE COUNT 165 a 124 c 150 g 159 t
ORIGIN
1 aggaaggcat gcggtgggcc ctactggtgc ttctagcttt cctgtctcct ggtgagtacg
61 ctgcctacag agaggctcac aggttgggtt ttgttttgtt ttcttcttga aaggggtgcc
121 atacaaagga atacctcatt gtattttgtg ttgttcccat tgcagccagt cagaaatctt
181 ccaacttgga agggagaacg aagtcagtca ccaggcagac tgggtcatct gctgaaatca
241 cttgcgatct tactgtaaca aataccttct acatccactg gtacctacac caggagggga
301 aggccccaca gcgtcttctg tactatgacg tctccaccgc aagggatgtg ttggaatcag
361 gactcagtcc aggaaagtat tatactcata cacccaggag gtggagctgg atattgagac
421 tgcaaaatct aattgaaaat gattctgggg tctattactg tgccacctgg cggacgaatt
481 attataagaa actctttggc agtggaacaa cacttgttgt cacaggtaag tatcggaaga
541 atacaacatt tccaaggtaa tagagggaag gcaggaaatg attaaactgg aataatgt
//