GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVAVPP 2757 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human mRNA for vav oncogene
ACCESSION X16316
KEYWORDS glycoprotein; oncogene; phosphoprotein; vav oncogene;
zinc finger protein.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2757)
AUTHORS Katzav,S., Martin-Zanca,D. and Barbacid,M.
TITLE vav, a novel human oncogene derived from a locus ubquitously
expressed in hematopoietic cells
JOURNAL EMBO J. 8, 2283-2290 (1989)
STANDARD full automatic
COMMENT SWISS-PROT; P15498; VAV$HUMAN.
*source: tissue=3rd cycle nude mouse tumor; library=lambda gt10;
*source: clone=pSK65; The nucleotides 1 - 167 are derived from
pSV2neo.
Data kindly reviewed (23-APR-1990) by Barbacid M.
From EMBL entry HSVAVPO; dated 12-JUL-1990.
FEATURES Location/Qualifiers
misc_feature 1..17
/note="SV40 early promoter"
misc_feature 18..167
/note="Tn5 bacterial transposase"
CDS 111..2501
/note="vav gene product (AA 1 - 797)"
/codon_start=111
misc_feature 168..2757
/note="vav human proto-oncogene"
misc_feature 2739..2744
/note="pot. polyA signal"
polyA_site 2757..2757
/note="polyA site"
BASE COUNT 693 a 713 c 809 g 542 t
ORIGIN
1 ctaggctttt gcaaaaagct tcacgctgcc gcaagcactc agggcgcaag ggctgctaaa
61 ggaagcggaa cacgtagaaa gccagtccgc agaaacggtg ctgaccccgg atgaatgtca
121 gctactgggc tatctggaca agggaaaacg caagcgcaaa gagaaagcag ttcctgtgcc
181 ttaagaacat tagaaccttc ctgtccacct gctgtgagaa gttcggcctc aagcggagcg
241 agctcttcga agcctttgac ctcttcgatg tgcaggattt tggcaaggtc atctacaccc
301 tgtctgctct gtcctggacc ccgatcgccc agaacagggg gatcatgccc ttccccaccg
361 aggaggagag tgtaggtgat gaagacatct acagtggcct gtccgaccag atcgacgaca
421 cggtggagga ggatgaggac ctgtatgact gcgtggagaa tgaggaggcg gaaggcgacg
481 agatctatga ggacctcatg cgctcggagc ccgtgtccat gccgcccaag atgacagagt
541 atgacaagcg ctgctgctgc ctgcgggaga tccagcagac ggaggagaag tacactgaca
601 cgctgggctc catccagcag catttcttga agcccctgca acggttcctg aaacctcaag
661 acattgagat catctttatc aacattgagg acctgcttcg tgttcatact cacttcctaa
721 aggagatgaa ggaagccctg ggcacccctg gcgcaccgaa tctctaccag gtcttcatca
781 aatacaagga gaggttcctc gtctatggcc gctactgcag ccaggtggag tcagccagca
841 aacacctgga ccgtgtggcc gcagcccggg aggacgtgca gatgaagctg gaggaatgtt
901 ctcagagagc caacaacggg aggttcactg cgcgacctgc tgatggtgcc tatgcagcga
961 gttctcaaat atcacctcct tctccaggag ctggtgaaac acacgcagga ggcgatggag
1021 caaggaaact gcggctggcc ctggatgcca tgagggacct ggctcagtgc gtgaacgagg
1081 tcaagcgaga caacgagaca ctgcgacaga tcaccaattt ccagctgtcc attgagaacc
1141 tggaccagtc tctggctcac tatggccggc ccaagatcga cggggaactc aagatcacct
1201 cggtggaacg gcgctccaag atggacaggt atgccttcct gctcgacaaa gctctactca
1261 tctgtaagcg caggggagac tcctatgacc tcaaggactt tgtaaacctg cacagcttcc
1321 aggttcggga tgactcttca ggagaccgag acaacaagaa gtggagccac atgttcctcc
1381 tgatcgagga ccaaggtgcc cagggctatg agctgttctt caagacaaga gaattgaaga
1441 agaagtggat ggagcagttt gagatggcca tctccaacat ctatccggag aatgccaccg
1501 ccaacgggca tgacttccag atgttctcct ttgaggagac cacatcctgc aaggcctgtc
1561 agatgctgct tagaggtacc ttctatcagg gctaccgctg ccatcggtgc cgggcatctg
1621 cacacaagga gtgtctgggg agggtccctc catgtggccg acatgggcaa gatttcccag
1681 gaactatgaa gaaggacaaa ctacatcgca gggctcagga caaaaagagg aatgagctgg
1741 gtctgcccaa gatggaggtg tttcaggaat actacgggct tcctccaccc cctggagcca
1801 ttggaccctt tctacggctc aaccctggag acattgtgga gctcacgaag gctgaggctg
1861 aacagaactg gtgggagggc agaaatacat ctactaatga aattggctgg tttccttgta
1921 acagggtgaa gccctatgtc catggccctc ctcaggacct gtctgttcat ctctggtacg
1981 caggccccat ggagcgggca ggggcagaga gcatcctggc caaccgctcg gacgggactt
2041 tcttggtgcg gcagagggtg aaggatgcag cagaatttgc catcagcatt aaatataacg
2101 tcgaggtcaa gcacacggtt aaaatcatga cagcagaagg actgtaccgg atcacagaga
2161 aaaaggcttt ccgggggctt acggagctgg tggagtttta ccagcagaac tctctaaagg
2221 attgcttcaa gtctctggac accaccttgc agttcccctt caaggagcct gaaaagagaa
2281 ccatcagcag gccagcagtg ggaagcacaa agtattttgg cacagccaaa gcccgctatg
2341 acttctgcgc ccgtgaccgt tcagagctgt cgctcaagga gggtgacatc atcaagatcc
2401 ttaacaagaa gggacagcaa ggctggtggc gaggggagat ctatggccgg gttggctggt
2461 tccctgccaa ctacgtggag gaagattatt ctgaatactg ctgagccctg gtgccttggc
2521 agagagacga gaaactccag gctctgagcc cggcgtggcg aggcagcgga ccaggggctg
2581 tgacagctcc ggcgggtgga gactttggga tggactggag gaggccagcg tccagctggc
2641 ggtgctcccg ggatgtgccc tgacatggtt aatttataac accccgattt tcctcttggg
2701 tcccctcaag cagacggggg ctcaaggggg ttacatttaa taaaaggatg aagatgg
//