GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMTEYMA 1721 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human mRNA for transmembrane epithelial tumour mucin antigen
ACCESSION X52229
KEYWORDS transmembrane protein; tumor antigen.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1721)
AUTHORS Wreschner,D.H.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1721)
AUTHORS Wreschener,D.H., Hareuveni,M., Tsarfaty,I., Smorodinsky,N.,
Horov,J., Zaretsky,J., Kotkes,P., Weiss,M., Lathe,R., Dion,A.S. and
Keydar,I.
TITLE Human epithelial tumor antigen cDNA sequences. Differential
splicing may generate multiple protein forms.
JOURNAL Eur. J. Biochem. 189, 463-473 (1990)
STANDARD full automatic
REFERENCE 3 (sites)
AUTHORS Hareuveni,M., Tsarfaty,I., Zaretsky,J., Kotkes,P., Horev,J.,
Zrihan,S., Weiss,M., Green,S., Lathe,R., Keydar,I. and
Wreschner,D.H.
TITLE A transcribed gene, containing a variable number of tandem repeats,
codes for a human epithelial tumor antigen. cDNA cloning,
expression of the transfected gene and over- expression in breast
cancer tissue.
JOURNAL Eur. J. Biochem. 189, 475-486 (1990)
STANDARD full staff_review
COMMENT SWISS-PROT; P17626; SETA$HUMAN.
*source: cell line=T47D breast tumour; library=lambda gt11; **map:
chromosome=1q21-24; See <X52228> for secreted tumour antigen.
From EMBL entry HSTEYMA; dated 21-JUN-1990.
FEATURES Location/Qualifiers
CDS 58..1602
/note="precursor polypeptide (AA -21 to 494)"
/codon_start=58
CDS 58..120
/note="signal peptide (AA -21 to -1)"
/codon_start=58
CDS 121..1602
/note="transmembrane tumor mucin antigen (AA 1 to 494)"
/codon_start=121
BASE COUNT 339 a 634 c 395 g 353 t
ORIGIN
1 gaattccctg gctgcttgaa tctgttctgc cccctcccca cccatttcac caccaccatg
61 acaccgggca cccagtctcc tttcttcctg ctgctgctcc tcacagtgct tacagttgtt
121 acaggttctg gtcatgcaag ctctacccca ggtggagaaa aggagacttc ggctacccag
181 agaagttcag tgcccagctc tactgagaag aatgctgtga gtatgaccag cagcgtactc
241 tccagccaca gccccggttc aggctcctcc accactcagg gacaggatgt cactctggcc
301 ccggccacgg aaccagcttc aggttcagct gccacctggg gacaggatgt cacctcggtc
361 ccagtcacca ggccagccct gggctccacc accccgccag cccacgatgt cacctcagcc
421 ccggacaaca agccagcccc gggctccacc gcccccccag cccacggtgt cacctcggcc
481 ccggacacca ggccgccccc gggctccacc gcccccccag cccacggtgt cacctcggcc
541 ccggacacca ggccgccccc gggctccacc gcgcccgcag cccacggtgt cacctcggcc
601 ccggacacca ggccggcccc gggctccacc gcccccccag cccatggtgt cacctcggcc
661 ccggacaaca ggcccgcctt ggcgtccacc gcccctccag tccacaatgt cacctcggcc
721 tcaggctctg catcaggctc agcttctact ctggtgcaca acggcacctc tgccagggct
781 accacaaccc cagccagcaa gagcactcca ttctcaattc ccagccacca ctctgatact
841 cctaccaccc ttgccagcca tagcaccaag actgatgcca gtagcactca ccatagcacg
901 gtacctcctc tcacctcctc caatcacagc acttctcccc agttgtctac tggggtctct
961 ttctttttcc tgtcttttca catttcaaac ctccagttta attcctctct ggaagatccc
1021 agcaccgact actaccaaga gctgcagaga gacatttctg aaatgttttt gcagatttat
1081 aaacaagggg gttttctggg cctctccaat attaagttca ggccaggatc tgtggtggta
1141 caattgactc tggccttccg agaaggtacc atcaatgtcc acgacgtgga gacacagttc
1201 aatcagtata aaacggaagc agcctctcga tataacctga cgatctcaga cgtcagcgtg
1261 agtgatgtgc catttccttt ctctgcccag tctggggctg gggtgccagg ctggggcatc
1321 gcgctgctgg tgctggtctg tgttctggtt gcgctggcca ttgtctatct cattgccttg
1381 gctgtctgtc agtgccgccg aaagaactac gggcagctgg acatctttcc agcccgggat
1441 acctaccatc ctatgagcga gtaccccacc taccacaccc atgggcgcta tgtgccccct
1501 agcagtaccg atcgtagccc ctatgagaag gtttctgcag gtaatggtgg cagcagcctc
1561 tcttacacaa acccagcagt ggcagccact tctgccaact tgtaggggca cgtcgccctc
1621 tgagctgagt ggccagccag tgccattcca ctccactcag ggctctctgg gccagtcctc
1681 ctgggagccc ccaccacaac acttcccagg catggaattc c
//