GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMTHR2 4957 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human gene encoding 5 exons of prothrombin. Exon 1 starts with
amino acid position 144 and exon 5 ends with amino acid 448 of
prothrombin.
ACCESSION V00596
KEYWORDS thrombin.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4957)
AUTHORS Friezner,d.S.J., MacGillivray,R.T. and Davie,E.W.
TITLE Characterization of the complementary deoxyribonucleic acid and
gene coding for human prothrombin
JOURNAL Biochemistry 22, 2087-2097 (1983)
STANDARD full automatic
COMMENT Data kindly reviewed (15-JUL-1983) by Degen S.J. Friezner
From EMBL entry HSTHR2; dated 06-JUL-1989.
FEATURES Location/Qualifiers
mRNA 1955..2269
/note="exon 1"
CDS 1955..2269
/note="prothrombin (part 1) (1955 is 2nd base in codon)
(2269 is 1st base in codon)"
/codon_start=1955
mRNA 2594..2722
/note="exon 2"
CDS 2594..2722
/note="prothrombin (part 2) (2594 is 2nd base in codon)
(2722 is 1st base in codon)"
/codon_start=2594
mRNA 2807..2933
/note="exon 3"
CDS 2807..2933
/note="prothrombin (part 3) (2807 is 2nd base in codon)
(2933 is 2nd base in codon)"
/codon_start=2807
mRNA 4091..4258
/note="exon 4"
CDS 4091..4258
/note="prothrombin (part 4) (4091 is 3rd base in codon)
(4258 is 2nd base in codon)"
/codon_start=4091
mRNA 4756..4929
/note="exon 5"
CDS 4756..4929
/note="prothrombin (part 5) (4756 is 3rd base in codon)
(4929 is 2nd base in codon)"
/codon_start=4756
BASE COUNT 1074 a 1386 c 1336 g 1161 t
ORIGIN
1 gaattcatgc caccttcaga gctggcgtca gtcattcaga tcatatctgt gcctattgct
61 cagtaaagtc agggaatcag gggatctgag tggggggatc tgccagcctc ctcctccccc
121 tccccactct tgacttcctt atggtctagg ctgtggctca ttccaaacat gcctcctttc
181 tgatcaaggc actcctccct ccgggaagcc ctccctagcc atttcagtcc acacaccctg
241 ttctgagtat cacagagcaa gccttgtgca gtttggcccg cgggattctg tcattattat
301 ttccttggtg tgttaagtag ctatagccac cccttccctg aggcagacca caataagcat
361 ttctttttcc catgagggtt ggcaggtgtg gctgcactcg ctaatgcgtc tgtagggtca
421 actgacggag gttggccctg gctgggtggc tctgattcaa ataatgggtc cagctgagtc
481 tggctcctcg ttgagggttg ggcctagatc tgctccacgt gcgttcatgc tggggctgag
541 gctgaaagaa ggtacctggg aaaactcttc ttatgctgat gacagacaca gaaaacaatg
601 aacagaaaag cgtcttctgt cctgaaggcc tggctcagaa caggcacagt cagccctgcc
661 cacgttccat tggccagagc aagtatatgt tcaaggccag ggtcaagagg taaactacac
721 ctcagcctgt aaaatcacag agcaagggat gtggatgcag gcaggggtaa agaatttgtg
781 ccgattacca gtccacaaac atgcgttagt gtttgttctc taggcaaccc tgtcgggccc
841 attgctcatt cctggggttg gtcttttttt tttttctttc taagaaggag tctcactccc
901 ttgcccaggc tgttggagtg cagtggccct atctcagctc actgcaacct ccgcctcctg
961 ggttcaagcg attcccctgc ttcagcctcc tgagtagcta ggattacagg cgtgtgccac
1021 cactcctggc taattttttt ttatgttagt agagacgggg tttcaccatg ttggccaggc
1081 tgatctcaaa ctcctgacct tgtgatcctc ccgcctcggc ctcccaaact gctgagatta
1141 caggggtgag gcactgcgcc cagccatttt tttttttttt tttttttgag atggagtctc
1201 actctcaccc aggctggagt gcagtggcat aatcttggct cactgcaacc tccacctcct
1261 gggttcaggc gattctctgc ctcagcctct catatagctg ggattacagg cacacgccac
1321 cacgccttgc taattttgta tttttagtag agacggggtt tcttcatgtt ggccttgcct
1381 gacttgaact ccttgttccg gtgatctgcc cagctcggcc tcccaaagtt ctgggattac
1441 aggtgtaagc cactgcgcct ggcccctggt attggtctta tagcaagttt atcccaacaa
1501 aaacagctac tatttactcc ccaaccccca tacacacgca cacacattga tgataaataa
1561 gttgcaggct tgcagaaatt ggcccatcca ggtgaacagc ctagtgatcc gagcaagcgt
1621 cctgctgtgc agctataaaa acatgactcc tccagcagct ccaggcagcc actaccagtt
1681 ggttacagat ggcctaggag gccaaacctg gttactatct ctggtttatt atgtgccaga
1741 cacttatgct gtatattttg tttaatcctc tcaacaaacc tgcaaaagtg gcattagtaa
1801 cccctttaaa ggcaaacggt cagaagccca gagaggttaa gtaacctgag gtcacacagg
1861 cagaaagcag caagaccggg gttcacaccc ctgtctgttc cggtccatgt gtggtctcac
1921 tcactctgct gcctccttgc ccctcaccca ccaggccagg atcaagtcac tgtagcgatg
1981 actccacgct ccgaaggctc cagtgtgaat ctgtcacctc cattggagca gtgtgtccct
2041 gatcgggggc agcagtacca ggggcgcctg gcggtgacca cacatgggct cccctgcctg
2101 gcctgggcca gcgcacaggc caaggccctg agcaagcacc aggacttcaa ctcagctgtg
2161 cagctggtgg agaacttctg ccgcaaccca gacggggatg aggagggcgt gtggtgctat
2221 gtggccggga agcctggcga ctttgggtac tgcgacctca actattgtgg tgagctgcct
2281 gggtaggggg cctgagttgc agggacaaat cctagtggga ataacaacag ccgcttctgc
2341 ttatcgaacg cttacctcat tgagtgcgct cattacagcc ttacagtaac caggtggggg
2401 gtaaggtcct gtgcccattt cacagataag tacactgagg ccccaggagg ttattgccta
2461 gtagcccaac tgtgcatgca cgcttaacct ctgcaccaaa tggcctccaa ggcccgtagg
2521 ggaactgggg ggatctaggg gatgggtgag gaatggccca gcccagtccc ggccggtgcc
2581 tgggtcccaa cagaggaggc cgtggaggag gagacaggag atgggctgga tgaggactca
2641 gacagggcca tcgaagggcg taccgccacc agtgagtacc agactttctt caatccgagg
2701 acctttggct cgggagaggc aggtgaggta gtgggcatcc gaggggatgc ggggctgcgg
2761 ggctggtggc caggacttgc ccctcactgc ttggcttgct ctgcagactg tgggctgcga
2821 cctctgttcg agaagaagtc gctggaggac aaaaccgaaa gagagctcct ggaatcctac
2881 atcgacgggc gcattgtgga gggctcggat gcagagatcg gcatgtcacc ttggtgtgtc
2941 ctggagccct gcgctaccat tcactcctgg gggcaggtgt gctgctggac ccccaccctc
3001 aggccctgcc tgcaggcctg ggctttacag atgacaacag ctgagcatcc aggatcccac
3061 caactccaca cagcagccac atgagatggg ttgtttactt cttttttttt tgtttcttag
3121 atggagtctt gctctgtcac ctaggctgga gtgcagtgct gcaatctcgg ctcactacct
3181 cgatctcagc tcactgcaac ttctgccttc cgggttcaaa cgattctctt gcctcagcct
3241 cctgagtagc tgaatttaca gacatgcgcc accacacccg gctaattttt gtattttaag
3301 tagagacagg gtttcaccat gttggccagg ctggtcttga actcctgacc tcaagtgatc
3361 cacctgcctc agcctcccaa agtgccggga ttacaggcat gagccaccac acccggccca
3421 tgggtccttt acttctaagc agatggtaaa gctgagactg acggagctgg tggctcacct
3481 ccgcgcacag ctaatgggtt tgaatccagt tcttctgatt ccagagctgt gctacgctat
3541 gtgaactctg gactggaagg acctagttag ggggtgcaaa aagcaggagg caggtcaggt
3601 gcagtggctc acccctgtaa tcccagcact ttgggaggcc aagacaggaa gatcacttga
3661 gggcaggagt tcgaggccag cttgggcaaa atggtaaaac cccgtctcta ctaaaaatgc
3721 aaaaattagc caggtgtagc agcatgtccc tgtagtccca gctactaagg aggctgaggc
3781 gggaggatcg cctgagccca agaggctgag gcttcagtaa gctgtgactg taccattgca
3841 ctccagcctg ggtgacaaga gtgagaccct gtctcaaaaa taaataaata aataaataaa
3901 aagtgtgagg cagcccctca gcatcacacg gaggctccag ccccaaaggc ggccagccca
3961 agcttggatc tgggccccgg aggcagctct gcccagctgg gttcttagac ctgggattgt
4021 tacttctagg gctggtgtag aggcagcccc ctcatcctca gctcctaatg cttcctgctg
4081 cccctcccag gcaggtgatg cttttccgga agagtcccca ggagctgctg tgtggggcca
4141 gcctcatcag tgaccgctgg gtcctcaccg ccgcccactg cctcctgtac ccgccctggg
4201 acaagaactt caccgagaat gaccttctgg tgcgcattgg caagcactcc cgcacaaggt
4261 acagaactgg tggcccgtgg gtgtctggca ggggtctgag tcctccaaag cgatcatgag
4321 gggccttggt ggctccggga cacataggat gttctgtata ccccccagaa tataacatcc
4381 cagcagtctc tgctggaaag ccatttggtc acgtcctgac tgaggcttgg agcgcgggga
4441 gaatccgtct gtctctggtc cctccaacac taggatatag cccatgtggg agtctctgaa
4501 aatagagtct gtctggacta gggcgtgcag cctgtgcccc tgtccccgtc ctccaggctg
4561 tctgactcca aagccctgca cggctttagg cccaggaaga aacacccagg gggctgccat
4621 ggcaggaacc agccctatcc cctccctggt ggcctgcagg acacactgtc tcccagaacc
4681 ccaagggcag gcagtttcct gctccttgct gggtgaacct gcagcttctc catttctttc
4741 ttggggtctc tgcaggtacg agcgaaacat tgaaaagata tccatgttgg aaaagatcta
4801 catccacccc aggtacaact ggcgggagaa cctggaccgg gacattgccc tgatgaagct
4861 gaagaagcct gttgccttca gtgactacat tcaccctgtg tgtctgcccg acagggagac
4921 ggcagccagg tgggccacca gatgcttgtt agcatga
//