GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKI 1394 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-I) gene (Va gene) ACCESSION X17262 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin; kappa light chain. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and Zachau,H.G. TITLE A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated. JOURNAL J. Mol. Biol. 183, 291-299 (1985) STANDARD full staff_review REFERENCE 2 (bases 1 to 1394) AUTHORS Klobeck,H.G. JOURNAL Unpublished (1989) STANDARD full automatic COMMENT *source: developmental stage=germline; tissue=placenta; *source: cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265> for other V kappa immunoglobulin genes. From EMBL entry HSVKI; dated 30-JUL-1990. FEATURES Location/Qualifiers mRNA <185..184 /note="exon 1" misc_feature 2..13 /note="(put.) pd regulatory element" misc_feature 33..42 /note="(put.) dc regulatory element" promoter 75..82 /note="TATA-box" CDS 130..184 /note="leader peptide (AA 1-18) (184 is 1st base in codon)" /codon_start=130 intron 185..310 /note="intron I" mRNA 311..606 /note="exon 2" CDS 311..606 /note="leader peptide/variable region (AA 19-117) (311 is 2nd base in codon)" /codon_start=311 misc_feature 609..615 /note="(non canonical) heptamer recombination signal" BASE COUNT 391 a 308 c 315 g 380 t ORIGIN 1 ctgcagctgt gtccagcctg cccatcctct gctcatttgc atattcccag aacacaacct 61 cctgccctga agacttctta ataggctggt cacacttctt gcaggagtca gacccactca 121 ggacacagca tggacatgag ggtccccgct cagctcctgg ggcttctgct gctctggctc 181 ccaggtaagg aaggagaaca ctaacagttt actcagccca gggggctcag tacagcctgg 241 ctattcaggg aaattctctt actacatgat taattgtgtg gaccatttgt gtttatgctt 301 ccaatctcag gtgccagatg tgccatccag ttgacccagt ctccatcctc cctgtctgca 361 tctgtaggag acagagtcac catcacttgc cgggcaagtc agggcattag cagtgcttta 421 gcctggtatc agcagaaacc agggaaagct cctaagctcc tgatctatga tgcctccagt 481 ttggaaagtg gggtcccatc aaggttcagc ggcagtggat ctgggacaga tttcactctc 541 accatcagca gcctgcagcc tgaagatttt gcaacttatt actgtcaaca gtttaataat 601 taccctcaca tagtgttaca aacccgaaca taaaccccca gggaagcaga tgtgtgagac 661 tgggctgccc cagctgcttc tcctgatgcc tccattggct gagagtgttc ctcagatgca 721 gccacactct gatggtgttg gtagaggagg atatgagatc acctctgcat cccaatttct 781 ttttcttttc tcagccccag ctgcacagac ataacaatgc ctctgctgat ttaataaaga 841 tagagatcat gacacctgaa gagtctagtt tatggctttg gttagaattc atataacaga 901 gaagaagcca ttatagatat tctaagcagg aatagtctta atagatagaa ttagagtcta 961 aagtattgaa gtctaaataa aatgtacaga taaatttagt gttttatttg ctaagaaatt 1021 tttgccaaat ggggcataca ggaaaactca atggtcttca atatgttgga agagcaaaga 1081 gttttataaa aagggaaatt attacctatt gttctttgag aaattttgtt ggctgtagta 1141 agggttggga gctggcaagc tcagactggt aagcagtggt ggtcaaactg aatcctagaa 1201 ttatattaag ttatctcaga agttgtgggt aaatttgctt tcaggttaca ataagccaaa 1261 gcagtgaagc ttgcagagaa ttttgttact gaaatgccag ggattcagta tagatcctgc 1321 ggctcaccac acagaaagcc aatcactaag acaacaagtg ttgtcaaaga acaggcttta 1381 atcaggtgct gcag //
GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKIB 885 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-I) gene (Vb gene) ACCESSION X17263 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin; kappa light chain. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and Zachau,H.G. TITLE A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated. JOURNAL J. Mol. Biol. 183, 291-299 (1985) STANDARD full staff_review REFERENCE 2 (bases 1 to 885) AUTHORS Klobeck,H.G. JOURNAL Unpublished (1989) STANDARD full automatic COMMENT *source: developmental stage=germline; tissue=placenta; *source: cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265> for other V kappa immunoglobulin genes. From EMBL entry HSVKIB; dated 30-JUL-1990. FEATURES Location/Qualifiers mRNA <186..185 /note="exon 1" misc_feature 2..13 /note="(put.) pd regulatory element" misc_feature 34..43 /note="(put.) dc regulatory element" promoter 76..83 /note="TATA-box" CDS 131..185 /note="leader peptide (AA 1-18) (185 is 1st base in codon)" /codon_start=131 intron 186..309 /note="intron I" mRNA 310..605 /note="exon 2" CDS 310..605 /note="leader peptide/variable region (AA 19-117) (310 is 2nd base in codon)" /codon_start=310 misc_feature 608..614 /note="(non canonical) heptamer recombination signal" BASE COUNT 207 a 240 c 208 g 230 t ORIGIN 1 ctgcagctgc gcccagcctg ccccatcccc tgctcatttg catgttccca gagcacagtc 61 tcctgacctg aagacttatt aacaggctga tcacaccctg tgcaggagtc agacccagtc 121 aggacacagc atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggtt 181 cccaggtaag aaaggagaac actaggatta tactcggtca gtgtgctgag tactgcttta 241 ctattcaggg aacttctctt acagcatgat taattgtgtg gacatttgtt tttatgtttc 301 caatctcagg ttccagatgc gacatccaga tgacccagtc tccatcttct gtgtctgcat 361 ctgtaggaga cagagtcacc atcacttgtc gggcgagtca gggtattagc agctggttag 421 cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct gcatccagtt 481 tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc tgggacagat ttcactctca 541 ctatcagcag cctgcagcct gaagattttg caacttacta ttgtcaacag gctaacagtt 601 tccctcccac agtgttacca acccgaacat aaacccccag ggaagcagat gtgtgaagct 661 gggctgcccc agctgctcct cctgatgcct ccattggctg agagtgttgc tcagatgcag 721 ccacactctg atggtgttgg tagaggggta cgtgaaatcg cctctgcacc ctaattcttt 781 tctctttctc agccccaact gcacagacat agcaatgcat ctcctgattt gataaataca 841 gagatcatga cacttgagga gtctagttta tggcttcagc ttgaa //
GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKII 906 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-II) gene (Vc gene) ACCESSION X17265 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin; kappa light chain. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and Zachau,H.G. TITLE A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated. JOURNAL J. Mol. Biol. 183, 291-299 (1985) STANDARD full staff_review REFERENCE 2 (bases 1 to 906) AUTHORS Klobeck,H.G. JOURNAL Unpublished (1989) STANDARD full automatic COMMENT *source: developmental stage=germline; tissue=placenta; *source: cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265> for other V kappa immunoglobulin genes. From EMBL entry HSVKII; dated 31-JUL-1990. FEATURES Location/Qualifiers mRNA <688..687 /note="exon 2" intron <1..377 /note="intron I" misc_feature 377..379 /note="stop codon (tga)" CDS 378..687 /note="leader peptide/variable region (103 AA) (378 is 2nd base in codon) (687 is 2nd base in codon)" /codon_start=378 mutation 626..626 /note="frameshift mutation" misc_feature 690..696 /note="(non canonical) heptamer recombination signal" BASE COUNT 242 a 219 c 210 g 235 t ORIGIN 1 ctgcagccac tgatgctaat atagttccat cccgccacct cccatgtgtg tcctgtcctc 61 gtgttagatg tgtcttgtcc tccaggatgg ggcatatgat gtctagatct gtgagagtga 121 ggaagattcc agaaggagca aggacatgta ctttagtgaa agctgtgaca cagaaagagg 181 gggatgggat aggtgacttc tagaggccgg ctttgccttg caaatattgg ttctttttaa 241 acctgtatgt tttgggagga ttaatcaaaa tcacacacac aaaaataatt gagcaaaaca 301 taaataacag acagaaaatg attaaaatga ctcacaatgt ttgcacataa ccttgcactt 361 ctctctcatt atttcatgat ccaatggaga tgctgcgaag acccaacctc cactctccct 421 gcccatcacc cctggagagc cagcctccat ctcctgcagg tctagtcaca gcccccttca 481 cagtaatgga tacatctatt tcaattggta cctacagaag ccaggccagc ctccttggct 541 cccaatctat ttagtttcca atcacgaccc tggagtccca gacaagttca gtggcagtgg 601 gtcggggaca gatttcatgc taaaatcagg aggatggatg ctgaggatgt tggggtttat 661 tgctgccagc aaagtacaca ttatcctccc acaatggtag agtcttgaac acaaacctcc 721 ccacttgctg tggcctagct gcccagatgt gctgtttctg tggagagcag gcactgtgga 781 ttctcttaga tgcctaaaga agaagatgtt ggagaactca gagggcttgg tgcagctgag 841 ggctcatgac cataaatttc tcggctacac ctcaggcatc acattttaag gtcccgtcag 901 ctgcag //
GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKIII 665 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-III) gene (Vg gene) ACCESSION X17264 KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin; kappa light chain. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and Zachau,H.G. TITLE A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated. JOURNAL J. Mol. Biol. 183, 291-299 (1985) STANDARD full staff_review REFERENCE 2 (bases 1 to 665) AUTHORS Klobeck,H.G. JOURNAL Unpublished (1989) STANDARD full automatic COMMENT *source: developmental stage=germline; tissue=placenta; *source: cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265> for other V kappa immunoglobulin genes. From EMBL entry HSVKIII; dated 31-JUL-1990. FEATURES Location/Qualifiers mRNA <132..131 /note="exon 1" promoter 22..29 /note="TATA-box" CDS 83..131 /note="leader peptide (AA 1-16) (131 is 1st base in codon)" /codon_start=83 intron 132..300 /note="intron I" mRNA 301..596 /note="exon 2" CDS 301..596 /note="leader peptide/variable region (AA 17-115) (301 is 2nd base in codon)" /codon_start=301 misc_feature 599..605 /note="heptamer recombination signal" BASE COUNT 174 a 183 c 146 g 162 t ORIGIN 1 ctgccctacc ttccagagcc catatcaatg cctgggtcag agctctgggg aggaactgct 61 cagttaggac ccagacggaa ccatggaagc cccagcgcag cttctcttcc tcctgctact 121 ctggctcaca ggtgagggga atatgaggtg tctttgcaca tcagtgaaaa ctcctgccac 181 ctctgctcag caagaaatat aattaaaatt caaaatagat caacaatttt ggctctactc 241 aaagacagtg ggtttgattt tgattacatg agtgcatttc tgttttattt ccaatttcag 301 ataccaccgg agaaattgtg ttgacacagt ctccagccac cctgtctttg tctccagggg 361 aaagagccac cctctcctgc agggccagtc agggtgttag cagctactta gcctggtacc 421 agcagaaacc tggccaggct cccaggctcc tcatctatga tgcatccaac agggccactg 481 gcatcccagc caggttcagt ggcagtgggc ctgggacaga cttcactctc accatcagca 541 gcctagagcc tgaagatttt gcagtttatt actgtcagca gcgtagcaac tggcatccca 601 cagtgattcc acatgaaaca aaaaccccaa caagaccatc agtgtttact agattattat 661 accag //