GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKI 1394 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-I)
gene (Va gene)
ACCESSION X17262
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
kappa light chain.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
Zachau,H.G.
TITLE A large section of the gene locus encoding human immunoglobulin
variable regions of the kappa type is duplicated.
JOURNAL J. Mol. Biol. 183, 291-299 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 1394)
AUTHORS Klobeck,H.G.
JOURNAL Unpublished (1989)
STANDARD full automatic
COMMENT *source: developmental stage=germline; tissue=placenta; *source:
cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
for other V kappa immunoglobulin genes.
From EMBL entry HSVKI; dated 30-JUL-1990.
FEATURES Location/Qualifiers
mRNA <185..184
/note="exon 1"
misc_feature 2..13
/note="(put.) pd regulatory element"
misc_feature 33..42
/note="(put.) dc regulatory element"
promoter 75..82
/note="TATA-box"
CDS 130..184
/note="leader peptide (AA 1-18) (184 is 1st base in
codon)"
/codon_start=130
intron 185..310
/note="intron I"
mRNA 311..606
/note="exon 2"
CDS 311..606
/note="leader peptide/variable region (AA 19-117) (311 is
2nd base in codon)"
/codon_start=311
misc_feature 609..615
/note="(non canonical) heptamer recombination signal"
BASE COUNT 391 a 308 c 315 g 380 t
ORIGIN
1 ctgcagctgt gtccagcctg cccatcctct gctcatttgc atattcccag aacacaacct
61 cctgccctga agacttctta ataggctggt cacacttctt gcaggagtca gacccactca
121 ggacacagca tggacatgag ggtccccgct cagctcctgg ggcttctgct gctctggctc
181 ccaggtaagg aaggagaaca ctaacagttt actcagccca gggggctcag tacagcctgg
241 ctattcaggg aaattctctt actacatgat taattgtgtg gaccatttgt gtttatgctt
301 ccaatctcag gtgccagatg tgccatccag ttgacccagt ctccatcctc cctgtctgca
361 tctgtaggag acagagtcac catcacttgc cgggcaagtc agggcattag cagtgcttta
421 gcctggtatc agcagaaacc agggaaagct cctaagctcc tgatctatga tgcctccagt
481 ttggaaagtg gggtcccatc aaggttcagc ggcagtggat ctgggacaga tttcactctc
541 accatcagca gcctgcagcc tgaagatttt gcaacttatt actgtcaaca gtttaataat
601 taccctcaca tagtgttaca aacccgaaca taaaccccca gggaagcaga tgtgtgagac
661 tgggctgccc cagctgcttc tcctgatgcc tccattggct gagagtgttc ctcagatgca
721 gccacactct gatggtgttg gtagaggagg atatgagatc acctctgcat cccaatttct
781 ttttcttttc tcagccccag ctgcacagac ataacaatgc ctctgctgat ttaataaaga
841 tagagatcat gacacctgaa gagtctagtt tatggctttg gttagaattc atataacaga
901 gaagaagcca ttatagatat tctaagcagg aatagtctta atagatagaa ttagagtcta
961 aagtattgaa gtctaaataa aatgtacaga taaatttagt gttttatttg ctaagaaatt
1021 tttgccaaat ggggcataca ggaaaactca atggtcttca atatgttgga agagcaaaga
1081 gttttataaa aagggaaatt attacctatt gttctttgag aaattttgtt ggctgtagta
1141 agggttggga gctggcaagc tcagactggt aagcagtggt ggtcaaactg aatcctagaa
1201 ttatattaag ttatctcaga agttgtgggt aaatttgctt tcaggttaca ataagccaaa
1261 gcagtgaagc ttgcagagaa ttttgttact gaaatgccag ggattcagta tagatcctgc
1321 ggctcaccac acagaaagcc aatcactaag acaacaagtg ttgtcaaaga acaggcttta
1381 atcaggtgct gcag
//GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKIB 885 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-I)
gene (Vb gene)
ACCESSION X17263
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
kappa light chain.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
Zachau,H.G.
TITLE A large section of the gene locus encoding human immunoglobulin
variable regions of the kappa type is duplicated.
JOURNAL J. Mol. Biol. 183, 291-299 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 885)
AUTHORS Klobeck,H.G.
JOURNAL Unpublished (1989)
STANDARD full automatic
COMMENT *source: developmental stage=germline; tissue=placenta; *source:
cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
for other V kappa immunoglobulin genes.
From EMBL entry HSVKIB; dated 30-JUL-1990.
FEATURES Location/Qualifiers
mRNA <186..185
/note="exon 1"
misc_feature 2..13
/note="(put.) pd regulatory element"
misc_feature 34..43
/note="(put.) dc regulatory element"
promoter 76..83
/note="TATA-box"
CDS 131..185
/note="leader peptide (AA 1-18) (185 is 1st base in
codon)"
/codon_start=131
intron 186..309
/note="intron I"
mRNA 310..605
/note="exon 2"
CDS 310..605
/note="leader peptide/variable region (AA 19-117) (310 is
2nd base in codon)"
/codon_start=310
misc_feature 608..614
/note="(non canonical) heptamer recombination signal"
BASE COUNT 207 a 240 c 208 g 230 t
ORIGIN
1 ctgcagctgc gcccagcctg ccccatcccc tgctcatttg catgttccca gagcacagtc
61 tcctgacctg aagacttatt aacaggctga tcacaccctg tgcaggagtc agacccagtc
121 aggacacagc atggacatga gggtccccgc tcagctcctg gggctcctgc tgctctggtt
181 cccaggtaag aaaggagaac actaggatta tactcggtca gtgtgctgag tactgcttta
241 ctattcaggg aacttctctt acagcatgat taattgtgtg gacatttgtt tttatgtttc
301 caatctcagg ttccagatgc gacatccaga tgacccagtc tccatcttct gtgtctgcat
361 ctgtaggaga cagagtcacc atcacttgtc gggcgagtca gggtattagc agctggttag
421 cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct gcatccagtt
481 tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc tgggacagat ttcactctca
541 ctatcagcag cctgcagcct gaagattttg caacttacta ttgtcaacag gctaacagtt
601 tccctcccac agtgttacca acccgaacat aaacccccag ggaagcagat gtgtgaagct
661 gggctgcccc agctgctcct cctgatgcct ccattggctg agagtgttgc tcagatgcag
721 ccacactctg atggtgttgg tagaggggta cgtgaaatcg cctctgcacc ctaattcttt
781 tctctttctc agccccaact gcacagacat agcaatgcat ctcctgattt gataaataca
841 gagatcatga cacttgagga gtctagttta tggcttcagc ttgaa
//GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKII 906 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-II)
gene (Vc gene)
ACCESSION X17265
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
kappa light chain.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
Zachau,H.G.
TITLE A large section of the gene locus encoding human immunoglobulin
variable regions of the kappa type is duplicated.
JOURNAL J. Mol. Biol. 183, 291-299 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 906)
AUTHORS Klobeck,H.G.
JOURNAL Unpublished (1989)
STANDARD full automatic
COMMENT *source: developmental stage=germline; tissue=placenta; *source:
cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
for other V kappa immunoglobulin genes.
From EMBL entry HSVKII; dated 31-JUL-1990.
FEATURES Location/Qualifiers
mRNA <688..687
/note="exon 2"
intron <1..377
/note="intron I"
misc_feature 377..379
/note="stop codon (tga)"
CDS 378..687
/note="leader peptide/variable region (103 AA) (378 is 2nd
base in codon) (687 is 2nd base in codon)"
/codon_start=378
mutation 626..626
/note="frameshift mutation"
misc_feature 690..696
/note="(non canonical) heptamer recombination signal"
BASE COUNT 242 a 219 c 210 g 235 t
ORIGIN
1 ctgcagccac tgatgctaat atagttccat cccgccacct cccatgtgtg tcctgtcctc
61 gtgttagatg tgtcttgtcc tccaggatgg ggcatatgat gtctagatct gtgagagtga
121 ggaagattcc agaaggagca aggacatgta ctttagtgaa agctgtgaca cagaaagagg
181 gggatgggat aggtgacttc tagaggccgg ctttgccttg caaatattgg ttctttttaa
241 acctgtatgt tttgggagga ttaatcaaaa tcacacacac aaaaataatt gagcaaaaca
301 taaataacag acagaaaatg attaaaatga ctcacaatgt ttgcacataa ccttgcactt
361 ctctctcatt atttcatgat ccaatggaga tgctgcgaag acccaacctc cactctccct
421 gcccatcacc cctggagagc cagcctccat ctcctgcagg tctagtcaca gcccccttca
481 cagtaatgga tacatctatt tcaattggta cctacagaag ccaggccagc ctccttggct
541 cccaatctat ttagtttcca atcacgaccc tggagtccca gacaagttca gtggcagtgg
601 gtcggggaca gatttcatgc taaaatcagg aggatggatg ctgaggatgt tggggtttat
661 tgctgccagc aaagtacaca ttatcctccc acaatggtag agtcttgaac acaaacctcc
721 ccacttgctg tggcctagct gcccagatgt gctgtttctg tggagagcag gcactgtgga
781 ttctcttaga tgcctaaaga agaagatgtt ggagaactca gagggcttgg tgcagctgag
841 ggctcatgac cataaatttc tcggctacac ctcaggcatc acattttaag gtcccgtcag
901 ctgcag
//GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMVKIII 665 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human germline kappa-immunoglobulin variable region (V-kappa-III)
gene (Vg gene)
ACCESSION X17264
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa immunoglobulin;
kappa light chain.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Pech,M., Smola,H., Pohlenz,H.D., Straubinger,B., Gerl,R. and
Zachau,H.G.
TITLE A large section of the gene locus encoding human immunoglobulin
variable regions of the kappa type is duplicated.
JOURNAL J. Mol. Biol. 183, 291-299 (1985)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 665)
AUTHORS Klobeck,H.G.
JOURNAL Unpublished (1989)
STANDARD full automatic
COMMENT *source: developmental stage=germline; tissue=placenta; *source:
cell line=placenta St; **map: chromosome=2p12; See <X17262-X17265>
for other V kappa immunoglobulin genes.
From EMBL entry HSVKIII; dated 31-JUL-1990.
FEATURES Location/Qualifiers
mRNA <132..131
/note="exon 1"
promoter 22..29
/note="TATA-box"
CDS 83..131
/note="leader peptide (AA 1-16) (131 is 1st base in
codon)"
/codon_start=83
intron 132..300
/note="intron I"
mRNA 301..596
/note="exon 2"
CDS 301..596
/note="leader peptide/variable region (AA 17-115) (301 is
2nd base in codon)"
/codon_start=301
misc_feature 599..605
/note="heptamer recombination signal"
BASE COUNT 174 a 183 c 146 g 162 t
ORIGIN
1 ctgccctacc ttccagagcc catatcaatg cctgggtcag agctctgggg aggaactgct
61 cagttaggac ccagacggaa ccatggaagc cccagcgcag cttctcttcc tcctgctact
121 ctggctcaca ggtgagggga atatgaggtg tctttgcaca tcagtgaaaa ctcctgccac
181 ctctgctcag caagaaatat aattaaaatt caaaatagat caacaatttt ggctctactc
241 aaagacagtg ggtttgattt tgattacatg agtgcatttc tgttttattt ccaatttcag
301 ataccaccgg agaaattgtg ttgacacagt ctccagccac cctgtctttg tctccagggg
361 aaagagccac cctctcctgc agggccagtc agggtgttag cagctactta gcctggtacc
421 agcagaaacc tggccaggct cccaggctcc tcatctatga tgcatccaac agggccactg
481 gcatcccagc caggttcagt ggcagtgggc ctgggacaga cttcactctc accatcagca
541 gcctagagcc tgaagatttt gcagtttatt actgtcagca gcgtagcaac tggcatccca
601 cagtgattcc acatgaaaca aaaaccccaa caagaccatc agtgtttact agattattat
661 accag
//