GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMIFNB3 14055 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human interferon-beta-3 gene. ACCESSION K03196 KEYWORDS interferon. SOURCE Human fetal DNA (library of T.Maniatis), clone lambda-B3. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Sehgal,P.B., May,L.T., Sagar,A.D., Laforge,K.S. and Inouye,M. TITLE Isolation of novel human genomic DNA clones related to human interferon-beta-1 cDNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80, 3632-3636 (1983) STANDARD full staff_review REFERENCE 2 (bases 2957 to 2996) AUTHORS Sagar,A.D., Sehgal,P.B., May,L.T., Inouye,M., Slate,D.L., Shulman,L. and Ruddle,F.H. TITLE Interferon-beta-related DNA is dispersed in the human genome JOURNAL Science 223, 1312-1315 (1984) STANDARD simple staff_review REFERENCE 3 (bases 1 to 14055) AUTHORS May,L.T. and Sehgal,P.B. JOURNAL Unpublished (1985) , Rockefeller U., 1230 N.Y.Ave, N.Y.,N.Y. 10021 STANDARD simple staff_review REFERENCE 4 (bases 13970 to 14053) AUTHORS May,L.T., Landsberger,F.R., Inouye,M. and Sehgal,P.B. TITLE Significance of similarities in patterns: An application to beta interferon related DNA on human chromosome 2 JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 4090-4094 (1985) STANDARD simple staff_review COMMENT [1] sites. The genomic clone lambda-B3 was isolated by hybridization to a previously isolated interferon-beta-1 encoding clone. [1] reports that lambda-B3 is likely to contain a functional interferon-beta gene. [4] presents a map of interferon-beta-1 homologous regions and Alu repeats within this locus (figure 4). A draft entry and computer-readable copy of this sequence was kindly sent by electronic mail by P.B.Sehgal (28-AUG-1985). FEATURES Location/Qualifiers conflict 2989..2989 /location=Science 223, 1312-1315 (1984) | 33..34 misc_feature 3319..3385 /note="putative VECTOR sequence Vector pUC19 (M11662)" repeat_region 7270..7501 /note="Alu repeat" misc_feature complement(7789..7811) /note="putative VECTOR sequence Bacteriphage M13mp18 (M11454)" BASE COUNT 4057 a 3181 c 3076 g 3741 t ORIGIN Chromosome 2p23-qter; 1 bp upstream of EcoRI site. 1 gaattcatcg ctgctgctga tgatgtgttt gtcattgttt acagaaagca agagaaagag 61 gagaaaagtt aaggagcatc cggtgcagtg gctcagtcct gtaagcccaa cactttggag 121 gccaagacag gagaatcgct tgagcccagc agtttgagac cagcctgggc aacatagcga 181 gactccatcc cttcaaaaaa atttaaataa attagccagg tgtggtggtg catgcctgta 241 gtcccagcta cttgggaggc tgagggcagg gaggatccgg atggagttac ccgcgacaag 301 ctcaaagcac tgaaacagcg ggaggcagca tgaaaccaat gatattcgat ctcaagctac 361 ctcattgggc ttttctgctt gagtgtccgt tctgtggcgg cggcgcagaa cttttttctg 421 atggtgatgg tgtctacgcc ggttgttcaa caaagcaatg cttgattaag ccgataactg 481 acacctatcc aacaaagcgc gatgcaattc gcgctggaat cggaggcatc atgacagaga 541 cgagataacg atacaggcga agcgttaagg cgcagatgtc cgtcaatagt aagaccagtc 601 agatcaagat cgcgtgtcgc aggatattta cgtaatatgg catttctggg gcattagctt 661 atatacatcc tagttacgta taggcgaaat tgccaggatc gaatataatt gggtttcatt 721 gctgtcctcc cagtctgttt caagttggct tgaagcttgt cggggttacg tacaatgccc 781 gggattcgct gtatgcatga ccttgtgcca gcagcttatc ctgtcatgcc atggcaagcc 841 gacaagaatt gctagataac gcctttcttc cgttaacaac gagcttgcaa ctgacactga 901 cactaaggat cggatggctg ggcagtttga cacgggaaag ggatggcttt ccggggcata 961 cgtacctact tcgtgaggat ctttacctct cgacaaatcg gcattagcca gcccagatat 1021 agcactggag agagactctc atgagcaggc acgtaagtta tgcaggtaaa tctcagagca 1081 ctgtcctgaa ctcgatgaat cagctcggtc aggcgtgctt aacggttctc tccgcttttg 1141 cataccagga ttattcaaga acgtgctgcc agcactccga aaatgtcgaa ttcgctgtga 1201 ctggtggcgg actttacaga ggcgcaagtg tttcaccaac aaggtctcat accatcggcg 1261 gaacgcctta ctgtcgaaat ctgatccagt gcgcggtctt taaagacatg gagcatttgt 1321 gcgcagctga tttgtgacag atcaatggtg gctcgacata acaagagatc gcgaccaaag 1381 gctttgattc atctcttcat acacgcgatg cggtttcacg gcacgttgtc gaagtgggtt 1441 ttgcgcagca taacgtgcgt ttacgctgct ggcagtcggc gaccattctt tacgacacgg 1501 cagacgaccg cttttgcatc tcctgcgcca tcaacagcag tgtcagcgcc gttagcatca 1561 gagcatacga gatcctgaga tcatatgagc aacttcagcc gctattgagg agttgtcgcc 1621 gaatgccata aacacaggag tctatggctg attccattct ctcaaaagta acgagatgaa 1681 aataattttc cctaatgttg aaaatatata ggaaataggt attgcatttc gcggaaaaac 1741 tggatagatt catctctaac gctggaatac gttcagtcgt tccgaagcca aaaaaattca 1801 agcccgaggt taacgccttg ggcttttttt atttctttgt ggcctaaatc gcttcgagcc 1861 aaaaaaacgc ggagaacgac atcacccctc tccgcaataa cgactcaatc tcatacccgc 1921 ttgtctttct tttatccaca aagaggtaaa gccataactt agtggaaatg gtaacagcta 1981 aaaactattt gaaaagctaa ttattttttg catcaactgg ctattcttaa ggattgttta 2041 attttttcct ttctagcgag aaagaagctc ggaaactatc aatcaataca ggctgacgtt 2101 ggcggacttt ttatcctagc aagcactcgc aagcaaagca gtaatatgta tgcgatgaca 2161 aactaaccga ctgctcctat gcgcttcagc cggagcatcc taaacggcat gtgaatgcct 2221 acagccccga gcagtgaacg ctatcggcgt gctggtgggt atcatcattg ccgtaatgac 2281 gtatctgaca aatctctatt tcaaaatccg cgaagacaac cgccgcagca ggagccgaga 2341 tgaacccaac gttagaataa gctggtgggt gccattgttg gcggatcagg ggcggtcact 2401 attgctgcag ccacaacctc ctgggcgcaa cgaatcctcc cacctgaacc ttgcaagtag 2461 ctgggactac aggcgcacac catcatacct gggctagttt tttgttgttg ttgttgttgt 2521 tttgtagttt tttttatagt ttttttttgt agaaatgaca tttcaccaca ttgcccaggc 2581 tggtctcaaa ctcctcccac tcaagtgatc ctctgccttg gcctttcaaa gtgctgggat 2641 tatgggcgtg aagcgtgccc agcaacaagt ctttaattta aatgagagat ataaaagtcc 2701 aattgccatg ttcaatgctt tctctacctc tcaaccatac tcccataaat attgaaaatg 2761 attgatttgg tctgtacacc aaggatacac tcctcaccct aaggggttat gacaacaggg 2821 aaatactcat ctcatttttg tgatgggctg attagagcca gaaaccttct gatttccttg 2881 atctaaatat tttttccctc ttgtagcttc aaaaaaaaaa atgctagcaa atgcacagtc 2941 catgtccttg gtattcaaag tgtgctccct gaatcagcag cagcagaatc acctgggagt 3001 gtgacggaaa tgcagtgtcc tggggaccca ctctgtgctg gatcttgctg aatcagaacc 3061 tacatttgga caggatcctt ggctcactgc aacctctgcc tcctgggttc aagcgattct 3121 cctgccgcag cctcccgagt aactcagact acaggtgtgc gccaccaaag cccggctaat 3181 ttttgtattt ttagtagaga tggggtttca ccatgttggc caggctggtc tggaactcct 3241 gacctctagt gatcgcaagc aacgatgcag ctttaatcga caacgaccac aagcattaaa 3301 atcgtcgtta atcgcaaagg cgatcctcta gagtcgacct gcaagcccaa gcttgggcgt 3361 aatcatggtc aataagctgt ttcctgtgtg aatgtatcgc tcacaatcca aacatacgag 3421 ctaaaggata gtaagtctct gcttagttaa agtagagagt aaaggaataa gcatttcaga 3481 gaaaaggaga aagcataata caggaacaga gtcaaatgac aggaaactct agatcacctt 3541 agagaataaa ctcttaaagt cagcagtctg tacacagaga agctctggtt tggtcatcct 3601 tcaggtagca ggtgcaacag ttagttgtag aaacatggat gtggttatct aattctgaga 3661 agactcagga cttcttcact gcaaagctca gcagagaaat ctatgtcaac agagacatct 3721 gtaatgcttg acacatccca ggcaaatgcc ggaacgcctc tgttcctata agatcttgca 3781 gtgctatgga gagagtgtaa agatgattaa gctactctcc ttagcctcaa gcaacttagc 3841 atggcagatg ggagataacc tgaaagctgc tgattagaat agaccaagag tgataaggac 3901 cttctgtgct ctgggtaggg gaggcatggg agatctagta gacaacggga gctcaatcac 3961 tggttgtgtg agtgtcctga gctgttattc tctctgaagc aattgcccta tttgtagatg 4021 gaatcaacta tattttatgg ctcccggatt cccaatttta ttggattgct ctcatgcctt 4081 ccatctagtt gctaaacaaa acaacaagaa agcctacctg cctcaatatt ctcatttagg 4141 ccaaataaac tgccctgtta catacaccaa cgcacctgaa cgagctcttt caaggaagaa 4201 cactcagctc tctaacatta aagacacaag gcaggaaacc atacatcaca ctgaggtgag 4261 gtcaggtgca ttaagcaggc tctaggctag agcgcagagt ccaagagcga cgcctgccta 4321 gatatggtcc tgtgctggaa cctagctact aacttctcct cctcttgaga tgagtctccc 4381 tctgtcgccc aggctggagt gcagtggcac gatctccgct cactgcaacc tctgcctcct 4441 aggttcaagc gattctcctg cctcagcctc tggagtagct cggactacac ttgtgtgcca 4501 ccatgctcag ctaatttttt gtatttttag ttgagatggg gtttcaccat gttggccagg 4561 ctggcctcga actcctgacc tcaagtgatc cgcctgcctc ggcctcccaa agtgctggga 4621 ttacaggtgt gagtcactgc accccgccaa agtttggtgg cctttctcta ttttctaaat 4681 gtgtttgaga ctctaaatac taggaaaatg taacagaggt cattaactga gggagcttac 4741 ctccaaaaca ttttccaaag ggcagagaag cataacatga tcattctgac agctgtgaca 4801 aatgtgggtt tatttgcctg actgcctctg tgtccattta tctatgatca ctgaggcctc 4861 atactcctgc tcaggaaatg tacccagctg tccacttaga ggtacagctg accaagagtc 4921 tcaaagtctt ccttgacaat ccgaaagtac ctaagcaccc atcgccattg gagagggtgc 4981 ccttgaaggg taaccacttt accatttggc acaaggactt cttggcccca tcgggacctt 5041 gacgatgacc tttgatcctc tgcagaggaa ccaacagttc agcatttgct gcgggcaagg 5101 agccaatagc aactactctg ccgaaattat cctctcccag gtcttactta ttaaattcag 5161 aagtgtccag ctctgaacta agaggggatt ttcctctgca tccataaaga tgctacggag 5221 gattattttc aatcttttac tgtgtggcct atatcttaca tgttgcctta tttaatagca 5281 tgatcaccag gagttggact gtaccctaaa agatgaggaa acacagccct gcctaagacc 5341 cacaaaagaa gcacctggct ccagaactgt cagatcctga agcatccgtg ttggttcatg 5401 cttttctaga gccatcctac tccctcaata tgaagagctc aaataagatg gctagacttt 5461 aaagtgaact tatttattca ttcaacctta ttcgtgaaag ggaccaggaa aatgagtggt 5521 aactagagag ggagacagag tcaggggagt tttgggatgt gacattaaag tgatgcacac 5581 tcatggccaa tctagagtga ggacactact acaggcagca gacacacccc gtagcagcat 5641 ggggtggggg ctgagacccc agaaggcccc ttctcccaca ggaaagggga agccagaccc 5701 acggctccaa catgggcagg ctggtggtaa gctgggtatc tggtgttggg aagatgggtg 5761 ctgaacattg cagaaagcag gagggagggg gttagatcac tcgcaaaacc ttggccttgc 5821 cagctgctgt ttcatgctgg ggcctacagg aaacagggtg gtcaccttct ccgttcacac 5881 cctagaaggg gtggaattta tgtgtcacat ttgggtctca gagttctccc cccaaagcag 5941 gcatgcttct gacgggtggt agagggaggg ggggtaaacg gcccccatca aggctaaagc 6001 agctgctctc tctctctccg tcgcgttatc atctctggga tggtatacac ttccctcatt 6061 cgttccattg cgctgccaaa gctttacctg agcccacggt gtaaaagttg ctatgggaac 6121 atgaaaataa atccaggctg aacttgccct caaagaacat atcctcctta tagaagactt 6181 acacacacaa gttagataaa ttaaggaggt tagcagggtt tggcagttta gggggagtag 6241 attaattcca gctggagcag cgtagtactt cccaacttta atgtatagaa gaatcacctg 6301 agacatttcc ctatgggtct ctttctcccc ataaaattct gttattcctg gatcttttta 6361 gagcagaaga caatgacttt gctgatggta tagtcctatg agttgaagaa tgtggccttt 6421 aacaataaat ctaacaaaga tgttaatcag aattatttcg accttatcac agagatccaa 6481 ggaaatttca aatttcacaa ctacaaaagg cttaaagtca ggaaactgca gttcaattgt 6541 taagcgtctc tctcttcaac ccatggagct aagaaggtac acatcagtgt ttgtgatcaa 6601 atccactacc ccaaactggg cctatcttag agtttagtaa tgttgataag tggcgcttca 6661 aaggaagccc acatcatcct aaaataagct gggaatgaga aaagtcccca gctgaaacag 6721 gaaggggatc acacacagac attccatttc caaatttcct tcccggcgga gatccgtgcc 6781 cttcggtaca gtgtcaggaa accggagggt ctgtgatgag ataagcagac acctgctctc 6841 cccacattct tggagctact cagttctccc cggagaatag aaatgggcca cagagctcat 6901 tacacattca agcatgaagc tgaaatatct ccatttaata acctagggtc ttcagagtaa 6961 caccatcaca gacgcattcc acctcttgtc aaggatgaga gtgaacaagg ccctgaggcc 7021 acaaaagaat gaggagcaga ggaggaggct tttcttaatc actagtaatt atcactatca 7081 tgttacaagc aaacaaatat cattttggaa atccagaaca atctccatga ggtaaagaat 7141 tttaactaac tgggcgggcc agaattctaa ctggcagcac ttactacaca ttgtcacaac 7201 aaaaaagtaa ttttattttt tcaaatgcat atgtagcaag gggctaaatt aaaaaggtat 7261 tggcggcctg gccaggtggt ggctcatgcc tgtaatctca gcactttggg aggccaaggc 7321 aggcggatca ctagaggtca ggagttccag accagcctgg ccaacatggt gaaaccccat 7381 ctctactcaa aaatacaaaa attcagccgg gctttggtgg cgcacacctg tagtctgagt 7441 tactcgggag gctgcggcag gagaatcgct tgaacccagg aggcagaggt tgcagtgagc 7501 caagatcctc tgcctcagcc tcccaagcta gctgggacta caggcatgca ccaccacacc 7561 tggctaatta tttaaatttt tttgaaggga tggagtctcg ctatgttgcc caggctggtc 7621 tcaaactgct gggctcaagc gacttctcct gtcttggcct cccaaagtgt tgggcttcaa 7681 aggactgagc cactgcaccc ggatgctcct taaacttttc tcctctttct ctttgccttt 7741 ctgttaaaaa ccaaagacac aaccaccatc atcagcagca ggcatgaatc gtaatcatgg 7801 tcatagctgt tcgtgtgaat gtatccgcta catcacacac acagagcgag ctaaggtagc 7861 ggcccacatg tcacacaaaa agtaatttat tttcaaatgc gtatgtagca agggctgaaa 7921 ttgaaaaagg ctattggcgc ccagccccag atttcttttt ctatgtagtg ctatgactat 7981 tactaactaa atgttcatca tctgcaaagc ctaacctttc gttcaatttc ttgccccaat 8041 agctaataat cataatagtg aataaggtaa acttataagt aggcagaaca atataaacag 8101 tttatgactt gtggctgaca tttaacgagc acctactatg tgaaaggtgc tttcatcaga 8161 ctataggtat ttatttccct ggatcctccc cagctgcagt gctggacagt tgtccatctc 8221 attttacatt ttacagagga ggaaactgaa tgtctggcct cccctaggcc tcaccagctg 8281 gtagatgggt caagctggga tacaaaccca gccttcttga ctaccctacc cactgttatt 8341 tcactgagcc aaggctgaga aacgcagtca ctctggttct acggaagagc tgccttctct 8401 gatgtgatgg ttgttcgatt attttaaaaa gtcggggtag gaaaggactg aaaaaattat 8461 acgcacacac cttaaacaat ttactggaac ggaaaacatt cattcctcaa tcttgtgaag 8521 gccaaggcct tctctttaga gtggggatct gctgactaga gttctgtggt ctttccggca 8581 acaaccacac cccatccaca caccctgcaa tgtcagattt caggttcctt caaggagagt 8641 ttcactactt acaaagtaga aaatcctcta gatttttttg ttttgttttg tttttgagat 8701 ggagactcgc tctgtcaccc aggctggagt gcaatggcgt gatctcagct cactgcaacc 8761 tccgccttct gcgttcaagc tattctcttg cctcagcctc ctgagctagc tgggactaca 8821 ggtgcccgcc cccatgcccg gctaattttt gtatttttag tagagatggg gtttcaccat 8881 gttggccagg ttggtctcaa tctcttgacc tcgtgatcca ccctcctcgg cctcccaaag 8941 tcctgagata acaggcgtga gccaccgtgc cggcctcaac ccttctagat tttacctaca 9001 ccatcccctc tttatttata ctgattgtct caaccacacc ttaaacaaca ggaatttctt 9061 tataagttgt tttgcaactc tttccaaaac acataactta gttttcaaaa aaagcagttc 9121 tcttttcaca ctaatatgtc atccgtgtat gtactatttt ggttacataa ttacaaaagc 9181 aagtacatgt ggcaaaaaaa aaaaaaaaaa caagtctggg ggaaaccgca actgatcagt 9241 aagcacagag ctcatctggg gagggacatg gcagggacaa ggaagagagc cactacaggc 9301 ccagtgcctg atggtcaatg acaggatgag acacagtcac tttgcagcag ccagtgcagc 9361 ctgttaagag agctccctcc agacccccca atccccatat acctgtgagc aacttggaaa 9421 cagtgaacat cctatcagaa aataaagcct gttagagaaa gaataaaagg atgagacaca 9481 attaagatgg tcaaataacc acaagtcttt tctagtccca gggtctctct gagcctcaat 9541 ccttgttgaa acgtacagtt aaaacaagat tccttgtgca gttgctgcag gaattaaata 9601 agaacactat ggaaagtgcc cagcccaggc cttggaacac agaaattact caataaacgg 9661 gctctttacc tgatttatcg tggtatctct ctcccacagt gcctagcaac atgctgtgaa 9721 gtaagtaagc tctgatggct ggacagaaag acggacagat ggtctgatgt cagaactgta 9781 aaaatcttca gtttatcact tgcttggctc aatggcccta aacaatcaat gtatctgtag 9841 ctggagtcag agtgtccact gaaataatct attaccatgc atgcatgaga gaccagagta 9901 ggaataaagg aagagataaa caagagaatt aaaaagtatc agacccagat gttaaacaaa 9961 aaaactggct cactggcaga taaatctttt ttcccctctt cccgccaatt gtggttatta 10021 agaatgagga cacattagaa taagtgtgat ttttttttca aggcacagag aaatttatag 10081 acaagctaaa tccagcaaaa agataaatca tttaccctta gttttcagta aatagaaagt 10141 ctccaaaagt tgaaaggaaa acagttccag aataaccacc atgtggtttt ggtttcaagt 10201 acttagcatt tcataacagg cgcaggttca ctgagaagat atttaaactc tgaaacgagg 10261 caggtgcaga atacatgcgt ttcaattgtg gatgtgatag gaatggaaag taggcagaaa 10321 ttgaaggctt tttttaattt aacgaatcaa tcagcagata aagctttcac tcactgtaaa 10381 ttttctgttt acaaaagctc cacatgctag gatgacacac ccaaagacta gggaggggac 10441 actatactgt ggaaagaaaa acatctccat tttcacagaa ggagcccaaa gtcaggccta 10501 ccctttgaag tttcagttag ctcccatctt cctgccaatc acccacctta agtccaagga 10561 ggctttacaa ctattagatc tcctagcgag cgcactctcc ttagcctagt aacatattta 10621 tattgatcca cctaagttgg aaatatgagt tgttaagaca gctccatgtt tcttctgggt 10681 tttttctttt ttcttttttc ttttttttgg agatgagttt cactcttgtt gcccagtctg 10741 cattgcaatg gcatgatctc ggctcactgc aacctctgcc tccgggttca agtgattctc 10801 agggctcaga ctctcaagta gctgagatta caggtgcaat gccacagcca cagcctggct 10861 aatttttgtg ttttagtaga gacagggtta gtcatattgg tcagtctggt ctcgactctg 10921 acctaggtga cgtctgctag ctcaatctga tacagcatag catcgccgct ctctgaatct 10981 taagcacgtg ttaagcctca gtttctcatc tgtgaacaga gcaatgaaac ctacttgagc 11041 cagccattgt gagaactaac aataacagac ttagcacata caataagttc tcaatccatg 11101 gtagctgctg attcttcttt ttgctctgca taattaaggg ggaaaactga gtatcttgag 11161 tcaataaaat ttggacgaga gaaaaaaatt ggtaacccct agtgttaata agacttccag 11221 agaagaagca tttggcaata caacagaagc ctacaaatgc ttacggccct cactcggcaa 11281 tcccacagtg aggactgcca tgcctaggga aataagatat gcaaaaagag tgcacaggat 11341 gccttctgca gcatcattta gaatactgga aacctctaca agcaaaagat aattaacagt 11401 gggggaaatg gccaaataaa cagttgtgtg ttcataggag ttgttcctgc agctccgagt 11461 agctgggatt acaggtatgt gccaccacgc ctggctaatt tttttatttt tggtagagtg 11521 gggtttctcc atgttggtca ggctggtttc gaactcctga cctcaggtga tctgcctgcc 11581 tcggcctccc aaagtgctgg gattacaggc atgagccact gcgccgggct agatttttgt 11641 ttttaaatga tcatattgta atcatttttc ctgctgcagc aagagaatcg cttgaactgg 11701 ggcaggcaga ggctgtggtg agccaagatc gcaccattgc actccaccct gggcaacaag 11761 agcgaaattc cgtctcaaaa aaaaaaaaaa aaaaaaaacc acggaaaatc tgtactcaaa 11821 actttcggga tttcatgtta taaatatatt taaaatagta tgtacccatt gtgtgtctat 11881 aaatattagg agaaaagtac aacaaaatac tacattaggt atttccaaat ggcaaaatta 11941 caggtaactt ttatatgttg tcagagaatt gtttgtattt ttgaaattct gtgcaagtaa 12001 tttatttaaa gtcaggaaaa agttattaaa aagtttgtgg gtgtgggtat gtgtctgtga 12061 tggagaggga caaagcacac actaaagaga accaactgga agcacgccat taattgctga 12121 tgcttgagta catactattt taaatatatt tataacatga atccaagttt gagtacatga 12181 aaatgagcaa tgcccatgtt cccaggtctt aaaggaaatg accacaggct taatgtaact 12241 caaaccgtgg gcctaaaggg aatcctattc tttctcttct ttctgtacta ttatttgtgc 12301 caaaagaaaa aaaagaaagc ctcccaaacc tcaaaccaca ttgaaatgca tgagcagcac 12361 ataattctgt agcattttgg tttccttggc aaccttatct ctgtcttctt tgatctcacc 12421 acagatgaaa aagtcttggt tctccaaagt ccctgagatc aattgccagc tagacagtag 12481 cagaacatgg tagaatgctc attctctaag aaagaatttc taattaatga gtttcttcac 12541 accaagctca ttccacaatg gattttagag aacagattct tgatgcattt accatttgag 12601 ttctgagctg tctgattttc atattaccac aatttaattt tagcatcacg taaacataat 12661 taatcttttc accaagtgaa tgaaacaagg aaattacatt taagcctcca attttgctaa 12721 atagtactgg tgctcctaaa tatttacctg ctctctccac ttcaggtccc ttgagcagga 12781 cgtggtgggg tttccaggcc taaatctaac ctgcaaatgt caaactggaa aacactgcta 12841 cagaggctgt gagcaaagcc ctgaggtctg aatactattg gcagaatgtt atgaagaaat 12901 caggagataa ttccaaatgg acatggagaa acctaagtca tccgattatg attcagtaag 12961 tataagaggg cttaaacatt tatggaattt gtgtccaccc ttaagtcatt ttctaagaaa 13021 tgtctagctg gataaactga atgaaattag gtatgtcata cacagattca ttgagccata 13081 aacgtttact gggggcctac tatatatgtg gcattgatag gtcttgaggc ccaaatgtag 13141 agaaggacat ttctgttcaa acacctgaac cagagaccct ctcaaaatag tgcatcaaaa 13201 atgcattttt cagcctaggt gcagtggctc acacctataa tccagcactt tgggaggctg 13261 aggtgagagg atcacttgag gccaagaggt tgagactagc cggaaacatg gagagaccta 13321 gtctctacaa aacaaacaaa cgaaaacgaa acattagcca gcatgtgctg cacctgtagt 13381 cctagtagct actcgagcta gcggagactg tttgagccaa gaggttgcag tgagctatga 13441 ttgcgctact cattccagcc tgggcaacag agcaagacct tgtcaccaat ttttaaaaga 13501 aaatacaatt ttcaatgtgt agaagaaaat ataaggctcc aatgaatgtt gggtggctag 13561 tcccatcttc acgatcctat caatggcaaa aatcttagga taaactcaaa ttattgcttc 13621 ccacgagaat ccaaaggacg ctgatttgag aacaggctat gcgggagtga tggtgtgtcc 13681 gctggggtat cacaaaagct taagcacacc agttaccaag ctttctcttt ttctgtcttg 13741 aactactgtc ccgaatctca tttctcgagt tgacgctcag catgattcaa tttaagctcc 13801 aaccttgact taaacccttt atcatgcgta tccagaaagc aaaaaggatc ataagcatct 13861 tactattttg agtactctaa gctgttaatg aaagtatttg cccatgttcc caaagagaca 13921 aaaccctcgc ccagcttcct cggcttaagt ggtgacagca acaatctttg ctctttcagg 13981 gcacgaaagg tctctcaccc gatttcaaag aaactatgat atcttccttc agaagctgct 14041 catgcaaatg aattc //