GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMIGHHIVA 417 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human IgH anti HIV1 antibody mRNA, VDJ-region.
ACCESSION M67500
KEYWORDS diversity exon; immunoglobulin heavy chain; joining exon;
variable region.
SOURCE Human adult blood B-cell, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 417)
AUTHORS Andris,J.S., Johnson,S., Zolla-Pazner,S. and Capra,J.D.
TITLE Molecular characterization of five human anti-HIV-1 antibody heavy
chains reveals extensive somatic mutation typical of an antigen-
immune response
JOURNAL Proc. Natl. Acad. Sci. U.S.A. (1991) In press
STANDARD full staff_entry
FEATURES Location/Qualifiers
sig_peptide complement(1..57)
/gene="IgH"
/codon_start=57
CDS 1..417
/product="anti-HIV1 antibody"
/gene="IgH"
/codon_start=1
mat_peptide 58..417
/product="anti-HIV1 antibody"
/gene="IgH"
/codon_start=58
/partial
BASE COUNT 75 a 133 c 105 g 104 t
ORIGIN
1 atgaaacacc tgtggttctt cctcctgctg gtggcagctc ccagatgggt cctgtccctc
61 ctgcaactac aggagtccgg ctcaggactg gtgaagcctt cacagaccct gtccctcacc
121 tgcactgtct ctggtggctc catcagcagt ggtgggtatg cctggacctg gatccggcag
181 ccaccaggga agggcctgga gtggattgga ttcatctatt attatggagg cgcctcttac
241 aacccgtccc tcgagagtcg agtcaccttg tcagcagaca cttccaagaa ccaaatctcc
301 cttcagctga cctctgcgac cgccgcggac acggccgtat attattgtgc cagatccttt
361 ggcgtctatt tctacctcga tctctggggc cgtagcaccc tggtctctgt ctcctca
//GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMIGHHIVE 432 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human IgH anti HIV1 antibody mRNA, VDJ-region.
ACCESSION M67504
KEYWORDS anti-HIV1 antibody; diversity exon; immunoglobulin heavy chain;
joining exon; variable region.
SOURCE Human adult blood B-cell, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 432)
AUTHORS Andris,J.S., Johnson,S., Zolla-Pazner,S. and Capra,J.D.
TITLE Molecular characterization of five human anti-HIV-1 antibody heavy
chains reveals extensive somatic mutation typical of an antigen-
immune response
JOURNAL Proc. Natl. Acad. Sci. U.S.A. (1991) In press
STANDARD full staff_entry
FEATURES Location/Qualifiers
sig_peptide complement(1..57)
/gene="IgH"
/codon_start=57
CDS 1..432
/product="anti-HIV1 antibody"
/gene="IgH"
/codon_start=1
/partial
mat_peptide 58..432
/product="anti-HIV1 antibody"
/gene="IgH"
/codon_start=58
/partial
BASE COUNT 94 a 123 c 120 g 95 t
ORIGIN
1 atggggtcaa ccgccagcct cgccctcctc ctggctgttc tccaaggagt ctgtgccgag
61 gtgcagctgg tgcagtctgg agcagaggtg aaaaagccgg gggagtctct gaagatctcc
121 tgtaagggtt ctggatacac ctttaacgac aactggatcg gctgggtgcg ccagatgccc
181 gggaaaggcc tggagtggat ggggatcatc tatcctgatg actctgacag cacagtcagt
241 ccgtcattcc aaggccaggt caccatctca gccgacaagt ccaccagcac cgcctacctg
301 cagtgcagca gcctgaaggc ctcggacacc gccatctatt actgtgcgag actaggcaca
361 tattactatg atggtattcc ttatacgtac tttgactatt ggggtcaggg aaccctggtc
421 accgtctcct ca
//