WEAKER@uthscsa.bitnet (05/27/91)
We are interested in mapping receptor tyrosine phosphatases. Does anyone know
the chromosomal assignment for LAR ?
Victor Sylvia
Cellular & Structurl Biology
U.T. Health Sci. Ctr.'
7703 Floyd Curl Dr.
San Antonio, TX 78284-7762
(512) 567-3843
(512) 567-6781 FAX
{ITNET: weaker@uthscsaBITNETRdadler@MILTON.U.WASHINGTON.EDU (David Adler) (05/27/91)
Hi LAR maps to 1p32-p34, Here is the OMIM entry: *179590 RECEPTOR-LINKED PROTEIN TYROSINE PHOSPHATASE LAR [LEUKOCYTE ANTIGEN RELATED TYROSINE PHOSPHORYLASE; LAR] -------------------------------------------------------------------------------- The LAR gene encodes a membrane protein that has a cytoplasmic domain | with homology to protein tyrosine phosphatase 1B (176885) and an | extracellular domain homologous to the neural cellular adhesion | molecule NCAM (116930). By in situ hybridization, Disteche et al. (1989) mapped the LAR gene to 1p34-p32. The related leukocyte | common antigen (LCA; CD45; 151460) also maps to chromosome 1. References Disteche, C. M.; Adler, D. A.; Tedder, T. F. and Saito, H.: Mapping of the genes for LYAM1, a new lymphocyte adhesion molecule, and for LAR, a new receptor-linked protein tyrosine phosphatase, to human chromosome 1. (Abstract) Cytogenet. Cell Genet. 51: 990 only, 1989. Last Edited: 2/4/91 We physically mapped this by in situ hybridization. You can get answers to such questions directly with an account at the Genome Database at Johns Hopkins (McKusick's database is also available via the same system). Accounts are free an accessible via INTERNET or dial up. David