joe@GENETICS.WASHINGTON.EDU (Joe Felsenstein) (06/06/90)
My apologies for posting a 153-line message. The following is material from the PHYLIP version 3.3 manual about programs distributed by others. Since I have just used the net to advertise my own programs, the programs by others should be mentioned too. Here are some of the other phylogeny packages that I know about: 1. David Swofford (Illinois Natural History Survey, Natural Resources Building, 607 East Peabody Drive, Champaign, Illinois 61820, U.S.A.) distributes PAUP (Phylogenetic Analysis Using Parsimony). Since December, 1985, Swofford has been distributing a precompiled executable object-code versions of PAUP for the IBM PC and other MSDOS systems. As of this writing (May, 1990) he was about to release version 3 (PAUP/Mac) for the Macintosh, and later in the year hopes to release version 3 for PCDOS systems and ultimately for mainframes. Its cost is $50. Orders received for the Mac version before its release will be filled but the printed documentation will arrive later, after the formal release. PAUP 3.0 is probably the most sophisticated parsimony program. It allows multistate characters, user-defined weights on individual state transitions, Wagner, Camin-Sokal and Dollo parsimony methods, bootstrap confidence intervals, and finding all most parsimonious trees by branch-and-bound. It also has provision for computing Lake's linear phylogenetic invariants. PAUP is (a great) many times faster than the parsimony programs in PHYLIP. 2. Swofford also distributes an older package of programs, BIOSYS-1, including some phylogeny estimation programs, for use with gene frequency data, with particular attention to distance methods. BIOSYS-1 is distributed on an IBM PC-formatted floppy disk. Included are precompiled versions for the IBM PC and source code for uploading to IBM, VAX/VMS, Unix, Prime and CDC mainframes and minicomputers. The price is $35.00. BIOSYS-2 is under development, but it is too early to anticipate a completion date. 3. If you have a Macintosh computer and any interest in discrete-state parsimony methods (including DNA and protein parsimony), you should definitely get MacClade. As of this writing it was distributed by Wayne Maddison, Department of Integrative Biology, University of California, Berkeley, California 94720. U.S.A. David Maddison and he have produced a program enabling you to use the mouse-window interface to specify and rearrange phylogenies by hand, and watch the number of character steps and the distribution of states of a given character on the tree change as you do so. MacClade is positively addictive and will give you a much better feel for the tree and your data. It's the closest thing to a phylogeny video game that I have seen. It has been influential in spurring the inclusion of interaction and graphics into other phylogeny programs. (I have tried to supply this functionality in PHYLIP by incorporating the programs MOVE, DOLMOVE, and DNAMOVE, which act somewhat like MacClade). MacClade does not have a sophisticated search algorithm to find best trees: it largely relies on you to do it by hand (which is surprisingly effective), with only a local rearrangement algorithm available to improve on that tree. Version 2.1 was released in March 1987. Version 3, with a spread-sheet data editor, support for polytomies, charting facilities, PHYLIP, PAUP, and HENNIG86 compatibility, and many other new features, is coming soon. The program is originally written in Lightspeed Pascal but is provided in pre-compiled form, and is available for distribution cost ($6 in North America, $8 overseas, or three or four Macintosh diskettes in barter). It requires a 512K Macintosh, Macintosh Plus, or larger. In the near future the distribution of version 3 will be on a commercial basis by Sinauer Associates of Sunderland, Massachusetts, although versions 1 and 2 will continue to be freely distributable. Version 2 is also available by electronic mail from the EMBL and Houston net servers which distribute free software for molecular data analysis, in their Mac software. 4. J. S. Farris (41 Admiral Street, Port Jefferson Station, New York 11776, U.S.A.) has produced Hennig86, a fast parsimony program including branch- and-bound search for most parsimonious trees and interactuve tree rearrangement. Although complete benchmarks have not been published it may be a bit faster than Swofford's PAUP; both are a great many times faster than the parsimony programs in PHYLIP. The program is distributed in executable object code only and costs $50. 5. Jotun Hein, currently at the Universite de Montreal has produced TreeAlign, a multiple sequence alignment program that builds trees as it aligns DNA or protein sequences. It uses a combination of distance matrix and approximate parsimony methods. The program is large, and is available in C source from either the EMBL or the Houston net servers, from which you can fetch PC, Mac, or VAX programs free for molecular data. On EARN or BITNET you can send an electronic mail message to NETSERV@EMBL with a "Subject: " line that reads HELP SOFTWARE. On BITNET or Internet you can send to the Houston server which is: genbank-server@uhnix2.uh.edu a message that has a "Subject: " line: SEND UNIX HELP or SEND VMS HELP to receive a file telling you how to get further sofware from them, including TreeAlign. TreeAlign uses so much memory that it cannot be run on PC's (DOS or Mac systems) but is really designed for a workstation or mainframe. You can also get TreeAlign over Internet by anonymous ftp from lavaca.uh.edu from the appropriate subdirectory of pub/genbank-server. 6. David Penny (Department of Botany and Zoology, Massey University, Palmerston North, New Zealand) has offered (I believe for free) a fast parsimony program, TurboTree. Contact him for details. 7. Andrey A. Zharkikh, Yu. V. Rzhetsky, and their co-workers in the Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences of the USSR, Novosibirsk 630090, USSR are offering VOSTORG, a package of programs for alignment and analyzing phylogenies for molecular sequences on IBM PC-compatibles that include some rather fancy graphics. I do not know the exact conditions of distribution: Zharkikh and Rzhetsky ask that interested parties contact them at that address. 8. Joyce Miller of the Department of Plant Pathology, University of Wisconsin, 1630 Linden Drive, Madison, Wisconsin 53706 is offering RESTSITE, a program for PC-compatibles to construct phylogenies from restriction site or restriction fragment data. It is distributed for free (send her two 360K PCDOS floppy diskettes) and includes programs to compute genetic distances from restriction site or fragment data and two PCDOS computer programs to do UPGMA and neighbor-joining methods for constructing phylogenies from the distance matrices. Some source code is also included. 9. J. S. Farris earlier released a package of phylogeny programs, PHYSYS, which, at about $5,000, was extremely expensive (in my opinion, which is certainly a biased one). 10. Kent Fiala's program CLINCH is available for doing compatibility analysis of characters. Fiala's program finds largest cliques of characters. It has more options and can handle more kinds of data than the compatibility program in PHYLIP. It is available in both mainframe and IBM PC versions (PC- CLINCH), for free. It is written in FORTRAN, and for the IBM PC the compiled source code is also distributed. For information, write Kent Fiala (Department of Ecology and Evolution, SUNY, Stony Brook, New York 11794, U.S.A.), 11. Walter Fitch (Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92717, U.S.A.) has available, as far as I know for free (or for media and mailing cost), a large number of FORTRAN programs for not only estimating trees but doing various other manipulations of data that might be needed in studies of molecular evolution (for example, looking for homologies among sequences). These programs were originally written for the Univac system at Wisconsin He has gradually been rewriting these to work on microcomputers, and as he does so, Fitch will be releasing them; some are available already. 12. Philip Taylor (MRC Institute of Virology, University of Glasgow, Glasgow G11 5JR, U.K.) offers a FORTRAN-66 program, DENDRON, for distance matrix analyses, which he says obtains results superior to those of my program FITCH (it does not, comparing his examples with my current version of that program). The conditions of distribution are not stated (Taylor, 1988). 13. Christopher Meacham (University Herbarium, University of California, Berkeley, California 94720, U.S.A.) distributes COMPROB, a FORTRAN program to compute probabilities that characters would be compatible at random, thus telling us which clique is "most surprising". Chris also makes his phylogeny plotting programs PLOTREE and PLOTGRAM available. These were formerly distributed in PHYLIP (up to version 3.2). Some code from them is incorporated into DRAWGRAM and DRAWTREE, but particularly PLOTREE is different in the kinds of diagrams it can draw from either of those programs. ----- Joe Felsenstein, Dept. of Genetics, Univ. of Washington, Seattle, WA 98195 Internet/ARPANet: joe@genetics.washington.edu (IP No. 128.208.128.1) BITNET/EARN: FELSENST@UWALOCKE UUCP: ... uw-beaver!uw-entropy!uw-evolution!joe