jaimatadi@sys.ife.ethz.ch (Perdeep Mehta) (01/24/91)
I am an user of GCG package, more precisely of multiple sequence analysis (MSA). But there, I don't really see any means to see significance of scores generated by profilesearches i.e. score distribution plots which truely are the graphic representation of the performance of probe sequences against an average database. The size of databases has doubled and I find many interesting sequences but even after GCG release 6.2, still, I manipulate all the data manually to construct histograms, where neither the time is saved nor a good quality is achieved. Recently in "Methods of Enzymol."(vol. 183) in an artical on Profile analysis by Gribskov et al., the Z-score distribution plots of even better representation have been shown. Any advice or means on this recurring problem are gratefully acknowledged. Perdeep Mehta Biochemisches Institut der Universitaet Zuerich E-mail: jaimatadi@sys.ife.ethz.ch