[bionet.sci-resources] NIH Guide for Grants and Contracts: 8 April 1988

CIMBALA@BIONET-20.ARPA (04/10/88)

From: Jim.Cassatt@BIONET-20.ARPA

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From:     CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU
Date:     Sat, 09 Apr 88  08:00:49 EDT
Subject:  NIH Guide 4/08/88

Enclosed is the Table of Contents and Items of Interest from the
NIH Guide to Grants and Contracts, April 8, 1988.

Jim Cassatt
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Vol. 17, No. 13, April 8, 1988


                                   NOTICES


NUMBERS OF COPIES OF APPLICATIONS TO BE SUBMITTED FOR AIDS
EXPEDITED REVIEW ..........................................(84/102)......... 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTE OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION


HUMAN SUBJECT (IRB) CERTIFICATIONS AND ANIMAL SUBJECT (IACUC) VERIFICATIONS -
AIDS EXPEDITED REVIEW .....................................(105/223)........ 1
National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration
Index:  NATIONAL INSTITUTES OF HEALTH
        ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION


RECEIPT DEADLINES FOR AIDS RESEARCH AND AIDS RESEARCH CENTER
GRANT APPLICATIONS ........................................(226/299)........ 2
Alcohol, Drug Abuse, and Mental Health Administration
Index:  ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION


APPLICATION ASSIGNMENT SUGGESTIONS ........................(302/323)........ 3
Division of Research Grants
Index:  DIVISION OF RESEARCH GRANTS


NIH REGIONAL SEMINAR IN GRANTS ADMINISTRATION .............(326/367)........ 4
National Institutes of Health
Index:  NATIONAL INSTITUTES OF HEALTH


                     DATED ANNOUNCEMENTS (RFAs AND RFPs)


LEARNING DISABILITIES:  MULTIDISCIPLINARY RESEARCH CENTERS (RFA) .(373/439). 4
National Institute of Child Health and Human Development         (644/1065)
National Institute of Neurological and Communicative Disorders and Stroke
Index:  CHILD HEALTH AND HUMAN DEVELOPMENT
        NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE


INVESTIGATION OF TISSUE COMPOSITION AND FUNCTION BY MRI USING PARAMAGNETIC
AND/OR SUPERPARAMAGNETIC CONTRAST AGENTS (RFA) ....(442/508, 1068/1348)..... 5
National Cancer Institute
Index:  CANCER


                        ONGOING PROGRAM ANNOUNCEMENTS


BASIC STUDIES IN BONE MARROW TRANSPLANTATION (PA) .........(514/598)........ 6
National Institute of Allergy and Infectious Diseases
Index:  ALLERGY AND INFECTIOUS DISEASES














                                   NOTICES


NUMBERS OF COPIES OF APPLICATIONS TO BE SUBMITTED FOR AIDS
EXPEDITED REVIEW

P.T. 34;  K.W. 0715120, 1014002

National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration

The number of copies of applications required for investigator-initiated AIDS
research project grant (R01) or First Independent Research Support and
Transition (FIRST) award (R29) applications for expedited review has been
increased to facilitate faster processing.  Commencing with the May 2, 1988,
receipt date, applicants to NIH and ADAMHA must now submit the original
application plus 32 legible copies if they wish the applications to receive
expedited review.  The number of copies of appendix materials remains at 6.
Applicants for other mechanisms of AIDS research, development and training
support should refer to earlier notices from the NIH and ADAMHA in the Guide
for Grants and Contracts (Vol.  17, No. 9, March 11, 1988), for the correct
numbers of copies to be submitted and other relevant information.


HUMAN SUBJECT (IRB) CERTIFICATIONS AND ANIMAL SUBJECT (IACUC) VERIFICATIONS -
AIDS EXPEDITED REVIEW

P.T. 34;  K.W. 0715120, 1014003, 0783005

National Institutes of Health
Alcohol, Drug Abuse, and Mental Health Administration

The following instructions apply to applications for all mechanisms of support
for AIDS research submitted to ADAMHA and NIH for expedited review commencing
with the September 1, 1988, receipt date:

  o  If the applicant has an approved assurance covering the research
     (multiple project assurance for human subjects/full Assurance of
     Compliance for animal subjects), the applicant should provide, with
     the application, certification of institutional review board (IRB)
     approval if humans are involved and verification of institutional
     animal care and use committee (IACUC) approval if animals are
     involved.  These reviews and approvals should occur PRIOR TO
     SUBMISSION OF the applications for award and the certifications and
     verifications should be SUBMITTED WITH the applications.  Failure
     to provide required certifications and verifications within
     applications could result in deferral or rejection.

  o  If animals or humans will be subjects of the research at
     PERFORMANCE SITES OTHER THAN THE APPLICANT ORGANIZATION, the
     applicants must identify, within the applications, the assurance
     status of each participant.  Failure to provide this information
     within applications could result in deferral or rejection.

Inquiries regarding the expedited processing of AIDS applications should be
addressed to the appropriate NIH or ADAMHA AIDS Coordinator:

National Institute of Child Health and Development
Dr. Antonio Novello
Telephone:  (301) 496-1848

National Institute of General Medical Sciences
Dr. Elke Jordan
Telephone:  (301) 496-7061

National Institute of Diabetes and Digestive and Kidney Diseases
Dr. Walter Stolz
Telephone:  (301) 496-7277

National Institute of Arthritis and Musculoskeletal and Skin Diseases
Dr. Steven Hausman
Telephone:  (301) 496-7495

National Heart, Lung, and Blood Institute
Dr. Frances Pitlick
Telephone:  (301) 496-7416



                                      1
National Institute of Dental Research
Dr. Matthew Kinnard
Telephone:  (301) 496-7784

Division of Research Resources
Dr. James O'Donnell
Telephone:  (301) 496-6023

National Institute of Environmental Health Sciences
Dr. Anne Sassaman
Telephone:  (919) 541-7723

National Institute of Allergy and Infectious Diseases
Dr. John Diggs
Telephone:  (301) 496-7291

Division of Research Grants
Dr. Hugh Stamper
Telephone:  (301) 496-7179

National Cancer Institute
Dr. Paul Rambaut
Telephone:  (301) 496-4218

National Institute of Neurological and Communicative Disorders and Stroke
Dr. John Dalton
Telephone:  (301) 496-9248

Division of Contracts and Grants
Mr. Curtis Tate
Telephone:  (301) 496-4422

National Center for Nursing Research
Dr. Jan Heinrich
Telephone:  (301) 496-0526

National Eye Institute
Dr. Jack McLaughlin
Telephone:  (301) 496-5983

National Library of Medicine
Mr. Arthur Broering
Telephone:  (301) 496-4621

Fogarty International Center
Dr. Bettie Graham
Telephone:  (301) 496-6688

National Institute on Aging
Dr. Miriam Kelty
Telephone:  (301) 496-9322

National Institute on Drug Abuse
Dr. Roy Pickens
Telephone:  (301) 443-6697

National Institute on Alcohol Abuse and Alcoholism
Mr. Steve Long
Telephone:  (301) 443-1284

National Institute of Mental Health
Dr. Lyle Bivens
Telephone:  (301) 443-3563


RECEIPT DEADLINES FOR AIDS RESEARCH AND AIDS RESEARCH CENTER
GRANT APPLICATIONS

P.T. 34;  K.W. 0715120, 1014002

Alcohol, Drug Abuse, and Mental Health Administration

The Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) reminds
applicants that the review schedule for the ADAMHA AIDS program announcements
listed below is no longer valid.  Applications submitted in response to ADAMHA
AIDS program announcements must be received on the special receipt dates (May
2, September 1, January 2), and will be handled in accordance with the
expedited procedures described in the earlier ADAMHA notice on expedited

                                      2
review and award of investigator-initiated AIDS grants applications in the NIH
Guide for Grants and Contracts (Vol.  17, No. 9, March 11, 1988).
Applications received after the AIDS special receipt dates will be delayed
until the next review cycle.

Applicants should also follow the instructions on number of application copies
and IRB certifications and IACUC verifications which are described in the
above notices on expedited review.

Alcohol, Drug Abuse, and Mental Health Aspects of Acquired Immunodeficiency
Syndrome (MH 86-09)

Research Grants on Alcohol and Immunology Including Acquired Immunodeficiency
Syndrome (AA 86-03)

Treatment of Intravenous Drug Abusers to Reduce the Spread of AIDS (DA 87-14)

Acquired Immunodeficiency Syndrome and the Prevention of Intravenous Drug
Abuse (DA 87-10)

Drug Abuse Aspects of the Acquired Immunodeficiency Syndrome (DA 87-11)

For the National Institute of Mental Health (NIMH) Request for Applications
(RFA) pertaining to AIDS Research Center Grants (MH-86-09), the June 1
deadline will be moved to Wednesday, May 25, 1988.  Thereafter, AIDS Research
Center applications must be received on the special AIDS receipt dates stated
above or on dates specified in particular RFAs.  NIMH plans to issue AIDS RFAs
in targeted, substantive areas.

For further information about ADAMHA AIDS programs, applicants should contact:

Sue Badman, Ph.D.
Deputy Director
Division of Basic Research, NIAAA
Room 14C-10
Telephone:  (301) 443-2530

Chief, Prevention Research Branch, NIDA
Room 10A-20
Telephone:  (301) 443-1514

Clinical Medicine Branch, NIDA
Room 10A-08
Telephone:  (301) 443-1801

Chief, Treatment Research Branch, NIDA
Room 10A-30
Telephone:  (301) 443-4060

Ellen Simon Stover, Ph.D.
Deputy Director
Division of Basic Sciences, NIMH
Room 11-103
Telephone:  (301) 443-3563

The mailing address for the above individuals is:

5600 Fishers Lane
Rockville, Maryland  20857


APPLICATION ASSIGNMENT SUGGESTIONS

P.T. 34;  K.W. 0710030, 1014002

Division of Research Grants

In accordance with the instructions for the application for a Public Health
Service grant, PHS 398 Rev. 9/86 (see page 11), principal investigators of
applications for research grants, research career development awards, and
individual postdoctoral and senior fellowships may suggest the PHS component
to which it could be appropriately assigned and up to three initial review
groups (study sections) that they would prefer to have review their
applications.  These recommendations must be submitted in a letter of
transmittal attached to the original copy of the application and should
include justifications for each of the recommendations made.  The Referral
Section, Referral and Review Branch of the Division of Research Grants will
consider these requests when determining the assignment.

                                      3
Listings of the funding components and membership of review groups may be
found in NIH Advisory Committees, a publication that is generally kept in
libraries and offices of sponsored research.


NIH REGIONAL SEMINAR IN GRANTS ADMINISTRATION

P.T. 42;  K.W. 1014002

National Institutes of Health

A two-day conference covering topics related to grants administration at the
National Institutes of Health is planned for June 27-28 at Wellesley College
in Wellesley, Massachusetts.  The conference is targeted for an audience of
researchers and research administrators at institutions in the Northeast
region which includes Connecticut, Maine, Massachusetts, New Hampshire, Rhode
Island, and Vermont.  Faculty and staff from small and minority colleges,
for-profit research organizations, hospitals, universities, and research
institutes are invited.  This two-day conference has a dual focus of interest
to both researchers and grants administrators.  Discussions of current issues
that affect NIH funding and grants administration are included to give
conference participants a comprehensive, up-to-date view of NIH-sponsored
research.

NIH staff will serve as faculty, representing several of the institutes, the
Division of Research Grants, the Division of Research Resources, and the
Office of the Director, NIH.  Preparation of a proposal and the NIH review
process are included as agenda topics, along with special concurrent sessions
for less research-intensive institutions, case studies in grant applications,
post-award grants administration, and current developments in Federal policy.
Presentations will cover review trends, research facilities, manpower
programs, financial management, the Florida Demonstration Project, and the
revision to OMB Circular A-110.  Policy and procedural issues affecting NIH
grants administration form the core of the program and this should be of
interest to faculty, departmental administrators, sponsored programs staff,
and business management staff.  NIH particularly encourages participation by
four-year colleges and other less research-intensive institutions.

Conference materials will be mailed to institutions in the Northeast Region in
mid-April with a deadline for conference registration on June 8.  Elizabeth
Lieberman at Wellesley College is in charge of conference arrangements.  For
more information, contact her or Kathleen Stackhouse at (617) 235-0320,
Extension 2393.

The next scheduled NIH Regional Seminar in Grants Administration is November
28-29, 1988, in San Francisco, California.  Information concerning this
program will be forthcoming.
INVESTIGATION OF TISSUE COMPOSITION AND FUNCTION BY MRI USING PARAMAGNETIC
AND/OR SUPERPARAMAGNETIC CONTRAST AGENTS

RFA AVAILABLE:  88-CA-10

P.T. 34;  K.W. 0706030, 0765035

National Cancer Institute

Application Receipt Date:  July 7, 1988

The Division of Cancer Treatment (DCT), of the National Cancer Institute
(NCI), through the Diagnostic Imaging Research Branch of the Radiation
Research Program, seeks applications for studies to improve and demonstrate
the ability to visualize selected tissues and to characterize their
composition and functional states by the employment of paramagnetic and/or
superparamagnetic resonance imaging (MRI) contrast agents.

The primary objective of this RFA is to promote studies employing paramagnetic
and superparamagnetic substances in the investigation of localization of
tumors, tissue composition, tissue function, and quantitative measurement of
normal and pathological processes, especially as these pertain to cancer.
Although the principal focus of this RFA is predominantly on detection and
diagnosis, diagnostic monitoring of treatment response is also an acceptable
area of investigation.  The employment of combined magnetic resonance imaging
and spectroscopy in conjunction with contrast agents would also fall within
the scope of this study.  A variety of paramagnetic and superparamagnetic
contrast agents have been developed and can be used in research and clinical
applications as molecular probes for the identification of specific tissues
and as agents to monitor pharmacokinetic behavior in the assessment of
physiologic function and pathology.

The mechanism of support for this award is NIH grant-in-aid for a duration of
three years.  The estimated total budget for the first year of this program is
$400,000.  It is anticipated that approximately three scientifically
meritorious applications can be funded.  This award is contingent upon the
availability of funds.  Non-profit organizations and institutions, governments

                                      5
and their agencies, for-profit organizations, and individuals are eligible to
apply.  The present RFA announcement is for a single competition with a
specified deadline of July 7, 1988.

Application for a Public Health Service Grant must be submitted on PHS 398
(Revised 9/86) form.  Application kits are available from most institutional
business offices or may be obtained from:

Division of Research Grants
National Institutes of Health
Westwood Building, Room 449
Bethesda, Maryland  20892

Applications must be received by July 7, 1988.  Applications received after
that date will be returned.  Also, the DRG will not accept any application in
response to this RFA that is the same as one currently being considered by
this or any other NIH Awarding Unit.

For copies of the complete RFA or for further information please contact:

Roger S. Powell, Program Director
Diagnostic Imaging Research Branch
Radiation Research Program
National Cancer Institute, NIH
Executive Plaza North, Suite 800
9000 Rockville Pike
Bethesda, Maryland  20892
Telephone:  (301) 496-9531
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