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From: Jim Cassatt <czj@nihcu.bitnet>
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To: science-resources@bionet-20.arpa
From: CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU
Date: Mon, 09 May 88 13:56:07 EDT
Subject: NIH Guide 5/6/88
Attached is the NIH Guide to Grants and Contracts, 5/6/88. Included
are the Table of Contents and Items of Interset to Molecular Biologists.
Jim Cassatt
***********************************************************************
Vol. 17, No. 17, May 6, 1988
NOTICES
FEDERAL HUMAN NUTRITION RESEARCH AND INFORMATION MANAGEMENT
(HNRIM) SYSTEM DATA BASE NOW AVAILABLE TO THE PUBLIC.........(84/132)....... 1
National Institutes of Health
Index: NATIONAL INSTITUTES OF HEALTH
GUIDELINES FOR LABORATORY PERSONNEL WORKING WITH HUMAN
IMMUNODEFICIENCY VIRUS ......................................(135/158)...... 1
National Institutes of Health
Index: NATIONAL INSTITUTES OF HEALTH
SCIENCE SCHOLARS PROGRAM.....................................(161/219)...... 2
Division of Research Grants
Index: RESEARCH GRANTS
DATED ANNOUNCEMENTS (RFPs AND RFAs)
BIOMEDICAL WORKSHOP ON SUPERCOMPUTING TECHNIQUES.............(225/262)...... 2
Division of Research Resources
Index: RESEARCH RESOURCES
INHALATION REPRODUCTIVE TOXICITY TESTING (RFP)...............(265/299)...... 3
National Institute of Environmental Health Sciences
Index: ENVIRONMENTAL HEALTH SCIENCES
PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEM (RFA)...(302/417)...... 3
National Institute of Allergy and Infectious Diseases (964/1256)
Index: ALLERGY AND INFECTIOUS DISEASES
DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES (RFA)...(420/529)... 5
Division of Research Resources (1259/1761)
Index: RESEARCH RESOURCES
MYCOLOGY RESEARCH UNITS (RFA)........................(532/607, 1765/2061)... 6
National Institute of Allergy and Infectious Diseases
Index: ALLERGY AND INFECTIOUS DISEASES
ASTHMA AND ALLERGIC DISEASE CENTERS (RFA)............(610/731, 2064/2427.... 7
National Institute of Allergy and Infectious Diseases
Index: ALLERGY AND INFECTIOUS DISEASES
DIABETES CENTERS (RFA)...............................(734/860).............. 9
National Institute of Diabetes and Digestive and Kidney Diseases
Index: DIABETES AND DIGESTIVE AND KIDNEY DISEASES
ONGOING PROGRAM ANNOUNCEMENTS
FACTORS CONTRIBUTING TO THE SEQUENCING OF ALCOHOL AND
OTHER DRUG USE (PA)..................................(866/949).............. 10
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse
Index: ALCOHOL ABUSE AND ALCOHOLISM; DRUG ABUSE
NOTICES
FEDERAL HUMAN NUTRITION RESEARCH AND INFORMATION MANAGEMENT
(HNRIM) SYSTEM DATA BASE NOW AVAILABLE TO THE PUBLIC
P.T. 16; K.W. 0710095, 1004008
National Institutes of Health
The Human Nutrition Research and Information Management (HNRIM) system data
base provides information on human nutrition research and research training
activities supported in whole or in part by the Federal Government. The data
base contains approximately 4,000 projects for each of fiscal years 1982-86,
and includes the following types of information about each project:
o sponsoring organization
o project identifier numbers
o project title
o principal investigator
o organization name, address
o nutrition classification categories
o project abstract (does NOT include research results)
o percent related to nutrition
o fiscal year and start date
The data base may be purchased through the National Technical Information
Service (NTIS), U.S. Department of Commerce (DOC), 5285 Port Royal Rd.,
Springfield, VA 22161, (703) 487-4807. Data are supplied on computer tape,
suitable for use on an IBM-compatible mainframe or minicomputer, and the
purchaser will need to create customized software in order to access the data.
Those wishing to purchase the data base should contact NTIS directly, and
should reference NTIS accession number PB88-161690/AS.
The HNRIM data base was developed in accordance with the National Agricultural
Research, Extension, and Teaching Policy Act of 1977 (7 USC 3177).
Participating agencies include the Department of Health and Human Services,
the U.S. Department of Agriculture, the Veterans Administration, the Agency
for International Development, the Department of Defense, and DOC-NOAA. The
data base is maintained at the office of the Nutrition Coordinating Committee,
National Institutes of Health, under the auspices of the Interagency Committee
on Human Nutrition Research.
For further information contact NTIS, or:
HNRIM System Coordinator
c/o Nutrition Coordinating Committee
Building 31, Rm. 4B63
National Institutes of Health
9000 Rockville Pike
Bethesda, Maryland 20892
Telephone: (301) 496-9035
GUIDELINES FOR LABORATORY PERSONNEL WORKING WITH HUMAN IMMUNODEFICIENCY VIRUS
P.T. 16; K.W. 1002045, 0715175
National Institutes of Health
The Division of Safety, National Institutes of Health announces the
availability of the Agent Summary Statement for Human Immunodeficienc Virus
(HIV) and guidelines for laboratory personnel working with HIV. Included in
this annotated version of "Biosafety in Microbiological and Biomedical
Laboratories" are the recommended facilities, and practices and procedures for
laboratory personnel working at Biosafety Level 2/3 and Biosafety Level 3.
Biosafety Level 2/3 includes activities involving clinical specimens, body
fluids and tissues from humans or inoculated animals. Guidelines for work
conducted at Biosafety Level 3 involving industrial-scale, large-volume
production or high concentrations and manipulation of concentrated HIV are
also described.
To receive a copy, send your request to:
NIH/DS
HIV Laboratory Practices
Building 31, Room 1C05
Bethesda, Maryland 20892
1
SCIENCE SCHOLARS PROGRAM
P.T. 34; K.W. 1014002, 0901026
Division of Research Grants
The Division of Research Grants (DRG) is pleased to announce its Science
Scholars Program. A small number of senior scientists from outside the
Federal Government will have the opportunity to participate in analyses of
extramural scientific merit review, in policy evaluation, and in the
formulation of recommendations for DRG. Science scholars will work in DRG on
short-term assignments, from 3 to 6 months.
ELIGIBILITY: Applicants for the Science Scholars Program may be basic or
applied scientists or clinicians. They must, however, have had extensive
biomedical or behavioral research experience and must have served on a DRG
Study Section or equivalent NIH initial review group.
CONTENT OF PROGRAM: Science scholars will be involved in evaluations and
analyses of peer review practices and trends using a variety of statistical
databases and resources. It is expected that the Scholars will also confer
widely with NIH staff and consultants. In addition to such reviews and
analyses, the Scholars may formulate and present conclusions and
recommendations on a broad range of issues affecting peer review. Studies may
involve particular fields or disciplines or may be broad-based. Science
Scholars will be encouraged to attend and participate in seminars related to
peer review, science administration, and policy.
INVITATIONAL PROCESS: Developing a proposal for the Science Scholars Program
is a joint effort involving prospective applicants and senior DRG staff.
Individuals interested in this program should contact the Director or Deputy
Director. A prospective applicant may have a specific project or study in
mind or seek advice from DRG staff about possible projects. Before submitting
a formal letter of application, applicants should have developed a specific
plan or protocol.
REVIEW PROCESS: In accord with pertinent Federal personnel policies and
regulations, the Director, DRG, will make recommendations or selections based
on qualifications of the individual, the proposed study protocol, and the
Division's priorities and resources.
APPOINTMENTS: Positions in the DRG Science Scholars Program may be filled by
a variety of special temporary appointments. For example, the
Intergovernmental Personnel Act (IPA) mechanism permits cost sharing
arrangements to be negotiated between the participating parties and may be
used for individuals seeking a sabbatical assignment.
Announcements of appointment will be publicized in relevant professional and
scientific journals and, as appropriate, other media.
DRG CONTACTS:
Jerome G. Green, M.D. Donald H. Luecke, M.D.
Director Deputy Director
Division of Research Grants Division of Research Grants
Room 450, Westwood Bldg. Room 448, Westwood Bldg.
National Institutes of Health National Institutes of Health
Bethesda, Maryland 20892 Bethesda, Maryland 20892
Telephone: (301) 496-7211 Telephone: (301) 496-7461
DATED ANNOUNCEMENTS (RFPs AND RFAs)
BIOMEDICAL WORKSHOP ON SUPERCOMPUTING TECHNIQUES
P.T. 42; K.W. 1004000
Division of Research Resources
Application Receipt Date: June 15, 1988
The Pittsburgh Supercomputing Center (PSC) is conducting a 4 and 1/2 day
workshop on supercomputing techniques for biomedical researchers August 8-12,
1988. It is funded by a National Institutes of Health (NIH) grant from the
Division of Research Resources' Biomedical Research Technology (BRT) Program.
2
The workshop is aimed at experienced FORTRAN programmers, but prior
supercomputing experience is not necessary. The topics include an
introduction to VMS (half-day, optional), the Cray-VAX interface, Cray job
control, optimization techniques, an overview of available biomedical
software, and a description of access paths to the PSC.
Travel, meals, and hotel accommodations are covered for academic participants
under the grant. A limited number of openings for industrially-based
biomedical researchers may be available for a fee of $1,000. THE DEADLINE FOR
THE SUBMISSION OF APPLICATIONS IS JUNE 15, 1988. Enrollment is limited to
twenty participants.
For application forms and additional information, call or write:
Cherolyn Brooks
User Services
Pittsburgh Supercomputing Center
4400 Fifth Avenue
Pittsburgh, Pennsylvania 15213
Telephone: (412) 268-5206
(800) 222-9310 - inside Pennsylvania
(800) 221-1641 - outside Pennsylvania
PROGRAM PROJECTS ON THE BIOLOGY OF THE IMMUNE SYSTEM
RFA AVAILABLE: 88-AI-10
P.T. 34; K.W. 0705040, 1002000, 1002004, 1002008, 0710065
National Institute of Allergy and Infectious Diseases
Letter of Intent Receipt Date: May 27, 1988
Application Receipt Date: July 15, 1988
BACKGROUND INFORMATION
The Immunobiology and Immunochemistry Branch of the Immunology, Allergic and
Immunologic Diseases Program of the National Institute of Allergy and
Infectious Diseases (NIAID), supports fundamental studies on the structure and
3
function of the immune system to gain an understanding of immune response
mechanisms at their basic cellular and molecular levels as they function in
health and disease. Program Projects on the Biology of the Immune System
represent an award mechanism which the Branch has employed to meet this
objective. They are intended to support integrated, multidisciplinary, basic
studies of immunologically-functional lymphocyte and other relevant cell
populations. Thirteen such program projects are currently funded although
support for two is scheduled to conclude in 1988. This request for
applications is intended to encourage the development of proposals from
collaborating investigators and to coordinate the submission and review of new
and renewal program project applications.
RESEARCH GOALS AND SCOPE
The goal of these Program Projects is the attainment of a complete
understanding of the structure and function of the immune system and its
products, its interaction with other body systems, and full knowledge of the
genetic and other factors which regulate its development and function. An
ultimate practical application of this information is the use of selected
cloned cells of the system, or their products, for the clinical care of
reconstitution of immunodeficient individuals, to alleviate allergic states,
to provide resistance to life-threatening infections and to correct aberrant
or defective immunoregulatory mechanisms.
The scope of these program projects includes studies of every facet of the
immune response, ranging from the initial step of antigen recognition to the
final elaboration of immunologically distinctive products of specific
immunocytes. Research currently supported by this mechanism was designed to
expand knowledge of the morphologic and functional heterogeneity of lymphocyte
populations and develop the capability for identification and selection of
lymphocyte subpopulations, with specific immune reactivity or molecular
composition, for use in somatic hybridization of such populations and
selective production of specific, biologically active, lymphocyte products.
Similar studies of macrophages, other accessory and effector cells, and
networks of cells and molecules that affect the activation, differentiation
and regulation of cells of the immune system are appropriate. Projects that
involve improving the efficiency or scale of preparing and selecting
hybridomas and other relevant cell lines for defined purposes, and projects
designed to modify genes encoding immunologically relevant macromolecules to
improve their biological efficiency, or diagnostic and therapeutic utility,
are encouraged.
MECHANISM OF SUPPORT
Program project grants are awarded to an institution on behalf of a program
director for the support of a broadly based, multidisciplinary, long-term
research program which has a specific major objective or basic theme. A
program project generally involves the organized efforts of groups of
investigators who conduct research projects related to the overall program
objective. The grant can provide support for the projects and for certain
core resources shared by individuals where the sharing facilitates the total
research effort. Each component project, supported under a program project
grant, is expected to contribute and be directly related to a common theme.
The projects should demonstrate an essential element of unity and
interdependence. At least two awards are planned for 1988.
METHOD OF APPLYING
Before preparing an application, the prospective applicant should request a
copy of the Information Brochure: Program Projects and Center Grants, NIAID,
from:
Dr. Nirmal Das
Executive Secretary
Allergy, Immunology and Transplantation
Research Committee
National Institute of Allergy
and Infectious Diseases
National Institutes of Health
Westwood Building, Room 706
Bethesda, Maryland 20892
Telephone: (301) 497-7966
STAFF CONTACT
For further programmatic information and a copy of the detailed RFA, contact:
4
Joseph F. Albright, Ph.D.
Chief, Immunobiology and Immunochemistry Branch, IAIDP
National Institute of Allergy and Infectious Diseases
Westwood Building, Room 757
National Institutes of Health
Bethesda, Maryland 20892
Telephone: (301) 496-7551
Prospective applicants are encouraged to submit a one-page letter of intent
that includes a descriptive title of the proposed research and identification
of any other participating institutions. The Institute requests such letters
by May 27, 1988, for the purpose of providing an indication of the number and
scope of applications to be received. A letter of intent is not binding. It
will not enter into the review of any application subsequently submitted and
is not a necessary requirement for application.
Letters of intent should be directed to Dr. Albright at the address shown.
MYCOLOGY RESEARCH UNITS
RFA AVAILABLE: 88-AI-11
P.T. 34; K.W. 1002029, 0715125, 0710030
National Institute of Allergy and Infectious Diseases
Letter of Intent Receipt Date: August 15, 1988
Application Receipt Date: October 14, 1988
BACKGROUND INFORMATION
The National Institute of Allergy and Infectious Diseases (NIAID) invites
applications for program project grants to be initiated during FY 1989 for
participation in an ongoing program of research in Mycology. The fungi of
medical importance include, but are not limited to, Coccidioides immitis,
Histoplasma capsulatum, Blastomyces dermatitides, Cryptococcus neoformans,
Candida albicans, and Aspergillus fumigatus. An active research program in
mycology and related areas is of crucial importance to help resolve the
serious public health problem of fungal disease.
RESEARCH GOALS AND SCOPE
A. The NIAID proposes to maintain its program initiative in mycology
and fungal disease research. The goal of this program is to
increase the knowledge of the biology of the causal microorganisms
6
and of host-parasite interactions. This fundamental knowledge will
then be applied to development and improvement of means of
diagnosis, prevention, and therapy of these infections.
B. The NIAID wishes to develop multidisciplinary mycology research
units to serve as foci for research in fungal diseases. These
units will be funded as program project grants. Studies of
interest include, but are not limited to the following areas of
mycology research: virulence, epidemiology, immunology,
pathogenesis, diagnosis, and chemotherapy. It is desirable that a
strong clinical component be made a part of any program project
application.
MECHANISM OF SUPPORT
Applications considered appropriate responses to this announcement are those
for research program projects (PO1). The NIAID plans to support at least two
awards contingent on the overall merit of the proposed research and the
availability of funds. NIAID is presently funding two Mycology Research
Units, whose support terminates on August 31, 1989. Support of new Mycology
Research Units or continuation of existing units will be on a competitive
basis. It is estimated that the direct costs for each of the research units
will be approximately $450,000 per year. Up to five years of support is
anticipated.
The initial review for scientific and technical merit will be made by a review
group to be convened by the Program Project Review Branch, NIAID; secondary
review will be made by the National Advisory Allergy and Infectious Diseases
Council. Funding decisions will be based upon relative scientific merit,
program relevance, and availability of appropriated funds. The receipt date
for applications will be October 14, 1988. Formal applications that are not
received by October 14, 1988 or are considered to be non-responsive to the RFA
will be returned to the investigator. The earliest possible start date will
be July 1, 1989.
STAFF CONTACT
For further information and for a detailed copy of this RFA, investigators are
encouraged to contact:
Darrel D. Gwinn, Ph.D.
Mycology Program Officer
Bacteriology and Virology Branch
National Institutes of Health
Westwood Building, Room 738
Bethesda, Maryland 20892
Telephone: (301) 496-7728
ASTHMA AND ALLERGIC DISEASE CENTERS
RFA AVAILABLE: 88-AI-09
P.T. 04; K.W. 0715110, 0705040, 0710030
National Institute of Allergy and Infectious Diseases
Application Receipt Date: October 14, 1988
BACKGROUND INFORMATION
The Asthma and Allergy Branch of the Immunology, Allergic and Immunologic
Diseases Program of the National Institute of Allergy and Infectious Diseases
(NIAID) sponsors fundamental and clinical research concerned with asthma,
allergic and immunologic diseases and with relevant mechanisms of
hypersensitivity and inflammation. For this purpose, twelve Asthma and
Allergic Disease Centers (AADC) are currently funded; support for one is
scheduled to conclude in 1989. This request for applications (RFA) is
intended to encourage submissions from clinical investigative groups meeting
the criteria and requirements for an AADC and to coordinate review of new and
renewal applications thus providing equitable opportunity for both to compete
for funds currently available for this programmatic activity.
RESEARCH GOALS AND SCOPE
The fundamental objective of the NIAID's AADC program is to foster
acceleration of the application of knowledge on the immune system emerging
from relevant biomedical sciences to clinical hypersensitivity disorders.
7
Especially sought as the requisite factors within a participating institution
are quality research in: (a) basic science(s), (b) clinical investigation
supported by adequate clinical facilities and staff expertise in diagnosis and
management of asthmatic and allergic patients, and (c) access to (an)
appropriate patient population(s) within a suitable academic/investigative
environment designed to favor multidisciplinary interaction.
The scope of the AADC program represents an effort to foster collaborative
approaches that will integrate basic concepts in allergy, immunology,
pathophysiology, genetics, microbiology, biochemistry, biostatistics,
bioinstrumentation, computer science and pharmacology into clinical
investigations, which, in addition to the fields of allergy and clinical
immunology, may include such areas as dermatology, rheumatology, infectious
diseases, pulmonary medicine, hematology, and otorhinolaryngology, when a high
degree of relevance to immunology exists. Because the role of
hypersensitivity and immune-related inflammatory mechanisms has become
increasingly evident in disorders of the skin, immunodermatologic studies are
especially encouraged within an AADC. Because of the alarming increase in
asthma mortality since 1979, studies are also sought to examine this trend.
Program objectives are: to encourage collaboration between basic and clinical
scientists; to provide a research environment favorable for such interaction;
and to implement clinical application of adequately tested research findings
and procedures.
In addition, a feature of the AADC program is the opportunity for directors to
implement educational or community activities. Within the research framework
of the center, a variety of outreach and demonstration projects may be
supported.
MECHANISMS OF SUPPORT
AADC grants are awarded to an institution on behalf of a program director for
the support of a broadly based, multidisciplinary, long-term research program
which may have a specific objective or basic theme, or may involve the
integration of several themes. An AADC generally involves the efforts of
groups of investigators who conduct research related to the overall program
objective. The grant can provide support for the projects and for certain
core resources shared by individuals where the sharing facilitates the total
research effort. Each component project supported under an AADC grant is
expected to contribute to, and be directly related to, a common theme; the
component projects should demonstrate an essential element of unity and
interdependence. In fiscal year 1989, the NIAID plans to fund at least one
new or competing renewal Asthma and Allergic Disease Center application,
depending on the availability of funds.
METHOD OF APPLYING
Before preparing an application, the prospective applicant should request a
copy of the NIAID Information Brochure on Program Projects from:
Dr. Nirmal Das
Executive Secretary
Allergy, Immunology and Transplantation
Research Committee
National Institute of Allergy and
Infectious Diseases
National Institutes of Health
Westwood Building, Room 707
Bethesda, Maryland 20892
Telephone: (301) 496-7966
STAFF CONTACT
A more detailed RFA may be obtained from:
Dorothy D. Sogn, M.D.
Chief, Asthma and Allergy Branch
Immunology, Allergic and Immunologic
Diseases Program
National Institute of Allergy
and Infectious Diseases
Westwood Building, Room 752
Bethesda, Maryland 20892
Telephone: (301) 496-8973
Prospective applicants are encouraged to submit a one-page letter of intent
that includes a descriptive title of the proposed research and identification
8
of any other participating institutions. The NIAID requests such letters by
June 15, 1988, for the purpose of providing an indication of the number and
scope of applications to be received. A letter of intent is not binding. It
will not enter into the review of any application subsequently submitted and
is not a necessary requirement for application. Letters of intent and
inquiries should be directed to Dr. Sogn at the above address.
THE RFA LABEL AVAILABLE IN THE 9/86 REVISION OF APPLICATION FORM 398 MUST BE
AFFIXED TO THE BOTTOM OF THE FACE PAGE. FAILURE TO USE THIS LABEL COULD
RESULT IN DELAYED PROCESSING OF YOUR APPLICATION SUCH THAT IT MAY NOT REACH
THE REVIEW COMMITTEE IN TIME FOR REVIEW.
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