CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU (07/14/88)
Attached is the Table of Contents and Items of Interest from the
NIH Guide to Grants and Contracts for July 1, 1988. Note that there
will be no Guide on July 8. Also I think that the Program Announcements
from NIGMS were posted separately.
Jim Cassatt
Vol. 17, No. 22, July 1, 1988
NOTICES
AVAILABILITY OF RETINAL DEGENERATION MUTANTS ............(84/229)........... 1
National Eye Institute
Index: EYE
THE ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH ADMINISTRATION
ESTABLISHES THE ADAMHA REVIEWERS RESERVE ................(241/274).......... 3
Alcohol, Drug Abuse, and Mental Health Administration
Index: ALCOHOL, DRUG ABUSE, AND MENTAL HEALTH
DATED ANNOUNCEMENTS (RFPs AND RFAs AVAILABLE)
PRIMARY RODENT PRODUCTION CENTERS (RFP)..................(280/318).......... 3
National Cancer Institute
Index: CANCER
MICROSTIMULATION OF THE SACRAL SPINAL CORD (RFP).........(321/350).......... 4
National Institute of Neurological and Communicative
Disorders and Stroke
Index: NEUROLOGICAL AND COMMUNICATIVE DISORDERS AND STROKE
REVERSIBLE CONTRACEPTION AND RISK OF HIV INFECTION IN WOMEN (RFP)........... 4
National Institute of Child Health and Human Development (353/390)
Index: CHILD HEALTH AND HUMAN DEVELOPMENT
LIVER TRANSPLANTATION COORDINATING CENTER (RFP)..........(401/456).......... 5
National Institute of Diabetes, and Digestive and Kidney Diseases
Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES
LIVER TRANSPLANTATION CENTERS (RFP)......................(459/516).......... 5
National Institute of Diabetes, and Digestive and Kidney Diseases
Index: DIABETES, DIGESTIVE AND KIDNEY DISEASES
CHARACTERIZATION OF THE GENOMES OF HUMANS AND MODEL
ORGANISMS (RFA)......................................(519/591, 724/1018).... 6
National Institute of General Medical Sciences
Index: GENERAL MEDICAL SCIENCES
NEW TECHNOLOGY FOR GENOMIC ANALYSIS (RFA)............(594/658, 1021/1312)... 7
National Institute of General Medical Sciences
Index: GENERAL MEDICAL SCIENCES
CHARACTERIZATION OF THE GENOMES OF HUMANS AND MODEL
ORGANISMS
RFA AVAILABLE: 88-GM-02
P.T. 34; K.W. 1002019, 0755045
National Institute of General Medical Sciences
Application Receipt Date: September 22, 1988
BACKGROUND INFORMATION
The National Institute of General Medical Sciences (NIGMS) supports research
in the field of genomic analysis, with the goal of developing detailed genetic
and physical maps and, eventually, determining the complete sequence of the
DNA of a number of organisms, including man. It is expected that this
knowledge will ultimately be applied to the prevention, diagnosis, and
treatment of human disorders. The objective of this Request for Applications
(RFA) is to stimulate innovative research that will rapidly improve our
ability to analyze the entire genome of an organism.
RESEARCH GOALS AND SCOPE
The NIGMS invites applications from interested investigators for research
which involves the further development of physical maps of the human genome;
development of physical maps and/or determination of the DNA sequence of the
genome of one of the following model organisms: yeast, Drosophila, mouse or
the nematode worm, Caenorhabditis elegans; or development of new approaches
for determination of such mapping or sequence information. [Research projects
directed toward these goals but which utilize other organisms are
appropriately submitted in response to an existing NIH Program Announcement
(NIH Guide for Grants and Contracts, Vol. 16, No. 18, p. 11; May 27, 1987)].
To be considered responsive to this RFA, proposals must be primarily directed
toward the development of new mapping and sequencing data or the development
of new methodological approaches which will increase the accuracy, ease, and
rapidity with which such mapping and sequence determination can be achieved.
Innovative approaches to obtaining such information are encouraged.
Utilization of physical mapping and DNA sequence data for the analysis and
Vol. 17, No. 22, July 1, 1988 - Page 6
characterization of genomic information is also encouraged as part of the
proposed projects. However, applications in which the primary goal is the
study of the biology of specific genomic regions (particularly regions related
to disease genes), and in which mapping or sequence data are to be obtained
only as a necessary first step toward that end, will not be considered
responsive to this announcement.
MECHANISM OF SUPPORT
Support will be through research grants including individual projects grants
(RO1, R29) and program projects (P01). The total amount of support for grants
under this RFA is contingent upon the appropriation of funds for this purpose.
The number of awards will be determined by the merit of the proposals, by
their relevance to the program goals, and availability of funds. It is
anticipated that in Fiscal Year 1989 up to five million dollars will be
allocated to the research initiatives described in this RFA, allowing
approximately 10-30 awards to be made. This amount may be increased if a
large number of highly meritorious applications are received and if funds are
available.
STAFF CONTACT
Applicants should request the complete RFA and obtain additional information
from:
Dr. Mark Guyer or Dr. Irene Eckstand
National Institute of General Medical Science
Westwood Building, Room 918
National Institute of Health
Bethesda, Maryland 20892
Telephone: (301) 496-7137
NEW TECHNOLOGY FOR GENOMIC ANALYSIS
RFA AVAILABLE: 88-GM-03
P.T. 34; K.W. 1002019, 0755045, 1004000, 0735000
National Institute of General Medical Sciences
Application Receipt Date: December 1, 1988
BACKGROUND INFORMATION
The National Institute of General Medical Science (NIGMS) supports research in
basic genetics, including research directed toward the construction of
detailed genetic and physical maps of the genomes of a number of organisms,
including man, and the determination of the complete sequence of the DNA of
those organisms. This knowledge will ultimately be applied in biomedical
research for the diagnosis, treatment, and prevention of human disease.
Significant advances have been made during the past decade in the techniques
available for determination of genomic structure and organization and of
nucleic acid sequences. The objective of the Request for Applications (RFA)
is to stimulate innovative research that will lead to further improvements in
the speed and efficiency of map construction and DNA sequence determination,
so that major research efforts such as determining the entire DNA sequence of
any organism will become practical in terms of both time and cost.
RESEARCH GOALS AND SCOPE
The NIGMS invites applications from investigators for research that will lead
to new or improved technology applicable to genomic analysis. The object of
this program is to make substantial improvements in the rapidity, efficiency
and accuracy with which genetic mapping, physical mapping, and DNA sequence
information can be obtained, analyzed, and distributed. Multi-disciplinary
approaches to the attainment of these goals are encouraged; in addition to
scientist in all areas of the biological sciences, we encourage the
participation of scientist in disciplines which have not previously received
major amounts of support from the National Institute of Health (NIH), such as
computer science, materials science, physics, mathematics and engineering.
MECHANISM OF SUPPORT
Support will be through research grants including individual project grants
(R01, R29) and program projects grants (P01). The total amount of support for
grants under this RFA is contingent upon the appropriation of funds for this
purpose. The number of awards will be determined by the merit of the
Vol. 17, No. 22, July 1, 1988 - Page 7
proposals and by the relevance to the program goals, as well as by
availability of funds. It is anticipated that in Fiscal Year 1989 up to five
million dollars will be allocated to the research initiatives described in
this RFA, allowing approximately 10-30 awards to be made. This amount may be
increased if a large number of highly meritorious applications are received
and if funds are available.
STAFF CONTACT
Applicants should request the complete RFA and obtain additional information
from:
Dr. Mark Guyer or Dr. Irene Eckstrand
National Institute of General Medical Sciences
Westwood Building, Room 918
National Institutes of Health
Bethesda, Maryland 20892
Telephone: (301) 496-7137