CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU (07/14/88)
Attached is the Table of Contents and Items of interest from the
NIH Guide to Grants and Contracts for July 15, 1988.
Jim Cassatt
Vol. 17, No. 23, July 15, 1988
NOTICES
Presolicitation: EPIDEMIOLOGIC STUDIES OF HIV-ASSOCIATED MALIGNANCIES ..... 1
National Cancer Institute (84/168)
Index: CANCER
DATED ANNOUNCEMENTS (RFPs AND RFAs)
IMMUNOTOXICOLOGICAL EVALUATION OF AIDS THERAPEUTICS (RFP) ...(174/200)...... 2
National Institute of Environmental Health Sciences
Index: ENVIRONMENTAL HEALTH SCIENCES
DEVELOPMENT OF DOSAGE FORMS AND DELIVERY SYSTEMS FOR NEW
ANTITUMOR AGENTS (RFP) ......................................(203/255)...... 2
National Cancer Institute
Index: CANCER
DEVELOPMENT AND PRODUCTION OF PHARMACEUTICAL DOSAGE FORMS (RFP) ..(258/327). 3
National Cancer Institute
Index: CANCER
NATIONAL RESEARCH SERVICE AWARD-INSTITUTIONAL GRANTS (RFA) ...(330/487)..... 4
National Institute of Dental Research (964/1401)
Index: DENTAL
PREVENTION CLINICAL TRIALS UTILIZING INTERMEDIATE ENDPOINTS AND THEIR
MODULATION BY CHEMOPREVENTIVE AGENTS (RFA) ........(490/568, 1404/2156)..... 6
National Cancer Institute
Index: CANCER
CARDIAC TRANSPLANT ATHEROSCLEROSIS (RFA) ..........(571/652, 2159/2543)..... 7
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY (RFA) ..(655/783, 2546/2992).... 8
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
HYPERGLYCEMIA AND CARDIOVASCULAR DISEASE RISK FACTORS: Field Centers,
Coordinating Center and Support Laboratories (RFA) ..(786/844, 2995/4294)... 9
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
DEVELOPMENT OF SEROLOGICAL TESTS FOR INVASIVE UREAPLASMA
UREALYTICUM INFECTIONS (RFA) ............................(847/890)..........10
National Institute of Allergy and Infectious Diseases
Index: ALLERGY AND INFECTIOUS DISEASES
PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY
RFA AVAILABLE: 88-HL-20
P.T. 34; K.W. 1002008, 0710030, 1002058, 0710060, 0785070, 0715165, 0715165
National Heart, Lung, and Blood Institute
Application Receipt Date: February 10, l989
The National Heart, Lung, and Blood Institute (NHLBI) announces the
availability of a Request for Applications (RFA) inviting grant applications
to develop Programs of Excellence in Molecular Biology. Each Program of
Excellence will support a multidisciplinary team of independent research
investigators, and will have two major objectives: (1) to foster utilization
of molecular biology approaches in important research areas within the mission
of the National Heart, Lung, and Blood Institute where the use of these
technologies has yet to be fully employed; and (2) to provide opportunities
for investigators who have the potential for independent research careers to
become skilled in the experimental strategies and techniques of molecular
biology and their application to research relevant to the mission of the
Institute.
A Program of Excellence will be multidisciplinary in nature, and should be
designed to share ideas, data, and facilities. The total scientific effort
must be directed toward a central, unifying theme. In keeping with the
tradition of investigator-initiated research, the NHLBI expects the applicants
to define their own theme and to develop the approaches that would be used to
accomplish the objectives of the proposed research program.
Each applicant has considerable flexibility in devising a plan to accomplish
the broad objectives of this RFA on the basis of the imagination and talents
of the investigators, the resources and commitment of their respective
institutions, and the unique features of this RFA. However, in order to
evaluate the proposed plans effectively, each application should include an
assessment of the applicant Institution's current research activities and how
these will serve as a basis for development of a program of research using
molecular biology approaches, a description of the proposed new program goals
to achieve the integration of molecular biology into areas related to the
mission of the NHLBI by the end of a seven year period, a description of the
scientific and administrative plans to attain these goals, and a summary of
anticipated research opportunities and directions that will be made possible
by a Program of Excellence.
Although the financial plans for fiscal year 1989 include $5 to $10 million in
total costs for this announcement, award of grants pursuant to this RFA is
contingent upon availability of funds for this purpose. It is anticipated
that 3-5 grants will be awarded under the program established by this
announcement. The specific number to be funded will, however, depend on the
merit and scope of the applications received and the availability of funds.
PROGRAM FEATURES
To provide a suitable structure for achieving the objectives of the RFA, a
Program of Excellence in Molecular Biology will have the following elements:
o SEVEN YEAR AWARD: This extended period will enable a Program of
Excellence to be innovative, to pursue new developments in rapidly
advancing areas, to embark on the application of molecular biology
to more complex experimental systems, and to develop new
experimental models.
o RECRUIT ESSENTIAL SCIENTIFIC EXPERTISE: In order to provide the
most effective combination of scientific disciplines, applicants
Vol. 17, No. 23, July 15, 1988 - Page 8
may request funds to recruit faculty to augment or strengthen the
skills and capabilities of existing faculty.
o INSTITUTIONAL ENVIRONMENT AND RESOURCES: Applicants may request
funds for incidental alteration and renovation of facilities
consistent with Public Health Service policy, as well as the
purchase of equipment needed to conduct research using the
technologies of molecular biology.
o EXPERIMENTAL DESIGN AND METHODS: In an effort to provide broader
degrees of research freedom, and to encourage innovative
approaches, the application requires only a brief description of
the preferred and alternative experimental approaches, strategies
and proposed research directions. The application will not require
specific details for individual experiments and protocols. In
addition, the application will use a simplified budgetary format.
o SUPPORT FOR NEW INVESTIGATORS: To provide for the development of
new research workers with skills required to conduct research
utilizing the technologies of molecular biology, applications may
include a request to support young investigators or investigators
new to the discipline of molecular biology.
APPLICATION
In 1987, the NHLBI initiated a two-phase strategy to establish a network of
Programs of Excellence in Molecular Biology to stimulate the application of
molecular biological strategies in conjunction with other pioneering and
conventional technologies. The Institute will complete the establishment of
this program through this announcement. A similar announcement was released
approximately one year earlier. This two-stage process was designed to
provide institutions with additional time to augment scientific expertise
and/or to solidify interactions among the various scientific disciplines. New
applications and amended applications will be accepted.
Applications should be submitted on the revised (9/86) form PHS 398 according
to the instructions provided with the form and according to Supplemental
Guidelines prepared by the NHLBI. Because of the unique features and goals of
the Programs of Excellence, applicants will require these Supplemental
Guidelines to prepare an acceptable application.
TIMETABLE
Letter of Intent October 4, 1988
Application Receipt Date February 10, 1989
First Stage of Technical Review May 1989
Second Stage of Technical Review July 1989
Advisory Council Review September 14-15, 1989
Award Date September 30, 1989
INQUIRIES
To obtain copies of the detailed RFA and the detailed Supplemental Guidelines
(which must be followed if an acceptable application is to be submitted)
contact:
Stephen C. Mockrin, Ph.D.
National Heart, Lung, and Blood Institute
National Institutes of Health
Federal Building - Room 4C10
7550 Wisconsin Avenue
Bethesda, Maryland 20892CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU (09/13/88)
Attached are the Table of Contents ant items of interest from the
Guide to Grants and Contracts 7/15/88.
Vol. 17, No. 23, July 15, 1988
NOTICES
Presolicitation: EPIDEMIOLOGIC STUDIES OF HIV-ASSOCIATED MALIGNANCIES ..... 1
National Cancer Institute (84/168)
Index: CANCER
DATED ANNOUNCEMENTS (RFPs AND RFAs)
IMMUNOTOXICOLOGICAL EVALUATION OF AIDS THERAPEUTICS (RFP) ...(174/200)...... 2
National Institute of Environmental Health Sciences
Index: ENVIRONMENTAL HEALTH SCIENCES
DEVELOPMENT OF DOSAGE FORMS AND DELIVERY SYSTEMS FOR NEW
ANTITUMOR AGENTS (RFP) ......................................(203/255)...... 2
National Cancer Institute
Index: CANCER
DEVELOPMENT AND PRODUCTION OF PHARMACEUTICAL DOSAGE FORMS (RFP) ..(258/327). 3
National Cancer Institute
Index: CANCER
NATIONAL RESEARCH SERVICE AWARD-INSTITUTIONAL GRANTS (RFA) ...(330/487)..... 4
National Institute of Dental Research (964/1401)
Index: DENTAL
PREVENTION CLINICAL TRIALS UTILIZING INTERMEDIATE ENDPOINTS AND THEIR
MODULATION BY CHEMOPREVENTIVE AGENTS (RFA) ........(490/568, 1404/2156)..... 6
National Cancer Institute
Index: CANCER
CARDIAC TRANSPLANT ATHEROSCLEROSIS (RFA) ..........(571/652, 2159/2543)..... 7
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY (RFA) ..(655/783, 2546/2992).... 8
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
HYPERGLYCEMIA AND CARDIOVASCULAR DISEASE RISK FACTORS: Field Centers,
Coordinating Center and Support Laboratories (RFA) ..(786/844, 2995/4294)... 9
National Heart, Lung, and Blood Institute
Index: HEART, LUNG, AND BLOOD
DEVELOPMENT OF SEROLOGICAL TESTS FOR INVASIVE UREAPLASMA
UREALYTICUM INFECTIONS (RFA) ............................(847/890)..........10
National Institute of Allergy and Infectious Diseases
Index: ALLERGY AND INFECTIOUS DISEASES
PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY
RFA AVAILABLE: 88-HL-20
P.T. 34; K.W. 1002008, 0710030, 1002058, 0710060, 0785070, 0715165, 0715165
National Heart, Lung, and Blood Institute
Application Receipt Date: February 10, l989
The National Heart, Lung, and Blood Institute (NHLBI) announces the
availability of a Request for Applications (RFA) inviting grant applications
to develop Programs of Excellence in Molecular Biology. Each Program of
Excellence will support a multidisciplinary team of independent research
investigators, and will have two major objectives: (1) to foster utilization
of molecular biology approaches in important research areas within the mission
of the National Heart, Lung, and Blood Institute where the use of these
technologies has yet to be fully employed; and (2) to provide opportunities
for investigators who have the potential for independent research careers to
become skilled in the experimental strategies and techniques of molecular
biology and their application to research relevant to the mission of the
Institute.
A Program of Excellence will be multidisciplinary in nature, and should be
designed to share ideas, data, and facilities. The total scientific effort
must be directed toward a central, unifying theme. In keeping with the
tradition of investigator-initiated research, the NHLBI expects the applicants
to define their own theme and to develop the approaches that would be used to
accomplish the objectives of the proposed research program.
Each applicant has considerable flexibility in devising a plan to accomplish
the broad objectives of this RFA on the basis of the imagination and talents
of the investigators, the resources and commitment of their respective
institutions, and the unique features of this RFA. However, in order to
evaluate the proposed plans effectively, each application should include an
assessment of the applicant Institution's current research activities and how
these will serve as a basis for development of a program of research using
molecular biology approaches, a description of the proposed new program goals
to achieve the integration of molecular biology into areas related to the
mission of the NHLBI by the end of a seven year period, a description of the
scientific and administrative plans to attain these goals, and a summary of
anticipated research opportunities and directions that will be made possible
by a Program of Excellence.
Although the financial plans for fiscal year 1989 include $5 to $10 million in
total costs for this announcement, award of grants pursuant to this RFA is
contingent upon availability of funds for this purpose. It is anticipated
that 3-5 grants will be awarded under the program established by this
announcement. The specific number to be funded will, however, depend on the
merit and scope of the applications received and the availability of funds.
PROGRAM FEATURES
To provide a suitable structure for achieving the objectives of the RFA, a
Program of Excellence in Molecular Biology will have the following elements:
o SEVEN YEAR AWARD: This extended period will enable a Program of
Excellence to be innovative, to pursue new developments in rapidly
advancing areas, to embark on the application of molecular biology
to more complex experimental systems, and to develop new
experimental models.
o RECRUIT ESSENTIAL SCIENTIFIC EXPERTISE: In order to provide the
most effective combination of scientific disciplines, applicants
Vol. 17, No. 23, July 15, 1988 - Page 8
may request funds to recruit faculty to augment or strengthen the
skills and capabilities of existing faculty.
o INSTITUTIONAL ENVIRONMENT AND RESOURCES: Applicants may request
funds for incidental alteration and renovation of facilities
consistent with Public Health Service policy, as well as the
purchase of equipment needed to conduct research using the
technologies of molecular biology.
o EXPERIMENTAL DESIGN AND METHODS: In an effort to provide broader
degrees of research freedom, and to encourage innovative
approaches, the application requires only a brief description of
the preferred and alternative experimental approaches, strategies
and proposed research directions. The application will not require
specific details for individual experiments and protocols. In
addition, the application will use a simplified budgetary format.
o SUPPORT FOR NEW INVESTIGATORS: To provide for the development of
new research workers with skills required to conduct research
utilizing the technologies of molecular biology, applications may
include a request to support young investigators or investigators
new to the discipline of molecular biology.
APPLICATION
In 1987, the NHLBI initiated a two-phase strategy to establish a network of
Programs of Excellence in Molecular Biology to stimulate the application of
molecular biological strategies in conjunction with other pioneering and
conventional technologies. The Institute will complete the establishment of
this program through this announcement. A similar announcement was released
approximately one year earlier. This two-stage process was designed to
provide institutions with additional time to augment scientific expertise
and/or to solidify interactions among the various scientific disciplines. New
applications and amended applications will be accepted.
Applications should be submitted on the revised (9/86) form PHS 398 according
to the instructions provided with the form and according to Supplemental
Guidelines prepared by the NHLBI. Because of the unique features and goals of
the Programs of Excellence, applicants will require these Supplemental
Guidelines to prepare an acceptable application.
TIMETABLE
Letter of Intent October 4, 1988
Application Receipt Date February 10, 1989
First Stage of Technical Review May 1989
Second Stage of Technical Review July 1989
Advisory Council Review September 14-15, 1989
Award Date September 30, 1989
INQUIRIES
To obtain copies of the detailed RFA and the detailed Supplemental Guidelines
(which must be followed if an acceptable application is to be submitted)
contact:
Stephen C. Mockrin, Ph.D.
National Heart, Lung, and Blood Institute
National Institutes of Health
Federal Building - Room 4C10
7550 Wisconsin Avenue
Bethesda, Maryland 20892
Telephone: (301) 496-1857