CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU (07/14/88)
Attached is the Table of Contents and Items of interest from the NIH Guide to Grants and Contracts for July 15, 1988. Jim Cassatt Vol. 17, No. 23, July 15, 1988 NOTICES Presolicitation: EPIDEMIOLOGIC STUDIES OF HIV-ASSOCIATED MALIGNANCIES ..... 1 National Cancer Institute (84/168) Index: CANCER DATED ANNOUNCEMENTS (RFPs AND RFAs) IMMUNOTOXICOLOGICAL EVALUATION OF AIDS THERAPEUTICS (RFP) ...(174/200)...... 2 National Institute of Environmental Health Sciences Index: ENVIRONMENTAL HEALTH SCIENCES DEVELOPMENT OF DOSAGE FORMS AND DELIVERY SYSTEMS FOR NEW ANTITUMOR AGENTS (RFP) ......................................(203/255)...... 2 National Cancer Institute Index: CANCER DEVELOPMENT AND PRODUCTION OF PHARMACEUTICAL DOSAGE FORMS (RFP) ..(258/327). 3 National Cancer Institute Index: CANCER NATIONAL RESEARCH SERVICE AWARD-INSTITUTIONAL GRANTS (RFA) ...(330/487)..... 4 National Institute of Dental Research (964/1401) Index: DENTAL PREVENTION CLINICAL TRIALS UTILIZING INTERMEDIATE ENDPOINTS AND THEIR MODULATION BY CHEMOPREVENTIVE AGENTS (RFA) ........(490/568, 1404/2156)..... 6 National Cancer Institute Index: CANCER CARDIAC TRANSPLANT ATHEROSCLEROSIS (RFA) ..........(571/652, 2159/2543)..... 7 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY (RFA) ..(655/783, 2546/2992).... 8 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD HYPERGLYCEMIA AND CARDIOVASCULAR DISEASE RISK FACTORS: Field Centers, Coordinating Center and Support Laboratories (RFA) ..(786/844, 2995/4294)... 9 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD DEVELOPMENT OF SEROLOGICAL TESTS FOR INVASIVE UREAPLASMA UREALYTICUM INFECTIONS (RFA) ............................(847/890)..........10 National Institute of Allergy and Infectious Diseases Index: ALLERGY AND INFECTIOUS DISEASES PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY RFA AVAILABLE: 88-HL-20 P.T. 34; K.W. 1002008, 0710030, 1002058, 0710060, 0785070, 0715165, 0715165 National Heart, Lung, and Blood Institute Application Receipt Date: February 10, l989 The National Heart, Lung, and Blood Institute (NHLBI) announces the availability of a Request for Applications (RFA) inviting grant applications to develop Programs of Excellence in Molecular Biology. Each Program of Excellence will support a multidisciplinary team of independent research investigators, and will have two major objectives: (1) to foster utilization of molecular biology approaches in important research areas within the mission of the National Heart, Lung, and Blood Institute where the use of these technologies has yet to be fully employed; and (2) to provide opportunities for investigators who have the potential for independent research careers to become skilled in the experimental strategies and techniques of molecular biology and their application to research relevant to the mission of the Institute. A Program of Excellence will be multidisciplinary in nature, and should be designed to share ideas, data, and facilities. The total scientific effort must be directed toward a central, unifying theme. In keeping with the tradition of investigator-initiated research, the NHLBI expects the applicants to define their own theme and to develop the approaches that would be used to accomplish the objectives of the proposed research program. Each applicant has considerable flexibility in devising a plan to accomplish the broad objectives of this RFA on the basis of the imagination and talents of the investigators, the resources and commitment of their respective institutions, and the unique features of this RFA. However, in order to evaluate the proposed plans effectively, each application should include an assessment of the applicant Institution's current research activities and how these will serve as a basis for development of a program of research using molecular biology approaches, a description of the proposed new program goals to achieve the integration of molecular biology into areas related to the mission of the NHLBI by the end of a seven year period, a description of the scientific and administrative plans to attain these goals, and a summary of anticipated research opportunities and directions that will be made possible by a Program of Excellence. Although the financial plans for fiscal year 1989 include $5 to $10 million in total costs for this announcement, award of grants pursuant to this RFA is contingent upon availability of funds for this purpose. It is anticipated that 3-5 grants will be awarded under the program established by this announcement. The specific number to be funded will, however, depend on the merit and scope of the applications received and the availability of funds. PROGRAM FEATURES To provide a suitable structure for achieving the objectives of the RFA, a Program of Excellence in Molecular Biology will have the following elements: o SEVEN YEAR AWARD: This extended period will enable a Program of Excellence to be innovative, to pursue new developments in rapidly advancing areas, to embark on the application of molecular biology to more complex experimental systems, and to develop new experimental models. o RECRUIT ESSENTIAL SCIENTIFIC EXPERTISE: In order to provide the most effective combination of scientific disciplines, applicants Vol. 17, No. 23, July 15, 1988 - Page 8 may request funds to recruit faculty to augment or strengthen the skills and capabilities of existing faculty. o INSTITUTIONAL ENVIRONMENT AND RESOURCES: Applicants may request funds for incidental alteration and renovation of facilities consistent with Public Health Service policy, as well as the purchase of equipment needed to conduct research using the technologies of molecular biology. o EXPERIMENTAL DESIGN AND METHODS: In an effort to provide broader degrees of research freedom, and to encourage innovative approaches, the application requires only a brief description of the preferred and alternative experimental approaches, strategies and proposed research directions. The application will not require specific details for individual experiments and protocols. In addition, the application will use a simplified budgetary format. o SUPPORT FOR NEW INVESTIGATORS: To provide for the development of new research workers with skills required to conduct research utilizing the technologies of molecular biology, applications may include a request to support young investigators or investigators new to the discipline of molecular biology. APPLICATION In 1987, the NHLBI initiated a two-phase strategy to establish a network of Programs of Excellence in Molecular Biology to stimulate the application of molecular biological strategies in conjunction with other pioneering and conventional technologies. The Institute will complete the establishment of this program through this announcement. A similar announcement was released approximately one year earlier. This two-stage process was designed to provide institutions with additional time to augment scientific expertise and/or to solidify interactions among the various scientific disciplines. New applications and amended applications will be accepted. Applications should be submitted on the revised (9/86) form PHS 398 according to the instructions provided with the form and according to Supplemental Guidelines prepared by the NHLBI. Because of the unique features and goals of the Programs of Excellence, applicants will require these Supplemental Guidelines to prepare an acceptable application. TIMETABLE Letter of Intent October 4, 1988 Application Receipt Date February 10, 1989 First Stage of Technical Review May 1989 Second Stage of Technical Review July 1989 Advisory Council Review September 14-15, 1989 Award Date September 30, 1989 INQUIRIES To obtain copies of the detailed RFA and the detailed Supplemental Guidelines (which must be followed if an acceptable application is to be submitted) contact: Stephen C. Mockrin, Ph.D. National Heart, Lung, and Blood Institute National Institutes of Health Federal Building - Room 4C10 7550 Wisconsin Avenue Bethesda, Maryland 20892
CZJ%NIHCU.BITNET@CUNYVM.CUNY.EDU (09/13/88)
Attached are the Table of Contents ant items of interest from the Guide to Grants and Contracts 7/15/88. Vol. 17, No. 23, July 15, 1988 NOTICES Presolicitation: EPIDEMIOLOGIC STUDIES OF HIV-ASSOCIATED MALIGNANCIES ..... 1 National Cancer Institute (84/168) Index: CANCER DATED ANNOUNCEMENTS (RFPs AND RFAs) IMMUNOTOXICOLOGICAL EVALUATION OF AIDS THERAPEUTICS (RFP) ...(174/200)...... 2 National Institute of Environmental Health Sciences Index: ENVIRONMENTAL HEALTH SCIENCES DEVELOPMENT OF DOSAGE FORMS AND DELIVERY SYSTEMS FOR NEW ANTITUMOR AGENTS (RFP) ......................................(203/255)...... 2 National Cancer Institute Index: CANCER DEVELOPMENT AND PRODUCTION OF PHARMACEUTICAL DOSAGE FORMS (RFP) ..(258/327). 3 National Cancer Institute Index: CANCER NATIONAL RESEARCH SERVICE AWARD-INSTITUTIONAL GRANTS (RFA) ...(330/487)..... 4 National Institute of Dental Research (964/1401) Index: DENTAL PREVENTION CLINICAL TRIALS UTILIZING INTERMEDIATE ENDPOINTS AND THEIR MODULATION BY CHEMOPREVENTIVE AGENTS (RFA) ........(490/568, 1404/2156)..... 6 National Cancer Institute Index: CANCER CARDIAC TRANSPLANT ATHEROSCLEROSIS (RFA) ..........(571/652, 2159/2543)..... 7 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY (RFA) ..(655/783, 2546/2992).... 8 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD HYPERGLYCEMIA AND CARDIOVASCULAR DISEASE RISK FACTORS: Field Centers, Coordinating Center and Support Laboratories (RFA) ..(786/844, 2995/4294)... 9 National Heart, Lung, and Blood Institute Index: HEART, LUNG, AND BLOOD DEVELOPMENT OF SEROLOGICAL TESTS FOR INVASIVE UREAPLASMA UREALYTICUM INFECTIONS (RFA) ............................(847/890)..........10 National Institute of Allergy and Infectious Diseases Index: ALLERGY AND INFECTIOUS DISEASES PROGRAMS OF EXCELLENCE IN MOLECULAR BIOLOGY RFA AVAILABLE: 88-HL-20 P.T. 34; K.W. 1002008, 0710030, 1002058, 0710060, 0785070, 0715165, 0715165 National Heart, Lung, and Blood Institute Application Receipt Date: February 10, l989 The National Heart, Lung, and Blood Institute (NHLBI) announces the availability of a Request for Applications (RFA) inviting grant applications to develop Programs of Excellence in Molecular Biology. Each Program of Excellence will support a multidisciplinary team of independent research investigators, and will have two major objectives: (1) to foster utilization of molecular biology approaches in important research areas within the mission of the National Heart, Lung, and Blood Institute where the use of these technologies has yet to be fully employed; and (2) to provide opportunities for investigators who have the potential for independent research careers to become skilled in the experimental strategies and techniques of molecular biology and their application to research relevant to the mission of the Institute. A Program of Excellence will be multidisciplinary in nature, and should be designed to share ideas, data, and facilities. The total scientific effort must be directed toward a central, unifying theme. In keeping with the tradition of investigator-initiated research, the NHLBI expects the applicants to define their own theme and to develop the approaches that would be used to accomplish the objectives of the proposed research program. Each applicant has considerable flexibility in devising a plan to accomplish the broad objectives of this RFA on the basis of the imagination and talents of the investigators, the resources and commitment of their respective institutions, and the unique features of this RFA. However, in order to evaluate the proposed plans effectively, each application should include an assessment of the applicant Institution's current research activities and how these will serve as a basis for development of a program of research using molecular biology approaches, a description of the proposed new program goals to achieve the integration of molecular biology into areas related to the mission of the NHLBI by the end of a seven year period, a description of the scientific and administrative plans to attain these goals, and a summary of anticipated research opportunities and directions that will be made possible by a Program of Excellence. Although the financial plans for fiscal year 1989 include $5 to $10 million in total costs for this announcement, award of grants pursuant to this RFA is contingent upon availability of funds for this purpose. It is anticipated that 3-5 grants will be awarded under the program established by this announcement. The specific number to be funded will, however, depend on the merit and scope of the applications received and the availability of funds. PROGRAM FEATURES To provide a suitable structure for achieving the objectives of the RFA, a Program of Excellence in Molecular Biology will have the following elements: o SEVEN YEAR AWARD: This extended period will enable a Program of Excellence to be innovative, to pursue new developments in rapidly advancing areas, to embark on the application of molecular biology to more complex experimental systems, and to develop new experimental models. o RECRUIT ESSENTIAL SCIENTIFIC EXPERTISE: In order to provide the most effective combination of scientific disciplines, applicants Vol. 17, No. 23, July 15, 1988 - Page 8 may request funds to recruit faculty to augment or strengthen the skills and capabilities of existing faculty. o INSTITUTIONAL ENVIRONMENT AND RESOURCES: Applicants may request funds for incidental alteration and renovation of facilities consistent with Public Health Service policy, as well as the purchase of equipment needed to conduct research using the technologies of molecular biology. o EXPERIMENTAL DESIGN AND METHODS: In an effort to provide broader degrees of research freedom, and to encourage innovative approaches, the application requires only a brief description of the preferred and alternative experimental approaches, strategies and proposed research directions. The application will not require specific details for individual experiments and protocols. In addition, the application will use a simplified budgetary format. o SUPPORT FOR NEW INVESTIGATORS: To provide for the development of new research workers with skills required to conduct research utilizing the technologies of molecular biology, applications may include a request to support young investigators or investigators new to the discipline of molecular biology. APPLICATION In 1987, the NHLBI initiated a two-phase strategy to establish a network of Programs of Excellence in Molecular Biology to stimulate the application of molecular biological strategies in conjunction with other pioneering and conventional technologies. The Institute will complete the establishment of this program through this announcement. A similar announcement was released approximately one year earlier. This two-stage process was designed to provide institutions with additional time to augment scientific expertise and/or to solidify interactions among the various scientific disciplines. New applications and amended applications will be accepted. Applications should be submitted on the revised (9/86) form PHS 398 according to the instructions provided with the form and according to Supplemental Guidelines prepared by the NHLBI. Because of the unique features and goals of the Programs of Excellence, applicants will require these Supplemental Guidelines to prepare an acceptable application. TIMETABLE Letter of Intent October 4, 1988 Application Receipt Date February 10, 1989 First Stage of Technical Review May 1989 Second Stage of Technical Review July 1989 Advisory Council Review September 14-15, 1989 Award Date September 30, 1989 INQUIRIES To obtain copies of the detailed RFA and the detailed Supplemental Guidelines (which must be followed if an acceptable application is to be submitted) contact: Stephen C. Mockrin, Ph.D. National Heart, Lung, and Blood Institute National Institutes of Health Federal Building - Room 4C10 7550 Wisconsin Avenue Bethesda, Maryland 20892 Telephone: (301) 496-1857