[bionet.sci-resources] NIH Guide 3/18/89

CZJ@nihcu.bitnet (03/16/89)

Attached is the Table of Contents and Items of Interest from the
NIH Guide to Grants and Contracts 3/15/89.  I would call special
attention to the item on Post-Doctoral Fellowships in the field
of Informatics issued by the National Library of Medicine.

Jim Cassatt
----------------------






Vol. 18, No. 9, March 17, 1989


                                   NOTICES


CHANGES IN THE NEW INDIVIDUAL FELLOWSHIP FORM .........(84/178).............. 1
National Institutes of Health
Index:  NATIONAL INSTITUTES OF HEALTH


NOTICE - AVAILABILITY OF A MOUSE GENETIC MODEL FOR HUMAN NEURAL
TUBE DEFECTS ..........................................(182/247)............. 2
National Institute of Child Health and Human Development
Index:  CHILD HEALTH, HUMAN DEVELOPMENT


                     DATED ANNOUNCEMENTS (RFPs AND RFAs)


ISOLATION, PURIFICATION, AND CHARACTERIZATION OF ANTIGENS FROM
PURIFIED MYCOBACTERIUM LEPRAE OBTAINED FROM ARMADILLO TISSUE (RFP) .......... 3
National Institute of Allergy and Infectious Diseases    (253/286)
Index:  ALLERGY, INFECTIOUS DISEASES


DETAILED DRUG EVALUATION AND DEVELOPMENT OF TREATMENT STRATEGIES
FOR CHEMOTHERAPEUTIC AGENTS (RFP) .......................(289/337)........... 3
National Cancer Institute
Index:  CANCER


SPECIALIZED CENTERS OF RESEARCH (SCOR) IN THROMBOSIS (RFA) .................. 4
National Heart, Lung, and Blood Institute           (340/373, 884/1337)
Index:  HEART, LUNG, BLOOD


PROGRAMS OF EXCELLENCE IN ENDOCRINOLOGY RESEARCH (RFA) ..(376/542, 1340/1589) 4
National Institute of Diabetes and Digestive and Kidney Diseases
Index:  DIABETES, DIGESTIVE AND KIDNEY DISEASES


NATIONAL RESEARCH SERVICE AWARD-INSTITUTIONAL GRANTS (T32) (RFA) ............ 6
National Institute of Dental Research                   (545/618, 1592/2056)
Index:  DENTAL RESEARCH


                        ONGOING PROGRAM ANNOUNCEMENTS


INDIVIDUAL MEDICAL INFORMATICS POSTDOCTORAL FELLOWSHIPS ...(624/755)......... 7
National Library of Medicine
Index:  LIBRARY OF MEDICINE


NATIONAL RESEARCH SERVICE AWARDS FOR PREDOCTORAL M.D./PH.D. FELLOWS ......... 9
Alcohol, Drug Abuse, and Mental Health Administration      (758/831)
Index:  ALCOHOL, DRUG ABUSE, MENTAL HEALTH
















                                   NOTICES


CHANGES IN THE NEW INDIVIDUAL FELLOWSHIP FORM

P.T. 22;  K.W. 1014006, 0720005

National Institutes of Health

As announced in the NIH Guide for Grants and Contracts, Vol. 18, No. 5,
February 17, 1989, the application form for competing Individual National
Research Service Awards, PHS 416-1, has just been revised.  This revision
(7/88), which should be used for the May 10, 1989 receipt date and subsequent
deadlines, has undergone major changes.

The kit now reflects the expedited review of individual fellowships, including
the submission of reference letters with the application.  Reference letters
in sealed envelopes must be attached to the front of the original copy of the
application.  Applications without at least three reference letters will be
returned without review.

The kit also reflects the following changes in PHS policy;

a) Deletion of the invention reporting requirements for fellows (NIH Guide for
Grants and Contracts, Vol. 17, No. 32, October 7, 1988);

b) Addition to the application face page of Item No. 6, Certification of
Non-Delinquency on Federal Debt.  See NIH Guide for Grants and Contracts, Vol.
17, No. 35, October 28, 1988, or the Important Notice flier now being inserted
in application kits; and

c) Addition to the Checklist page of the Scientific Fraud (Misconduct)
Assurance.  As with research grant application (NIH Guide for Grants and
Contracts, Vol. 17, No. 2, January 15, 1988), the Assurance is not required
until the DHHS regulations are final.  But the sponsoring institution can
check the block on the Checklist page if it already has procedures in place to
review reports of misconduct.  The Notice of Proposed Rulemaking requesting
public comment on the development of the regulations was published in the
Federal Register on September 19, 1988 (NIH Guide for Grants and Contracts,
Vol. 17, No. 31, September 30, 1988).  A future announcement in the Guide will
note the date of the final regulations.

Additional recent policies include:

a) Debarment and Suspension.  See NIH Guide for Grants and Contracts, Vol. 17,
No. 38, November 18, 1988, or the Important Notice flier on Debarment and
Suspension now being inserted in application kits, for the required
certifications by fellowship applicants and sponsoring institutions; and

b) Requirements for a Drug-Free Workplace.  See NIH Guide for Grants and
Contracts, Vol. 18, No. 1, January 13, 1989, for certifications required from
sponsoring organizations and individual applicants effective March 18, 1989.
Such certifications are given by individuals when signing the application face
page and by Officials Signing for Sponsoring Institutions when signing the
Facilities and Commitment Statement.  Notice and interim final rules regarding
drug-free workplace requirements were published in the Federal Register, Vol.
54, No. 19, January 31, 1989.

Many items on the application form have been consolidated and relocated.  This
is most evident on page 2, which serves as a summary of the entire application
(applicant, sponsor and research project).  Other changes include:

a) Design of pages 1 and 2 for optical character recognition;

b) Expansion of the Human Subjects and Vertebrate Animal items (Nos.  9 and
10) on page 1 to include the institutional assurance numbers and IRB and IACUC
review dates.  A separate HHS 596 form or letter giving this information is no
longer necessary unless required for a follow-up certification;

c) Relocation of the sponsoring institution's Entity Identification Number and
Business Official items (Nos.  12 and 14) to page 1;

d) Addition of a Table of Contents page;

e) Deletion of the Institutional Allowance item from the Facilities and
Commitment Statement.  This allowance is automatic, at the maximum level
specified in the program announcement;


                   Vol. 18, No. 8, March 17, 1989 - Page 1
f) Inclusion on the Checklist page of the Senior Fellowship budget
information; and

g) Clarification and expansion of the instructions, including a table of
contents page for the entire kit and a glossary.

Direct any questions or comments on the new form to:

Mr. Nicholas Moriarty
Program Analyst
Division of Research Grants
Westwood Building, Room A-25
National Institutes of Health
Bethesda, Maryland  20892
Telephone:  (301) 496-7221

Consult the February 17, 1989, issue of the NIH Guide for Grants and Contracts
for sources of application kits.



NOTICE - AVAILABILITY OF A MOUSE GENETIC MODEL FOR HUMAN NEURAL TUBE DEFECTS

P.T. 34; K.W. 0755020, 1002002

National Institute of Child Health and Human Development

The National Institute of Child Health and Human Development has long been
interested in the normal process of neuroembryological development as well as
the pathogensis of neural tube defects.  This animal model is provided to
stimulate interest in characterizing a mammalian model and to search for clues
to etiologic mechanisms which could be applicable to the human condition.
Mouse embryos homozygous for the curly tail mutation (ct/ct) develop spinal
neural tube defects as a result of delay in neural fold closure at the
posterior neuropore (Copp, 1985).  The defects are similar in site, form and
associated anomalies to those occurring in humans; 1-5 percent have defects
resembling anencephaly, 55-60 percent have lower spine defects, ranging from
all tail flexion defects (curly tails) to open lumbosacral meningomyelocoele,
which can be associated with elevated amniotic fluid alpha fetoprotein and
hydrocephalus; and the remaining 40 percent are morphologically normal.  The
mutation is inherited as an autosomal recessive trait with incomplete
penetrance and results in viable homozygous individuals (Gruneberg, 1954).
The ct/ct embryos developing in whole embryo culture produce defects that
resemble those that develop in vivo in both type and frequency.

The size of the posterior neuropore at 10 days gestation (25-30 somites),
prior to the normal time when spinal neurulation is complete, can distinguish
embryos destined to develop spinal defects from their normally developing
littermates (Copp, 1985).  This morphological marker is consistent, reliable
and has been used to identify localized regions of reduced cell proliferation
(Copp, et al, 1988) and hyaluronate accumulation (Copp & Bernfield, 1988) in
affected ct/ct embryos.

The ct/ct mouse is a suitable experimental model for spinal neural tube
defects in humans because of the similar neurulation process in these species,
the similarities of the morphologic and associated defects, the ability to
distinguish affected mouse embryos from their normal littermates prior to
completion of neurulation and the fidelity of the abnormal phenotype in
culture.  Further genetic, molecular genetic and biochemical characterization
of the mutation could help delineate the etiology and pathogenesis of human
neural tube defects.

The ct/ct mice are on a CBA/Gr genetic background and are maintained as a
closed random-bred colony.  Breeding nuclei, produced in the laboratory of Dr.
Merton Bernfield as part of contract NO1-HD-6-2926, together with information
on how to detect future abnormal embryos are available, upon request, from:

Danuta Krotoski, Ph.D.
Health Scientist Administrator
Genetics and Teratology Branch
Center for Research for Mothers and Children
National Institute of Child Health and Human Development
Building EPN, Room 643
Bethesda, Maryland  20892
Telephone:  (301) 496-5541




                   Vol. 18, No. 9, March 17, 1989 - Page 2
REFERENCES

Copp, A.J. (1985) J. Embryol. Exp. Morph. 88:39-54.
Copp, A.J. and Bernfield, M. (1988) Devel. Biol. 130:583-590.
Copp, A.J., Brook, F.A., and Roberts, J.J. (1988)
  Development 104:285-295.
Gruneberg, J. (1954) J. Genet. 15:52-67.


                     DATED ANNOUNCEMENTS (RFPs AND RFAs)


ISOLATION, PURIFICATION, AND CHARACTERIZATION OF ANTIGENS FROM PURIFIED
MYCOBACTERIUM LEPRAE OBTAINED FROM ARMADILLO TISSUE

RFP AVAILABLE:  RFP-NIH-NIAID-MIDP-90-14

P.T. 34; K.W. 0780005, 0710060

National Institute of Allergy and Infectious Diseases

The Microbiology and Infectious Diseases Program of the National Institute of
Allergy and Infectious Diseases has a requirement for Isolation, Purification,
and Characterization of Antigens From Purified Mycobacterium Leprae Obtained
from Armadillo Tissues.  The successful offeror should have demonstrated
adequacy of procedures and plans for maintaining and separation of M. Leprae
bacilli from infected armadillo tissues.  This NIAID-sponsored project will
take approximately five years to complete.  One cost-reimbursement contract is
anticipated.

RFP NIH-NIAID-90-14 will be issued on or about March 24, 1989, with a closing
date for receipt of proposals tentatively set for May 15, 1989.  To receive a
copy of the RFP, please supply this office with two (2) self-addressed mailing
labels.  All responsible sources may submit a proposal which will be
considered by NIAID.

Request for the RFP shall be directed:

Mr. William C. Roberts
National Institute of Allergy and Infectious Diseases
Westwood Building, Room 707
5333 Westbard Avenue
Bethesda, Maryland 20892
Telephone:  (301) 496-2508

This advertisement does not commit the Government to award a contract.


DETAILED DRUG EVALUATION AND DEVELOPMENT OF TREATMENT STRATEGIES FOR
CHEMOTHERAPEUTIC AGENTS

RFP AVAILABLE:  NCI-CM-07315-72

P.T. 34; K.W. 0740020, 0755060

National Cancer Institute

The Developmental Therapeutics Program, Division of Cancer Treatment (DCT),
National Cancer Institute (NCI), is seeking a contractor to evaluate compounds
for anticancer activity in experimental in vivo tumor models.  Studies will
focus on agents identified by the program's disease-oriented, in vitro drug
screen and will employ human tumors growing in immuno-deficient (athymic)
mice.  Experiments will be designed and conducted to optimize drug activity
and evaluate the drug's therapeutic potential.  Some in vivo studies may
involve mouse tumors growing in pathogen-free immune-competent mice and some
cell culture support will be required for use of the human tumors.  Compounds
to be studied will be selected and assigned by the Government.  As compounds
of a commerically confidential nature (discreet) may be evaluated,
pharmaceutical and chemical firms will be excluded from the competition.
Also, since structural formulas of discreet materials may be provided by the
Government on occasion, the organization must be willing to sign a
confidentiality of information sheet.  Facilities for handling pathogen-free
immune-competent and immune-deficient mice and utilize methods to protect the
facilities from pathogenic organisms are required.  Additionally, facilities/
equipment are required for:  frozen storage of tumors, tumor transplantation,
drug preparation, and treatment; the handling of potentially carcinogenic or
hazardous materials; and the propagation and testing human tumor lines in
vitro.

                   Vol. 18, No. 9, March 17, 1989 - Page 3
One incrementally-funded contract will be awarded for a period of five (5)
years, on a "level of effort" basis specifying approximately 95,000 labor
hours over five years.  The current effort is being performed by Southern
Research Institute, Contract No N01-CM-73726.

RFP No. NCI CM-07315-72 will be available on or about March 13, 1989.
Responses will be due by April 25, 1989.  All responsible sources may submit a
proposal for consideration by the NCI.  Copies of the RFP may be obtained by
sending a request to:

Ms. Jacqueline Ballard
Contracting Officer Representative
Treatment Contracts Section
Research Contracts Branch, OAM, NCI
Executive Plaza South, Room 603
Bethesda, Maryland  20892
Telephone:  (301) 496-8620


SPECIALIZED CENTERS OF RESEARCH (SCOR) IN THROMBOSIS

RFA AVAILABLE:  NIH-89-HL-08-B

P.T. 04;  K.W. 0715040, 0745020, 0745027, 0745070

National Heart, Lung, and Blood Institute

Application Receipt Date:  January 22, 1990

The Division of Blood Diseases and Resources of the National Heart, Lung, and
Blood Institute (NHLBI), National Institutes of Health, announces the
availability of a Request for Applications (RFA) for Specialized Centers of
Research (SCOR) in Thrombosis.  New applications and applications for renewal
of existing programs are invited.  Copies of the RFA and Instructions for the
Preparation of Applications are currently available from NHLBI staff.

The objective of this program is to expedite the development and application
of new knowledge essential for improved prevention, diagnosis, and treatment
of thrombosis and thromboembolic disorders by focusing resources, facilities,
and manpower on the problems of thrombosis and other related derangements of
hemostasis.  Applications for this program are required to contain both basic
and clinical research projects.

The requirements and format for applications submitted in response to this
announcement and copies of the RFA may be obtained from:

Carol H. Letendre, Ph.D.
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute
National Institutes of Health
Federal Building, Room 516
Bethesda, Maryland  20892
Telephone:  (301) 496-8966


PROGRAMS OF EXCELLENCE IN ENDOCRINOLOGY RESEARCH

RFA AVAILABLE:  89-DK-05

P.T. 34;  K.W. 0785050, 0765033, 0745020, 0745070, 0760020, 0765010, 0790000

National Institute of Diabetes and Digestive and Kidney Diseases

BACKGROUND

Endocrinology represents one of the broadest areas of biomedical research
endeavors.  Through investigator-initiated research, acquisition of basic
knowledge in endocrinology has progressed rapidly.  New techniques in
molecular and cell biology and immunology are directly relevant to research in
endocrinology and will permit further growth of knowledge in this field.
Research in endocrinology has led to fundamental new understandings of intra-
and inter-cellular communication, of regulation of gene expression, cell
growth and metabolism, and of the integration of the endocrine system with the
immune and nervous systems.  These advances in our understanding of
fundamental endocrinology are relevant not only to diseases of the endocrine
system but also to cancer, osteoporosis, and cardiovascular, neurologic,
immunologic and psychiatric disorders.


                   Vol. 18, No. 9, March 17, 1989 - Page 4
RESEARCH GOALS AND SCOPE

The goal of this RFA is to solicit applications for the support of coordinated
multi-disciplinary research programs in areas of particular importance to the
Endocrinology Research Program of the National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK).  The long range purpose is to enhance
our fundamental knowledge of endocrine processes, and to facilitate
application of that knowledge to the study of human physiology and disease.

To achieve this goal, program project grants will be awarded for the support
of multi-disciplinary research with a specific major objective.  Areas of
investigation of interest to NIDDK include, but are not limited to:  (1) the
pathogenesis, diagnosis and therapy of endocrine disorders; (2) thyroid,
parathyroid, adrenal, pituitary, endocrine hypothalamic and pineal physiology
and pathophysiology; (3) the regulation and integration of endocrine systems;
(4) the biosynthesis, processing, secretion, transport and metabolism of
hormones and hormone-like agents; (5) mechanisms of hormone action, including
hormone binding to receptors, synthesis and regulation of receptors, second
messengers, and hormonal regulation of gene expression; (6) growth factors,
cytokines, neuropeptides, gastrointestinal peptides, vitamin D, hormones of
the immune system, prostaglandins, paracrine and autocrine factors and other
substances with hormone-like activity; (7) the structure and function of the
hypothalamic releasing hormones as they affect endocrine function; (8) bone
active hormones and cytokines and the endocrine control of bone metabolism;
(9) endocrine aspects of osteoporosis and of the metabolic bone disease
associated with renal failure; (10) endocrine regulation of human growth
including the roles of growth factors, somatomedins, somatostatin and GHRH;
(11) the regulation of the growth and proliferation of endocrine cells
including benign endocrine neoplasia; (12) endocrine aspects of obesity,
growth disorders, stress, atherosclerosis, hypertension, cancer and other
diseases in which endocrinology plays a major role.

MECHANISM OF SUPPORT

The administrative and funding mechanism will be the program project award.  A
Program Project award is for the support of a broadly-based multidisciplinary
or multifaceted research program which has a specific major objective or
central theme.  The regulations and the policies that govern the research
grant programs of the Public Health Service will prevail.  The award may
support:  (a) research projects, (b) core functions, and (c) feasibility
studies.  Collectively, these projects should demonstrate essential elements
of unity and interdependence and result in a greater contribution to program
goals than if each project were pursued individually.

Although this solicitation is included in the funding plans for Fiscal Year
1990 for NIDDK, the award of grants pursuant to this RFA is contingent upon
the receipt of appropriated funds for this purpose.  The duration of proposed
projects may be up to five years.  Projects may be extended through competing
continuation applications.  A program project application may request up to
$6.25 million in direct costs over a 5-year period.

The NIDDK plans to designate a total of $3.0 million (direct and indirect
costs) in FY 1990 contingent on the receipt of highly meritorious applications
in response to this solicitation.  However, the specific amount to be funded
will depend upon the overall merit and scope of applications received.

REVIEW PROCEDURES AND CRITERIA

All applications responsive to the RFA will be reviewed for scientific and
technical merit by an NIDDK initial review group (IRG), which will be convened
solely to review these applications.  It is not anticipated that site visits
will be part of the review process; therefore, each proposal should be
complete in itself and should be prepared as if no visit is expected.
Following the IRG review, the applications will be reviewed by the National
Diabetes and Digestive and Kidney Diseases Advisory Council.

METHOD OF APPLYING

Applicants should request NIDDK Administrative and Review Guidelines for
Program Project Grant Applications.  These guidelines contain important
additional information on the format of applications and review criteria.
Prospective applicants should request the complete text of this RFA and
NIDDK's program project guidelines from one of the program administrators
indicated below.





                   Vol. 18, No. 9, March 17, 1989 - Page 5
Format for Application:

Applications should be submitted on the standard PHS 398 application form
available at most institutional business offices or from the Division of
Research Grants, NIH, (301) 496-7441.  On item 2 of the face page of the
application, applicants should enter:  RFA:  Programs of Excellence in
Endocrinology Research and the RFA number, 89-DK-05.  The RFA label available
in the 9/86 revision of Application Form 398 must be affixed to the bottom of
the face page.  Failure to use this label could result in delayed processing
of the application to the extent that it may not reach the review committee in
time for review.

Application Procedure:

Applications must be received by September 20, 1989; the original and four
copies of the application should be sent or delivered to:

Application Receipt
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, Maryland  20892**

Two additional copies of the application should be sent to:

Review Branch
National Institute of Diabetes and Digestive and
Kidney Disease
Westwood Building, Room 406
Bethesda, Maryland  20892

Timetable:

A letter of intent should be submitted no later than June 30, 1989.
Applications must be received by September 20, 1989.  Any applications
received after this date will be considered ineligible for this special
solicitation.

APPLICATION RECEIPT DATE  INITIAL REVIEW  COUNCIL REVIEW  EARLIEST START
    Sept. 20, 1989        Feb./Mar. 1990     May 1990       July 1, 1990

Inquiries:

Inquiries regarding this announcement, the guidelines for structuring a
program project application and method of applying should be directed to the
program administrators:

Judith A. Fradkin, M.D.                 Robert A. Tolman, Ph.D.
Chief, Endocrinology and Metabolic      Director, Endocrinology
 Diseases Programs Branch                Research Program
NIDDK                                   NIDDK
Westwood Building, Room 603             Westwood Building, Room 605
Bethesda, Maryland  20892               Bethesda, Maryland  20892
Telephone:  (301) 496-7791              Telephone:  (301) 496-7504

Francisco O. Calvo, Ph.D.
Associate Director, Endocrinology
 Research Program
NIDDK
Westwood Building, Room 603
Bethesda, Maryland  20892
Telephone:  (301) 496-7341


INDIVIDUAL MEDICAL INFORMATICS POSTDOCTORAL FELLOWSHIPS

P.T. 22;  K.W. 1004017, 1004000, 1004008, 1004015

National Library of Medicine

Application Receipt Dates:  January 10, May 10, September 10

BACKGROUND

There is a growing need for qualified, talented investigators, well equipped
to address fundamental issues in the use of computers and automated
information systems in health care, health professions education, and
biomedical research.  These investigators will contribute to the growth of
science by their studies of knowledge management and by advancing the

                   Vol. 18, No. 9, March 17, 1989 - Page 7
frontiers of the computer sciences for organizing, retrieving, and utilizing
health knowledge.  Medical informatics, as a discipline with an integral role
in academic medicine, will also be enhanced.  It is expected that the fellows
will become able, cross-disciplinary translators, taking the computer sciences
to all of medicine.

The recent designation of the National Library of Medicine (NLM) as the
National Center for Biotechnology intensifies the Library's interest and
responsibilities in a special area of informatics.  The appearance of new
experimental methods in the past several years has greatly increased the rate
at which data are accumulating about the molecular control of life processes.
Because of their size and complexity, the data that are generated by such
undertakings must be analyzed and compared using computerized techniques for
storage, searching, and analysis.  The computer databases that hold this
information, currently numbered in millions of nucleotide base pairs and
thousands of amino acids, are expected to grow by three orders of magnitude to
encompass sequences totaling billions of nucleotides.

GOALS AND SCOPE

The discipline of medical informatics goes beyond the use of the computer as a
computational tool and extends into the process of knowledge representation,
storage, retrieval, and manipulation largely to support inferential reasoning
and to rationalize decision-making in the health sciences.  To support these
pursuits, the span of relevant disciplines is far ranging.  Engineering,
computational linguistics, computer science, information science, statistics
and cognitive sciences must all be brought to bear in the context of the
health sciences to achieve the desired goals.

Appropriately trained individuals able to conduct these types of
multidisciplinary informatics research are in very short supply.  A fellowship
program in medical informatics research training will assist in alleviating
the shortages.

The NLM's Long Range Plan counts medical informatics training and career
development among its top priorities.  There is a large and growing number of
qualified individuals seeking training in this field - a number which exceeds
the combined capabilities of currently active institutional training sites.
Clearly, other institutions are providing, or can also provide, quality
training in medical informatics and a number of these have the requisite
institutional environment for training in the special informatics area of
biotechnology; i.e., the representation and analysis of molecular biology data
by computer.  The scope of this announcement is intended to encompass research
fellowship applications in medical informatics generally or in the
biotechnology category of informatics.

MECHANISM OF SUPPORT

Individual postdoctoral fellowship applications in medical informatics are
welcomed from persons trained in the physical or computer sciences who desire
to bring such approaches to medical informatics research or from biologists
and physicians who wish to acquire research training in biocomputation,
knowledge representation, inferential reasoning or other areas related to
informatics.

Individuals must be, at the time of application, citizens or noncitizen
nationals of the United States, or have been lawfully admitted to the United
States for permanent residence and have in their possession an Alien
Registration Receipt Card (I-151 or I-551).  Before submitting an application,
an applicant must arrange for appointment to an appropriate institution and
acceptance by a sponsor, who will supervise the training and research
experience.

The stipend level for the individual postdoctoral fellowship ranges from
$17,000 to $31,500 depending on years of relevant experience subsequent to the
award of the doctorate degree.  In addition, the applicant's
institution/organization may request an institutional allowance up to $3,000
per year for support of supplies, equipment, travel, tuition, fees, insurance
and other training related costs.

Individual postdoctoral fellowships are made for project periods of up to
three years.

APPLICATION AND REVIEW PROCEDURES

Applications must be submitted on Form PHS 416-1 (Rev.  7/88).  These forms,
with appropriate descriptive information about NLM's Individual Medical
Informatics Postdoctoral Fellowship program, may be obtained from:

                   Vol. 18, No. 9, March 17, 1989 - Page 8
Roger W. Dahlen, Ph.D.
Chief, Biomedical Information
   Support Branch
Extramural Programs
National Library of Medicine
Bethesda, Maryland 20894
Telephone:  (301) 496-4221

Applications will be accepted in accordance with the usual receipt dates for
new fellowship applications:  January 10, May 10, September 10.  The review
process will be completed approximately six months after the respective
receipt dates.  Applications received too late for one cycle of review will be
held until the next receipt date.

Applications will be received by the NIH's Division of Research Grants (DRG)
and referred to the Biomedical Library Review Committee for scientific and
technical merit review.  The review criteria customarily employed by the NIH
for fellowship applications will prevail.

The original and two (2) copies of the application should be directed to:

Application Receipt Office
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, Maryland  20892**

NOTE:  Please type the following information in Item 3, page 1, the face page
of the application form:  "Medical Informatics (NLM)."

This program is described in the Catalog of Federal Domestic Assistance,
Medical Library Assistance, 13.879.  Grants will be awarded under the
authority of the Public Health Act, Section 472 (42 USC 286b-3) and
administered under PHS grant policies and Federal Regulations, most
specifically at 42 CFR 61.


NATIONAL RESEARCH SERVICE AWARDS FOR PREDOCTORAL M.D./PH.D. FELLOWS

P.T. 22;  K.W. 0404003, 0404009, 0715095, 0715129, 0404000

National Institute of Mental Health
National Institute on Alcohol Abuse and Alcoholism
National Institute on Drug Abuse

The Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) provides
National Research Service Awards (NRSAs) to individuals for research training
in specified areas of biomedical and behavioral research.  The purpose of the
NRSA for Predoctoral M.D./Ph.D. Fellows is to help ensure that highly trained
physicians/scientists will be available in adequate numbers and in appropriate
research areas to meet the Nation's alcohol, drug abuse, and mental health
needs.  An applicant for an ADAMHA NRSA M.D./Ph.D. individual fellowship must
show evidence of high academic performance and evidence of significant
interest in research.  He or she must be enrolled in an M.D./Ph.D. program at
an approved medical school, accepted in a related scientific Ph.D. program,
and supervised by a mentor in the scientific discipline when the application
is submitted.  The ADAMHA NRSA M.D./Ph.D. fellowship program provides combined
medical school and predoctoral Ph.D. support for a maximum of 6 years.  The
annual stipend for predoctoral fellows at all levels is $8,500.

ADAMHA expects to begin support of up to 15 of these fellowships in 1990, 20
in 1991, and 25 in 1992.  Approximately $375,000 will be set aside for this
purpose in 1990, $875,000 in 1991, and $1,500,000 in 1992.

Applications in response to this announcement will be accepted and reviewed
once each year according to the following schedule:

Receipt Date--September 10
Initial Review Group Meeting--February
Notification--March to June
Earliest Possible Start Date--July 1

Potential applicants interested in obtaining further
information should contact one of the following:





                   Vol. 18, No. 9, March 17, 1989 - Page 9
National Institute of Mental Health

Leonard Lash, Ph.D.
Division of Clinical Research
Room 10-99
Telephone:  (301) 443-3264

National Institute on Alcohol Abuse and Alcoholism

David B. Lozovsky, M.D., Ph.D.
Division of Basic Research
Room 14C-20
Telephone:  (301) 443-4223

Elsie Taylor
Division of Clinical and Prevention Research
Room 16C-03
Telephone:  (301) 443-1677

National Institute on Drug Abuse

Charles Sharp
Division of Preclinical Research
Room 10A-31
Telephone:  (301) 443-6300

The mailing address for all of the above is:

Parklawn Building
5600 Fishers Lane