kristoff@GENBANK.BIO.NET (Dave Kristofferson) (03/23/90)
NOTE: The NIH Guide may be split into more than one mail message to avoid truncation during e-mail distribution. The first message always begins with the RFP/RFA summary sections followed by the appended texts of the full RFP/RFAs. ---------------------------------------------------------------------- NIH GUIDE - Vol. 19, No. 12, March 23, 1990 NOTICES NOTICE OF SOLICITATION OF PUBLIC COMMENTS FOR THE NATIONAL PANEL FOR RESEARCH IN NEUROLOGICAL DISORDERS .......................(84/131)........... 1 National Institute of Neurological Disorders and Stroke Index: NEUROLOGICAL DISORDERS, STROKE NOTICES OF AVAILABILITY (RFPs AND RFAs) CONTROLLED CLINICAL TRIALS FOR IMPROVED ANTIMICROBIAL THERAPY OF SYSTEMIC MYCOTIC INFECTIONS (RFP) ........................(137/171).......... 1 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES RFP FOR SUBCONTRACTORS FOR THE LIVER TISSUE PROCUREMENT DISTRIBUTION SYSTEM (RFP) ................................(174/199).......... 2 National Institute of Diabetes, Digestive and Kidney Diseases Index: DIABETES, DIGESTIVE DISEASES, KIDNEY DISEASES CLINICAL COORDINATING CTR. FOR ASYMPTOMATIC CARDIAC ISCHEMIA PILOT STUDY(RFP).2 National Heart, Lung, and Blood Institute (202/255) Index: HEART, LUNG, BLOOD ESTABLISHMENT OF AN ACUTE VIRAL RESPIRATORY DISEASES UNIT (RFP) ............. 3 National Institute of Allergy and Infectious Diseases (258/312) Index: ALLERGY, INFECTIOUS DISEASES PEPTIDE ANTAGONISTS OF LHRH AS GONADOTROPIN INHIBITORS (RFP) ..(321/357)..... 4 National Institute of Child Health and Human Development Index: CHILD HEALTH, HUMAN DEVELOPMENT ENTERIC DISEASES VACCINE AND TREATMENT EVALUATION UNIT (RFP) ..(360/391)..... 4 National Institute of Allergy and Infectious Diseases Index: ALLERGY, INFECTIOUS DISEASES PATHOBIOLOGY OF PNEUMOCYSTIS CARINII IN THE LUNG (RFA 90-HL-08-L) ........... 5 National Heart, Lung, and Blood Institute (401/441, 964/1303) Index: HEART, LUNG, BLOOD RESEARCH DEMONSTRATION GRANTS FOR THE PREVENTION OF YOUTH SUICIDE AND SUICIDAL BEHAVIOR (RFA MH-90-15) ..................(444/504)............. 5 National Institute of Mental Health Index: MENTAL HEALTH MCKINNEY RESEARCH DEMONSTRATION PROGRAM FOR HOMELESS MENTALLY ILL ADULTS ..... 6 National Institute of Mental Health (RFA MH-90-14) (507/548) Index: MENTAL HEALTH RESEARCH DEMONSTRATION GRANTS FOR THE PREVENTION OF SERIOUS AND CHRONIC CONDUCT PROBLEMS (RFA MH-90-13) ...............(561/614)............. 7 National Institute of Mental Health Index: MENTAL HEALTH RESEARCH DEMONSTRATIONS ON EMERGENCY MENTAL HEALTH SERVICES FOR CHILDREN AND ADOLESCENTS (RFA MH-90-19) ...............(617/684)............. 7 National Institute of Mental Health Index: MENTAL HEALTH ONGOING PROGRAM ANNOUNCEMENTS NIAID SMALL GRANTS PROGRAM: CHANGE OF INITIAL REVIEW GROUP ASSIGNMENT ...... 8 National Institute of Allergy and Infectious Diseases (690/727) Index: ALLERGY, INFECTIOUS DISEASES RESEARCH ON EFFECTIVENESS AND OUTCOMES OF MENTAL HEALTH SERVICES ..(730/776). 9 National Institute of Mental Health Index: MENTAL HEALTH RESEARCH ON SERVICES FOR PERSONS WITH MENTAL DISORDERS THAT CO-OCCUR WITH ALCOHOL AND/OR DRUG ABUSE DISORDERS ...............(779/832)............ 9 National Institute of Mental Health Index: MENTAL HEALTH EPIDEMIOLOGIC AND SERVICES RESEARCH DEMONSTRATIONS ON MENTAL DISORDERS THAT CO-OCCUR WITH DRUG AND/OR ALCOHOL DISORDERS AMONG AMERICAN INDIANS, ALASKAN NATIVES, AND NATIVE HAWAIIANS ..................(835/923)............10 National Institute of Mental Health Index: MENTAL HEALTH NOTICES NOTICE OF SOLICITATION OF PUBLIC COMMENTS FOR THE NATIONAL PANEL FOR RESEARCH IN NEUROLOGICAL DISORDERS P.T. 42; K.W. 0715138, 0705010, 1002030, 0710030 National Institute of Neurological Disorders and Stroke Notice is hereby given that the National Panel of the National Advisory Neurological Disorders and Stroke Council plans to solicit public comments in order to increase its knowledge and understanding of the needs and opportunities for research on brain and nervous system disorders in the 1990s. Information from scientists, physicians and representatives of interested organizations and institutions may be shared with the National Panel at the National Meeting for Research in Neurological Disorders on April 17, 1990, from 9:00 a.m. until 5:00 p.m., at the Department of Health and Human Services, Hubert H. Humphrey Building, Conference Room 800, 200 Independence Avenue, S.W., Washington, D.C. The 1990s have been declared the Decade of the Brain by the President and the Congress. The "Decade" will bring into focus the significant opportunities in neurological research that can be realized through an expanded research effort. The Advisory Council of the National Institute of Neurological Disorders and Stroke has appointed a National Panel to frame a research plan for the implementation of the Decade of the Brain. The plan will document specific research objectives to be achieved, the steps to be initiated to achieve those objectives, and the resources required to reach the specified goals. The attendance and the number of presentations during the conference will be limited to the time and space available. Thus, all individuals representing organizations and institutions who wish to make an oral presentation at the meeting must arrange for a written statement of their testimony to be sent to Dr. Michael D. Walker, Executive Director, National Panel for Research in Neurological Disorders. Statements must be received by Social and Scientific Systems, Inc., 7101 Wisconsin Avenue, Suite 610, Bethesda, Maryland 20814-4805 by 5:00 p.m., April 2, 1990. Prior notification of those desiring to present oral testimony would be helpful (complete name, affiliation, address and telephone number). Only speakers discussing subjects relevant to research in neurological disorders will be scheduled. Each speaker will be limited to 10 minutes to summarize or highlight the written statement. Those who cannot attend the meeting but would like to submit a written statement are encouraged to do so by the April 2 deadline. All statements may not exceed three pages but may include limited addenda. For information about the meeting contact: Ms. Johanna McDonough Telephone: (301) 986-487 NOTICES OF AVAILABILITY (RFPs AND RFAs) CONTROLLLED CLINICAL TRIALS FOR IMPROVED ANTIMICROBIAL THERAPY OF SYSTEMIC MYCOTIC INFECTIONS RFP AVAILABLE: RFP-NIH-NIAID-DMID-91-4 P.T. 34; K.W. 0755015, 0740005, 0715103 National Institute of Allergy and Infectious Diseases The Division of Microbiology and Infectious Diseases and the Division of Acquired Immune Deficiency Syndrome of the National Institute of Allergy and Infectious Diseases, is soliciting proposals from investigators having the capabilities and facilities to perform collaborative clinical trials directed at improving antibiotic therapy of serious disseminated fungal infections of man. The clinical research will be performed by an antifungal therapy clinical trials group comprised of satellite medical institutions coordinated by the contracting institution. The issuance of the Request for Proposals (RFP) will be on March 30, 1990. Responses are due by the close of business on April 30, 1990. It is expected that the contract will be awarded for five years. Approximately one (1) award is anticipated. NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 1 To receive a copy of this RFP, please reference RFP-NIH-NIAID-DMID-91-4 and send two self-addressed mailing labels to: Ms. Ann Linkins Contract Management Branch National Institute of Allergy and Infectious Diseases Westwood Building, Room 707 5333 Westbard Avenue Bethesda, MD 20892 This advertisement does not commit the Government to award a contract. RFP FOR SUBCONTRACTORS FOR THE LIVER TISSUE PROCUREMENT DISTRIBUTION SYSTEM RFP AVAILABLE: NIH N01-DK-6-2274 P.T. 34; K.W. 0780020, 0780000 National Institute of Diabetes, Digestive and Kidney Diseases The University of Minnesota was awarded a 5-year renewal of the Liver Tissue Procurement Distribution System (LTPADS) and is now eliciting an announcement for subcontractors for the next 4 1/2 years. The purpose of LTPADS is to provide access to human liver for investigators throughout the United States in order that they may utilize this tissue for research. Subcontractors would provide at least 15-25 "normal" or pathologic livers per year. If you are interested in becoming a subcontractor, an RFP proposal will be sent to you. The due date for the completed RFP will be April 16, 1990. Final selection will be made by May 14, 1990, with possible activation by May 29, 1990. Proposal forms can be obtained from: Harvey L. Sharp, M.D. Principal Investigator, LTPADS c/o Elizabeth Webster Box 279 UMHC University of Minnesota Hospitals Minneapolis, Minnesota 55455 Telephone: (612) 624-1133 CLINICAL COORDINATING CENTER FOR ASYMPTOMATIC CARDIAC ISCHEMIA PILOT STUDY RFP AVAILABLE: NIH-NHLBI-HV-90-07 P.T. 34; K.W. 0755015, 0755018, 0715040 National Heart, Lung, and Blood Institute The National Heart, Lung, and Blood Institute will do a pilot multicenter clinical trial to assess the feasibility of and test the methodology required for a full-scale clinical trial of asymptomatic cardiac ischemia therapies. The primary objective is to determine the relative efficacy of usual symptom-guided medical care; stepped ambulatory ECG-directed maximal medical therapy; and mechanical revascularization to provide freedom from myocardial ischemia. Other objectives are to confirm the frequency of asymptomatic cardiac ischemia in the target patient subgroups, validate current detection and monitoring systems, and clarify other issues important for a full-scale clinical trial, such as the availability of patients for randomization and compliance with assigned treatment. The study population will consist of a total of 600 patients with coronary artery disease (CAD) documented by contrast angiographic and radionuclide studies and who have been identified by both exercise stress testing and 48-hour ambulatory ECG monitoring: 300 patients with coronary artery disease (CAD) and exertional angina, and 300 patients with asymptomatic CAD. The Clinical Coordinating Center (CCC) will work with the investigators from the (10-12) Clinical Units, as well as the Cardiac Diseases Branch staff, in the development of the final Study Protocol and the detailed Manual of Operations for the ACIP Study. Throughout the study the CCC will be responsible for updating and distributing the Manual of Operations, and collecting, editing, storing, and analyzing data submitted from the Clinical Units. The Clinical Coordinating Center will provide the means for monitoring performance and quality control of diagnostic procedures incorporated in the protocol. The procedures are: (1) Forty-eight (48) hour ambulatory ECG monitoring; (2) resting and exercise ECG; (3) radionuclide scintigraphy (myocardial perfusion and left venticular function); and (4) contrast angiography and left ventriculography. One award is anticipated. This incrementally funded contract will be awarded for 36 months. NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 2 This is not a Request for Proposals. RFP NHLBI-HV-90-07 will be released on or about March 10, 1990, with proposals due on or about April 30, 1990. One (1) award is anticipated by the Government. Your written request should include three (3) labels, self-addressed with your mailing address, and must cite RFP No. NHLBI-HV-90-07. Request for copies of the RFP should be sent to the following address: Sharon M. Kraft, Contract Specialist HLVD Contracts Section, Contracts Operations Branch, DEA National Heart, Lung, and Blood Institute Federal Building, Room 4C04 National Institutes of Health Bethesda, MD 20892 Telephone: (301) 496-6838 ESTABLISHMENT OF AN ACUTE VIRAL RESPIRATORY DISEASES UNIT RFP AVAILABLE: RFP-NIH-NIAID-DMID-91-06 P.T. 34; K.W. 0705065, 1002045, 0715165, 0765035, 0755015 National Institute of Allergy and Infectious Diseases The Viral Respiratory Diseases Program of the National Institute of Allergy and Infectious Diseases (NIAID) is seeking an organization to establish an Acute Viral Respiratory Disease Unit (AVRDU). The overal goal of the Unit would be to develop a systematic and centralized approach towards the understanding of the impact of acute viral respiratory diseases on selective populations. Specifically, the AVRDU would: o Evaluate the etiology of acute viral respiratory infections in selective populations (e.g. infants, asthmatics, elderly, and those with other chronic pulmonary diseases). o Assess the pathophysiologic impact of the various respiration viruses in the above selective populations. o Develop improved, rapid diagnostic techniques for selective viral respiratory infections. o Identify and/or expand the knowledge on the correlates of immunity associated with protection against viral respiratory diseases. o Perform clinical trials with promising new vaccines or therapies. The NIAID solicits proposals from medical/research institutions qualified to serve as the sole Contracting Unit or as the Central Unit of a collaborative group. The Contractor must have demonstrated capacity to organize and administer both research and clinical studies. One contract may be awarded as a result of this solicitation. It is expected that the contract will have a five-year period of performance. Any responsible offeror may submit a proposal which will be considered by the Government. The issuance date of the RFP will be on or about March 28, 1990; proposals will be due by the close of business on May 8, 1990. Requests for the RFP should be directed to: Mr. Frank M. Fountain Contract Specialist Contract Management Branch National Institutes of Health Westwood Building, Room 707 Bethesda, MD 20892 Please provide this office with two (2) self-addressed mailing labels. This advertisement does not commit the Government to award a contract. NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 3 PEPTIDE ANTAGONISTS OF LHRH AS GONADOTROPIN INHIBITORS RFP AVAILABLE: NICHD-CD-90-15 P.T. 34; K.W. 0760035, 0760060, 0760025, 1003006 National Institute of Child Health and Human Development The Contraceptive Development Branch of the Center for Population Research, National Institute of Child Health and Human Development (NICHD), is interested in stimulating further investigations into the design, synthesis, and testing of peptide antagonists of LHRH as gonadotropin inhibitors. Such investigations will also involve biological evaluation of the peptides, preferably by the Contractor. The Contraceptive Development Branch is prepared, however, to evaluate such peptides if the contractor is unable to do so. The goal is to obtain LHRH antagonists which are more potent than those currently available and are devoid of histamine releasing properties. Proposals to merely collect peptides from various sources and/or only perform biological assays are excluded from consideration at this time. Organizations must have adequate facilities and capabilities to carry out the proposed peptide program. All responsible sources may submit an offer which shall be considered by the agency. It is anticipated that four cost-reimbursement, incrementally funded type contracts will be awarded under the Request for Proposals (RFP) for a period of two years each, beginning November 1, 1990. This is not an RFP. RFP-NICHD-CD-90-15 will be issued on or about March 22, 1990. Proposals will be due approximately 60 days thereafter. Copies of the RFP may be obtained by sending written requests to Mr. Paul J. Duska at the address listed below. Please enclose a self-addressed label. Requests may also be made by FAX Telephone 301-496-0962. Paul J. Duska, Contracting Officer Contracts Management Section, OGC National Institute of Child Health and Human Development Executive Plaza North, Room 610 9000 Rockville Pike Bethesda, MD 20892 ENTERIC DISEASES VACCINE AND TREATMENT EVALUATION UNIT RFP AVAILABLE: RFP-NIH-DMID-91-03 P.T. 34; K.W. 0755015, 0715085, 0740075, 0745070 National Institute of Allergy and Infectious Diseases The Enteric Diseases Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, has a requirement for one Enteric Diseases Vaccine and Treatment Evalution Unit (VTEU). The VTEU conducts Phase I and Phase II clinical trials to evaluate candidate vaccines and other prophylactic/therapeutic measures for infectious enteric diseases. Issuance of the Request for Proposals (RFP) will be on or about March 27, 1990. Proposals will be due by close of business on May 25, 1990. One (1) award is anticipated, and it is expected that a level-of-effort contract will be funded over a period of five years. Any responsible offeror may submit a proposal which will be considered by the Government. To recieve a copy of RFP-NIH-NIAID-DMID-91-03, please supply this office with a written request, citing the RFP number together with two self-addressed mailing labels addressed to: Mr. Thomas C. Porter Contractive Officer National Institute of Allergy and Infectious Diseases Contract Management Branch 5333 Westbard Avenue Bethesda, MD 20892 This advertisement does not commit the Government to make an award. NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 4 PATHOBIOLOGY OF PNEUMOCYSTIS CARINII IN THE LUNG RFA AVAILABLE: 90-HL-08-L P.T. 34; K.W. 0715008, 0765035, 0715165 National Heart, Lung, and Blood Institute Letter of Intent Receipt Date: July 16, 1990 Application Receipt Date: September 14, 1990 The Structure and Function Branch and the Airway Diseases Branch of the Division of Lung Diseases, National Heart, Lung, and Blood Institute (NHLBI), announce the availability of a Request for Applications (RFA) on the above subject. Copies of the RFA are currently available from NHLBI staff. This program will support basic research on the underlying mechanisms by which Pneumocystis carinii, the organism causing most of the pulmonary morbidity and mortality in patients with AIDS, attaches to and injures host lung cells. The primary objectives of this special grant program are to elucidate the cellular and molecular mechanisms underlying the interactions between P. carinii and lung cells in the alveolus, and to explore how these events are affected by immunosuppression and infection with human immunodeficiency virus (HIV). It is expected that research applications will encompass a variety of approaches and will require expertise from a number of disciplines including cell and molecular biology, pathology, parasitology, virology, infectious diseases, and pulmonary medicine. A letter of intent is requested by July 16, 1990, and the deadline for receipt of applications is September 14, 1990. The earliest award date for successful applications is March 1, 1991. Awards will be made to foreign institutions only for research of very unusual merit, need, and promise. Requests for copies of this RFA should be addressed to: Dorothy Berlin Gail, Ph.D. Chief, Structure and Function Branch Division of Lung Diseases, NHLBI 5333 Westbard Avenue, Room 6A07 Bethesda, MD 20892 Telephone: (301) 496-7171 RESEARCH DEMONSTRATION GRANTS FOR THE PREVENTION OF YOUTH SUICIDE AND SUICIDAL BEHAVIOR RFA AVAILABLE: MH-90-15 P.T. 34; K.W. 0404020, 0745027, 0715020, 0403004 National Institute of Mental Health Application Receipt Date: June 18, 1990 The National Institute of Mental Health (NIMH) seeks applications for research demonstration projects aimed at the prevention of youth suicide and suicidal behavior. These projects are expected to use multi-faceted preventive or treatment interventions with components for which there is an empirical or conceptual basis for expecting preventive effects and involve comprehensive and scientifically rigorous evaluations of these preventive effects in large, representative populations. Applications may be submitted by any nonprofit or for-profit organization including units of State and local government. Women and minority investigators are encouraged to apply. Applicants are urged to give added attention (where feasible and appropriate) to the inclusion of women and minorities in study populations. If women and minorities are not to be included, a clear rationale for their exclusion must be provided. Support for research demonstration projects under this announcement should be requested through applications for research demonstration grants (R18). In fiscal year 1990, it is expected that up to $1,000,000 will be available to support research demonstration awards under this Request for Applications (RFA). Funding in future years will depend on annual appropriations. Applications must be received by the receipt date of June 18, 1990. NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 5 Potential applicants should contact the following NIMH staff as early as possible for information and guidance in planning high quality research demonstrations: Peter Muehrer, Ph.D. Prevention Research Branch Room 10-104 Telephone: (301) 443-5944 Irma Lann, M.Ed. Child and Adolescent Disorders Research Branch Room 10-104 Telephone: (301) 443-5944 Kelly Kelleher, M.D., M.P.H. Biometric and Clinical Applications Branch Room 18C-14 Telephone: (301) 443-1330 The address for all of the above is: National Institute of Mental Health 5600 Fishers Lane Rockville, MD 20857 MCKINNEY RESEARCH DEMONSTRATION PROGRAM FOR HOMELESS MENTALLY ILL ADULTS RFA AVAILABLE: MH-90-14 P.T. 34; K.W. 0715129, 0403004 National Institute of Mental Health Application Receipt Date: June 18, 1990 This request for applications (RFA) is aimed at generating new knowledge on the effectiveness of comprehensive community mental health services coordinated with an appropriate range of housing alternatives for severely mentally ill homeless individuals. Applications may be submitted by public or private nonprofit entities including universities, units of State or local government, and other public or private nonprofit organizations. Applications are encouraged from women and minority investigators and minority faculty and from historically minority institutions. Applicants are urged to give added attention (where feasible and appropriate) to the inclusion of minorities and women in the research demonstration. If they are not included, a clear rationale for their exclusion should be provided. It is anticipated that approximately $5 million will be available in fiscal year 1990 to support first-year direct and indirect costs of five to seven new 3-year research demonstration projects. Applications will be accepted under the single receipt date of June 18, 1990. For further information, applicants should contact Dr. Levine as early as possible for information and guidance in initiating the application process and planning high quality research designs: Irene S, Levine, Ph.D., Director Office of Programs for the Homeless Mentally Ill National Institute of Mental Health 5600 Fishers Lane, Room 7C-06 Rockville, MD 20857 Telephone: (301) 443-3706 NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 6 RESEARCH DEMONSTRATION GRANTS FOR THE PREVENTION OF SERIOUS AND CHRONIC CONDUCT PROBLEMS RFA AVAILABLE: MH-90-13 P.T. 34; K.W. 0715020, 0745027, 0403004 National Institute of Mental Health Application Receipt Date: June 18, 1990 The National Institute of Mental Health (NIMH) seeks applications for research demonstration projects aimed at the prevention of serious and chronic conduct disorders during adolescence and early adulthood. These projects are expected to use multi-faceted preventive interventions with components for which there is an empirical or conceptual basis for expecting significant preventive effects and are expected to involve comprehensive and scientifically rigorous evaluations of these preventive effects in large, representative populations. Applications may be submitted by any nonprofit or for-profit organization including units of State and local government. Women and minority investigators are encouraged to apply. Applicants are urged to give added attention (where feasible and appropriate) to the inclusion of women and minorities in study populations. If minorities and women are not included, a clear rationale for their exclusion should be provided Support for research demonstration projects under this announcement should be requested through applications for research demonstrations (R18). In fiscal year 1990, it is estimated that approximately $4,000,000 will be available to support research demonstration projects under this announcement. Funding in future years will depend on annual appropriations. Applications must be received by the June 18, 1990, deadline. Potential applicants should contact the following NIMH staff as early as possible for information and guidance in planning high quality research demonstrations: Doreen Spilton Koretz, Ph.D. Prevention Research Branch, NIMH Room 14C-02, 5600 Fishers Lane Rockville, MD 20857 Telephone: (301) 443-4283 or James Breiling, Ph.D. Antisocial and Violent Behavior Branch, NIMH Room 18-105, 5600 Fishers Lane Rockville, MD 20857 Telephone: (301) 443-3728 RESEARCH DEMONSTRATIONS ON EMERGENCY MENTAL HEALTH SERVICES FOR CHILDREN AND ADOLESCENTS RFA AVAILABLE: MH-90-19 P.T. 34, AA; K.W. 0715129, 0730050, 0403004 National Institute of Mental Health Application Receipt Date: June 18, 1990 The National Institute of Mental Health (NIMH), Alcohol, Drug Abuse, and Mental Health Administration, in collaboration with the Pediatric Emergency Medical Services Program, Bureau of Maternal and Child Health and Resources Development, Health Resources and Services Administration. The purpose of this announcement is to encourage research demonstrations to provide emergency mental health services to children and adolescents who are in need of acute psychiatric intervention, who have suffered a physical injury that may be associated with an antecedent emotional disturbance, or who present with other physical conditions or physical trauma that place them and/or their families at risk for mental health problems. Research NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 7 demonstrations to be supported under this announcement are expected to provide services to children and their families and incorporate a sophisticated and rigorous evaluation of the services provided. The demonstrations may also include training for emergency medical and psychiatric personnel who will be caring for these families and children. Special emphasis is given in this announcement to projects for minority and rural populations. Applications may be submitted by any public or private nonprofit or for-profit organization including units of State and local government. Women and minority investigators are especially encouraged to apply. Applicants may request support for up to five years of research demonstration projects. It is recognized that applicants may want to extend the time to continue a longitudinal study of subjects. When such a design is considered, applicants should outline the full scope of the project and propose to reapply after four years for competitive continuation funding. It is anticipated that up to $500,000 will be available to support new grant awards under this announcement during fiscal year 1990, subject to availability of funds. Funding in future years will depend on annual appropriations. Applications must be submitted by June 18, 1990. Inquiries and requests for additional information and consultation may be directed to: Ann A. Hohmann, Ph.D., M.P.H. Biometric and Clinical Applications Branch Division of Biometry and Applied Sciences National Institute of Mental Health Alcohol, Drug Abuse, and Mental Health Administration 5600 Fishers Lane, Room 18-C-14 Rockville, MD 20857 Telephone: (301) 443-3364 Arthur S. Funke, Ph.D. Child/Adolescent Health Office of Maternal and Child Health Bureau of Maternal and Child Health and Resource Development Health Resources and Services Administration 5600 Fishers Lane, Room 9-21 Rockville, MD 20857 Telephone: (301) 443-4026 ONGOING PROGRAM ANNOUNCEMENTS NOTICE: NIAID SMALL GRANTS PROGRAM: CHANGE OF INITIAL REVIEW GROUP ASSIGNMENT P.T. 34; K.W. 0715008, 0785035, 0745000, 0715125, 0755015, 0755010 National Institute of Allergy and Infectious Diseases A National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Program Announcement entitled "Small Grants Program for Laboratory Research Related to the Clinical Evaluation of AIDS Therapies" was published in the September 22, 1989 (Vol. 18, No. 33, page 5) issue of the NIH Guide for Grants and Contracts. It stated that responsive applications will be subjected to initial scientific review by the Acquired Immunodeficiency Research Review Committee (AIDSRRC). The applications that were received for the December 12, 1989 deadline have undergone initial scientific review by a subcommittee of the AIDSRRC. However, the group of applications expected for the next round, whose receipt date is May 4, 1990, will be reviewed by one of the Division of Research Grants (DRG) study sections now responsible for conducting expedited peer review of R01 and R29 AIDS applications. This change of initial review group (IRG) may be a one-time occurrence only. By mutual agreement between NIAID and DRG staff, future IRG assignments of these applications will depend largely on workload distribution of AIDS applications. Questions regarding the review aspects of the upcoming applications should be directed to: NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 8 Chief, Immunology, Virology and Pathology Review Section Referral and Review Branch Division of Research Grants National Institutes of Health Westwood Building, Room A19 Bethesda, MD 20892 Telephone: (301) 496-0892 RESEARCH ON EFFECTIVENESS AND OUTCOMES OF MENTAL HEALTH SERVICES P.T. 34; K.W. 0730050, 0715129, 0755030 National Institute of Mental Health The purpose of this announcement is to encourage research on the effectiveness of mental health services with special emphasis on studying the care provided for persons with severe, disabling disorders and on studies that assess client outcomes. Applications may be submitted by any public or private, nonprofit or for-profit organization including units of State and local governments. Women and minority investigators are especially encouraged to apply. Support under this announcement may be requested through applications for a regular research grant, small grant, or First Independent Research and Transition (FIRST) Award. Applicants are urged to give attention (where feasible and appropriate) to the inclusion of women and minorities in study populations for research into the etiology of diseases, research in behavioral and treatment outcome, research on the dynamics of health care and its impact on disease, and appropriate interventions for disease prevention and promotion. If women or minorities are to be excluded in any given study, a clear rationale for their exclusion should be provided. To qualify for fiscal year 1990 funding, applications must be submitted for the receipt date of June 1, 1990, and be complete at time of submission. In subsequent years, the regular receipt and review dates will apply. For further information, potential applicants should contact: Charles Windle, Ph.D. Telephone: (301) 443-4233 or Ann Hohmann, Ph.D. Telephone: (301) 443-3364 The address for both of the above is: Biometric and Clinical Applications Branch Division of Biometry and Applied Sciences, NIMH 5600 Fishers Lane, Room 18C-14 Rockville, MD 20857 RESEARCH ON SERVICES FOR PERSONS WITH MENTAL DISORDERS THAT CO-OCCUR WITH ALCOHOL AND/OR DRUG ABUSE DISORDERS P.T. 34; K.W. 0715129, 0730050, 0404003, 0404009 National Institute of Mental Health The National Institute of Mental Health (NIMH) in collaboration with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA) seeks to encourage research and research demonstration applications for studies of alcohol, drug, and mental health services for individuals whose multiple diagnoses include mental disorder(s) as well as alcohol and/or drug abuse disorder(s). This research initative is intended to improve the understanding of service use by persons with these multiple diagnoses and to identify ways to improve the effectiveness of services delivered to them. This announcement, originally issued in January 1989, has been revised to incorporate funding for research demonstrations (R18). Support may be requested through applications for a regular research grant, small grant, NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 9 First Independent Research Support and Transition (FIRST) Award, Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA) Scientist Development Award, and ADAMHA Scientist Development Award for Clinicians. Applicants are urged to give added attention (where feasible and appropriate) to the inclusion of women and minorities in study populations. In addition, special encouragement is given to applicants to promote collaboration between academic researchers and public sector agencies in planning and undertaking research pertaining to persons with co-occurring mental disorder(s) and substance abuse disorder(s). Applicants may request support for up to 5 years for research or research demonstration projects (with the exception of small grants which are limited to 2 years). Annual awards will be made, subject to continued availability of funds and progress achieved. To qualify for fiscal year 1990 funding, applications must be submitted by June 1, 1990. Thereafter, applications will be accepted and reviewed in accordance with the regular review schedule. Fiscal year 1990 awards will be made in consultation with NIAAA and NIDA. Potential applicants are encouraged to discuss their planned research with NIMH staff listed below before submitting a formal grant application. A technical assistance workshop is planned for potential applicants. Contact: Dave Larson, M.D., M.S.P.H., or Charles Windle, Ph.D. Biometric and Clinical Applications Branch Division of Biometry and Applied Sciences, NIMH Room 18C-24, 5600 Fishers Lane Rockville, MD 20857 Telephone: Dr. Larson (301) 443-1330 Telephone: Dr. Windle (301) 443-4233 EPIDEMIOLOGIC AND SERVICES RESEARCH DEMONSTRATIONS ON MENTAL DISORDERS THAT CO-OCCUR WITH DRUG AND/OR ALCOHOL DISORDERS AMONG AMERICAN INDIANS, ALASKAN NATIVES, AND NATIVE HAWAIIANS P.T. 34; K.W. 0715129, 0730050, 0785055, 0403004, 0404003, 0404009 National Institute of Mental Health The National Institute of Mental Health (NIMH), in collaboration with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA), research institutes which comprise the Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA), are sponsoring this new initiative which is intended to encourage research on the prevalence of mental disorders that co-occur with drug and/or alcohol disorders, and on drug, alcohol, and mental health services use by American Indians, Alaskan Natives, and Native Hawaiians. The purpose of this announcement is to extend the knowledge of the prevalence and treatment of mental disorders ascertained from the Epidemiologic Catchment Area (ECA) and other major epidemiologic and services use studies. The Institutes will provide funding to support the development of scientific knowledge on the epidemiology and services use for drug, alcohol, and mental disorders by adults and children who are American Indians, Alaskan Natives, and Native Hawaiians. All applicants for research support under this announcement are expected to design a two-phase research plan, to allow specific attention to the issues of sampling and culturally appropriate assessment of psychopathology, impaired functioning, and services use, before actually beginning a large-scale data collection effort. In Phase I, which will occur in the first 2 years of the project, diagnostic and mental health services survey instruments will be developed and evaluated in a pilot test with the target population of native people chosen for the research. In Phase II, which will occur in the subsequent years of the project, a cross-sectional survey of the target population will be conducted. Longitudinal research designs will not be accepted as part of this announcement, although funded grantees will be encouraged to submit competing continuation applications to continue the research on a longitudinal basis. Applicants are urged to consider the inclusion of women in the study populations for all clinical research efforts. Exceptions would be studies of NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 10 diseases which exclusively affect males or where involvement of pregnant women may expose the fetus to undue risk. Gender differences should be noted and evaluated. If women are not to be included, a clear rationale should be provided for their exclusion. Applications may be submitted by any public or private nonprofit or for-profit organization including units of State and local government. Women and minority investigators are especially encouraged to apply. Support under this announcement may be requested through applications for a regular research grant (R01), and First Independent Research Support and Transition (FIRST) Award (R29). To qualify for FY 1990 funding, applications must be submitted by June 1, 1990 and will follow a one-time only special review schedule. Inquiries and requests for additional information and consultation may be directed to: Ann A. Hohmann, Ph.D., M.P.H. Biometric and Clinical Applications Branch Division of Biometry and Applied Sciences National Institute of Mental Health Alcohol, Drug Abuse, and Mental Health Administration 5600 Fishers Lane, Room 18-C-14 Rockville, MD 20857 Telephone: (301) 443-3364 Richard K. Fuller, M.D. Division of Clinical and Prevention Research National Institute on Alcohol Abuse and Alcoholism Alcohol, Drug Abuse, and Mental Health Administration 5600 Fishers Lane, Room 16-C-10 Rockville, MD 20857 Telephone: (301) 443-1206 Edgar H. Adams, Sc.D. Division of Epidemiology and Statistical Analysis National Institute on Drug Abuse Alcohol, Drug Abuse, and Mental Health Administration 5600 Fishers Lane, Room 11-C-55 Rockville, MD 20857 Telephone: (301) 443-6504 NIH GUIDE - Vol. 19, No. 12, March 23, 1990 - Page 11