kristoff@GENBANK.BIO.NET (Dave Kristofferson) (02/22/91)
NIH GUIDE - Vol. 20, No. 8, February 22, 1991
NOTICES
NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS" ....................... 1
National Institutes of Health
Food and Drug Administration
Index: NATIONAL INSTITUTES OF HEALTH
FOOD AND DRUG ADMINISTRATION
BIOMEDICAL ASPECTS OF OBESITY--PREVENTION AND TREATMENT .................... 2
National Institutes of Health
Index: NATIONAL INSTITUTES OF HEALTH
NOTICES OF AVAILABILITY (RFPs AND RFAs)
INDUCTIVELY POWERED MICROSTIMULATOR (RFP) .................................. 3
National Institute of Neurological Disorders and Stroke
Index: NEUROLOGICAL DISORDERS, STROKE
ONGOING PROGRAM ANNOUNCEMENTS
RESEARCH AND DEMONSTRATION GRANTS RELATING TO OCCUPATIONAL
SAFETY AND HEALTH (PA OH-91-923) ........................................... 3
National Institute for Occupational Safety and Health
Index: OCCUPATIONAL SAFETY, OCCUPATIONAL HEALTH
DEVELOPMENT OF HIGH CONNECTIVITY NONMAMMALIAN MODELS (PA-91-26) ............ 6
National Center for Research Resources
Index: RESEARCH RESOURCES
NOTICES
NATIONAL WORKSHOPS ON "PROTECTION OF HUMAN SUBJECTS"
P.T. 42; K.W. 0783005
National Institutes of Health
Food and Drug Administration
The National Institutes of Health (NIH) and the Food and Drug Administration
(FDA) are continuing to sponsor a series of workshops on the responsibilities
of researchers, Institutional Review Boards (IRBs), and institutional
officials for the protection of human subjects in research. The workshops are
open to everyone with an interest in research involving human subjects. The
meetings should be of special interest to those persons currently serving or
about to begin serving as a member of an IRB. Issues discussed at these
workshops are relevant to all other Public Health Service agencies. The
current schedule includes the following:
I. MIDEAST WORKSHOP
DATES: March 4-5, 1991
WORKSHOP SITE:
Friday Center
Laurel Hill Parkway
Chapel Hill, NC 27599-1020
SPONSORS:
University of North Carolina at Chapel Hill
300 Bynum Hall
Chapel Hill, NC 27599-4100
Shaw University
118 E. South Street
Raleigh, NC 27611
REGISTRATION CONTACT:
Mr. Al Dawson
Director
Friday Center
Laurel Hill Parkway
C. B. 1020
Chapel Hill, NC 27599-1020
Telephone: (919) 962-1106
TOPIC: "Interpreting the Federal Code for the Protection of Human Subjects"
II. MIDWEST WORKSHOP
DATES: April 11-12, 1991
WORKSHOP SITE:
Ramada Inn, Lakeshore
4900 South Lake Shore Drive
Chicago, IL 60615
SPONSORS:
University of Chicago
970 East 58th Street
Chicago, IL 60637
Chicago State University
95th Street at King Drive
Chicago, IL 60628
REGISTRATION CONTACT:
Mr. Arnold L. Aronoff
Associate Director
Faculty and Administrative Services
University Research Administration
University of Chicago
970 East 58th Street
Chicago, IL 60637
Telephone: (312) 702-8669
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 1
TOPIC: "Cultural Diversity, Ethics, and Research: A Workshop on Human
Subject Protection"
NIH/FDA have planned national human subject protections workshops in other
parts of the United States. For further information regarding these workshops
contact:
Darlene Marie Ross
Executive Assistant for Education
Division of Human Subject Protections
Office for Protection from Research Risks
National Institutes of Health
9000 Rockville Pike
Building 31, Room 5B59
Bethesda, MD 20892
Telephone: (301) 496-8101
BIOMEDICAL ASPECTS OF OBESITY--PREVENTION AND TREATMENT
P.T. 34; K.W. 0715145, 0745027, 0745070, 0765020, 0710095
National Institutes of Health
The purpose of this notice is to inform the scientific community of plans
underway at the National Institutes of Health (NIH) to pursue various
activities related to research on the prevention and treatment of obesity. A
planning meeting on Biomedical Aspects of Obesity-- Prevention and Treatment
was held at NIH on August 3, 1990. The meeting was sponsored by the NIH
Nutrition Coordinating Committee (NCC) Obesity Work Group, which comprises
representatives of the 11 institutes and centers at the NIH that currently
support obesity-related research: the National Institute of Diabetes and
Digestive and Kidney Diseases; the National Heart, Lung, and Blood Institute;
the National Center for Research Resources; the National Institute of Child
Health and Human Development; the National Cancer Institute; the National
Institute on Aging; the National Center for Nursing Research; the National
Institute of Neurological Disorders and Stroke; the National Institute of
Arthritis and Musculoskeletal and Skin Diseases; the National Institute of
Environmental Health Sciences; and the National Institute on Deafness and
Other Communication Disorders. Other participants included extramural
scientists who are conducting research into various aspects of obesity.
The Public Health Service (PHS) is committed to achieving the health promotion
and disease prevention objectives of Healthy People 2000, a PHS-led national
activity for setting priority areas. This notice is related to the priority
area of nutrition.
The purposes of this preliminary meeting were to identify the major issues in
obesity that should be addressed by the NIH, to make recommendations on
activities to address these issues, and to prioritize topics and the
mechanisms for NCC-and institute-sponsored activities to be initiated in 1991.
The meeting discussions encompassed research questions, technology transfer
activities, and public policy issues. Topics addressed included the current
understanding of energy balance, issues in the prevention and treatment of
obesity, special concerns regarding high-risk groups, risks associated with
obesity, genetic and behavioral aspects of obesity, practices of weight loss
programs, public awareness and information dissemination, and ways to
stimulate basic and clinical obesity research. Activities recommended for NIH
attention included investigating the clinical, molecular, and behavioral
aspects of energy balance; working with other agencies towards providing the
public with information on the prevention and treatment of obesity; targeting
the prevention of obesity in childhood; improving understanding of special
issues related to high-risk populations, such as women and certain ethnic
groups; developing scientifically based weight standards, including
considerations of age, gender, and ethnicity; increasing the emphasis on
behavioral aspects of both energy intake and expenditure in obesity prevention
and treatment; and applying the techniques of molecular genetics to an
understanding of obesity. Various mechanisms, such as workshops, expert
panels, technology assessment conferences, requests for applications, requests
for proposals, and program announcements, to address some specific aspects of
these topics were also discussed.
Currently, plans to pursue several of the recommended activities are in
development. As details of these plans are developed further, participation
of the scientific community will be invited and information on the activities
to be conducted will be broadly disseminated.
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 2
For further information contact:
Darla Danford, D.Sc.
Chairman, NIH Nutrition Coordinating Committee
National Institutes of Health
Building 31, Room 4B63
Bethesda, MD 20892
Telephone: (301) 496-9281
NOTICES OF AVAILABILITY (RFPs AND RFAs)
INDUCTIVELY POWERED MICROSTIMULATOR
RFP AVAILABLE: NIH-NINDS-91-05
P.T. 34; K.W. 0745047, 0740050
National Institute of Neurological Disorders and Stroke
The Neural Prosthesis Program of the National Institute of Neurological
Disorders and Stroke, NIH, is developing implantable neural stimulating
systems for sensory and motor handicapped individuals. To overcome problems
with interconnect cables between electrodes and stimulators, an effort has
been initiated to develop an implantable microstimulator that integrates an
inductively coupled, addressable stimulator with its stimulating electrodes.
The Contractor will be required to exert its best efforts to further develop
and enhance the reliability of implantable, microsized receiver-stimulators
(microstimulators) that are powered and controlled by inductive coupling from
an extracorporeal transmitter and coil. In-vivo testing is not required. It
is anticipated that one award will be made in September of 1991 for a period
of three years.
This is not a Request for Proposals (RFP). To receive a copy of the RFP,
please submit a written request to the following address, and supply this
office with two self-addressed mailing labels. All responsible sources shall
be considered by the agency. The RFP will be issued on or about February 20,
1991, with proposals due on April 20, 1991.
Contracting Officer
Contracts Management Branch, DEA
National Institute of Neurological Disorders and Stroke, NIH
Federal Building, Room 901
7550 Wisconsin Avenue
Bethesda, MD 20892
Attention: RFP No. NIH-NINDS-91-05
ONGOING PROGRAM ANNOUNCEMENTS
RESEARCH AND DEMONSTRATION GRANTS RELATING TO OCCUPATIONAL SAFETY AND HEALTH
PA: OH-91-923
P.T. 34; K.W. 0725020, 0403004, 0715027
Centers for Disease Control
National Institute for Occupational Safety and Health
The National Institute for Occupational Safety and Health (NIOSH) is
soliciting grant applications for fiscal year (FY) 1991 for research and
demonstration projects relating to occupational safety and health.
The purposes of this grant program are to develop knowledge on the underlying
characteristics of occupational safety and health problems in industry and on
effective solutions in dealing with them; to eliminate or control factors in
the work environment that are harmful to the health and/or safety of workers;
and to demonstrate technical feasibility or application of a new or improved
occupational safety and health procedure, method, technique, or system.
In 1983, NIOSH published a suggested list of ten leading work-related diseases
and injuries as part of a national goal to improve the health of the American
people through prevention activities. To provide guidance on priorities for
action, NIOSH sponsored the development of "Proposed National Strategies for
the Prevention of Leading Work-Related Diseases and Injuries." Implementation
of the prevention strategies requires commitment from a broad array of
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 3
organizations and scientific and professional disciplines. The extramural
research program is an important means of facilitating progress in these
preventive efforts.
Additional guidance is found in the document, "Healthy People 2000: National
Health Promotion and Disease Prevention Objectives." The document contains
measurable objectives and strategies for creating a healthier society over the
next decade. The objectives and strategies are organized broadly into 3 major
categories: Health Promotion, Health Protection, and Preventive Services.
There are a total of 22 priority areas. The tenth priority area,
"Occupational Safety and Health," is applicable to this program announcement.
Overall objectives in this priority area are to reduce work-related deaths,
injuries, and illnesses. Research is needed on the following: identification
of new stressors affecting workers, new measurement tools for assessing worker
exposures, biomarkers of workers' exposure and response, identification of
populations and individuals at special risk of work-related disease and
injury, mechanisms of insult and intoxication, hazard surveillance, disease
and injury identification and surveillance, development of control approaches,
and effective use of controls.
ELIGIBILITY
Eligible applicants include non-profit and for-profit organizations. Thus,
universities, colleges, research institutions, and other public and private
organizations, including State and local governments, and small,
minority-and/or woman-owned businesses, are eligible for these research and
demonstration grants.
MECHANISMS OF SUPPORT
The support mechanisms for this program are the individual research project
grants (R01); demonstration project grants (R18); special emphasis research
career award (SERCA) grants (K01); and small grants (R03). Approximately
$6,501,000 is available for FY 1991 to fund these grants: $4,158,000 for
non-competing continuation awards and $2,343,000 for new and competing renewal
awards. The estimated breakdown for the new and competing renewal awards is
as follows: R01 and R18 grants - 13 awards for $1,834,000 (total costs of
these awards range from $50,000 to $250,000 with the average award being about
$130,000); K01 grants - 4 awards for $216,000; and R03 grants - 14 awards for
$293,000.
Grants are usually funded for 12-month budget periods within project periods
up to 5 years for research project grants and demonstration project grants, up
to 3 years for SERCA grants, and up to 2 years for small grants.
Brief descriptions on the types of grants NIOSH supports are provided below.
More detailed information is provided in the complete program announcement
that may be obtained by calling or writing the contacts listed under
"INQUIRIES."
R01s should be designed to establish, discover, develop, elucidate, or confirm
information relating to occupational safety and health, including innovative
methods, techniques, and approaches for dealing with occupational safety and
health problems. These studies may generate information that is readily
available to solve problems or contribute to a better understanding of
underlying causes and mechanisms.
R18s should address, either on a pilot or full-scale basis, the technical or
economic feasibility, or application of a new or improved procedure, method,
technique, or system, or an innovative method, technique, or approach for
preventing occupational safety or health problems.
K01s are intended to provide opportunities for individuals to acquire
experience and skills essential to the study of work-related hazards, and in
so doing create a pool of highly qualified investigators who can make future
contributions to research in the area of occupational safety and health.
Candidates must hold a doctoral degree, have research experience at or above
the doctoral level, not be above the rank of associate professor, and be
employed at domestic institutions. Candidates must be citizens or non-citizen
nationals of the U.S. or its possessions or territories or must have been
lawfully admitted to the U.S. for permanent residence at the time of
application. A minimum of 60 percent time must be committed to research,
although full-time is desirable. This non-renewable award provides support
for a three-year project period for individuals engaged in full-time research
and related activities. Awards will not exceed $50,000 in direct costs per
year. The indirect cost rate is limited to 8 percent or the actual indirect
cost rate, whichever results in the lesser amount.
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 4
R03s are intended to provide financial support to carry out exploratory or
pilot studies, to develop or test new techniques or methods, or to analyze
data previously collected. This program is intended for predoctoral graduate
students, post-doctoral researchers (within 3 years following completion of a
doctoral degree or completion of a residency or public health training) and
junior faculty members (no higher than assistant professor). If university
policy requires that a more senior person be listed as Principal Investigator,
the application should include appropriate justification for this arrangement.
Salaries are allowed for necessary support staff, but are not allowed for the
Principal Investigator as well as that of the junior investigator. Direct
costs are limited to $15,000 in direct costs per year, and project periods are
limited to 2 years for this non-renewable award.
The NIOSH program priorities applicable to this program are as follows:
occupational lung diseases, musculoskeletal injuries, occupational cancers,
severe occupational traumatic injuries, cardiovascular diseases, disorders of
reproduction, neurotoxic disorders, noise-induced loss of hearing,
dermatologic conditions, psychological disorders, control techniques, and
respirator research. Investigators may also apply in other areas related to
occupational safety and health. These priority areas represent the leading
diseases and injuries related to risks on the job, and NIOSH intends to
support projects that facilitate progress in preventing such adverse effects
among workers. Potential applicants with questions concerning the
acceptability of their proposed work are strongly encouraged to call or write
the technical information contact listed under "INQUIRIES."
INCLUSION OF MINORITIES AND WOMEN IN STUDY POPULATIONS
Applicants should include, where feasible and appropriate, women as well as
men and minorities in the study of populations for all clinical and research
efforts and to analyze, where appropriate, differences among these
populations. If women and minorities are not to be included, a clear
rationale for their exclusions should be provided.
APPLICATIONS AND REVIEW PROCEDURES
Applications must be prepared on form PHS 398 (revised 10/88). State and
local government applicants may use Form PHS-5161-1 (revised 3/89); however,
form PHS 398 is preferred. Forms and the complete program announcement are
available from the NIOSH and CDC addresses cited below. Please refer to
Announcement Number 923 when requesting information.
To identify responses to this announcement, check "yes" and type "NIOSH
Announcement Number OH-91-923" under item 2 of page 1 of the PHS 398 or at the
top of the face page of the PHS-5161-1.
Receipt dates for new R01s and R18s are February 1, June 1, and October 1
(competing continuation deadlines are 1 month later). Receipt dates for K01s
and R03s are March 1, July 1, and November 1. This is a continuous
announcement, consequently, these receipt dates will be ongoing until further
notice.
Applications must be received by these receipt dates. However, an application
received after the deadline may be acceptable if (1) it carries a legible
proof-of-mailing date assigned by the carrier and (2) the proof-of-mailing
date is no later than 1 week prior to the deadline date. The receipt date
will be waived only in extenuating circumstances. To request such a waiver,
an explanatory letter must be included with the signed completed application.
No waiver will be granted prior to the receipt of the application.
The original and six copies of the PHS 398 or the original and two copies of
the PHS 5161-1 application must be submitted to the address below on or before
the specified receipt dates provided above:
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD 20892**
Applications received under this announcement will be assigned to an Initial
Review Group (IRG). The IRGs, consisting primarily of non-Federal scientific
and technical experts, will review the applications for scientific and
technical merit. Notification of the review recommendations will be sent to
the applicant after the initial review. Awards will be made based on results
of initial and secondary reviews, as well as availability of funds.
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 5
INQUIRIES
For Technical Information: For Business Information:
Roy M. Fleming, Sc.D. Ms. Carole J. Tully
Associate Director for Grants Grants Mgmt. Specialist
CDC, NIOSH CDC, PGO, GMB
1600 Clifton Road, NE Room 300, MS-E14
Building 1, Room 3053, MS-D30 255 E. Paces Ferry Rd, NE
Atlanta, GA 30333 Atlanta, GA 30305
Telephone: (404) 639-3343 Telephone: (404) 842-6630
This program is described in the Catalog of Federal Domestic Assistance No.
93.262. This program is authorized under the Public Health Service Act, as
amended, Section 301 (42 U.S.C. 241); the Occupational Safety and Health Act
of 1970, Section 20(a)(29 U.S.C. 669(a)); the Federal Mine Safety and Health
Amendments Act of 1977, as amended, Section 501(30 U.S.C. 951) and
administered under PHS grant policies and Federal Regulations 42 CFR Part 52.
This program is not subject to review as governed by Executive Order 12372,
Intergovernmental Review of Federal Programs.
DEVELOPMENT OF HIGH CONNECTIVITY NONMAMMALIAN MODELS
PA: PA-91-26
P.T. 34; K.W. 0755020, 1004005
National Center for Research Resources
Application Receipt Dates: June 1, October 1, February 1
PURPOSE
The Biological Models and Materials Research Program (BMMRP) of the National
Center for Research Resources (NCRR) is issuing this announcement to encourage
the submission of applications for the development of high connectivity
nonmammalian models for biomedical research, including all poikilotherms, but
not homeotherms. Appropriate model systems include: lower organisms (such as
fishes, invertebrates, and microorganisms); in vitro systems (cell and tissue
culture from both nonmammalian and mammalian sources); and nonbiological
models (such as mathematical and computer simulations).
RESEARCH GOALS AND SCOPE
The overall objective of this announcement is to stimulate research in the
development of nonmammalian models for biomedical research in the following
areas:
o Research on systems that are high connectivity models, including
both organismic and symbolic models. Symbolic (theoretical) models
include computer, mathematical, and physical models. High
connectivity is defined in the following ways:
- those models where the body of knowledge about the system is large
and has resulted in extensive cross information, or connection,
with other systems. Examples of organisms that have many
characterized properties or functions include, but are not limited
to, Drosophila melanogaster, Caenorhabditis elegans, Aplysia,
Xenopus, Arabidopsis, Escherichia coli, and sea urchins.
- a function or property that is broadly retained across many taxa.
Examples include cytoskeleton structure, cell adhesion, cytochrome
c, hormones, and hormone receptors.
o Research involved with broad intertaxonomic projects.
o Formulation of mathematical or computer models, in particular when
closely coupled to biological experimentation involving
nonmammalian systems. There are opportunities for mathematical
modeling in many areas of biomedical research and at all levels of
biological organization.
MECHANISM OF SUPPORT
The support mechanism for this program will be the individual
investigator-initiated research grant (R01), or the FIRST Award (R29) as
applicable. Under these mechanisms, the applicant will plan, direct, and
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 6
carry out the research program. The proposed project period during which the
research will be conducted should adequately reflect the time required to
accomplish the stated goals and be consistent with the policy for grant
support.
APPLICATION AND REVIEW PROCEDURES
Deadline
Applications will be accepted in accordance with the usual receipt dates for
new research grant applications, i.e., June 1, October 1 and February 1.
Method of Applying
Applications will be received by the National Institutes of Health (NIH),
Division of Research Grants (DRG), and referred to an appropriate Initial
Review Group (IRG) for scientific and technical review. Institute assignment
decisions will be governed by normal programmatic considerations as specified
in the NIH Referral Guidelines. Some applications may receive secondary
assignments. Following the initial scientific review, the applications will
be evaluated by the National Advisory Research Resources Council or another
appropriate Institute council.
Applications must be submitted on form PHS 398 (rev. 10/88) that is available
in the business or grants and contracts offices at most academic and research
institutions and from the DRG.
To identify the applications as a response to this announcement, check "yes"
in Item 2 on the face page of the application and enter the PA number and the
title "HIGH CONNECTIVITY NONMAMMALIAN MODELS."
The original and six (6) copies of the application must be directed to:
Applications Receipt Office
Division of Research Grants
National Institutes of Health
Westwood Building, Room 240
Bethesda, MD 20892**
Potential applicants are encouraged to request further information by
contacting:
Louise E. Ramm, Ph.D.
Director, Biological Models and Materials Research Program
National Center for Research Resources
Westwood Building, Room 8A07
5333 Westbard Avenue
Bethesda, MD 20892
Telephone: (301) 402-0630
This program is described in the Catalog of Federal Domestic Assistance, No.
93.198, Biological Models and Materials Resources. Awards will be made under
the authority of the Public Health Service Act, Title III, Section 301 (Public
Law 78-410, as amended; 42 USC 241) and administered under PHS grant policies
and Federal Regulations 42 CFR Part 52 and 45 CFR Part 74). This program is
not subject to the intergovernmental review requirements of Executive Order
12372 or Health Systems Agency review.
**THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF
RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE
CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO
USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S
REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD
BUILDING IS:
5333 Westbard Avenue
Bethesda, Maryland 20816
NIH GUIDE - Vol. 20, No. 8, February 22, 1991 - Page 7