kristoff@GENBANK.BIO.NET (Dave Kristofferson) (05/18/91)
$$P3 BEGIN PA-91-51 **************************************************** MINORITY SCHOOL FACULTY DEVELOPMENT AWARD PA: PA-91-51 P.T. 34; K.W. 0720005, 0715040, 0715165, 0745027, 0785070 National Heart, Lung, and Blood Institute Application Receipt Date: August 23, 1991 I. OBJECTIVES OF THE PROGRAM The Minority School Faculty Development Award is intended to: 1. Encourage the development of faculty investigators at minority schools in areas relevant to cardiovascular, pulmonary, and hematologic* diseases. 2. Stimulate cardiovascular, pulmonary, and hematologic disease research, prevention, control, and education by offering minority school faculty members the opportunity to enhance their research capabilities in these areas. II. BACKGROUND The proportion of biomedical investigators who are members of minority groups is strikingly lower than the percentage of minority U.S. citizens. While 12 percent of the population is Black, less than 0.25 percent of persons holding a Ph.D. in science are Black. The figures are even lower for Black Ph.D.s in the biomedical sciences. Furthermore, the number of doctorates, both M.D.s and Ph.D.s, in other ethnic minority groups (such as Native Americans or Hispanics) is proportionally lower than for Blacks. Vigorous recruitment is underway throughout the government, academic institutions, hospitals, research institutions, and industry. One method of addressing this problem is by increasing capabilities of faculty members at minority schools. In so doing, the pool of biomedical and behavioral investigators in cardiovascular, pulmonary, and hematologic research will be increased. Furthermore, their graduate and undergraduate students, most of whom will be minority individuals, will become more cognizant of research opportunities in cardiovascular, pulmonary, and hematologic disease areas. The Minority School Faculty Development Program is designed to address this problem by providing research support to minority school faculty members who have the interest and capabilities of doing modern, sophisticated research in cardiovascular, pulmonary, or hematologic disease areas. Despite a recent decline in the death rate from coronary heart disease, cardiovascular disease continues to be the number one cause of death in the United States. Arteriosclerosis and hypertension account for almost one million deaths annually. An estimated 40 million Americans have diseases of the heart and blood vessels, resulting in a large burden of acute and chronic illness and disability. Heart and blood vessel diseases cost the economy more then $50 billion per year in wages, lost productivity, and expenses for medical care. A wide range of opportunities for research into the causes, diagnosis, treatment, and prevention of heart and vascular diseases has been enumerated in the 15th Report of the Director, National Heart, Lung, and Blood Institute, Volume 2, Heart and Vascular Diseases (NIH publication No. 89-2206). Diseases of the lung constitute a major national health problem. About one in every five persons has some chronic respiratory problem resulting in an annual estimated cost to the nation of over $29 billion. In the newborn, the most common cause of death is neonatal respiratory distress syndrome (RDS). Neonatal RDS may be implicated in development of adult respiratory diseases as well. Of the adult respiratory diseases, emphysema and chronic bronchitis are the major causes of death. Fibrotic and immunologic lung diseases are major causes of lung problems in the young adult and may contribute to the development of chronic obstructive pulmonary diseases. Asthma, emphysema, and chronic bronchitis represent particularly pressing health problems affecting an estimated 17 million Americans. Moreover, the death rate and prevalence of these conditions have increased at an alarming rate over the past 15 years. As a disabling disease, emphysema is a leading cause of worker retirement on Social Security disability payments. Disorders of the blood, including congenital and acquired disorders and deficiencies, are critical contributors to health problems of mankind. As a consequence, they are major causes of death and disability in the United States. Disorders of the blood affect not only the blood itself, but the tissues and organs through which it flows. Recent research findings have revealed the widespread involvement of thrombosis in the pathology of numerous disorders, including the development of atherosclerosis and coronary thrombosis. Aggressive therapy for cancer has resulted in the increased susceptibility of patients to bleeding disorders and has increased the demand for blood products for therapeutic purposes. A significant segment of the population has inherited disorders, such as sickle cell disease, hemophilia, or Cooley's anemia, that require life-long hematologic attention and support. Other diseases may be acquired or represent temporary demands, such as replacement therapy as a result of surgical or accidental trauma. Research opportunities in blood resources and transfusion medicine range from basic to clinical. They cover such diverse topics as the development of new blood products, methods to improve and assure the stability and safety of these products, and ways to improve the benefits and safety of transfusion. III. ELIGIBILITY A. Minority School A minority school is defined as a domestic medical or non-medical college, university, or equivalent school in which (1) students of minority ethnic groups, including Blacks, Hispanics, American Indians, and Asian or Pacific Islanders, comprise a majority or significant proportion of the school enrollment and (2) few or no members of its faculty are actively engaged in biomedical research. The commitment of the institution to the faculty candidate's research and development must clearly be presented in the application, including statement(s) from the sponsor and the department chairman. B. Faculty Development Award Candidate Candidates for this award are minority school faculty members who (1) are citizens of the United States, non-citizen nationals, or permanent residents at the time of application, (2) have a doctoral degree or equivalent in a biomedical or behavioral science, (3) wish to receive specialized training in cardiovascular, pulmonary, or hematologic research, and (4) have the background and potential to benefit from the training. Applicants may not apply for, or accept, other Public Health Service research grant support or its equivalent at the time of Minority School Faculty Development Award application, nor may they apply concurrently for any other type of academic award. However, they may apply for, and accept, research grant support subsequent to award of the Minority School Faculty Development Award. C. Mentor at Research Center Each candidate must also identify and complete arrangements with a nearby mentor (within approximately 100 miles) who is recognized as an accomplished investigator in the research area proposed and who will provide guidance for the awardee's development and research plan. Plans for the intensive training during the summer period (two to three months) as well as during the academic years must be developed with the mentor. The commitment of the mentor and her/his institution to both the summer and academic year training period must be evidenced in the application. A commitment from the mentor's department chairman must be included in the application. IV. IMPLEMENTATION The awards will be made to the minority institution on behalf of the awardee. Each award will have a duration of five years and is non-renewable. These awards may not be transferred to another institution. Funding beyond the first year of the grant is contingent upon satisfactory progress during the preceding year. The status of the minority school faculty development award program will be reviewed periodically from the date of the first award to determine whether the program should be continued. In addition, to assess the effectiveness of the program in fulfilling its objectives, the NHLBI intends to follow the progress of the recipient for a period of five years after completion of each grant to determine: (1) the investigator's professional affiliation(s), (2) his/her record of subsequent grant or contract support, (3) his/her record of scientific publications, and (4) the institution's research programs. V. PROVISIONS OF THE AWARD The mechanism of support will be the K14. A. Salary The awardee will receive salary support up to a maximum of $50,000 plus fringe benefits per year for five years. All funds must be used to support the original awardee. Support will be based upon the candidate's actual salary and must be consistent with the established salary structure of the minority institution for persons of equivalent qualifications, experience, and rank. The actual amount will be determined by the proportion of effort devoted to this program. Awardees must commit 100 percent of effort during summer and/or off-quarter periods and at least 25 percent of effort during the academic year. Support for up to 10 percent of the mentor's salary during the summer experience may also be requested. Details of how or if this will be needed must be agreed upon by the mentor's institution and included in the application. B. Research Support Up to $20,000 per year will be provided for research support. Details regarding the apportionment of these funds between the minority institution and the research center must be worked out with the mentor at the research center and agreed to by representatives of both institutions. A statement of agreement must be provided in the application. These research support funds may be used for: Equipment: specialized research equipment essential to the proposed program, in accordance with PHS policy, title to such equipment will vest with the grantee institution; Supplies: consumable supplies essential to the proposed program; Travel: domestic travel for the awardee that is essential to the proposed program; Tuition and fees: if essential to the awardee's individual research development program; and Other: personnel, publication costs, computer costs, and other costs necessary for the research program. Indirect costs will be provided at a rate of 8 percent of the total direct costs of each award, exclusive of tuition, fees, and expenditures for equipment. VI. INCLUSION OF WOMEN IN STUDY POPULATIONS NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Section 2, A-D of the Research Plan AND summarized in Section 2, E, Human Subjects. Applicants/offerors are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognize that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to the policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies.Clinical research findings should be of benefit to all persons at risk of the disease regardless of gender. If further clarification of the policy is needed or there are questions regarding the policy, please contact the NHLBI staff listed below. VII. REVIEW PROCEDURES All applications will be reviewed for scientific and technical merit by the Research Training Review Committee of the Division of Extramural Affairs, NHLBI, followed by a second level review by the National Heart, Lung, and Blood Advisory Council. Review Criteria The factors to be considered in the evaluation of the proposed training program are: o the overall merit of the candidate's five-year plan for research and the development of research skills; o the background and potential of the proposed candidate for development into an independent biomedical investigator; o the candidate's commitment to a research career; o the ability of both the minority institution and the training center to provide facilities, resources, and opportunities necessary for the candidate's research development; o the qualifications, ability, and plans of the sponsor who will provide the candidate with the guidance necessary for career development in research. VIII. APPLICATION PROCEDURE Submit applications on the research grant application form PHS 398 (rev. 10/88). This form is available at the applicant institution's office of sponsored research. An application may also be obtained from the three program offices of the NHLBI listed below. When submitting the application, identify the NHLBI Minority School Faculty Development Award on line 2 of the application face page. Special instructions for preparing the application are included in the guidelines that must be obtained from the program staff listed below. A. Letter of Intent Applicants are asked to submit a letter of intent at least one month prior to the receipt date to: Scientific Review Administrator Research Training Review Committee Division of Extramural Affairs National Heart, Lung, and Blood Institute National Institutes of Health Westwood Building, Room 550 Bethesda, MD 20892 A letter of intent is not binding and will not be considered in the review of any application submitted subsequently. The letter should list the applicant institution and program, the name of the Principal Investigator, the mentor at the research center, and the area of research training proposed. Applicants are strongly urged to contact the appropriate individual listed under program information prior to submission of an application. B. Applications Send the completed application and four (4) signed exact photocopies by the announced receipt date to: Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Two additional copies of the application must be sent to the Scientific Review Administrator of the Research Training Review Committee listed above. Program Information Information regarding this program may be obtained from one of the following: John Fakunding, Ph.D. Research Training and Development Branch Division of Heart and Vascular Diseases National Heart, Lung, and Blood Institute National Institutes of Health Federal Building, Room 3C04 Bethesda, MD 20892 Telephone: (301) 496-1724 Joan Wolle, Ph.D. Division of Lung Diseases National Heart, Lung, and Blood Institute National Institutes of Health Westwood Building, Room 640 Bethesda, MD 20892 Telephone: (301) 496-7668 Helena Mishoe, Ph.D. Division of Blood Diseases and Resources National Heart, Lung, and Blood Institute National Institutes of Health Federal Building, Room 504D Bethesda, MD 20892 Telephone: (301) 496-6931 For fiscal and administrative matters, please contact: Grants Operations Branch Division of Extramural Affairs National Heart, Lung, and Blood Institute Westwood Building, Room 4A15C Bethesda, Maryland 20892 Telephone: (301) 496-7255 * Within NHLBI, the term "hematologic" covers research on thrombosis and hemostasis, immunohematology, blood cell disorders, sickle cell disease, blood resources including blood component and derivative therapy, blood substitutes and blood resource management, aspects of AIDS products in AIDS prevention and treatment, and AIDS-related bone marrow and hematologic disorders. Other Institutes of the NIH are responsible for research on disorders of white cells, including the leukemias and other blood malignancies, and basic immunology related to the lymphoid system. Therefore, NHLBI cannot provide support for such studies. This program is described in the Catalog of Domestic Assistance Nos. 93.837, 93.838, and 93.839. Awards will be made under the authority of the Public Health Service Act, Title III, Section 301 (Public Law 78-410 as amended; 42 USC 241) and administered under PHS grant policies and Federal Regulation 42 CFR Part 52 and 45 CFR Part 74. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P3 END *************************************************************** $$P4 BEGIN PA-91-52 **************************************************** RESEARCH ON MENTAL DISORDERS IN RURAL POPULATIONS PA: PA-91-52 P.T. 34; K.W. 0715129, 0403004 National Institute of Mental Health The National Institute of Mental Health seeks applications for the support of research and research demonstration projects on mental disorders in rural populations. This announcement supersedes the prior announcement issued in March 1990 for "Research on Mental Disorders in Rural Populations," and will govern competitive renewals for research and research demonstration projects funded under the prior announcement. Research issues of interest include: the epidemiology of mental health problems in rural populations; the availability, responsiveness, effectiveness, and efficiency of delivery of clinical services to persons in rural areas with mental disorders; effective outreach forms of service delivery and mechanisms for coordinating diverse types of care in rural areas; the roles of the general medical care sector in serving mentally ill persons in rural areas; the structure and functioning of the mental health service system in rural areas of various types; economic and other stresses in rural areas and health-related behavior of rural populations; mental health problem prevention in rural populations; economic and financing issues concerning mental health related services in rural areas; special problems of distinctive rural subpopulations such as migrants, ethnic and cultural minorities, the elderly, persons with Alzheimer's disease, children and adolescents, the homeless mentally ill, and persons with co-occurring mental health and other types of disorders such as substance abuse and physical disorders; and distinctive methods needed for research in rural areas. Applications for research demonstration projects must involve the transfer and application of interventions derived from a solid theoretical or research base, be designed to test effectiveness through a rigorous research design that measures the project's impact, and generate conclusions that are generalizable to other sites. Applications may be submitted by any nonprofit or for-profit organization, including units of State and local governments. SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDY POPULATIONS NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group. In addition, gender and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Section 2, A-D of the Research Plan AND summarized in Section 2, E, Human Subjects. Applicants/offerors are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognizes that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial/ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks, Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the application will be returned. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. Preference will be given to projects consistent with the National Institute of Mental Health Public-Academic Liaison initiative (bringing together public sector service providers and academic researchers), those involving high-risk populations (e.g. homeless and severely mentally ill persons), and those that include females and minorities in study populations. Support for research on rural mental health that does not include funds for demonstration services may be requested through applications for a regular individual research grant (R01), the First Independent Research and Transition (FIRST) award (R29), and a small grant (R03). Support for research demonstration awards that include funds for services necessary for the conduct of the research may be requested through applications for research demonstration grants (R18). Research demonstration applications will be subject to review and comment by States, through procedures that may be obtained from the State's single point of contact (SPOC). Criteria for the various grant mechanisms should be requested from the contact listed below. Applications may request support for up to 5 years for research and research demonstration projects. Small grants are limited to 2 years and may not be renewed. FIRST awards may be made for up to 5 years, but are not renewable. Annual awards will be made, subject to continued availability of funds and progress achieved. During Fiscal Year 1990, the National Institute of Mental Health funded approximately $8 million for rural mental health research through all mechanisms. The earliest receipt date is June 1, 1991. Applications submitted by that date, if complete at time of submission, will be eligible for an expedited review so that funding in September, 1991, is possible. Thereafter, the usual receipt dates of Oct. 1, Feb. 1, and June 1 and the usual review schedule apply. Staff consultation to applicants during proposal development is available. For further information and to request a copy of the full announcement, prospective applicants should contact: Charles Windle, Ph.D. Acting Director Office of Rural Mental Health Research Division of Applied and Services Research Parklawn Building, Room 18C-14 National Institute of Mental Health Rockville, MD 20857 Telephone: (301) 443-4233 Inquiries pertaining to grants management should be directed to: Steven Hudak Chief, Grants Management Section Grants Management Branch Parklawn Building, Room 7C-23 National Institute of Mental Health Rockville, MD 20857 Telephone: (301) 443-4456 This program is described in the Catalog of Federal Domestic Assistance No. 93.242, Mental Health Research Grants. Under the authority of Section 301 of the Public Health Service Act (42 U.S.C. 241) and subject to availability of funds, the National Institute of Mental Health will accept applications in response to this announcement. $$P4 END *************************************************************** $$P5 BEGIN PA-91-53 **************************************************** RESEARCH ON THE EFFECTS OF POWER FREQUENCY ELECTRIC AND MAGNETIC FIELDS PA: PA-91-53 P.T. 34; K.W. 0725015, 1013026 National Institute of Environmental Health Sciences The National Institute of Environmental Health Sciences (NIEHS), the National Institute of Neurological Disorders and Stroke (NINDS), and the National Institute of Child Health and Human Development (NICHD) invite grant applications through a joint Program Announcement (PA) for basic studies on the effects of electric and magnetic fields. This solicitation is issued to encourage investigator-initiated research projects in areas of special programmatic interest to the National Institutes of Health (NIH). Applicants funded under the PA are supported through traditional research grants in accordance with Public Health Service (PHS) policies applicable to research grants. It is noted that only Research Project (R01, R29) grant applications will be considered to be responsive to this PA. Grant applications in response to this announcement will be reviewed in accordance with the usual Public Health Service Peer Review Procedures. BACKGROUND The NIEHS is the principal NIH component for support of basic research on environmental factors that contribute to human health problems and disease. Major emphasis by NIEHS is placed upon research examining those physical and chemical substances to which humans are exposed in their general environment as a result of human activities such as modern technologies and industrial and commercial processes. In addition to the NIEHS, the NINDS also supports research on those factors that impinge on the nervous and sensory systems. The NICHD is interested in factors such as EMF that may affect reproduction and development. As a result of electrification of our homes and work places, people from all walks of life and of all ages are now exposed to power frequency (60 Hz) electric and magnetic fields. Increasingly scientists, regulators and lay people are asking whether human exposure to these fields involves risks to human health. Electromagnetic fields (EMF) cause biological effects in human beings, in laboratory animals, and in cells and tissues from humans and animals. However, the extant literature does not provide a basis for assessing the risks, if any, from exposure to these fields. Thus there is a need for additional research on the biological effects of EMF exposure particularly at the frequencies of power lines and electrically powered devices. The results of studies on the biological effects of EMF are controversial. One reason for controversy is the finding of positive and negative effects in some similar studies. Also, there are scientists who believe that power frequency fields cannot cause biological effects other than the well known hazards of electrical shock and burn. This position is based on two points. One, the energy of a 60 Hz electromagnetic wave is too weak to break chemical bonds. Two, natural electric fields in the body are orders of magnitude greater than those induced by common EMF exposure. On the other hand, there are reports of biological effects of EMF at many levels of biological organization. These studies have examined a wide range of endpoints but, for the most part, have been phenomenological rather than hypothesis based. For example, in vitro studies report effects on the cell membrane, DNA synthesis, RNA transcription, ornithine decarboxylase activity, calcium-ion efflux, cellular response to hormones and cancer cells. These responses to EMF at the cellular level display a considerable complexity including resonant responses in frequency and field strength, complex time dependencies, and dependence on the ambient DC magnetic field created by the earth. Animal systems have been used for studies under a range of electric and magnetic field intensities for varied exposure conditions and durations. A few examples are studies of animal behavior with and without drugs, melatonin synthesis in the pineal gland, and circadian rhythms. In general, research is needed to determine if in vivo EMF exposure has a deleterious effect on animals and to define exposure conditions that may be effective. The results of epidemiological studies are controversial because some studies report no association between residential EMF exposure and cancer while other work suggests a possible association. For example, a study published in 1979 reported increased incidence of leukemia and brain tumors in children exposed to EMF. Criticisms of the report led to a second study that addressed many of the study design problems. This work also found a weak association between EMF exposure and leukemia and brain tumors. However, another epidemiological study in 1980 failed to demonstrate an association between residential EMF exposure and childhood leukemia. In addition, some but not all studies of occupational exposure of electrical workers have suggested an increased incidence of leukemia and brain cancer; however, the causative agent for this pattern remains unknown. RESEARCH OBJECTIVES AND SCOPE This announcement is issued to encourage and foster investigator-initiated basic and applied research on the possible health effects of EMF. Because of the limited data on EMF biological effects it is anticipated that some projects may be more focused on identification of EMF effects than on the possible mechanisms of EMF actions. Such applications must state the means by which the information generated will be useful in risk assessment and/or developing mechanistic hypotheses. Collaborative research efforts among toxicologists, physicists, engineers, and scientists in closely related disciplines are encouraged to ensure quality in all aspects of the proposed study. Research interests include, but are not limited to studies designed to: A. Determine the effects/mechanisms of action of EMF on cellular responses such as DNA synthesis, modulation of ion binding, and interaction with hormones and growth factors. B. Determine the effects on cancer processes in vivo and in vitro. C. Determine the effects of EMF on reproductive/developmental and nervous systems in vivo and in vitro. D. Development of well-characterized EMF exposure systems for assessing biological effects. HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led national activity for setting priority areas. This Program Announcement, Research on the Effects of Power Frequency Electric and Magnetic Fields, is related to the priority area of environmental health. Potential applicants may obtain a copy of "Healthy People 2000" (Full Report: Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report: Stock No. 017-001-00473-1) through the Superintendent of Documents, Government Printing Office, Washington, D.C. 20402-9325 (telephone 202-783-3238). SPECIAL INSTRUCTIONS TO APPLICANTS REGARDING IMPLEMENTATION OF NIH POLICIES CONCERNING INCLUSION OF WOMEN AND MINORITIES IN CLINICAL RESEARCH STUDIES. NIH and ADAMHA policy is that applicants for NIH/ADAMHA clinical research grants and cooperative agreements will be required to include minorities and women in study populations so that research findings can be of benefit to all persons at risk of the disease, disorder or condition under study; special emphasis should be placed on the need for inclusion of minorities and women in studies of diseases, disorders and conditions which disproportionately affect them. This policy is intended to apply to males and females of all ages. If women or minorities are excluded or inadequately represented in clinical research, particularly in proposed population-based studies, a clear compelling rationale should be provided. The composition of the proposed study population must be described in terms of gender and racial/ethnic group, together with a rationale for its choice. In addition, general and racial/ethnic issues should be addressed in developing a research design and sample size appropriate for the scientific objectives of the study. This information should be included in the form PHS 398 in Section 2, A-D of the Research Plan AND summarized in Section 2, E, Human Subjects. Applicants are urged to assess carefully the feasibility of including the broadest possible representation of minority groups. However, NIH recognize that it may not be feasible or appropriate in all research projects to include representation of the full array of United States racial /ethnic minority populations (i.e., Native Americans (including American Indians or Alaskan Natives), Asian/Pacific Islanders, Blacks. Hispanics). The rationale for studies on single minority population groups should be provided. For the purpose of this policy, clinical research includes human biomedical and behavioral studies of etiology, epidemiology, prevention (and preventive strategies), diagnosis, or treatment of diseases, disorders or conditions, including but not limited to clinical trials. The usual NIH policies concerning research on human subjects also apply. Basic research or clinical studies in which human tissues cannot be identified or linked to individuals are excluded. However, every effort should be made to include human tissues from women and racial/ethnic minorities when it is important to apply the results of the study broadly, and this should be addressed by applicants. For foreign awards, the policy on inclusion of women applies fully; since the definition of minority differs in other countries, the applicant must discuss the relevance of research involving foreign population groups to the United States' populations, including minorities. If the required information is not contained within the application, the review will be deferred until the information is provided. Peer reviewers will address specifically whether the research plan in the application conforms to these policies. If the representation of women or minorities in a study design is inadequate to answer the scientific question(s) addressed AND the justification for the selected study population is inadequate, it will be considered a scientific weakness or deficiency in the study design and will be reflected in assigning the priority score to the application. All applications for clinical research submitted to NIH are required to address these policies. NIH funding components will not award grants or cooperative agreements that do not comply with these policies. MECHANISM OF SUPPORT The mechanism of support for this activity will be the individual research grant (RO1) or First Independent Research Support and Transition (FIRST) Award (R29) as applicable. APPLICATION AND REVIEW PROCEDURES Applications will be accepted in accordance with the usual receipt dates for new research grant applications; i.e., February 1, June 1, and October 1. The earliest possible award dates will be approximately nine months after the respective receipt dates. Applications received too late for one cycle of review will be held until the next receipt date. Applications will be received by the NIH's Division of Research Grants (DRG) and referred to an appropriate study section for scientific and technical merit review. Institute assignment decisions will be governed by the normal programmatic considerations as specified in the NIH Referral Guidelines. The review criteria customarily employed by the NIH for regular research grant applications will prevail. Following the initial scientific review, the applications will be evaluated by an appropriate advisory council. METHOD OF APPLYING Applications must be submitted on form PHS 398 (revised 10/88) which is available in the business or contracts offices at most academic and research institutions and from the DRG. To identify the application as a response to this announcement, check "yes" in Item 2 on the face page of the application and enter the title "Research on the Effects of Power Frequency Electric and Magnetic Fields, PA-91-53." The original and six (6) copies of the application must be directed to: Applications Receipt Office Division of Research Grants National Institutes of Health Westwood Building, Room 240 Bethesda, MD 20892** Inquires related to this Program Announcement should be directed to: Dr. Michael J. Galvin Program Administrator, Scientific Programs Branch Division of Extramural Research and Training National Institute of Environmental Health Sciences P.O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-7825 Dr. Eugene Streicher or Dr. W. Watson Alberts Division of Fundamental Neurosciences National Institute of Neurological Disorders and Stroke Federal Building, Room 916 Bethesda, MD 20892 Telephone: (301) 496-5745 Dr. Felix de la Cruz Chief, Mental Retardation and Developmental Disabilities Branch National Institute of Child Health and Human Development EPN, 631 Bethesda, MD 20892 Telephone: (301) 496-1383 Grants management inquiries should be directed to: David L. Mineo Chief, Grants Management Branch Division of Extramural Research and Training National Institute of Environmental Health Sciences P. O. Box 12233 Research Triangle Park, NC 27709 Telephone: (919) 541-1373 This program is described in the Catalog of Federal Domestic Assistance Numbers 93.112, Characterization of Environmental Health Hazards, and 93.113, Biological Response to Environmental Health Hazards. Awards are made under the authority of Section 487, Public Health Service Act as amended (42 USC 288) and administered under PHS Grants Policies and Title 42 of the Code of Federal Regulations, Part 66. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. $$P5 END *************************************************************** **THE MAILING ADDRESS GIVEN FOR SENDING APPLICATIONS TO THE DIVISION OF RESEARCH GRANTS OR CONTACTING PROGRAM STAFF IN THE WESTWOOD BUILDING IS THE CENTRAL MAILING ADDRESS FOR THE NATIONAL INSTITUTES OF HEALTH. APPLICANTS WHO USE EXPRESS MAIL OR A COURIER SERVICE ARE ADVISED TO FOLLOW THE CARRIER'S REQUIREMENTS FOR SHOWING A STREET ADDRESS. THE ADDRESS FOR THE WESTWOOD BUILDING IS: 5333 Westbard Avenue Bethesda, Maryland 20816 FULL TEXT OF RFAs FOR ONLINE ACCESS