seavey@portia.PRC.Unisys.COM (Beverly Seavey) (04/22/88)
Is there a classification scheme, similiar to the Enzyme Commision convention, for proteins that do not form or break covalent bonds? I'm thinking of histones and repressors in particular.
BAIROCH@CGECMU51.BITNET (05/09/88)
From: <BAIROCH%CGECMU51.BITNET@CUNYVM.CUNY.EDU> <From: seavey@portia.prc.unisys.com (Beverly Seavey) <Subject: classification scheme for proteins <Date: 21 Apr 88 20:20:43 GMT < <Is there a classification scheme, similiar to the Enzyme Commision <convention, for proteins that do not form or break covalent bonds? <I'm thinking of histones and repressors in particular. ------------------------------------------------------------------ To my knowledge no. There are more or less official classification schemes for specific group or families of proteins but no global scheme similar to that of enzymes. For histones, apart from the classification into the H1, H2A, H2B, H3 and H4 families there seems to be no real consistent sub-classification for the different forms of H1, H2A and H2B that exist in some species. H3 and H4 do not need any sub-classification as there is only one sequence by specy and the sequence of these two histones are very conserved in all eukayrotes. For repressors in general I have not seen anything, but for related protein such as the Polymerase Sigma factors, there seems to a consensus in naming then now with "sigma nn" names where nn is a number printed in superscript. For example E.coli Hptr has been renamed Sigma-32 and NtrA have been renamed Sigma-54 (for a recent paper listing Sigma factors see J. Bacteriol. 170:1568- 1574(1988). Amos