[bionet.molbio.evolution] Does simulated evolution work better than evolution? Why?

joe@uw-evolution.UUCP (Joe Felsenstein) (12/18/88)

[this one already sent also to sci.bio newsgroup on Usenet]

I note the strong claims made for the magicality of the "genetic algorithm",
e.g.:

>                                Genetic algorithms derive largely
>from this genetic search theory (GST) which falls within the field
>of mathematical genetics.)  
...
>
>The observed efficiency of genetic algorithms at locating ever-better
>local optima on a wide variety of complex performance surfaces,
>without becoming trapped on a local optimum anywhere,
...
>Dan Offutt                                 offutt@caen.engin.umich.edu

I recently acted as reviewer on a paper in the optimization-by-simulated-
evolution literature, and was disturbed to find in it assertions that
biologists have proven that this strategy is incredibly powerful.  Now we are
told that computer scientists have proofs of powerfulness that we biologists
should be reassured by.  I suspect neither is true.

Genetic systems optimize pretty well, but only when there is a rather
uncomplex relationship between genotype and phenotype.  In their most
sophisticated form (Sewall Wright's "Shifting Balance Theory") they can only
cope with moderate interaction among genetic elements.  Real genetic systems
mostly do not interact enormously strongly (your keratin genes which affect
hair and toenails are unlikely to affect the oxygen-carrying properties of
your blood, and so on).  If they did not have this partial decoupling of
effects, they would not evolve very well: every mutant would reduce the
organism to a disorganized mess, and no progress would be made.  Presumably 
organisms whose genes interacted too strongly just never evolved well and
died out.

Does anyone have real proofs that simulated evolution is much more powerful
as a mathematical optimization method than biologists have concluded evolution
is as a real evolutionary process?   I note Offutt's citations of work by
Holland, but are there others?  What do they really show?

I would expect SA to work pretty well, but only if the genotype-to-phenotype
mapping is not too tightly interactive.  It should not be the magical 
all-purpose optimization method everyone is looking for.  Pandas can't fly.

Note -- this is NOT intended as an argument against creationists.
---
Joe Felsenstein, Dept. of Genetics SK-50, Univ. of Washington, Seattle WA 98195
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