SATY@kcgl1.eng.ohio-state.edu (Saty Raghavachary) (12/25/88)
A CENTRALIZED DATABASE FOR THERMODYNAMIC DATA ON LIPID MESOMORPHIC PHASE
TRANSITIONS AND MISCIBILITY
The systematic study of the mesomorphic phase properties of synthetic
and biologically derived lipids began some 20 years ago. In the past decade,
interest in this area has grown enormously. As a result, there exists a wealth
of information on lipid phase behavior, but unfortunately, this data is
scattered throughout the literature in a variety of journals, both foreign and
domestic. We are in the process of compiling this data with a view to providing
ready access to the data itself and to the appropriate literature. The
compilation will facilitate review of what has thus far been accomplished and
will highlight what remains to be done in this active research area. As such it
represents a convenient summary of the existing data which, when evaluated,
will enable us to: (a) formulate a plan of action to establish where the
deficits in the data lie; (b) distill from the data the fundamental
physicochemical principles of lipid phase behavior; and (c) more completely
understand lipid phase relations in biological and reconstituted systems.
The intention is to compile evaluated data in a single, continuously
revised computer file. The compilation is being prepared in two parts. The
first is a tabulation of all known and of evaluated mesomorphic and polymorphic
phase transition temperatures and enthalpies for synthetic and biologically-
derived lipids in the dry and in the partially and fully hydrated states. Also
included will be the effect of pH, and of salt and metal ion concentration on
these thermodynamic values. The second part of the compilation concerns the
miscibility properties of lipids. Here, data is being graphically presented
in the form of evaluated isobaric and isothermal phase diagrams. These will
include the biologically derived and synthetic lipids with water as one of the
variable components or alternatively, in excess aqueous medium. The effects
of protein and of non-aqueous solvents as well as of pressure on lipid phase
behavior will also be included.
To ensure that the compilation is as complete and up to date as
possible, we are requesting contributions in the form of reprints (preferably)
or photocopies of or, at the very least, references to work relating to lipid
phase behavior.
Contact Information:
Prof. Martin Caffrey / Dr. Saty Chary,
Dept. of Chemistry, The Ohio State University,
120, W 18th Avenue, Columbus, OH 43210
Phone: (614)-292-8437 / (614)-292-1395
Fax: (614)-292-1685
e-mail: SATY@kcgl1.eng.ohio-state.edu - ARPANET
TS7074@OHSTVMA - BITNET
*****************************************************************************