gbb@WOZ.MAYO.EDU (Geoffrey Brunkhorst) (12/07/90)
oivindb@ulrik.uio.no(\ivind Braathen) writes: > I work as a medical geneticist-in-training at the Institute of >medical genetics, University of Oslo, Norway. > I am on the look-out for two types of computer programs, >preferably ftp-able from some site: > 1) Programs for linkage calculations and/ or risk calculations, >knowing markers/ recombination frequencies / prior probabilities >of disease. > 2) Graphics programs to draw pedigrees from basic family information >(i.e. typed from the keyboard or put in a file). > Programs to run under Unix would be of most interest, but >also DOS-programs. > Any hint on where to get programs of this kind would be appreciated. > \ivind I am forwarding this response for Dan Schaid, Ph.D. (Schaid@mayo.edu) - Geoff ---------------------------------------------------------------------------- In response to the request for information regarding computer programs for medical genetics risk calculation and pedigree drawing, here are some sources which should be helpful: 1) Genetic linkage analysis and risk calculations: Several sources are available: a) Jurg Ott Tel. (212) 960-2504 Columbia University, Box 58 FAX (212) 795-5886 722 West 168 Street EARN/Bitnet: Ott@NYSPI New York, NY 10032 I believe that Dr. Ott only supplies PC-based versions of LINKAGE program package, but does have available other genetic analysis programs, as well as a short course on how to use these programs. b) Dr. Mark Lathrop (now in Paris, and I believe his Tel. No. is 011-331-4249-9867) has personally written much of the LINKAGE program package, and would be an excellent source of information regarding what versions may be available other than PC-based. His co-worker, Peter Cartwright, is a computer programer who enhanced the programs to make them more user-friendly and I believe that he has been working on VMS and UNIX versions. Peter is currently at : Howard Hughes Medical Institute Research Laboratories University of Utah 603 Wintrobe Building Salt Lake City, Utah 84132 U.S.A. 2) Pedigree Drawing: You can recieve a Macintosh program for pedigree drawing by sending an 800Kb 3.5 inch Macinttosh diskette, and a stamped self-addressed diskette mailer to : Pedigree/Draw Department of Genetics Southwest Foundation for Biomedical Research P.O. Box 28147 San Antonio, TX 78284 U.S.A. A program disk with printed user guide (55 pages) is available for $25 (International Air Mail), with check made out to SFBR (C.O.D. not accepted)