DHIGGINS@vax1.tcd.ie (Des Higgins) (07/27/89)
CLUSTAL: multiple DNA or protein sequence alignment software. I am distributing a program for performing multiple sequence alignments. This is a VAX/VMS Fortran version of a package that I normally distribute on floppy disk for PC's. The program can handle up to 100 sequences of max. length 5000 residues. In cases where the sequences to be aligned are reasonably similar, the results are excellent and very difficult to improve by eye. Also, the alignments are very fast for short sequences (say 500 residues or less). To get the VAX version, send me a mail message at the e-mail adress below and I will send it to you. If you have difficulties mailing me, give me a call and I may be able to mail you. If you want the PC version, send me 1 high density (1.2 mb.) 5.25 inch, formatted diskette or 3 low density (360 kb.) diskettes. Des Higgins Genetics Department, Trinity College, Dublin 2, Ireland. dHiggins@vax1.tcd.ie (irl.) 1-772941 ext. 1969 Higgins, D.G. and Sharp, P.M. (1988) Clustal: a package for performing multiple sequence alignment on a microcomputer. Gene, vol. 73, pp. 237-244. Higgins, D.G. and Sharp, P.M. (1989) Fast and sensitive multiple sequence alignments on a microcomputer. CABIOS, vol. 5, pp. 151-153.
hrmbdkc@UUNET.UU.NET (10/02/89)
Please send me a copy of your multiple sequence alignment program by mail. My address is Dept. Biochemistry, Hong Kong University, Sassoon Rd., Hong Kong. Thanks a lot. We have a VAX 6220. Dr. Kathy Cheah
smith@mito.harvard.edu (Steven Smith) (06/26/91)
The Genetic Data Environment (GDE) is now available via anonymous ftp
to golgi.harvard.edu. The GDE is a set of programs for multiple sequence
alignment and analysis. The GDE currently runs on SUN SparcStations using
OpenWindows 2.0 or MIT X11R4. The programs use an expandable user interface
which allows the addition of external analysis functions without any rewriting
of code. Analysis functions can be written in any language ('C',Fortran, PascalBasic, shell scripts), and can be seamlessly merged into the systems menu/
dialog box interface.
The system supports several data types, nucleic and amino acid sequences,
text, and masking sequence, and three forms of color highlighting. The system
can handle enormous alignments limited only by the amount of virtual memory
on your workstation.
Sequences can be edited under several levels of protection, as well
as by aligned groups. The system has several external analysis
functions included for such things as automated alignment, searching,
homology recognition, and phylogenetic analysis.
The programs are not in the public domain, but are and will continue to be
available for free. Distribution includes full source code, and binaries
along with a users manual.
Steven Smith
Director of Computation
Harvard Genome Lab
smith@nucleus.harvard.edu
--