daemon@ig.UUCP (11/11/87)
From: Elizabeth C. Theil <THEIL@BIONET-20.ARPA> POSTDOCTORAL POSITION-MOLECULAR BIOLOGY OF FERRITIN AVAILABLE:SUMMER,FALL-1988 FOR COMPLETE INFORMATION CONTACT-DR. ELIZABETH C. THEIL DEPARTMENT OF BIOCHEMISTRY NORTH CAROLINA STATE UNIVERSITY RALEIGH,NC 27695 919-737-2581 FERRITIN ,A PROTEIN THAT STORES IRON IN PLANTS, ANIMALS, AND BACTERIA IS REGULATED DEVELOPMENTALLY, CELL SPECIFICALLY AND ENVIRONMENTALLY. CELL SPECIFIC FEATURES OF STRUCTURE ARE ENCODED IN A MULTIGENE FAMILY. EXPRESSION IS REGULATED TRANSCRIPTIONALLY AND BY STORAGE OF STABLE MRNA. CLONED CDNA FOR THREE DIFFERENTIALLY REGULATED SUBUNITS IS BEING EXPRESSED IN E. COLI FOR COMPARISON TO ALTERED PROTEINS PRODUCED BY SITE DIRECTED MUTAGENESIS WITH THE AIM OF RELATING CELL SPECIFICITY OF STRUCTURE TO FUNCTION. THE SAME CLONES ARE BEING ENINGEERED -------