CABELL.ANDREWS@BIONET-20.BIO.NET (Paul Andrews) (03/24/89)
PERMANENT POSITION SOUGHT:
I am presently a post-doctoral research fellow at the University of
Texas at Austin and am searching for a permanent position as an analytical
chemist. I would be willing to relocate back to Canada, or move anywhere in
the USA or Europe. I am a Canadian citizen and have been at the University of
Texas for two years.
I have extensive experience in HPLC of drug metabolites, DNA-adducts,
proteins and peptides, and mass spectrometry of polar biological compounds. I
am also acquainted with many other chromatographic methods as well as
techniques in inorganic analysis. I use computers extensively in my work for
data acquisition and telecommunications. I feel that my skills as an
analytical chemist along with my background in toxicology, biochemistry, and
computers make me a an ideal candidate for a position in either private
industry or government.
I have included the E-mail address for the molecular biology computer
facility I use in California, and a FAX number for the College of Pharmacy at
the University of Texas at Austin. I will also be attending the American
Chemical Society meeting in Dallas in April and will be staying at the Park
Inn Plaza hotel.
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RESUME FOR PAUL ANDREWS
PERSONAL DATA
Address: 610A Genard St; Austin, Texas, USA, 78751
Birthdate: June 16,1954
Citizenship: Canadian
Marital Status: Married
Phone: Home: (512) 323-5972, Work: (512) 471-3659, 471-1731
E-Mail (ARPANET): CABELL.ANDREWS@BIONET-20.BIO.NET
FAX (512) 471-8783
EDUCATIONAL DATA
UNIVERSITY: PhD.,Chemistry, McMaster University, Hamilton,
Ontario,Canada, August, 1987.
MSc., Analytical Toxicology, Queen's University,
Kingston, Ontario, Canada, June, 1981.
BSc., Chemistry, McMaster University, Hamilton,
Ontario, Canada, May, 1978.
HONOURS AND AWARDS
1973: Ontario Scholar
1978: Queen's Graduate Fellowship
WORK EXPERIENCE
Aug.1987-Aug. 1989: Post Doctoral Research Fellow, University of Texas,
Austin, Texas, USA.
Jan.-Apr. 1986: Lecturer, Mohawk College, Hamilton, Ontario, Canada.
Sept.1978-April 1986: Teaching assistant, McMaster University, Queen's
University, Kingston, Ontario
May-Aug.1977-1978: Summer research assistant, McMaster University
Aug. 1972-1984: Games operator, Canada's Conklin Shows,
Jan.-July 1974: Greenstacker operator, British Columbia Forest Products,
McKenzie, British Columbia.
May-Aug. 1973: Ford Motor Co., Oakville, Ontario
REFERENCES
1. Dr. Creed Abell, PhD., Henry M. Burlage Endowed Centennial Professor,
College of Pharmacy, Division of Medicinal Chemistry, University of Texas
at Austin, Austin, TX, USA, Zip:78712, Phone: (512) 471-5715.
2. Dr.Dennis McCalla, PhD., Vice President Health Sciences, Health Science
Center, Rm 2E1, McMaster University, Hamilton, Ontario, Canada,
Postal Code:L8N 3Z5, Phone:(416) 525-9104.
3. Dr. Micheal A. Quilliam, PhD., Associate Research Officer, Atlantic
Research Laboratory, National Research Council, 1411 Oxford St, Halifax,
Nova Scotia, Code:B3H 3Z1, Phone (902) 426-9736.
PROFESSIONAL ESSAY
Throughout my research career, I have tried to become proficient in the
area of organic analytical chemistry with emphasis on trace analysis by HPLC
and mass spectrometry. In addition I also wanted to develop computer skills
for the acquisition and manipulation of experimental data.
I specialized in analytical courses when obtaining an undergraduate
degree in chemistry. As an undergraduate summer research assistant I
developed methods for determining isotope incorporation by mass spectrometry
and gas phase analysis of PCBs by gas chromatography.
My MSc.analytical chemistry courses at Queen's University allowed me to
obtain hands on experience in many inorganic analytical methods, as well as
organic analytical methods such as GC, HPLC and GC-MS. I also learned
techniques in animal surgery, toxicology, and biochemistry. My MSc. research
involved the development of new extraction and derivatization methods for the
GC and GC-MS analysis of alkaloids from a biological matrix.
In my PhD. courses I developed skills in solving non-routine problems
such as the analysis of PAHs in oil sands. My PhD. research dealt with the
isolation and characterization of adducts formed between DNA and the
metabolites of nitrated aromatic hydrocarbons. I extensively investigated
methods for the gentle derivatization and ionization of these nonvolatile,
polar compounds by mass spectrometry. Some the techniques used were EI, CI,
FAB, GC-MS, and LC-MS. This research involved the use of state-of-the-art
HPLC for multi wavelength detection of metabolites and DNA-adducts. As most
of the equipment was controlled by computer systems, I learned to acquire and
manipulate data by computers as well as learning computer languages such as
BASIC and FORTRAN.
My post-doctoral research centers on HPLC and mass spectrometric (probe
and GC-MS) characterization of proteins, peptides, and riboflavin analogues.
I was responsible for the acquisition, set up, and management of a Beckman
System Gold HPLC system which is used for the computer control of other HPLC
systems and detectors used in our laboratory. I am acquainted with
telecommunications protocols because I am responsible for maintaining computer
communications to BIONET, a molecular biology computer facility in California.
In order to improve my skills in computer programming I am teaching myself
"C", a programming language. I have also helped in the drafting of several
major research grant proposals.
My experiences in various laboratories has allowed me to gain wide
experience in HPLC and mass spectrometry, especially in area of toxicology and
biochemistry. By developing skills in solving problems in many areas of
organic analytical chemistry I will be an asset to a firm interested in
someone who can deal with situations that call for a wide range of problem
solving abilities.
PUBLICATIONS
Papers in Refereed Journals.
1. N.H. Werstiuk and Paul Andrews. "Base-catalysed hydrogen isotope exchange
of thiocamphor:alpha-thioenolization rate constants", Canadian Journal of
Chemistry, 56, 2605-2606, (1978).
2. F. Messier, C. Lu., P. Andrews, B. McCarry, M. Quilliam, and D. McCalla.
"The metabolism of 1-nitropyrene and formation of DNA adducts in
Salmonella typhimurium". Carcinogenesis, 2, 1007-1011, (1981).
3. M. Quilliam, F. Messier, C. Lu, P. Andrews, B. McCarry and D. McCalla,
"The metabolism of nitro-substituted polycyclic aromatic hydrocarbons in
Salmonella typhimurium", in: Polynuclear Aromatic Hydrocarbons :Physical
and biological Chemistry., ed. M. Cook, A. Dennis and G. Fisher, Battelle
Press, pp 667-672 (1982).
4. D. Bryant, S. Vitakunes, M. Gouin, P.Andrews,G. Anderson, B. McCarry, M.
Quilliam and D. McCalla, "Metabolism of nitro-polycyclic aromatic
hydrocarbons and formation of DNA adducts in Salmonella typhimurium", in
:Polynuclear Aromatic Hydrocarbons:Formation, Metabolism and Measurement,
ed M. Cooke and A. Dennis, Battelle Press, pp 89-98, (1983).
5. J.Brien, P. Andrews, C. Loomis and J. Page, "Gas chromatographic
determination of salsolinol in the striatum of the rat", Canadian Journal
of Physiology and Pharmacology, 61,632-640, (1983).
6. P. Andrews, M. Quilliam, B. McCarry, D. Bryant, and D. McCalla,
"Identification of the DNA adduct formed by the metabolism of 1,8-
dinitropyrene in Salamonella typhimurium", Carcinogenesis, 7, 105-110,
(1986).
7. P. Andrews, J. Orr, I. Lambert, D. Bryant, L. Davidson, B.. McCarry, and
D. McCalla, "The fate of 1,8-dinitropyrene in Salmonella
typhimurium:Metabolism and DNA adduct formation" in Polynuclear Aromatic
Hydrocarbons, ed M. Cooke, Battelle Press, (1986).
8. I. Lambert, P. Andrews, L. Davidson, D. Bryant, and D. McCalla, "The
detection of dinitropyrene adducts in DNA", Environmental Mutation
Society, 8, Supp. 6, 43, (1986).
CONTRIBUTED CONFERENCE PAPERS
1. D.McCalla, B. McCarry, M. Quilliam, P. Andrews, and C. Lu,"Mutagenicity of
nitropyrenes in Salmonella typhimurium: Activation by endogenous
reductases and formation of DNA adducts", 13th International Cancer
Congress, Seattle, (1982).
2. D. McCalla, M. Quilliam, B. McCarry, C. Lu, F. Messier and P. Andrews,
"Metabolism of nitropyrenes and formation of DNA adducts in Salmonella
typhimurium" 5th CIIT Conference on toxicology, The Chemical Industry
Institute of Toxicology, Raleigh, NC, (1982).
3. M. A. Quilliam, P.J. Andrews, R. Gergely, and R. Smith, "Mass Spectrometry
of the 1,8-Dinitropyrene-Nucleoside Adduct", 34th Annual Conference on
Mass Spectrometry and Allied Topics. Cincinnati, OH, June 8-13, 1986 (pp.
333-334).
4. D.R. McCalla, D.W. Bryant, B.E. McCarry, M.A. Quilliam, J. Orr, P.
Andrews, and G. Anderson, "Mutagenic Action of Nitropyrenes and
Dinitropyrenes in Salmonella", Conference on the Genetic Toxicology and
Carcinogenicity of Nitropyrenes", Bethesda,MD, November, 1984.
5. D. R. McCalla, P.J. Andrews, B.E. McCarry, M.A. Quilliam, D.W. Bryant and
J. Orr, "Metabolic Activation of 1,8-Dinitropyrene", Environmental
Mutagenesis Intl. Congress, Stckholm, Sept. 1985.
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