AVAIDYA@BIONET-20.BIO.NET (Akhil Vaidya) (06/02/89)
A postdoctoral position to investigate unusual mitohondria-like DNA of malarial parasites is available immediately in the Malaria Research Group, Department of Microbiology and Immunology, Hahnemann University, Philadelphia. The project involves studying organization and expression of 6 kb tandemly arrayed DNA that encodes cytochrome oxidase subunit I, cytochrome b, and rRNA genes in bizarre pieces. A paper describing this initial work will appear in the June, 1989 issue of Mol. Biochem. Parasitol. (Vaidya et al.). The 6 kb DNA is one of two apparent mitochondrial genomes of malarial parasites. The relationship between the 6 kb DNA and a 35 kb circular DNA is not known, but these two molecules do not cross-hybridize. Hence the organelle genomes of malarial parasites seem to have originated from two separate endosymbiotic events. We are very excited about the possibility of unravelling secrets of this novel genetic system. If trypanosome mitochondria have the bizarre RNA editing, could malarial mitochondria have their own idiosyncrasy? If you are a Ph.D. with a molecular biolgy background and an adventurous flair, and are interested in a postdoctoral position, please contact (through e-mail or snail-mail): Akhil B. Vaidya, Ph.D. Professor Department of Microbiology M.S. 405 Hahnemann University Philadelphia, Pa 19102-1192 E-mail : AVAIDYA@BIONET-20.BIO.NET -------