GOLUB@BIONET-20.BIO.NET (ELLIS E. GOLUB) (11/15/88)
POSTDOCTORAL RESEARCH POSITIONS: Postdoctoral research positions are available to study protein structure/function relationships using a variety of biochemical/biophysical techniques. Applicants should have expertise in one or more of the following fields: enzymology, protein chemistry, NMR spectroscopy (1H, 13C, 15N, 1D, 2D) computer programming, microbiology, and/or molecular biology. These research projects are collaborations between The University of Pennsylvania and the Institute for Cancer Research at Fox Chase. Applicants should send a curriculum vitae to Dr. E. K. Jaffe, University of Pennsylvania, 4001 Spruce Street, Philadelphia, PA 19104-6002, or GOLUB @ BIONET-20.BIO.NET, or GOLUB @ PENNDRLS (Bitnet). -------
cyano@uhccux.uhcc.hawaii.edu (Greg Patterson) (02/09/89)
Hawaii Postdoctoral Research Position Available
Begins June 1, 1989 - Honolulu
Position involves isolation, identification, and
cultivation of blue-green algae (cyanobacteria) for determination
of antineoplastic and anti-AIDS activity.
The project is aimed at examination of a large number of
clonal isolates of cyanobacteria for potential production of
useful drug or drug precursor compounds. The sucessful applicant
would be responsible for the following areas:
o Isolation and identification of new isolates for
screening purposes.
o Taxonomic review of existing isolates.
o Culture studies to optimize yields of biologically
active metabolites.
Applicants should have a background in Phycology, with
some research experience in taxonomy of blue-green algae.
Experience in algal physiology or fermentation technology
preferred.
Annual salary is approximately $29,000 U.S., plus fringe
benefits. Anticipated starting date is on or about June 1, 1989.
Submit letter of application, curriculum vitae, and names
of three references to Dr. Gregory M.L. Patterson, Department
of Chemistry, 2545 The Mall, University of Hawaii at Manoa,
Honolulu, Hawaii 96822. Email enquires invited.
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Greg Patterson, Chemistry, 2545 The Mall | University of Hawaii |
BITNET: CYANO@UHCCUX.BITNET |Honolulu, Hawaii, 96822|
ARPA: cyano%helium.chem.hawaii.edu@rutgers.edu
INTERNET: cyano@helium.chem.hawaii.edu Phone: (808) 948-6031CSJOEL@weizmann.bitnet ("Prof. Joel L. Sussman") (05/12/89)
WEIZMANN INSTITUTE OF SCIENCE
Rehovot, Israel
PROTEIN CRYSTALLOGRAPHER
The Protein Crystallography Group at the Weizmann Institute has an
immediate opening for a protein crystallographer at the post-doctoral
level to work on the 3-D structure of acetyl-cholinesterase. Candidates
with a strong background in X-ray data collection, structure determina-
tion and refinement are preferred. The X-ray laboratory is well
equipped for cryogenic protein data collection on a Xentronics area
detector and 2 rotating anode diffractometers. Two PS390 computer
graphics systems, a VAX cluster and a CONVEX C220 super computer are
available for data processing and refinement.
The appointment would be initially for 1 year, extendable up to 3 years,
within the framework of the Weizmann Institute Post-Doctoral Program.
Further details are available by writing (with enclosed CV) to:
Prof. Joel L. Sussman
Dept. of Structural Chemistry Bitnet: CSJOEL@WEIZMANN
Weizmann Institute of Science FAX: 972-8-466966
Rehovot 76100 Israel
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++JMH14@phoenix.cambridge.ac.uk (06/22/89)
UNIVERSITY OF CAMBRIDGE
DEPARTMENT OF GENETICS
ENGLAND
POST-DOCTORAL RESEARCH ON THE REGULATION OF DROSOPHILA MOBILE ELEMENTS
A three year post doctoral position is available to study the
molecular biology and evolution of naturally occurring genetic systems
of regulation of the mobile P and hobo elements that cause hybrid
dysgenesis in Drosophila. Recent molecular and genetic analysis of
the regulation of P element transposition from world wide populations
of D.melanogaster reveals that there are seemingly two operationally
distinct systems: one classified as P cytotype (inherited through
females and probably involving mutations in the 4th exon of a P
element) and the other involving the transcribed KP element, a
multicopy P element deletion derivative. This latter system is
inherited through both sexes, and probably involves an RNA, or
polypeptide, product that directly interferes with P produced
transposase. For details of the KP system see Black et al. 1987 EMBO
J 6 4125 4135; and Jackson et al. 1988 Genetics 120 1003 1013, (copies
available on request). The recent development of a sensitive assay
involving eye colour mosaics has been used to directly quantify the
effects of different numbers of introduced KP elements into genotypes
containing 2 3 99B, a strong constitutive producer of transposase.
From these experiments it is clear that the position of KP elements in
addition to their copy number, is an important component of KP effects
on transposase.
Studies on the hobo system of hybrid dysgenesis reveal high copy
numbers of one specific deletion derivative, the Th element. Is this
accumulation in world wide populations due to its beneficial
regulation of hobo element transposition, along the lines of the KP
element?
The post doctoral associate will be expected to pursue
investigations, using currently available molecular and genetic
techniques in Drosophila, into the different systems of P and hobo
element regulation. These studies will involve a degree of
collaboration with Professor Margaret Kidwell in Tucson, Arizona. The
post doctoral associate will be expected to co operate with and guide
the research of a post graduate student working on the same systems.
The Department of Genetics has a strong tradition in Drosophila
genetics, with groups working on the molecular evolution of Drosophila
multigene families, single copy genes, gene expression and
development. At the same time the University of Cambridge has a high
density of research activities into most aspects of biological
research, from which post docs can benefit. When the sun is shining
nothing can go wrong!
The position is available from 1st October 1989. Interested
persons should send c.v. and names of referees as soon as possible to
Dr. Gabriel A. Dover, Department of Genetics, University of Cambridge,
Downing Street, Cambridge CB2 3EH, U.K. Or telephone (0)223 333965 or
FAX (0)223 333992. E-mail: JMH14@phx.cam.ac.uklasky@NET.BIO.NET (Stephen Lasky) (09/30/89)
POSTDOCTORAL POSITION AVAILABLE
We have an opening for a qualified postdoc in a well funded
molecular biology laboratory at Roger Williams General Hospital and
Brown University School of Medicine in Providence, Rhode Island. The
primary goal of the research will be to investigate the mechanism of anti-
proliferative action of the seco-steroid hormone, vitamin D. The cell line
that we are working with was developed at this hospital and therefore of-
fers some exclusiveness for these studies.
The project will include investigations into the effects of vitamin
D on steroid hormone receptor function, oncogene expression, tyrosine
phosphorylation, and other signal transduction systems. The candidate
should have a strong background in molecular biology or biochemistry.
The appointee will have the freedom to develop related projects and
pursue funding after the first year.
To apply for this position, send a CV with the names of three
references to S. R. Lasky PhD, Roger Williams General Hospital, 825
Chalkstone Avenue, Providence, RI 02908, or reply by e-mail to my
bionet address: lasky@bionet-20.bio.net.
Roger Williams General Hospital is and Affirmative Action and
Equal Opportunity Employer and encourages applications from members
of protected groups.