[bionet.jobs] POSTDOC WANTED

mfarrall@mrc-crc.ac.uk (Martin Farrall) (08/03/89)

POSTDOCTORAL POSITION IN MAMMALIAN DEVELOPMENTAL MOLECULAR GENETICS


      Most developmental malformations in humans have complex
aetiologies that are poorly understood.  However, several
rare 'single gene' syndromes have been identified which are
amenable to 'reverse genetic' strategies.  A phenotypically
similar developmental mutation in humans and mice that maps
to homologous chromosomal segments has been described, Greig
cephalopolysyndactyly syndrome (GCPS, human chromosome 7p13)
and extra-toes (Xt, proximal mouse chromosome 13).  GCPS has
been localized by cytogenetic analysis of translocation
breakpoints and linkage analysis, Xt has been mapped by
linkage to proximal chromosome 13 markers.  We propose to
localize the GCPS translocation breakpoints within a long
range restriction map, chromosome walk and/or jump towards
the breakpoint and identify potential coding sequences.
Progress towards this goal will be monitored by genetic
mapping of conserved sequences in mice using interspecific
crosses segregating for Xt.  Candidate genes will be cloned
for expression and sequencing studies.  Subsequent gene
analysis (in situ expression studies and transgenic mice to
confirm the identity of 'candidate' genes) will dissect the
molecular basis of these malformation syndromes.

      I have recently received funding from the Medical
Research Council (UK) to commence this 'reverse genetic'
project aimed at cloning the gene(s) mutated in GCPS and Xt
(over 5 years).  I am looking for a postdoctoral research
assistant to make a committed contribution to this project, a
training in molecular genetics is essential.  Work will
include 'HTF island' cosmid library construction, pulse field
mapping and cDNA library construction and screening.


	If you are interested in further details please contact:

Martin Farrall, Division of Molecular Medicine, Clinical
Research Center, Northwick Park Hospital, Watford Road,
Harrow, Middlesex, HA1 3UJ, UK.

Telephone: +44 1 422 1442        FAX: +44 1 423 1275

E-mail: mfarrall%uk.ac.crc@ac.uk  JANET/EARN/BITNET

PSHARP@vax1.tcd.ie (01/02/90)

POSTDOCTORAL POSITION  ----  MOLECULAR BIOLOGY / MOLECULAR EVOLUTION

    at BAYLOR COLLEGE OF MEDICINE and UNIVERSITY OF TEXAS
         at the TEXAS MEDICAL CENTER, in HOUSTON

Qualification: a Ph.D. degree or equivalent, with experience in gene
  cloning and sequencing work.

Successful applicant will work on joint project headed by Dr. Larry Chan
(Departments of Cell Biology and Medicine, Baylor College of Medicine) and
Dr. Wen-Hsiung Li (Graduate School of Biomedical Sciences, U. Texas).
Objective is to clone and sequence apolipoprotein genes from various mammals.
Bench work conducted in Dr. Chan's laboratory. The Postdoc may pick up
statistical analysis of DNA sequence data from Dr. Li, if he or she likes
to do so.

Annual salary: $20,000 or higher depending on qualification.


contact :   Wen-Hsiung Li
            Genetics Centers, G.S.B.S., University of Texas,
            P.O. Box 20334,
            Houston,   Texas 77225
            telephone:   713-792-4619
            bitnet:    gsbs005@utsph.bitnet

mfarrall@mrc-crc.ac.uk (Martin Farrall) (05/30/90)

                  POST-DOCTORAL RESEARCH ASSISTANT

               HUMAN DEVELOPMENTAL MOLECULAR GENETICS

     A postdoctoral research post is now available in the Division
of Molecular Medicine to investigate human genes with roles in the
control of embryogenesis.  'Reverse genetic' techniques will be used
to isolate and clone the gene mutated in Greig cephalopolysyndactyly
syndrome (GCPS), a condition with characteristic abnormal
craniofacial and limb morphogenesis.  Applicants must have received
a training in molecular genetic techniques, applications from
students who are 'writing up' are welcomed.

For informal enquiries, please contact Dr. Martin Farrall
(Tel. 081 869 3244, FAX 081 422 1442)

Clinical Research Center, Northwick Park Hospital, Watford Road,
Harrow HA1 3UJ, UK)