CABELL.ANDREWS@BIONET-20.BIO.NET (Paul Andrews) (02/09/89)
Organic Analytical Chemist:
I am just about finished my post-doctoral work here in Creed Abell's
lab at the University of Texas at Austin and I am seeking a PERMANENT
position. I have extensive experience in all type of HPLC (normal phase,
reverse phase,ion exchange, GPC, peptides, proteins) as well as mass
spectrometry (FAB, DCI, DEI, FD, LC-MS, GC-MS) as well as some synthetic
work. In addition, I am responsible for telecommunications in our lab and I
am quite familiar with the IntelliGenetics suite of programs. Please respond
to the address given below or E-MAIL (ARPANET) to:
CABELL.ANDREWS@BIONET-20.BIO.NET
Thanks,
Paul Andrews, PhD.
############################################################################
RESUME FOR PAUL ANDREWS
PERSONAL DATA:
Address: 610A Genard St; Austin, Texas, USA, 78751
Birthdate: June 16,1954
Citizenship: Canadian
Marital Status:Married
Phone: Home: (512) 323-5972, Work: (512) 471-3659, 471-1731
E-Mail (ARPANET):CABELL.ANDREWS@BIONET-20.BIO.NET
EDUCATIONAL DATA:
UNIVERSITY: PhD.,Chemistry, McMaster University, Hamilton, Ontario,
Canada, August, 1987.
MSc., Analytical Toxicology, Queen's University, Kingston,
Ontario, Canada, June, 1981.
BSc., Chemistry, McMaster University, Hamilton, Ontario,
Canada, May, 1978.
SECONDARY: Oakville Trafalgar Secondary School, Oakville, Ontario.
HONOURS AND AWARDS:
1973: Ontario Scholar
1978: Queen's Graduate Fellowship
WORK EXPERIENCE:
Aug.1987-Aug. 1989: Post Doctoral Research Fellow, University
of Texas, Austin, Texas, USA.
Jan.-Apr. 1986: Lecturer, Mohawk College, Hamilton, Ontario, Canada
May-Aug. 1977-1978: Summer research assistant, McMaster University
Aug. 1972-1984: Games operator, Canada's Conklin Shows, Toronto, Ontario.
Jan.-July 1974: Greenstacker operator, British Columbia Forest Products,
McKenzie, British Columbia.
May-Aug. 1973: Ford Motor Co., Oakville, Ontario
Sept.-Dec.1973: Borg-Warner Co.,Ltd., Oakville, Ontario.
REFERENCES
1. Dr. Creed Abell, PhD., Henry M. Burlage Endowed Centennial Professor,
College of Pharmacy, Division of Medicinal Chemistry, University of Texas at
Austin, Austin, Tx, USA, Zip:78712, Phone: (512) 471-5715.
2. Dr.Dennis McCalla, PhD., Vice President Health Sciences, Health Science
Center, Rm 2E1, McMaster University, Hamilton, Ontario, Canada, Code:L8N 3Z5,
Phone:(416) 525-9104.
3. Dr. Mike A. Quilliam,PhD., Senior Research Scientist, Atlantic Research
Laboratory, National Research Council, 1411 Oxford St, Halifax, Nova Scotia,
B3H 3Z1, (902) 426-9736.
INTERESTS
Member Canadian Amateur Swimming Association
Member American Swimming Association
Bicycling
Reading
------------------------------------------------------------------------------
PROFFESIONAL ESSAY
Throughout my research career, I have tried to become proficient in the
area of organic analytical chemistry with emphasis on trace analysis by HPLC
and mass spectrometry. In addition I also also wished to develop computer
skills for acquisition and manipulation of experimental data.
I specialized in analytical courses when obtaining an undergraduate
degree in chemistry. As an undergraduate summer research assistant I
developed methods for determining isotope incorporation by mass spectrometry
gas phase analysis of PCBs by gas chromatography.
My MSc. analytical chemistry courses at Queen's University allowed me to
obtain hands on experience in many inorganic analytical methods such as AA,
XRF, polarography,and ASV, as well as organic analytical methods such as GC,
HPLC and GC-MS. I also learned techniques in animal surgery, toxicology,
biochemistry, and analytical problems associated with analysis of biological
matrices. My MSc. work research involved the development of new extraction and
derivatization methods for the GC and GC-MS analysis of alkaloids from a
biological matrix.
My PhD courses at McMaster University addressed problems in applied
toxicology and developing approaches to solving non-routine problems such as
the analysis of PAHs in oil sands. My PhD research dealt with the isolation
and characterization of adducts formed between DNA and nitrated aromatic
hydrocarbons. I extensively investigated methods for the gentle
derivatization and ionization of these nonvolatile, polar compounds by mass
spectrometry. Some the techniques used were EI, CI, FAB, GC-MS, LC-MS, and
FD. During this work I gained expertise in in the handling and synthesis of
radioactive compounds, and the use of bacteria as markers of toxicity. Most
of the research involved the use of state of the art HPLC for multi wavelength
detection of metabolites and DNA-adducts. As most of the equipment was
controlled by computer systems, I learned to acquire and manipulate data by
computers as well as learning computer languages such as BASIC and FORTRAN.
My post-doctoral research centers on HPLC and mass spectrometric (probe
and GC-MS) characterization of proteins, peptides, and riboflavin analogues.
I set up and manage a Beckman System Gold HPLC system which is responsible for
the computer control of a number of other HPLC systems used in our laboratory.
I also developed software for the graphical analysis of data obtained from
these HPLCs and am presently teaching myself C, a programming language. I am
acquainted with telecommunications and network protocols because I am
responsible for maintaining computer communications to BIONET, a molecular
biology computer facility in California. I make extensive use of the
Intelligenetics Suite of programs on BIONET, and electronic bulletin board
facilities to make contact with other researchers all over the world. I have
also helped in the drafting of several major research grant proposals.
My experiences in various laboratories has allowed me to gain wide
experience in the area of HPLC and mass spectrometry, especially in area of
toxicology. Yet, by developing skills in solving problems in many areas of
organic analytical chemistry I hope to be an asset to a firm interested in
someone who can deal with situations that call for a wide range of problem
solving abilities. My ability to manage people and to delegate
responsibility would also aid me in a mangerial position.
PUBLICATIONS
Papers in Refereed Journals.
1. N.H. Werstiuk and Paul Andrews. "Base-catalysed hydrogen isotope exchange
of thiocamphor:alpha-thioenolization rate constants", Canadian Journal of
Chemistry, 56, 2605-2606, (1978).
2. F. Messier, C. Lu., P. Andrews, B. McCarry,D. Bryant, and D. McCalla. "The
metabolism of 1-nitropyrene and formation of DNA adducts in Salmonella
typhimurium". Carcinogenesis, 2, 1007-1011, (1981).
3. M. Quilliam, F. Messier, C. Lu, P. Andrews, B. McCarry and D. McCalla, "The
metabolism of nitro-substituted polycyclic aromatic hydrocarbons in Salmonella
typhimurium", in: Polynuclear Aromatic Hydrocarbons :Physical and biological
Chemistry., ed. M. Cook, A. Dennis and G. Fisher, Battelle Press, pp 667-672
(1982).
4. P. Andrews, D. Bryant, S. Vitakunes, M. Gouin, G. Anderson, B. McCarry, M.
Quilliam and D. McCalla, "Metabolism of nitro-polycyclic aromatic hydrocarbons
and formation of DNA adducts in Salmonella typhimurium", in :Polynuclear
Aromatic Hydrocarbons:Formation, Metabolism and Measurement, ed M. Cooke and
A. Dennis, Battelle Press, pp 89-98, (1983).
5. P. Andrews, J. Brien, C. Loomis and J. Page, "Gas chromatographic
determination of salsolinol in the striatum of the rat", Canadian Journal of
Physiology and Pharmacology,
6. P. Andrews, M. Quilliam, B. McCarry, D. Bryant, and D. McCalla,
"Indentification of the DNA adduct formed by the metabolism of 1,8-
dinitropyrene in Salamonella typhimurium", Carcingenesis, 7, 105-110, (1986).
7. P. Andrews, J. Orr, I. Lambert, D. Bryant, L. Davidson, B.. McCarry, and D.
McCalla, "The fate of 1,8-dinitropyrene in Salmonella typhimurium:Metabolism
and DNA adduct formation" in Polynuclear Aromatic Hydrocarbons, ed M. Cooke,
Battelle Press, (1986).
8. I. Lambert, P. andrews, L. Davidson, D. Bryant, and D. McCalla, "The
detection of dinitropyrene adducts in DNA", Environmental Mutation Society,
8, Supp. 6, 43, (1986).
CONTRIBUTED CONFERENCE PAPERS
1. D.McCalla, B. McCarry, M. Quilliam, P. Andrews, and C. Lu,"Mutagenicity of
nitropyrenes in Salmonella typhuimurium: Activation by endogenous reductases
and formation of DNA adducts", 13th International Cancer Congress, Seattle,
(1982).
2. D. McCalla, M. Quilliam, B. McCarry, C. Lu, F. Messier and P. Andrews,
"Metabolism of nitropyrenes and formation of DNA adducts in Salmonella
typhimurium" 5th CIIT Conference on toxicology, The Chemical Industry
Institute of Toxicology, Raleigh, NC, (1982).
-------DID1290@VM.NRC.CA (Paul andrews) (08/29/90)
Aug 29,1990
Bureau of Drug Research
Health and Welfare Canada
Tunney's Pasture
Ottawa, Ontario, Canada
K1A 0L2
I presently hold the position of National Science and
Engineering Council Research Council Visiting Fellow at Health and
Welfare Canada and am seeking employment. As a Canadian citizen
under the terms of the US-Canada Free Trade Agreement, I am
eligible for an H-1 or TC (Treaty Canada) visa allowing me to work
in the U.S.A.
During my research career I gained extensive experience in the
HPLC and GC analysis of drugs and their metabolites, DNA-adducts,
proteins and peptides, and mass spectrometry of polar biological
compounds. I am also proficient in other chromatographic methods as
well as techniques in inorganic analysis. Computers have played an
important role in my research for data acquisition and
telecommunications. I am familiar with PC/MS-DOS, Unix, and VM/CMS
computer operating systems. My skills as an analytical chemist and
my background in analytical toxicology, biochemistry and computer
systems make me an ideal candidate for either a technical or
managerial position.
The following text is my resume which includes my E-mail
address for the computer facility I use at the National Research
Council in Ottawa, and a FAX number for the Bureau of Drug
Research, Health and Welfare Canada. Thank you for your
consideration in this matter.
Paul Andrews, PhD
NSERC Visiting Fellow
=================================================================
====
RESUME FOR PAUL JOHN ANDREWS
PERSONAL DATA
Address 2074 Carling Avenue, Ottawa, Ontario, Canada K2A
1G8.
Birthdate June 16, 1954
Citizenship Canadian
Phone Home:(613)729-8826. Work:(613)957-3506
E-Mail (Bitnet/Netnorth) DID1290@VM.NRC.CA
FAX (613) 957-1907
EDUCATIONAL DATA
1987 PhD., Chemistry, McMaster University,Hamilton,
Ontario, Canada.
1981 MSc., Analytical Toxicology, Queen's University,
Kingston, Ontario, Canada.
1978 BSc., Chemistry, McMaster University, Hamilton,
Ontario, Canada.
HONOURS AND AWARDS
1973 Ontario Scholar
1978 Queen's Graduate Fellowship
1989 National Science and Engineering Research Council of
Canada Visiting Fellow Award
WORK EXPERIENCE
1989-Present National Science and Engineering Research Council
of Canada Visiting Fellow, Bureau of Drug Research,
Ministry of Health and Welfare, Tunney's Pasture,
Ottawa, Ontario, Canada.
1987-1989 Post Doctoral Research Fellow, College of Pharmacy,
Division of Medicinal Chemistry, University of
Texas, Austin, Texas, USA.
1986 Lecturer, Mohawk College, Hamilton, Ontario, Canada.
1978-1986 Teaching assistant, McMaster University, Queen's
University.
1977-1978 Summer research assistant, McMaster University.
REFERENCES
1. Dr. Creed Abell, PhD., Henry M. Burlage Endowed
Centennial Professor, College of Pharmacy,
Division of Medicinal Chemistry, University of
Texas at Austin, Austin, Texas, USA 78712.
Phone:(512)471-5715.
2. Dr. Michael A. Quilliam, PhD., Associate Research
Officer, Atlantic Research Laboratory, National
Research Council, 1411 Oxford St., Halifax,
Nova Scotia, Canada B3H 3Z1. Phone:(902)426-9736.
3. Dr. Brian Foster, PhD., Research Scientist, Bureau
of Drug Research, Health and Welfare Canada, Sir
Frederick Banting Building, Tunney's Pasture,
Ottawa, Ontario, Canada K1A 0L2. Phone:(613)957-
3506.
PROFESSIONAL ESSAY
During my research career I have become proficient in the area
of organic analytical chemistry with emphasis on trace analysis by
GC, HPLC and mass spectrometry. I also developed computer skills
for the acquisition and manipulation of experimental data.
Currently, at Health and Welfare Canada, I am a member of the
Biotechnology Section of the Bureau of Drug Research. My major
responsibility is to conduct studies into the metabolism of a
series of nitroimidazoles by fungi which have the unique ability to
mimic mammalian metabolism. This study, which is funded by the US-
FDA, will gain insight into the evaluation of the toxicity of
protein-bound drug residues. Other regulatory duties include the
assessment of federal IRAP grants and assisting in evaluating drug
submissions. I am also responsible for coordinating the
Bitnet/Internet/Netnorth newsgroups of interest to other scientists
in the Health Protection Branch.
My post-doctoral research centred on HPLC and mass
spectrometric (probe and GC-MS) characterization of proteins,
peptides and riboflavin analogues. Protein isolation and
characterization techniques were developed for other members of my
research group. I also aided in the drafting of several major
research grant proposals. I was responsible for the acquisition,
set up, and management of a Beckman System Gold HPLC system which
was used for the computer control of other HPLC systems and
detectors used in our laboratory. My familiarity with the
"Intelligenetics" suite of molecular biology software played an
important role in my research. My skills in telecommunications
networks using TCP/IP and Telnet under TOPS-20, UNIX, and VM/CMS
operating systems were important in my research. In order to
improve my skills in computer programming I taught myself "C", a
programming language, and expanded my knowledge of PC-DOS, UNIX,
and IBM 3270 VM/CMS operating systems.
Research for my PhD dealt with the isolation and
characterization of adducts formed between DNA and the metabolites
of nitrated aromatic hydrocarbons. I extensively investigated
methods for the gentle derivatization and ionization of these
nonvolatile, polar compounds by mass spectrometry. Some of the
techniques used we EI, CI, FAB, GC-MS, and LC-MS. I learned to
acquire and manipulate data using data analysis packages such as
Lotus 1-2-3 and Excel. In my PhD courses I developed skills in
solving non-routine analytical chemistry problems such as the
analysis of inorganics and PAHs in oil sands.
My MSc research involved the development of new extraction and
derivatization methods for the GC and GC-MS analysis of alkaloids
from a biological matrix. Graduate analytical chemistry courses
allowed me to obtain hands-on experience in many inorganic and
organic analytical methods such as GC, HPLC, and GC-MS.
Experience gained in various laboratories has allowed me to
become an expert in GC, HPLC and mass spectrometry, especially in
the area of organic analytical chemistry. My skills in solving
problems in many areas of analytical chemistry will be an asset to
a firm interested in someone who can deal with situations that call
for a wide range of problem solving abilities.