OLIVER@calstate.bitnet (OLIVER SEELY) (02/03/90)
I searched MELVYL, the University of California card catalog, using
the subject keyword INBREEDING and came up with 24 references at
all libraries. I eliminated those that I felt were not relevant
to your query about marriage between cousins. Here are the ones
which might be of interest.
4. Fisher, Ronald Aylmer, Sir, 1890-1962.
The theory of inbreeding, by Sir Ronald A. Fisher. 2d ed. New York,
Academic Press, 1965 [c1949].
LBL Donner S494 .F5 1965
UCB BioSci QH431 .F53 1965
UCB BioSci QH431 .F53 1965 (another copy)
UCD HealthSci S494 F56 1965
UCI Biomed S494 .F535t 1965
UCI Main Lib S494 .F56 1965
UCSB Library SF105 .F5 1965 Sci-Engrg
UCSD Central S494 .F56
UCSF General S494 F53t, 1965
SRLF A 0003726874 Type EXP SRLF for loan details.
CSL Main Lib S 494 F56 General Coll
7. Galippe, Victor, 1848-1922.
L'heredite des stigmates de degenerescence et les familles souveraines /
par le Dr V. Galippe ; preface de M. Henri Bouchot. Paris : Masson, 1905.
UCLA URL HV 4967 G134h
14. King, Helen Dean, 1869-
Studies on inbreeding [by] Helen Dean King. Philadelphia, Pa., The
Wistar Institute of Anatomy and Biology, 1919.
UCB BioSci QH431 .K57
UCD Main Lib QH431 .K5
UCLA Biomed QH 431 K582s 1919
15. Littlewood, Robert Alden.
An analysis of inbreeding and effective breeding size in the Tasmanian
hybrid population of Bass Strait. [Los Angeles], 1962.
UCLA URL LD 791.9 A6L735
UCSC Science QH470.M52O74
UCSD Biomed QY 60 R6 O693 1978
UCSF General QH470.M52 O74 1978
18. Sanders, Laura Eileen.
Population extinction : a laboratory study of the long-term effects of
inbreeding / by Laura Eileen Sanders. 1987.
UCSD Biomed W 4 C153SD S215p 1987
UCSD Central No call number Spec Coll Archives Diss
20. Schull, William J.
The effects of inbreeding on Japanese children / William J. Schull and
James V. Neel ; in collaboration with Arthur L. Drew ... [et al.]. New
York : Harper & Row, c1965.
UCB BioSci HV4995.J3 S3 Shelved at BIOSCIENCES OFF CAMPUS
COLLECTION
UCB PubHealth HV4995.J3 S3
UCD HealthSci HV4995 J3 S3
UCD Main Lib HV4995.J33 I58 1965
UCLA Biomed QZ 50 S386e 1965
UCLA URL HV 4995 J3S38
UCSB Library HV4995.J3 S3
UCSD Biomed QH 431 S386e 1965
UCSF General HV4995.J3 S386e 1965
22. Shine, Ian.
Serendipity in St. Helena; a genetical and medical study of an isolated
community. With the assistance of Reynold Gold, and a foreword by Sir Max
Rosenheim. [1st ed.]. Oxford, New York, Pergamon Press [1970].
UCB PubHealth RA395.S3 S5 1970
UCD HealthSci WA900 HA72 S5
UCI Biomed QZ 50 S556s 1970
UCLA Biomed WA 900 HA72 S556s 1970
UCR Bio-Ag RA395.S3 S5 1970
UCSC Science RA395.S3S5
UCSD Biomed WA 900 HA 72 S556s 1970
UCSF General RA395.S3 S5565s 1970
SRLF A 0005825146 Type EXP SRLF for loan details.C0613@umrvmb.bitnet ("Ronald L. Frank") (02/03/90)
We all have a small percentage of mutations which interrupt a few of our genes and prevent their function. Being diploid, i.e., two copie of all genes, the second gene is usually sufficient to provide the necessary function and the defect is unnoticed throughout life. With the large number of genes we have, the likelihood that two individuals randomly chosen from a population would have a defect in the same gene is extremely rare. However, we will pass this defective gene to one-half of our children. They will be normal because they inherited their second (normal functioning) gene from our spouse. Likewise all children arrying the defective gene unnoticed will pass it to one-half their children. Cousins, therefore, have a very high (relative to the general population, about 1/16) likelihood of carrying the same gene defect. The result of the defect when it is finally manifested in the children of this consnguineous marriage can range in severity from totally undetectable to sligh t inborn errors of metabolism to retardation to severe birth defects to death, and everything in between. The defect depends on the function of the gene invo lved. Quite often the death symptom can go unnoticed also as spontaneous abort ion very early in development (before a person knows they're pregnant). Unfortunately, new and previously undescribed genetic diseases will continue to be introduced into the world as long as cousins continue to marry each other. rlf