[bionet.molbio.bio-matrix] Advice

hunter-larry@YALE.ARPA (04/08/88)

From: Larry Hunter <hunter-larry@YALE.ARPA>

Hello -

I'm new to this list, and I'd like to introduce myself.

I'm in the process of finishing my Ph.D. in artificial intelligence at
Yale, under the direction of Roger Schank.  My thesis work is a
computerized information retrieval and consultation system in lung tumor
pathology called IVY.  The system gradually gains expertise by discovering
"paradigm cases" in its experiences.  By paradigm case, I mean not
necessarily a prototypical instance, but a case that embodies some
particular prescription for accomplishing a useful task (e.g. it is helpful
in distinguishing between two commonly confused phenomena).  The program
finds paradigm cases by a process of knowledge acquisition planning:
It develops knowledge goals (things it would like to know about) based
on problems it had previously, and then it can figure out what aspects
of its knowledge or of future experiences might be useful in finding
out that information.  An experience that can be used to satisfy a
knowledge goal is saved as a paradigm case.  The program is quite efficient
in that it can find many useful cases without an exhaustive search. I
believe that I can apply this technology to the domain of genetics and
molecular biology, generating programs that can plan for and achieve
particular knowledge acquisition goals by making inferences and looking
up information from multiple databases.  The knowledge acquisition planning
process is quite flexible, so other compuational methods for making
inferences from biological databases can easily be integrated into it.
Brief discussions I have had with Christian Burks at LANL, Clay Saunders
at the Human Gene Mapping Library and Larry Kingsland at the National
Library of Medicine have all been very encouraging.


I'd now like to ask for some advice.   I'm thinking about where I should
go after I get my degree.   Where are the significant projects in
computational biology?  What are their research interests and inclinations?
Who is interested in hiring AI people with some biological background?
I've been talking to Stanford and the National Library of Medicine, but
there have to be other projects out there.  I'm particularly interested
in assistant professor positions, but I'm open to other possibilities.
Anybody have any suggestions?

                                           Thanks!

                                           Larry Hunter
                                           HUNTER@YALE.EDU
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