[bionet.molbio.bio-matrix] first principles

karp@SUMEX-AIM.STANFORD.EDU (Peter Karp) (05/23/89)

In a recent paper, I argue that the meaning of the term "first
principles" is at best highly sensitive to the particular domain
of discourse, and at worst, vaccuous.  (See "An Analysis of the
Distinction Between Deep and Shallow Expert Systems", by Karp and
Wilkins in an upcoming International Journal of Expert Systems).
If someone would like to offer a precise definition of first versus
other types of principles, I would be very interested.

I actually don't think the message that we're all refering to
(written by Dan Davison?) was meant to inspire such serious debate --
but perhaps it should have.  I for one would not mind seeing a tighter
definition of the goals of The Matrix; such a definition should
probably not include words like "evangelize."

Although I am not a physicist, my understanding is that we need not
envy the "first principles" of physicists, because they are often
computationally intractable -- consider the three-body problem and the
fact that (I think) quantum mechanics is too complex to be applied to
single large atoms.  Biological first principles, such as those used
to compute protein structures, may also have this property.  Thus we
turn to approximations and abstractions.

Peter Karp
CS Dept
Stanford