[bionet.molbio.bio-matrix] size transforms in biological knowledge

mckee@CORWIN.CCS.NORTHEASTERN.EDU (George McKee) (05/26/89)

David Kristofferson wants more people to contribute to the list,
so here's a tidbit (less than 2 cents worth, but US coinage doesn't
go below 1...)

	The greatest difficulty in representing scientific knowledge
is that there's no single representation possible for anything.
Multiple representations are superficially redundant, so researchers
are very reluctant to dilute their work by representing facts more
than once. (Logicist AI is an extreme example of this, trying to
fit all thought into first order logic.)  The great strength of
the matrix approach is that it has multiple representations as a
fundamental principle.

	But viewing each dimension of the matrix as a linear vector
of properties doesn't work, though it would be nice if it did.  The
urge to derive explanations from "first principles" seems to me to
be an attempt to find some fundamental axiom set from which everything
can be deduced.  But even in physics "it's no use, it's turtles all the
way down" as the builders of particle colliders are busily finding out.

	It seems to me that each dimension of the knowledge matrix
should be viewed as a continuum that can be sampled at varying resolutions,
producing a hierarchy of theory-slices that need to link together only
the observations at a particular scale.  The theory-slices are connected
by metatheories that show how the whole picture fits together.  Evolution,
for instance, is one of the metatheories, while population genetics is
one of the theory-slices within the evolutionary dimension.

	In neuroscience, Terry Sejnowski has constructed a very nice
diagram showing how important classes of neural structures can be identified
at 7 of the 8 orders of magnitude in size between molecules and human CNS
(fig.1 in P.S.Churchland and T.J.Sejnowski, Science 242,p.741, 4 Nov.1988).
Counting planetary ecology, biology includes 6 more orders of magnitude
simply in physical scale.

	I think it was Laplace who wanted to do things like predict species
extinctions by enumerating the molecules in the Amazon jungle, but who
can collect that kind of data?  Theories of knowledge have to accept the
fact that some facts are in principle knowable, but the data is simply
inaccessible.

	- George McKee
	  NU Computer Science

Disclaimer: I'm not an expert in anything, particularly this stuff.