WILKISOND@medcolwi.bitnet (03/01/91)
Now that the wires have cooled down, I would like to make a call to the biologists nonmoleculaire. Remembering that the biomatrix is built on the philosophy of analogy and homology of the entire spectrum from DNA to behavior and function, let here from those doing work other than gene analysis (trying to keep it noninflammatory). Anyway, I am looking for some insight into possible neuronal simulation programs and techniques which run on a PC. I would like to develop some simulations of pharmacology in individual neurons. If I can work on someone else's basic simulated neuron without having to develop de novo a simulation it would save a year's time. Anyone with a system or who knows of a package please contact me or post a bit on the BBS. Thanks in advance. Douglas M. Wilkison Pharmacology Med. College of Wisconsin 8701 Watertown Plank Rd. Milwaukee, WI 53226 WILKISOND@MEDCOLWI.bitnet
sticklen@cps.msu.edu (Jon Sticklen) (03/01/91)
doug, do you have to be working on a PC? my group has been applying an MBR technique called functional reasoning to biological systems. so far we have modeled a fragment of the immune system (the complement system), and a couple of landscape ecologies. we have in progress now a project to model a landscape level agricultural ecology. i'd like to know more about your project - maybe our stuff could play. but... right now we only run on MACs and SUNs. ---jon--- ------------------------------------------------------ Jon Sticklen tele: 517-353-3711 AI/KBS Lab - Comp Sci Dept FAX: 517-336-1061 A714 Wells Hall office in A392 Eng Bldg Michigan State University East Lansing, MI 48824-1027
hunter@work.nlm.nih.gov (Larry Hunter) (03/02/91)
Douglas Wilison asks about neuronal simulation programs and techniques for the simulation of pharmcology of individual neurons. Doing detailed, realistic computer models of neurons (as would be needed for most inquiries in pharmacology) is technically and conceptually challenging. I suspect it will be difficult to find an adequate package that runs on a PC, but I do have a reference I would suggest: "Connectionist Modelling and Brain Function: The Developing Interface," ed. by S.J. Hanson and C.R. Olson, MIT Press 1990. This book contains both excellent review chapters and several specific models. I hope you find it helpful. Larry -- Lawrence Hunter, PhD. National Library of Medicine Bldg. 38A, MS-54 Bethesda. MD 20894 (301) 496-9300 (301) 496-0673 (fax) hunter@nlm.nih.gov (internet) hunter%nlm.nih.gov@nihcu (bitnet/earn)