The.Bird@f38.n135.z1.fidonet.org (The "Bird") (09/25/90)
BACKGROUND Both local and systemic hyperthermia have been investigated over the past 20 years as treatment modalities for various malignancies. Currently, the concensus is that the use of hyperthermia as a single form of cancer therapy is unwarranted because clinical reponse is typically extremely short. Thus, at major university centers where hyperthermia is being explored, it is always used in combination with either chemotherapy, radiation therapy, or treatment with biological response modifiers. The use of hyperthermia to treat HIV-related KS or to treat chronic human viral infections has never been reported. The effect of heat on HIV and its life cycle is of considerable interest to laboratory scientists attempting to learn how best to control the virus. One group of investigators has reported that heat shock can upregulate production of HIV from chronically infected cell lines. Interestingly, a common sequalae of systemic hyperthermia is activation of latent herpes simplex virus type I. (continued) -- Uucp: ...{gatech,ames,rutgers}!ncar!asuvax!stjhmc!135!38!The."Bird" Internet: The."Bird"@f38.n135.z1.fidonet.org