finin@PRC.UNISYS.COM (10/19/88)
AI SEMINAR
UNISYS PAOLI RESEARCH CENTER
EXPERT SYSTEMS IN PREDICTIVE TOXICOLOGY
Marilyn S. Arnott and Ina B. Snow
LogiChem Inc.
Boyertown, PA 19512
A prototype system focusing on the possible teratogenicity of members
of one class of chemicals, aliphatic acids, has been developed and
validated. The system evaluates any chemical which can be metabolized
to an aliphatic acid, then performs structure-activity relationship
(SAR) analysis on the resulting acid to determine its potential
teratogenicity. The prototype was validated by comparing results from
the system to laboratory results from three types of teratogenesis
bioassays on 36 aliphatic acids. The outcome cast doubt on the
usefulness of one of the bioassays, and, additionally, detected an
error in the published structure of one of the compounds tested.
We are presently in the early design phase of an expert system to
predict carcinogenic potential of chemicals. The system is being
developed in cooperation with senior scientists at the EPA, who use
SAR analysis to evaluate the potential health hazards of new chemicals
under review by the agency.
Wednesday, October 19, 2:00
BIC Conference Room
Unisys Paoli Research Center
Paoli Pa
-- non-Unisys visitors who are interested in attending should --
-- send email to finin@prc.unisys.com or call 215-648-7446 --