shan@mcf.UUCP (01/29/87)
I'm posting this for a colleague, please mail replies to him at the
address below:
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We are a cancer research institution, with a recently established
VAX Computer Facility. (This is a DEC VAX 11/750 running 4.2bsd)
Investigators in our Chemistry Department are involved in studies
of mechanisms of drug action related to protein and nucleic acid
biosynthesis. We are slightly aware of the emerging field
of computer-aided analysis of molecular structure and design, but
as yet have no practical experience, and seek advice in getting
started.
Specifically, we have immediate needs to study antibiotics which
inhibit protein synthesis, including chloramphenicol and
puromycin (mol. wts. ~300-400 daltons). We wish to examine the
similarities and differences between the molecular structure of
such compounds and the structure of tRNA molecules - particularly
the amino acid carrying end. We wish to look at molecular overlap,
both regular and inversion (or retroversion).
Any advice on hardware, software, and analytical approaches would
be appreciated. We are novices, but ambitious, and assistance at
any level will be both appreciated and useful.
Dr. Phil Paine
Please e-mail replies to the address below:
...{back bone}..!ihnp4!mb2c!mcf!phil
or telephone (313)-833-0710 x 262
michigan cancer foundation
110 east warren avenue
detroit, michigan 48201