[sci.med] HICN228 News Part 1/1

ATW1H%ASUACAD.BITNET@oac.ucla.edu (Dr David Dodell) (07/11/89)

Volume  2, Number 28                                            July 10, 1989

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                         Editor: David Dodell, D.M.D.
                   St. Joseph's Hospital and Medical Center
    10250 North 92nd Street, Suite 210, Scottsdale, Arizona 85258-4599 USA
                           Telephone (602) 860-1121

     (c) 1989 - Distribution on Commercial/Pay Systems Prohibited without
                              Prior Authorization

             International Distribution Coordinator: Robert Klotz
                            Nova Research Institute
            217 South Flood Street, Norman, Oklahoma 73069-5462 USA
                           Telephone (405) 366-3898

The Health Info-Com Network Newsletter is distributed weekly.  Articles  on  a
medical  nature  are  welcomed.  If  you  have an article,  please contact the
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the distribution system please contact the distribution coordinator.

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                       T A B L E   O F   C O N T E N T S

1.  Comments & News from the Editor
     HICNet Newsletter Now Available via ftp on Internet  ..................  1

2.  Medical News
     Medical News Items for week ending June 9, 1989 .......................  2

3.  Columns
     New Organ Preservation Solution Extens Transplant Times ...............  8

4.  Articles
     Global Education for Disabled Children on Telecom Networks ............ 10

5.  Volunteer Needed for Studies/Research
     Phase I study of a new nucleoside analog, AzdU, Volunteers Wanted ..... 13

6.  Call for Papers
     Studies in Technological Innovation and Human Resources ............... 14

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===============================================================================
                        Comments & News from the Editor
===============================================================================

              HICNet Newsletter Now Available via ftp on Internet

Courtesy of the facilities at Nodak.Edu,  HICNet Newsletter is  now  available
via  anonymous  ftp  request on the Internet.  To get the newsletter this way,
you should make an "anonymous" ftp request of "vm1.nodak.edu".  Change to  the
directory HICNEWS and you should see the issues available there.

If  you  have  any  questions,  or  problems,  contact  me  at any of my email
addresses.

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===============================================================================
                                 Medical News
===============================================================================

                Medical News Items for week ending June 9, 1989
            Source: USA TODAY/Gannett National Information Network
                          Reproduced with Permission

                                July 3-4, 1989

                         REACHING PEAK AT 70 POSSIBLE:

   Physiologists recently found that people in the 70s who exercise vigorously
can bring their exercise capacity to its peak for their age.  Doctors  at  the
University  of  Maryland's  Center for Aging found that a group of patients in
their 70s increased  their  maximum  cardiovascular  capacity  by  22  percent
through a program of fast walking. (From the USA TODAY Life section.)

                        N.Y. DOCTORS GET CAP ON HOURS:

   Medical  residents  at  New  York  hospitals  will  no  longer  work  their
traditional 36-hour shifts and 100-hour weeks.  As of  July  1,  residents  in
hospitals  throughout  the  state  were  limited to 24-hour shifts and 80-hour
weeks.  The law was prompted by concerns for  high-quality  patient  care  and
optimum physician training.  (From the USA TODAY Life section.)

                       DENTISTS CAN DETECT ABUSE SIGNS:

   Because  physical abuse cases often involve injuries to the head,  face and
mouth, dentists can often be the first to detect the signs of abuse,  a survey
showed.  Researchers  at  the  University  of  Colorado polled more than 3,000
dentists and found that 3 percent reported treating patients for abuse-related
injuries.  Another 7.6 percent reportedly had  suspicions  of  abuse  in  some
cases.

                        ETHNICITY SHAPES DRUG RESPONSE:

   Researchers  have  found  that  patients  of  differing  ethnic backgrounds
metabolize certain drugs differently.  Doctors at the  National  Institute  of
General  Medical Sciences found that American men of Chinese descent were more
sensitive to the blood pressure drug propranolol than men of European descent.
They say the difference is rooted in genetically inherited factors.

                        NEW ALZHEIMER'S THEORY STUDIED:

   Alzheimer's disease might be the result  of  a  protective  mechanism  gone
awry, researchers report. Doctors at Harvard University are studying an enzyme
inhibitor called alpha-1 antichymotrypsin - or ACT - a component of the senile
plaques  that  develop  in the brains of Alzheimer's patients.  Normally,  ACT
helps keep the body's enzymes and their inhibitors in balance.

                        DAILY WATER INTAKE - 2 LITERS:

   The average American drinks  just  more  than  2  liters  of  water  daily,
according  to a Department of Agriculture study.  The study,  which questioned

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more than 26,000 Americans,  found that an average  person  drinks  about  1.2
liters  of tap water from the faucet each day as drinking water and in coffee,
tea and other beverages. The rest comes from water packaged in foods.

                          DOCTORS FIND LIVER PROTEIN:

   Researchers at the National Institutes of Health are trying to discover why
the body's immune system attacks the  liver  of  biliary  cirrhosis  patients.
Doctors  at  NIH  have  found the proteins the immune system attacks,  and are
searching for the disease's cause.  Two theories: An immune system malfunction
causes the disease or an earlier  event  changes  the  liver,  triggering  the
immune response.

                         TRANSPLANT ORGANS SUSTAINED:

   Researchers   at  the  University  of  Kentucky  have  kept  animal  organs
functioning for 60 hours outside the body,  the  July  Discover  reports.  The
heart,  lungs,  liver  and  kidneys of a dog were left intact,  submerged in a
saline solution and maintained by a mechanical respirator.  Doctors  hope  the
research lengthens the time human organs remain healthy for organ transplants.

                          FLUORIDE KICKING CAVITIES:

   About  50 percent of American children are free from tooth decay,  a recent
survey from the National Institute of Dental Research shows.  That's  up  from
the  early 1970s,  when only about 28 percent of children were free from tooth
decay.  Fluoridation of America's drinking water,  which began in 1945 and was
greatly expanded in the 1960s, has had a major effect, the survey said.

                        COCAINE-USE PERSONALITY MAPPED:

   A  pioneering  study  at  the  University  of Iowa has found a link between
cocaine abuse and clinical personality disorders.  The study, published in the
July  American  Journal of Public Health,  found that cocaine abusers are more
likely than non-users to exhibit narcissistic tendencies,  desiring to be  the
center of attention and obsessed with power and control.

                        GM TEAM TRIES TO REDUCE INJURY:

   Researchers  at General Motors are designing safety systems to minimize the
injuries that accompany sudden deceleration. A GM team using advanced computer
technology and anatomical models,  are creating new mathematical models of the
damage  caused  by  crash  forces.  Their research is based on the theory that
force has different effects on different types of body tissue.

                        YOUNG FALLING DOWN ON FITNESS:

   The American Academy of Pediatrics recently named declining fitness  levels
and  the  use  of  illegal  steroids  as  the  two most urgent problems facing
America's physical education programs. The academy said the general fitness of
the nation's young people has been declining during the past two  decades  and
the  trend  might  contribute  to  future  cases  of  heart  disease and other
illnesses.

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                                 July 5, 1989

                          DISEASE THRIVES IN SUMMER:

   A new disease  is  coming  this  summer.  It's  called  hand-foot-and-mouth
disease.  Doctors say most people will catch the disease, but few will realize
it,  since its most common symptoms - a sore throat and fever - are most often
mistaken  for a cold.  It is most common among children younger than 4.  (From
the USA TODAY Life section.)

                          DISEASE NOT SERIOUS THREAT:

   The most drastic symptoms of hand-foot-and-mouth disease can include fever,
sore throat,  swollen glands,  wart-like sores  on  the  hands  and  feet  and
sometimes  in  the  mouth.  The disease - common in the summer months - is not
considered a serious health threat.  It normally lasts a week to 10 days,  but
requires no treatment. (From the USA TODAY Life section.)

                        LYME DISEASE RESEARCH QUICKENS:

   Scientists  are  increasing  the pace of research into Lyme disease and the
tick that spreads it.  Researchers,  responding  to  rising  numbers  of  Lyme
disease  cases,  are  advancing  new  theories  on the microbe that causes the
disease and how it is spread from the ticks that carry it to humans, Tuesday's
New York Times reports.

                             BABY NEEDS SOME SUN:

   Letting a baby crawl around in the sun for  a  few  minutes  each  day  can
provide  all the needed Vitamin D.  Researchers at Children's Hospital Medical
Center,  Cincinnati,  have found that babies can maintain adequate  Vitamin  D
levels  by  staying out in the sun for 30 minutes a week.  Vitamin D is needed
for the baby to absorb calcium and phosphate.

                         EXPERT SAYS NEW FOCUS NEEDED:

   Cancer prevention should focus more on stopping the cancer process  in  the
body  and  less  on  environmental  contributors to the disease,  a well-known
researcher said recently.  Georgetown University's  Dr.  John  Higginson,  who
first linked environmental causes such as smoking to cancer 35 years ago, said
efforts to cut cancer by eliminating such factors had met with little success.

                            PATHOLOGISTS USE HDTV:

   Washington, D.C.-area pathologists soon will use high-definition television
to  examine  human  tissue samples miles from their hospitals,  the Washington
Post reports. Corabi Telemetics Inc.  said a Bell Atlantic fiber optics system
using  HDTV-based  technology  would  provide  twice the resolution of current
televisions, allowing pathologists to accurately examine slides.

                         PYGMY HEIGHT THEORY ADVANCED:

   Researchers at Northwestern University might have finally found why African
pygmies are so short.  A report in Friday's New England  Journal  of  Medicine
notes  that  while  pygmies  have  normal amounts of a hormone responsible for

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growth,  they might have fewer growth hormone receptors proteins on  a  cell's
surface that bind the hormone. Scientists are conducting more research.

                          MORE EVIDENCE AGAINST FAT:

   A  study  at  the  University  of  Illinois confirms that fat content - not
calorie count - is the key to weight reduction. In a six-month study, 18 women
lost weight faster on a 20 percent fat diet than on a 40-percent fat diet with
fewer calories.  The diet showed equal results regardless of the women's level
of obesity prior to starting the diet.

                                 July 6, 1989

                         HERPES ESTIMATE GOES WAY UP:

   A  study  released  Wednesday  claims many more Americans are infected with
herpes simplex II than  previously  thought.  The  study,  in  Thursday's  New
England Journal of Medicine,  estimates 16.4 percent of the population between
15 and 74 years old has the disease - about 25 million people.  (From the  USA
TODAY Life section.)

                        NYU MAPS BRAIN MAGNETIC FIELDS:

   New  technology  is  unlocking  the  secret of the brain's magnetic fields.
Researchers at New York University said Wednesday that by  using  new,  highly
sensitive  detectors,  they  could  monitor  the location,  force and shape of
magnetic fields in the brain for the first time.  All the fields combined in a
single human brain have less magnetic energy than a common message magnet.

                        TRANSPLANTS INCREASE SURVIVAL:

   Patients  who  undergo  liver transplants because of a fatal disease have a
higher survival rate than others who opt for more conservative  treatments,  a
study  shows.  The  seven-year  study,  in  Thursday's  New England Journal of
Medicine,  showed that the survival rate for  patients  with  primary  biliary
cirrhosis who have transplants is twice as high as non-transplant patients.

                        DOCTOR WORKING ON JET LAG PILL:

   A  doctor  at  the  University of Texas is developing a "jet lag pill" that
could help travelers combat the effects of cross-country travel. The pills are
made of melatonin,  a naturally produced chemical that  causes  drowsiness.  A
traveler  would  take  a  pill  when  it  is about 2 a.m.  at his destination,
becoming drowsy, sleeping, and adjusting his system to the time there.

                       EYE TEST COULD FIND ALZHEIMER'S:

   Simple tests during routine eye exams could  spot  Alzheimer's  disease,  a
study shows. The study, by doctors at Philadelphia's Wills Eye Hospital, shows
that  while  patients'  visual  acuity remains normal,  they uniformly display
abnormalities in color vision,  depth  perception  and  the  ability  to  copy
diagrams.

                          BOTTLED WATER USAGE RISING:

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   Health-conscious Americans are consuming more bottled water than ever,  and
the market for bottled water  is  growing.  The  International  Bottled  Water
Association said bottled water,  almost unheard of in the United States only a
decade ago,  had grown  to  a  $300  billion-a-year  industry.  Producers  are
introducing several flavored waters. (From the USA TODAY Life section.)

                         NEW EYE SURGERY HEALS FASTER:

Doctors  are combining ultrasound technology and tiny,  foldable lens implants
to create a new form of cataract surgery that reduces discomfort  and  healing
time. The technique, recently developed at St. Luke's Cataract and Intraocular
Lens  Institute,  requires  a much smaller incision than conventional surgery,
reducing healing time and visual distortion.

                         FDA CLEARS NEW ACNE MEDICINE:

   The Food and Drug Administration on Wednesday  cleared  Cleocin  T  topical
lotion  for  the  treatment of acne.  The lotion was designed specifically for
patients with dry,  sensitive skin.  The lotion,  produced  by  pharmaceutical
giant Upjohn Co.,  has a water base, which adds more moisture to the skin than
oil- or alcohol-based solutions, Upjohn officials said.

                                July 7-9, 1989

                       ONE-THIRD HAVE HIGH CHOLESTEROL:

   More than one-third of all Americans have borderline  or  high  cholesterol
levels,  a  study  shows.  The  study,  published  in  Friday's Journal of the
American Medical Association, says that in 1986,  60 million Americans between
20  and  74  years  old - about 36 percent of the population - had cholesterol
levels high enough to need medical help. (From the USA TODAY Life section.)

                        DOCTORS TRACK MEASLES OUTBREAK:

   The United States appears to  be  in  the  midst  of  a  measles  outbreak.
According  to  the  Morbidity  and Mortality weekly report for the week ending
June 30,  7,022 cases of measles have been reported  so  far  this  year.  The
average  number  of  cases  recorded by this week in previous years was 1,750.
Some 484 cases were reported last week alone,  compared to 78 in the same week
last year.

                        DOCTORS TO TEST LIQUID SHADES:

   Researchers  are  developing  liquid  sunglasses  that wearers will someday
simply apply to their eyes like eye drops. USA WEEKEND reports that doctors at
the University  of  Southern  California  are  developing  the  liquid,  which
contains  the non-toxic chemical chromophore.  They say the liquid will absorb
up to 98 percent of harmful ultraviolet rays for  up  to  eight  hours  before
dissolving.

                          SOME TESTS MISS AIDS VIRUS:

   Current tests are failing to detect the AIDS virus in some blood samples, a
study found.  The study, published in Friday's Journal of the American Medical
Association, said that some samples of commercial plasma were found to contain

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human immunodeficiency virus, which causes AIDS. The study said the plasma was
not dangerous, since processing kills the disease.

                        HEART SHOCK DELIVERED BY PHONE:

   A St.  Louis woman received a lifesaving cardiac shock from a defibrillator
connected to doctors by telephone. MEDphone Corp.  said Wednesday that doctors
at  the  Jewish  Hospital  of St.  Louis shocked Ada Evans last week using the
MDphone transtelephonic defibrillator.  Evans was suffering from  tachycardia,
or abnormally rapid heartbeat. She is now in stable condition at the hospital.

                         LASER TO TREAT SKIN LESIONS:

   The  National  Institutes of Health on Thursday awarded a grant to a Boston
company to develop a laser to treat benign pigmented lesions. Researchers from
Candela Laser Corp.  and Boston University will develop  a  flashlamp  excited
pulsed  dye  laser  to  evaporate  the excess pigment at the skin's surface in
patients with lesions and return the skin to its normal color.

                         ENZYMES KEY TO CPR SURVIVAL:

   The amount of two enzymes in the cerebrospinal fluid might hold the key  to
survival  for  cardiac arrest victims,  a study concludes.  The study,  in the
July issue of the Archives of Neurology,  said the amount  of  the  enzymes  -
creatine  kinase  isozyme  and  neuron-specific enolase - could be an accurate
predictor of  a  patient's  chances  of  survival  after  cardiac  arrest  and
resuscitation.

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===============================================================================
                                    Columns
===============================================================================

 NEW ORGAN PRESERVATION SOLUTION EXTENDS PRESERVATION TIMES, HOLDS PROMISE OF
                  MAJOR IMPACT ON LIVER, PANCREAS TRANSPLANTS
                 from the American Council on Transplantation

     A  solution  that  increases  the  time  organs  can  be  preserved   for
transplantation,  developed by researchers at the University of Wisconsin, has
been cleared by the Federal Drug Administration for use in the United States.

     The  Belzer/UW Organ Preservation Solution,  developed by Folkert Belzer,
M.D. and James Southard, Ph.D., has been shown in clinical trials conducted at
the University of Pittsburgh to triple the time available  from  the  time  of
donation of a liver or pancreas to its transplantation in a recipient.

     The UW Solution increases the storage time for livers and pancreases from
approximately  six  to  36  hours,  and  from  24 to 36 hours for kidneys.  In
addition,  experience with the solution has shows  the  organs  are  not  only
preserved better, but function better and sooner after transplantation.

     "The longer preservation time increases the availability of organs - they
can  be  harvested  in  one  part of the country and safely shipped to waiting
patients hundreds of miles away.  An international network to match organs and
recipients can be come a reality with this solution,"  explained  Dr.  Belzer,
co-inventor  of  the  solution  and  professor  and chairman of the UW Medical
School Department of Surgery.

     The solution also will enable surgeons to perform  transplant  that  once
had  to  be  done  immediately  on  a non-emergency basis,  Dr.  Belzer added.
"Formerly, liver and pancreas transplants had to be performed within six to 10
hours of harvest.  With longer preservation, the operation becomes less rushed
and safer for patients."

     Dr.  Belzer and his colleagues have been pioneers in  organ  preservation
for the past 20 years and have played a major role in development of means for
preserving  kidneys  for  up  to  72  hours.  It  was this success that led to
efforts to find the similar answers for other organs.

     Dr. Belzer and biochemist Southard, UW Medical School associate professor
of surgery,  began exploring means to extend the  life  of  donor  livers  and
pancreases.  Donor livers and pancreases formerly had been preserved in a cold
storage  solution  that  also was used to store kidneys.  However,  they found
that the kidney's metabolism is different than the liver and pancreas, leading
them to search for a different mixture of preservation chemicals.

     "We needed an effective impermeant  for  the  liver  and  pancreas,"  Dr.
Southard  explained.  They  found  it  in  the  form  of a solution containing
loctobionate,  a substance that suppresses swelling and deterioration  in  the
cells  of  the  liver  and pancreas.  The loctobionate replaced glucose in the
solution which,  they found,  entered the organs cells and  produced  swelling
that caused structural damage.

     An  report  in  the  February  1989  issue of the Journal of the American

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Medical Association noted "the remarkable effectiveness of  the  solution  has
revolutionized  liver  transplantation  at  almost  every level.  The enhanced
margin of safety has permitted more effective use of organs that can be stored
safely while waiting for operating room  facilities  or  personnel  to  become
available."

     Du  Pont  Pharmaceuticals has been licensed to manufacture and market the
Belzer/UW Organ Preservation Solution in the United States and Europe.

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===============================================================================
                                   Articles
===============================================================================

          Global Education for Disabled Children on Telecom Networks
           "Robert D. Carlitz" <carlitz@uwapa2.phys.washington.edu>

This paper was written by Dr Robert Carlitz,  concerning global education  for
disabled  children  on Telecom networks.  Robert Carlitz is a professor in the
department of physics and astonomy in the University of Pittsburgh.  This is a
charming paper.

The  following  item  was  stimulated  by  the  comments  of Norman Coombs and
Tzipporah BenAvraham.  An international children's network can cross political
boundaries.  It can also cross the  boundaries  which  sometimes  isolate  the
physically handicapped.

  **************************************************************************

                        POSSIBILITIES FOR COMMUNICATION

Telecommunications  technology  has developed an exciting potential during the
last  decade.  Inexpensive  microcomputers  now  facilitate  the  exchange  of
electronic  messages  around  the  world,  using  existing telephone and radio
links.  These same computers have  transformed  the  human  interface  to  the
message  system,   allowing  open  access  regardless  of  a  user's  physical
abilities.  And they enable the messages themselves to be transformed  through
organizing  and  indexing  for  general  access.  The resulting communications
system is one which  can  satisfy  the  literal  meaning  of  the  Latin  root
"communicare" by making common the shared knowledge of the entire human race.

The  technology  for assembling a universally accessible communications system
now  exists.  It  is  being  applied  piecemeal  by  governments,  businesses,
organizations  and  individuals  throughout  the world.  In this note we would
like to discuss the new modes of communication that this  technology  permits.
And  we  will  advance  a principle which can help guide further technological
development and maximize its  benefits  for  the  people  of  the  world.  The
principle   is   one   which   would  guarantee  universal  access  to  global
communications.

To implement this principle  we  propose  that  a  portion  of  each  nation's
telecommunications  system  be allocated for educational use and that a global
electronic network be created  for  the  use  of  school  children  and  their
teachers.  In  developed  countries  the  establishment  of this network would
represent a small subsidy to educational  training.  In  developing  countries
the  childrens'  network would form the basis for other national networks.  In
all cases the cost of establishing the network would serve as an investment in
humankind's future ability to utilize its shared knowledge.

We are presently at a stage in the development  of  communications  technology
where  it  is  possible  to recognize some trends and make some choices.  Wise
choices now will let us  exploit  future  developments  more  fully.  Accurate
observation  of  technological trends will let us see what choices exist to be
made.  This is not always easy,  and in a field which is rapidly evolving,  it

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is especially difficult.

One obvious trend is toward increasing connectivity.  Individual computers are
connected  in local networks;  local networks are linked in regional networks;
and regional networks are linked in national or  international  ensembles.  At
each junction point there are technical issues of transmission protocols which
must  be  dealt  with.  But from the users' viewpoint the result is a seamless
link which disregards regional boundaries.  The  children's  network  that  we
propose   to  implement  makes  the  trend  toward  universal  connectivity  a
fundamental goal.

An important consequence of universal  connectivity  is  universal  access  to
data.  Computer networks are a unique communications medium in that they allow
the  possibility  of storing and organizing all messages that are entered into
the system.  Children who learn to use a global  communications  system  would
contribute to a database of shared human knowledge and would learn how extract
needed information from this database.

A  second  trend  involves  the  complexity  of  the  user interface.  As more
powerful processors have been developed,  computer displays have  become  more
elaborate.  Simple  textual  displays  have  been  superseded by multi-layered
graphical displays.  An alternative use of this local processing power  is  to
replace   display   screens  with  realistic  and  easily  comprehended  voice
synthesizers or to substitute for conventional keyboards - joysticks,  paddles
or  voice  recognition  devices  for  the  physically  impaired.   This  trend
obviously supports the  universal  access  to  which  our  children's  network
aspires.

There  is  one  corollary  of  this  trend  which  we  should  probably try to
discourage.  This is the tendency to transmit large  quantities  of  graphical
information.  Once could contrast the possibilities of transmitting a code for
the letter ``a'' with a picture of this letter.  The coded form conventionally
requires  7  binary  digits of information.  The picture,  by contrast,  could
involve perhaps 1500 bits for moderately crisp resolution and more for  higher
resolution. (Compression schemes can reduce the bandwidth requirement for both
text  and  graphics,  but  graphics  remain  intrinsically  more  expensive to
transmit.) Coded text can be indexed, sorted and scanned with ease.  Graphical
data can be indexed only if it is attached to textual material or if  by  some
scanning process it is converted to textual material.

This  suggests  that  we  choose  textual  material  as  the  basis for global
exchange.   Graphical  material  can  always  be  represented  through  direct
encoding  schemes or through page description languages,  so no flexibility is
lost in this approach.  This choice simplifies access by  providing  a  lowest
common   denominator  -  equilavent  to  a  ``dumb''  teletype  terminal.   It
guarantees that access will remain open independent  of  details  of  a  given
user's  terminal  and  hence  independent  of  that  user's  level of physical
abilities.

Having chosen to  emphasize  textual  material,  we  must  face  a  number  of
interesting challenges.  These involve dealing with the different languages of
the world and their different written representations.  Computers,  of course,
are ideal aids for these tasks.  The  problems  here  are  ones  which  hinder
international   commerce   and  politics.   Development  of  an  international
children's network allows  their  resolution  in  a  forum  which  is  neither

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Volume  2, Number 28                                            July 10, 1989

commercial nor political - and which is hence noncontentious.  And development
along  the  lines  proposed here will maintain open access for all nations and
all individuals.

Robert D. Carlitz
Department of Physics and Astronomy
University of Pittsburgh
Pittsburgh, PA USA 15250

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===============================================================================
                     Volunteer Needed for Studies/Research
===============================================================================

                Phase I study of a new nucleoside analog, AzdU
                         Mike Polis, MD (301) 496-9565
                         National Institutes of Health
                            Email: OPM@NIHCU.BITNET

Title:  A Phase I-II Dose Escalation Study to Evaluate the Safety,  Anti-Viral
and  Immune  Enhancing  Effects  of  3'-Azido-2',3'-dideoxyuridine  (AzdU)  in
Patients with Human Immunodeficiency Virus Type 1 (HIV-1) Infection.

   This study is designed to evaluate the safety  and  efficacy  of  AzdU,  an
orally administered nucleoside analog, in adults with HIV infection.  AzdU has
been  shown  in  laboratory  studies  to  be  effective  in  inhibiting  HIV-1
replication and may be less toxic than AZT.

   Study participants are being sought who have HIV infection and:

1.  CD4 count between 200 and 400/cu mm.
2.  No previous use of AZT.
3.  Over 18 years of age.
4.  Able to participate in weekly clinic visits and blood-drawing
    as defined by the study.

   Participants will need a primary  physician  involved  in  their  care  and
available  to  communicate  with the NIH doctors and nurses during the time of
study enrollment.  We expect to enroll 15 patients in the initial phase of the
study.

   Eligible participants chosen for this outpatient  study  will  be  serially
assigned to one of five dose groups.  There will be frequent sampling of blood
and  urine  during  the  course  of the study for monitoring and evaluation to
minimize potential toxicities.  After the twelve week study  course,  patients
showing  a  beneficial  response  to  the  drug  may be eligible for continued
treatment with AzdU.  Participants will be assessed monthly for 3  months  and
then every 3 months after being on drug.

  AzdU  has  not  been  given  to humans so that the side effects are unknown.
Animal studies have shown toxicities only  at  extra-ordinarily  large  doses.
Other  nucleosides  have  caused  elevations of liver function tests,  nausea,
headache, and bone marrow suppression.

  For  further  information,  contact  Dianne  Lee,   RN  at  (301)  496-7196,
Laboratory  of Immunoregulation,  National Institute of Allergy and Infectious
Diseases, National Institutes of Health, Building 10 Bethesda, Maryland 20892.

Health InfoCom Network News                                             Page 13
Volume  2, Number 28                                            July 10, 1989

===============================================================================
                                Call for Papers
===============================================================================

            Studies in Technological Innovation and Human Resources
               MANAGEMENT AND TECHNOLOGY-MEDIATED COMMUNICATION

Studies in Technological Innovation and Human Resources is a bi-annual  series
of books, published by de Gruyter (Berlin and New York), which brings together
research,  critical analysis,  and proposals for change in this fairly new and
highly important field of inquiry:  Technological  innovations  and  how  they
affect  people  in the workplace.  Technology includes computers,  information
systems,   telecommunications,   computer-aided  design   and   manufacturing,
artificial intelligence and other related forms.

The  first  volume  of Technological Innovation and Human Resources dealt with
Managing Technological Development:  Strategic and Human Resources Issues  and
was  published  in  1988.  The second volume,  entitled End User Training,  is
scheduled to appear at the beginning of 1990.

The upcoming Volume III,  MANAGEMENT  AND  TECHNOLOGY-MEDIATED  COMMUNICATION,
will particularly include papers that are:

                        - international
                        - interdisciplinary
                        - theoretical
                        - empirical
                        - macro
                        - micro

Authors are encouraged to think creatively about subject matter possibilities,
including manuscripts that:

      * are critical and reflective;
      * report on cases of successful technology-mediated communication in
            organizational settings;
      * report on failures;
      * attempt to demonstrate change in communication content, patterns and
            quality due to technology;
      * investigate how speed and complexity may be affected by technology-
            mediated communication;
      * compare various communication means such as telephone, computer mail,
            video and typewritten and other communication processes and
            outcomes;
      * assess efficiency, costs, benefits and effectiveness;
      * combine some of these issues.

Each  manuscript  must  have  a  concluding  section entitled IMPLICATIONS FOR
RESEARCH AND MANAGEMENT.

                             PUBLICATION PROCEDURE

Papers should conform strictly to the rules of the APA (American Psychological

Health InfoCom Network News                                             Page 14
Volume  2, Number 28                                            July 10, 1989

Association) style guide (3rd Edition).  All submissions must be original work
which has not appeared elsewhere,  and  which  is  not  being  considered  for
publication  by  any other outlet at this time.  Since the review process will
be anonymous,  please prepare your manuscript accordingly.  Five copies should
be  submitted  to  the  address below.  Deadline for submission is February 1,
1990.

If you would like to discuss your topic, please call Urs E.  Gattiker at (403)
320-6966 (mountain standard time) or Laurie Larwood at (518) 442-4910 (Eastern
Standard Time).

               Please submit five copies of your manuscript to:

                                Urs E. Gattiker
                      Technology Assessment Research Unit
                             School of Management
                         The University of Lethbridge
                              Lethbridge, Alberta
                               CANADA  T1K  3M4

FAX:     (403) 329-2022
E-Mail:  GATTIKE%VP@UNCAEDU.BITNET

Health InfoCom Network News                                             Page 15