ATW1H%ASUACAD.BITNET@oac.ucla.edu (Dr David Dodell) (07/11/89)
Volume 2, Number 28 July 10, 1989 +------------------------------------------------+ ! ! ! Health Info-Com Network ! ! Newsletter ! +------------------------------------------------+ Editor: David Dodell, D.M.D. St. Joseph's Hospital and Medical Center 10250 North 92nd Street, Suite 210, Scottsdale, Arizona 85258-4599 USA Telephone (602) 860-1121 (c) 1989 - Distribution on Commercial/Pay Systems Prohibited without Prior Authorization International Distribution Coordinator: Robert Klotz Nova Research Institute 217 South Flood Street, Norman, Oklahoma 73069-5462 USA Telephone (405) 366-3898 The Health Info-Com Network Newsletter is distributed weekly. Articles on a medical nature are welcomed. If you have an article, please contact the editor for information on how to submit it. If you are intrested in joining the distribution system please contact the distribution coordinator. E-Mail Address: Editor: FidoNet = 1:114/15 Bitnet = ATW1H @ ASUACAD Internet = ddodell@stjhmc.fidonet.org LISTSERV = MEDNEWS @ ASUACAD anonymous ftp = vm1.nodak.edu Distribution: North America Australia/Far East Europe FidoNet = 1:19/9 David More Henk Wevers Usenet = krobt@mom.uucp FidoNet = 3:711/413 Fidonet Internet = krobt%mom@uokmax.ecn.uoknor.edu 2:500/1 Sponsors ======== Dr. Edward Delgrosso Black Bag BBS (FidoNet 1:150/101) Tel 1-302-731-1998 =============================================================================== T A B L E O F C O N T E N T S 1. Comments & News from the Editor HICNet Newsletter Now Available via ftp on Internet .................. 1 2. Medical News Medical News Items for week ending June 9, 1989 ....................... 2 3. Columns New Organ Preservation Solution Extens Transplant Times ............... 8 4. Articles Global Education for Disabled Children on Telecom Networks ............ 10 5. Volunteer Needed for Studies/Research Phase I study of a new nucleoside analog, AzdU, Volunteers Wanted ..... 13 6. Call for Papers Studies in Technological Innovation and Human Resources ............... 14 Health InfoCom Network News Page i Volume 2, Number 28 July 10, 1989 =============================================================================== Comments & News from the Editor =============================================================================== HICNet Newsletter Now Available via ftp on Internet Courtesy of the facilities at Nodak.Edu, HICNet Newsletter is now available via anonymous ftp request on the Internet. To get the newsletter this way, you should make an "anonymous" ftp request of "vm1.nodak.edu". Change to the directory HICNEWS and you should see the issues available there. If you have any questions, or problems, contact me at any of my email addresses. Health InfoCom Network News Page 1 Volume 2, Number 28 July 10, 1989 =============================================================================== Medical News =============================================================================== Medical News Items for week ending June 9, 1989 Source: USA TODAY/Gannett National Information Network Reproduced with Permission July 3-4, 1989 REACHING PEAK AT 70 POSSIBLE: Physiologists recently found that people in the 70s who exercise vigorously can bring their exercise capacity to its peak for their age. Doctors at the University of Maryland's Center for Aging found that a group of patients in their 70s increased their maximum cardiovascular capacity by 22 percent through a program of fast walking. (From the USA TODAY Life section.) N.Y. DOCTORS GET CAP ON HOURS: Medical residents at New York hospitals will no longer work their traditional 36-hour shifts and 100-hour weeks. As of July 1, residents in hospitals throughout the state were limited to 24-hour shifts and 80-hour weeks. The law was prompted by concerns for high-quality patient care and optimum physician training. (From the USA TODAY Life section.) DENTISTS CAN DETECT ABUSE SIGNS: Because physical abuse cases often involve injuries to the head, face and mouth, dentists can often be the first to detect the signs of abuse, a survey showed. Researchers at the University of Colorado polled more than 3,000 dentists and found that 3 percent reported treating patients for abuse-related injuries. Another 7.6 percent reportedly had suspicions of abuse in some cases. ETHNICITY SHAPES DRUG RESPONSE: Researchers have found that patients of differing ethnic backgrounds metabolize certain drugs differently. Doctors at the National Institute of General Medical Sciences found that American men of Chinese descent were more sensitive to the blood pressure drug propranolol than men of European descent. They say the difference is rooted in genetically inherited factors. NEW ALZHEIMER'S THEORY STUDIED: Alzheimer's disease might be the result of a protective mechanism gone awry, researchers report. Doctors at Harvard University are studying an enzyme inhibitor called alpha-1 antichymotrypsin - or ACT - a component of the senile plaques that develop in the brains of Alzheimer's patients. Normally, ACT helps keep the body's enzymes and their inhibitors in balance. DAILY WATER INTAKE - 2 LITERS: The average American drinks just more than 2 liters of water daily, according to a Department of Agriculture study. The study, which questioned Health InfoCom Network News Page 2 Volume 2, Number 28 July 10, 1989 more than 26,000 Americans, found that an average person drinks about 1.2 liters of tap water from the faucet each day as drinking water and in coffee, tea and other beverages. The rest comes from water packaged in foods. DOCTORS FIND LIVER PROTEIN: Researchers at the National Institutes of Health are trying to discover why the body's immune system attacks the liver of biliary cirrhosis patients. Doctors at NIH have found the proteins the immune system attacks, and are searching for the disease's cause. Two theories: An immune system malfunction causes the disease or an earlier event changes the liver, triggering the immune response. TRANSPLANT ORGANS SUSTAINED: Researchers at the University of Kentucky have kept animal organs functioning for 60 hours outside the body, the July Discover reports. The heart, lungs, liver and kidneys of a dog were left intact, submerged in a saline solution and maintained by a mechanical respirator. Doctors hope the research lengthens the time human organs remain healthy for organ transplants. FLUORIDE KICKING CAVITIES: About 50 percent of American children are free from tooth decay, a recent survey from the National Institute of Dental Research shows. That's up from the early 1970s, when only about 28 percent of children were free from tooth decay. Fluoridation of America's drinking water, which began in 1945 and was greatly expanded in the 1960s, has had a major effect, the survey said. COCAINE-USE PERSONALITY MAPPED: A pioneering study at the University of Iowa has found a link between cocaine abuse and clinical personality disorders. The study, published in the July American Journal of Public Health, found that cocaine abusers are more likely than non-users to exhibit narcissistic tendencies, desiring to be the center of attention and obsessed with power and control. GM TEAM TRIES TO REDUCE INJURY: Researchers at General Motors are designing safety systems to minimize the injuries that accompany sudden deceleration. A GM team using advanced computer technology and anatomical models, are creating new mathematical models of the damage caused by crash forces. Their research is based on the theory that force has different effects on different types of body tissue. YOUNG FALLING DOWN ON FITNESS: The American Academy of Pediatrics recently named declining fitness levels and the use of illegal steroids as the two most urgent problems facing America's physical education programs. The academy said the general fitness of the nation's young people has been declining during the past two decades and the trend might contribute to future cases of heart disease and other illnesses. Health InfoCom Network News Page 3 Volume 2, Number 28 July 10, 1989 July 5, 1989 DISEASE THRIVES IN SUMMER: A new disease is coming this summer. It's called hand-foot-and-mouth disease. Doctors say most people will catch the disease, but few will realize it, since its most common symptoms - a sore throat and fever - are most often mistaken for a cold. It is most common among children younger than 4. (From the USA TODAY Life section.) DISEASE NOT SERIOUS THREAT: The most drastic symptoms of hand-foot-and-mouth disease can include fever, sore throat, swollen glands, wart-like sores on the hands and feet and sometimes in the mouth. The disease - common in the summer months - is not considered a serious health threat. It normally lasts a week to 10 days, but requires no treatment. (From the USA TODAY Life section.) LYME DISEASE RESEARCH QUICKENS: Scientists are increasing the pace of research into Lyme disease and the tick that spreads it. Researchers, responding to rising numbers of Lyme disease cases, are advancing new theories on the microbe that causes the disease and how it is spread from the ticks that carry it to humans, Tuesday's New York Times reports. BABY NEEDS SOME SUN: Letting a baby crawl around in the sun for a few minutes each day can provide all the needed Vitamin D. Researchers at Children's Hospital Medical Center, Cincinnati, have found that babies can maintain adequate Vitamin D levels by staying out in the sun for 30 minutes a week. Vitamin D is needed for the baby to absorb calcium and phosphate. EXPERT SAYS NEW FOCUS NEEDED: Cancer prevention should focus more on stopping the cancer process in the body and less on environmental contributors to the disease, a well-known researcher said recently. Georgetown University's Dr. John Higginson, who first linked environmental causes such as smoking to cancer 35 years ago, said efforts to cut cancer by eliminating such factors had met with little success. PATHOLOGISTS USE HDTV: Washington, D.C.-area pathologists soon will use high-definition television to examine human tissue samples miles from their hospitals, the Washington Post reports. Corabi Telemetics Inc. said a Bell Atlantic fiber optics system using HDTV-based technology would provide twice the resolution of current televisions, allowing pathologists to accurately examine slides. PYGMY HEIGHT THEORY ADVANCED: Researchers at Northwestern University might have finally found why African pygmies are so short. A report in Friday's New England Journal of Medicine notes that while pygmies have normal amounts of a hormone responsible for Health InfoCom Network News Page 4 Volume 2, Number 28 July 10, 1989 growth, they might have fewer growth hormone receptors proteins on a cell's surface that bind the hormone. Scientists are conducting more research. MORE EVIDENCE AGAINST FAT: A study at the University of Illinois confirms that fat content - not calorie count - is the key to weight reduction. In a six-month study, 18 women lost weight faster on a 20 percent fat diet than on a 40-percent fat diet with fewer calories. The diet showed equal results regardless of the women's level of obesity prior to starting the diet. July 6, 1989 HERPES ESTIMATE GOES WAY UP: A study released Wednesday claims many more Americans are infected with herpes simplex II than previously thought. The study, in Thursday's New England Journal of Medicine, estimates 16.4 percent of the population between 15 and 74 years old has the disease - about 25 million people. (From the USA TODAY Life section.) NYU MAPS BRAIN MAGNETIC FIELDS: New technology is unlocking the secret of the brain's magnetic fields. Researchers at New York University said Wednesday that by using new, highly sensitive detectors, they could monitor the location, force and shape of magnetic fields in the brain for the first time. All the fields combined in a single human brain have less magnetic energy than a common message magnet. TRANSPLANTS INCREASE SURVIVAL: Patients who undergo liver transplants because of a fatal disease have a higher survival rate than others who opt for more conservative treatments, a study shows. The seven-year study, in Thursday's New England Journal of Medicine, showed that the survival rate for patients with primary biliary cirrhosis who have transplants is twice as high as non-transplant patients. DOCTOR WORKING ON JET LAG PILL: A doctor at the University of Texas is developing a "jet lag pill" that could help travelers combat the effects of cross-country travel. The pills are made of melatonin, a naturally produced chemical that causes drowsiness. A traveler would take a pill when it is about 2 a.m. at his destination, becoming drowsy, sleeping, and adjusting his system to the time there. EYE TEST COULD FIND ALZHEIMER'S: Simple tests during routine eye exams could spot Alzheimer's disease, a study shows. The study, by doctors at Philadelphia's Wills Eye Hospital, shows that while patients' visual acuity remains normal, they uniformly display abnormalities in color vision, depth perception and the ability to copy diagrams. BOTTLED WATER USAGE RISING: Health InfoCom Network News Page 5 Volume 2, Number 28 July 10, 1989 Health-conscious Americans are consuming more bottled water than ever, and the market for bottled water is growing. The International Bottled Water Association said bottled water, almost unheard of in the United States only a decade ago, had grown to a $300 billion-a-year industry. Producers are introducing several flavored waters. (From the USA TODAY Life section.) NEW EYE SURGERY HEALS FASTER: Doctors are combining ultrasound technology and tiny, foldable lens implants to create a new form of cataract surgery that reduces discomfort and healing time. The technique, recently developed at St. Luke's Cataract and Intraocular Lens Institute, requires a much smaller incision than conventional surgery, reducing healing time and visual distortion. FDA CLEARS NEW ACNE MEDICINE: The Food and Drug Administration on Wednesday cleared Cleocin T topical lotion for the treatment of acne. The lotion was designed specifically for patients with dry, sensitive skin. The lotion, produced by pharmaceutical giant Upjohn Co., has a water base, which adds more moisture to the skin than oil- or alcohol-based solutions, Upjohn officials said. July 7-9, 1989 ONE-THIRD HAVE HIGH CHOLESTEROL: More than one-third of all Americans have borderline or high cholesterol levels, a study shows. The study, published in Friday's Journal of the American Medical Association, says that in 1986, 60 million Americans between 20 and 74 years old - about 36 percent of the population - had cholesterol levels high enough to need medical help. (From the USA TODAY Life section.) DOCTORS TRACK MEASLES OUTBREAK: The United States appears to be in the midst of a measles outbreak. According to the Morbidity and Mortality weekly report for the week ending June 30, 7,022 cases of measles have been reported so far this year. The average number of cases recorded by this week in previous years was 1,750. Some 484 cases were reported last week alone, compared to 78 in the same week last year. DOCTORS TO TEST LIQUID SHADES: Researchers are developing liquid sunglasses that wearers will someday simply apply to their eyes like eye drops. USA WEEKEND reports that doctors at the University of Southern California are developing the liquid, which contains the non-toxic chemical chromophore. They say the liquid will absorb up to 98 percent of harmful ultraviolet rays for up to eight hours before dissolving. SOME TESTS MISS AIDS VIRUS: Current tests are failing to detect the AIDS virus in some blood samples, a study found. The study, published in Friday's Journal of the American Medical Association, said that some samples of commercial plasma were found to contain Health InfoCom Network News Page 6 Volume 2, Number 28 July 10, 1989 human immunodeficiency virus, which causes AIDS. The study said the plasma was not dangerous, since processing kills the disease. HEART SHOCK DELIVERED BY PHONE: A St. Louis woman received a lifesaving cardiac shock from a defibrillator connected to doctors by telephone. MEDphone Corp. said Wednesday that doctors at the Jewish Hospital of St. Louis shocked Ada Evans last week using the MDphone transtelephonic defibrillator. Evans was suffering from tachycardia, or abnormally rapid heartbeat. She is now in stable condition at the hospital. LASER TO TREAT SKIN LESIONS: The National Institutes of Health on Thursday awarded a grant to a Boston company to develop a laser to treat benign pigmented lesions. Researchers from Candela Laser Corp. and Boston University will develop a flashlamp excited pulsed dye laser to evaporate the excess pigment at the skin's surface in patients with lesions and return the skin to its normal color. ENZYMES KEY TO CPR SURVIVAL: The amount of two enzymes in the cerebrospinal fluid might hold the key to survival for cardiac arrest victims, a study concludes. The study, in the July issue of the Archives of Neurology, said the amount of the enzymes - creatine kinase isozyme and neuron-specific enolase - could be an accurate predictor of a patient's chances of survival after cardiac arrest and resuscitation. Health InfoCom Network News Page 7 Volume 2, Number 28 July 10, 1989 =============================================================================== Columns =============================================================================== NEW ORGAN PRESERVATION SOLUTION EXTENDS PRESERVATION TIMES, HOLDS PROMISE OF MAJOR IMPACT ON LIVER, PANCREAS TRANSPLANTS from the American Council on Transplantation A solution that increases the time organs can be preserved for transplantation, developed by researchers at the University of Wisconsin, has been cleared by the Federal Drug Administration for use in the United States. The Belzer/UW Organ Preservation Solution, developed by Folkert Belzer, M.D. and James Southard, Ph.D., has been shown in clinical trials conducted at the University of Pittsburgh to triple the time available from the time of donation of a liver or pancreas to its transplantation in a recipient. The UW Solution increases the storage time for livers and pancreases from approximately six to 36 hours, and from 24 to 36 hours for kidneys. In addition, experience with the solution has shows the organs are not only preserved better, but function better and sooner after transplantation. "The longer preservation time increases the availability of organs - they can be harvested in one part of the country and safely shipped to waiting patients hundreds of miles away. An international network to match organs and recipients can be come a reality with this solution," explained Dr. Belzer, co-inventor of the solution and professor and chairman of the UW Medical School Department of Surgery. The solution also will enable surgeons to perform transplant that once had to be done immediately on a non-emergency basis, Dr. Belzer added. "Formerly, liver and pancreas transplants had to be performed within six to 10 hours of harvest. With longer preservation, the operation becomes less rushed and safer for patients." Dr. Belzer and his colleagues have been pioneers in organ preservation for the past 20 years and have played a major role in development of means for preserving kidneys for up to 72 hours. It was this success that led to efforts to find the similar answers for other organs. Dr. Belzer and biochemist Southard, UW Medical School associate professor of surgery, began exploring means to extend the life of donor livers and pancreases. Donor livers and pancreases formerly had been preserved in a cold storage solution that also was used to store kidneys. However, they found that the kidney's metabolism is different than the liver and pancreas, leading them to search for a different mixture of preservation chemicals. "We needed an effective impermeant for the liver and pancreas," Dr. Southard explained. They found it in the form of a solution containing loctobionate, a substance that suppresses swelling and deterioration in the cells of the liver and pancreas. The loctobionate replaced glucose in the solution which, they found, entered the organs cells and produced swelling that caused structural damage. An report in the February 1989 issue of the Journal of the American Health InfoCom Network News Page 8 Volume 2, Number 28 July 10, 1989 Medical Association noted "the remarkable effectiveness of the solution has revolutionized liver transplantation at almost every level. The enhanced margin of safety has permitted more effective use of organs that can be stored safely while waiting for operating room facilities or personnel to become available." Du Pont Pharmaceuticals has been licensed to manufacture and market the Belzer/UW Organ Preservation Solution in the United States and Europe. Health InfoCom Network News Page 9 Volume 2, Number 28 July 10, 1989 =============================================================================== Articles =============================================================================== Global Education for Disabled Children on Telecom Networks "Robert D. Carlitz" <carlitz@uwapa2.phys.washington.edu> This paper was written by Dr Robert Carlitz, concerning global education for disabled children on Telecom networks. Robert Carlitz is a professor in the department of physics and astonomy in the University of Pittsburgh. This is a charming paper. The following item was stimulated by the comments of Norman Coombs and Tzipporah BenAvraham. An international children's network can cross political boundaries. It can also cross the boundaries which sometimes isolate the physically handicapped. ************************************************************************** POSSIBILITIES FOR COMMUNICATION Telecommunications technology has developed an exciting potential during the last decade. Inexpensive microcomputers now facilitate the exchange of electronic messages around the world, using existing telephone and radio links. These same computers have transformed the human interface to the message system, allowing open access regardless of a user's physical abilities. And they enable the messages themselves to be transformed through organizing and indexing for general access. The resulting communications system is one which can satisfy the literal meaning of the Latin root "communicare" by making common the shared knowledge of the entire human race. The technology for assembling a universally accessible communications system now exists. It is being applied piecemeal by governments, businesses, organizations and individuals throughout the world. In this note we would like to discuss the new modes of communication that this technology permits. And we will advance a principle which can help guide further technological development and maximize its benefits for the people of the world. The principle is one which would guarantee universal access to global communications. To implement this principle we propose that a portion of each nation's telecommunications system be allocated for educational use and that a global electronic network be created for the use of school children and their teachers. In developed countries the establishment of this network would represent a small subsidy to educational training. In developing countries the childrens' network would form the basis for other national networks. In all cases the cost of establishing the network would serve as an investment in humankind's future ability to utilize its shared knowledge. We are presently at a stage in the development of communications technology where it is possible to recognize some trends and make some choices. Wise choices now will let us exploit future developments more fully. Accurate observation of technological trends will let us see what choices exist to be made. This is not always easy, and in a field which is rapidly evolving, it Health InfoCom Network News Page 10 Volume 2, Number 28 July 10, 1989 is especially difficult. One obvious trend is toward increasing connectivity. Individual computers are connected in local networks; local networks are linked in regional networks; and regional networks are linked in national or international ensembles. At each junction point there are technical issues of transmission protocols which must be dealt with. But from the users' viewpoint the result is a seamless link which disregards regional boundaries. The children's network that we propose to implement makes the trend toward universal connectivity a fundamental goal. An important consequence of universal connectivity is universal access to data. Computer networks are a unique communications medium in that they allow the possibility of storing and organizing all messages that are entered into the system. Children who learn to use a global communications system would contribute to a database of shared human knowledge and would learn how extract needed information from this database. A second trend involves the complexity of the user interface. As more powerful processors have been developed, computer displays have become more elaborate. Simple textual displays have been superseded by multi-layered graphical displays. An alternative use of this local processing power is to replace display screens with realistic and easily comprehended voice synthesizers or to substitute for conventional keyboards - joysticks, paddles or voice recognition devices for the physically impaired. This trend obviously supports the universal access to which our children's network aspires. There is one corollary of this trend which we should probably try to discourage. This is the tendency to transmit large quantities of graphical information. Once could contrast the possibilities of transmitting a code for the letter ``a'' with a picture of this letter. The coded form conventionally requires 7 binary digits of information. The picture, by contrast, could involve perhaps 1500 bits for moderately crisp resolution and more for higher resolution. (Compression schemes can reduce the bandwidth requirement for both text and graphics, but graphics remain intrinsically more expensive to transmit.) Coded text can be indexed, sorted and scanned with ease. Graphical data can be indexed only if it is attached to textual material or if by some scanning process it is converted to textual material. This suggests that we choose textual material as the basis for global exchange. Graphical material can always be represented through direct encoding schemes or through page description languages, so no flexibility is lost in this approach. This choice simplifies access by providing a lowest common denominator - equilavent to a ``dumb'' teletype terminal. It guarantees that access will remain open independent of details of a given user's terminal and hence independent of that user's level of physical abilities. Having chosen to emphasize textual material, we must face a number of interesting challenges. These involve dealing with the different languages of the world and their different written representations. Computers, of course, are ideal aids for these tasks. The problems here are ones which hinder international commerce and politics. Development of an international children's network allows their resolution in a forum which is neither Health InfoCom Network News Page 11 Volume 2, Number 28 July 10, 1989 commercial nor political - and which is hence noncontentious. And development along the lines proposed here will maintain open access for all nations and all individuals. Robert D. Carlitz Department of Physics and Astronomy University of Pittsburgh Pittsburgh, PA USA 15250 Health InfoCom Network News Page 12 Volume 2, Number 28 July 10, 1989 =============================================================================== Volunteer Needed for Studies/Research =============================================================================== Phase I study of a new nucleoside analog, AzdU Mike Polis, MD (301) 496-9565 National Institutes of Health Email: OPM@NIHCU.BITNET Title: A Phase I-II Dose Escalation Study to Evaluate the Safety, Anti-Viral and Immune Enhancing Effects of 3'-Azido-2',3'-dideoxyuridine (AzdU) in Patients with Human Immunodeficiency Virus Type 1 (HIV-1) Infection. This study is designed to evaluate the safety and efficacy of AzdU, an orally administered nucleoside analog, in adults with HIV infection. AzdU has been shown in laboratory studies to be effective in inhibiting HIV-1 replication and may be less toxic than AZT. Study participants are being sought who have HIV infection and: 1. CD4 count between 200 and 400/cu mm. 2. No previous use of AZT. 3. Over 18 years of age. 4. Able to participate in weekly clinic visits and blood-drawing as defined by the study. Participants will need a primary physician involved in their care and available to communicate with the NIH doctors and nurses during the time of study enrollment. We expect to enroll 15 patients in the initial phase of the study. Eligible participants chosen for this outpatient study will be serially assigned to one of five dose groups. There will be frequent sampling of blood and urine during the course of the study for monitoring and evaluation to minimize potential toxicities. After the twelve week study course, patients showing a beneficial response to the drug may be eligible for continued treatment with AzdU. Participants will be assessed monthly for 3 months and then every 3 months after being on drug. AzdU has not been given to humans so that the side effects are unknown. Animal studies have shown toxicities only at extra-ordinarily large doses. Other nucleosides have caused elevations of liver function tests, nausea, headache, and bone marrow suppression. For further information, contact Dianne Lee, RN at (301) 496-7196, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Bethesda, Maryland 20892. Health InfoCom Network News Page 13 Volume 2, Number 28 July 10, 1989 =============================================================================== Call for Papers =============================================================================== Studies in Technological Innovation and Human Resources MANAGEMENT AND TECHNOLOGY-MEDIATED COMMUNICATION Studies in Technological Innovation and Human Resources is a bi-annual series of books, published by de Gruyter (Berlin and New York), which brings together research, critical analysis, and proposals for change in this fairly new and highly important field of inquiry: Technological innovations and how they affect people in the workplace. Technology includes computers, information systems, telecommunications, computer-aided design and manufacturing, artificial intelligence and other related forms. The first volume of Technological Innovation and Human Resources dealt with Managing Technological Development: Strategic and Human Resources Issues and was published in 1988. The second volume, entitled End User Training, is scheduled to appear at the beginning of 1990. The upcoming Volume III, MANAGEMENT AND TECHNOLOGY-MEDIATED COMMUNICATION, will particularly include papers that are: - international - interdisciplinary - theoretical - empirical - macro - micro Authors are encouraged to think creatively about subject matter possibilities, including manuscripts that: * are critical and reflective; * report on cases of successful technology-mediated communication in organizational settings; * report on failures; * attempt to demonstrate change in communication content, patterns and quality due to technology; * investigate how speed and complexity may be affected by technology- mediated communication; * compare various communication means such as telephone, computer mail, video and typewritten and other communication processes and outcomes; * assess efficiency, costs, benefits and effectiveness; * combine some of these issues. Each manuscript must have a concluding section entitled IMPLICATIONS FOR RESEARCH AND MANAGEMENT. PUBLICATION PROCEDURE Papers should conform strictly to the rules of the APA (American Psychological Health InfoCom Network News Page 14 Volume 2, Number 28 July 10, 1989 Association) style guide (3rd Edition). All submissions must be original work which has not appeared elsewhere, and which is not being considered for publication by any other outlet at this time. Since the review process will be anonymous, please prepare your manuscript accordingly. Five copies should be submitted to the address below. Deadline for submission is February 1, 1990. If you would like to discuss your topic, please call Urs E. Gattiker at (403) 320-6966 (mountain standard time) or Laurie Larwood at (518) 442-4910 (Eastern Standard Time). Please submit five copies of your manuscript to: Urs E. Gattiker Technology Assessment Research Unit School of Management The University of Lethbridge Lethbridge, Alberta CANADA T1K 3M4 FAX: (403) 329-2022 E-Mail: GATTIKE%VP@UNCAEDU.BITNET Health InfoCom Network News Page 15