eesnyder@boulder.Colorado.EDU (Eric E. Snyder) (08/06/89)
Well, alt.drugs has been pretty dead recently (or does this have something to do with the lightning strike at CU recently...) so here is something to think about....: In the latest volume of the ACS publication Annual Review of Medicial Chemistry there was an article on antipsychotic agents mentioning sigma receptors as a sub-class of adrenergic or dopaminergic receptors.... At NIDA, I ran a few sigma opioid receptor binding assays for Michael Kuhar.... For the blanks, spiroperidol was used (to compete all specific binding off the tissue). Think spiroperidol -> think haloperidol.... I have been out of the literature for a while.... what is the current thinking on sigma receptors? What is their endogenous ligand? A opioid peptide? a monoamine? ------------------------------------------------------------------------- AAGGTGCAATGATGAGGAATTTTATCGTAGTTATGAATAATCCTGCAAGAGGTGCAAAACCCAGAGTACCTCA Eric E. Snyder Department of Molecular, I thought it was rain for a minute; Cellular and Developmental Biology I thought the game had been called. University of Colorado, Boulder TTCCACGTTACTACTCCTTAAAATAGCATCAATACTTATTAGGACGTTCTCCACGTTTTGGGTCTCATGGAGT -------------------------------------------------------------------------