conslt01@zeus.unomaha.edu (The Oracle) (04/02/91)
I am doing research about using laboratory animals for scientific research. I need case studies desperately, as the paper is due on the 11th? or 14th? of April, and I do not have any case studies. I have exhausted all the resource areas I know, and have not come up with any case studies. Any help in this area would be greatly appreciated. As I have stated, this is due very soon, and I need this information very soon. I am on both sides of the issue- meaning that I recognize the need for using animals for research, but feel that too many animals are being used, as there is too much unnecessary killing going on with duplication of studies that have already been proven time and time again (or disproven) I thank you all for your immediate responses and all you help in advance. Alex. -- ************************************************************************ * Conslt16@Zeus.unomaha.edu * Main account Internet address Vax/Vms* * Conslt16@Unoma1 * Main account Bitnet address Vax/Vms * *----------------------------------------------------------------------* * Computing & Data Communication * * University of Nebraska @ Omaha * ************************************************************************
demikhov@neuro.usc.edu (V P Demikhov) (04/03/91)
In article <11869.27f795ed@zeus.unomaha.edu> conslt01@zeus.unomaha.edu (The Oracle) writes: >I am doing research about using laboratory animals for scientific research. >I need case studies desperately, as the paper is due <in about two weeks>... >I recognize the need for using animals for research, but feel that too many >animals are being used ... with duplication of studies that have already >been proven time and time again (or disproven) ... Case Study #1 Take, for example, the enormous literature demonstrating the memory for conditioned taste aversion in the rat depends critically on the insular neocortex. Numerous experiments by investigators over the past 30 years demontrate that destruction of the insular cortex abolishes preexisting memory for taste aversion. However, no previous investigator took care to avoid damage to the middle cerebral artery in the course of excising the insular cortex. When you carefully avoid any damage to this artery while removing the insular neocortex the memory remains unharmed. This means that although the experiment has been repeated many times by many investigators -- they were all wrong -- the effect came from infarcting over half of the brain; not from the destruction of the insular cortex. The simple lesson then is that you cannot just trust the literature --- even if the literature has grown to a substantial volume of experiments by a large number of investigators over the years. In the words of one of one of our greatest leaders (on detent): "TRUST ... BUT VERIFY!!!" VPD