davison@bnl44.UUCP (Dan Davison) (01/03/86)
This is probably a tad esoteric, but have any net.bio'ers heard this before? I was told some time ago (or possibly read) that high doses of aspirin inhibit oxidative phosphorylation. Is this true? For arthritis-related reasons I sometimes take 5 or 6 aspirin at one time (yes, I *know* that's a bad idea) but is the resulting fatigue due to my mitochondria getting annoyed? thanks in advance, dan davison uucp...decvax!philabs!sbcs!bnl44!davison bitnet bchs6 at uhupvm1.bitnet arpa: davison at sumex-aim, davison at bnl44 and from the laws of the laboratory, the non-reciprocal laws of expectation: positive expectations yield negative results negative expectations yield negative results ...this happened to me throughout grad school (*sigh*, and now, too)
larry@kitty.UUCP (Larry Lippman) (01/06/86)
> I was told some time ago (or possibly read) that high doses of aspirin > inhibit oxidative phosphorylation. > Is this true? > For arthritis-related reasons I sometimes take 5 or 6 aspirin at one time > (yes, I *know* that's a bad idea) but is the resulting fatigue due to my > mitochondria getting annoyed? The major pharmacological action of aspirin is inhibition of various prostagladins, resulting in: 1. Diminished perception of pain, since prostaglandins are believed to sensitive nerve endings to the pain-producing effects of bradykinin. 2. Reducing body temperature (antipyretic effect) since prostaglandins E1 ans E2 are used for temperature regulation. In addition, aspirin is known to: 1. Uncouple oxidative phosphorylation [you're right], resulting in increased oxygen consumption. 2. Inhibit synthesis of mucopolysaccharides. 3. Affect thyroid function by interfering with the binding of thyroxine by plasma proteins. 4. Lower blood sugar levels and deplete liver glycogen. 5. Upset acid-base balance in excessive dosages, resulting in respiratory alkalosis in some circumstances, and metabolic acidosis in others (usually infants and young children, though). I don't you why you feel tired, but with dosages as you have indicated, it could very well be more than one of the above reasons. ==> Larry Lippman @ Recognition Research Corp., Clarence, New York <== ==> UUCP {decvax|dual|rocksanne|rocksvax|watmath}!sunybcs!kitty!larry <== ==> VOICE 716/741-9185 {rice|shell}!baylor!/ <== ==> FAX 716/741-9635 {G1, G2, G3 modes} duke!ethos!/ <== ==> burl!gladys!/ <== ==> "Have you hugged your cat today?" ihnp4!/ <==
ems@amdahl.UUCP (ems) (01/07/86)
In article <688@kitty.UUCP>, larry@kitty.UUCP (Larry Lippman) writes: > > I was told some time ago (or possibly read) that high doses of aspirin > > inhibit oxidative phosphorylation. ... > The major pharmacological action of aspirin is inhibition of various > prostagladins, resulting in: > ... list of effects ... Not listed was another: aspirin sensitizes the inner ear to nerve damage and deafness. If you take lots of aspirin, don't go to loud places!! The length of time you need to be exposed and the loudness to which you must be exposed to cause deafness are reduced. Why? I don't know. -- E. Michael Smith ...!{hplabs,ihnp4,amd,nsc}!amdahl!ems This is the obligatory disclaimer of everything.
jcp@osiris.UUCP (Jody Patilla) (01/08/86)
> Not listed was another: aspirin sensitizes the inner ear to nerve > damage and deafness. If you take lots of aspirin, don't go to loud > places!! The length of time you need to be exposed and the loudness > to which you must be exposed to cause deafness are reduced. > Why? I don't know. > In fact, a symptom that you are taking too much aspirin is that your ears start ringing. -- jcpatilla "If we can send a man to the moon, why can't we send all of them ?"
werner@aecom.UUCP (Craig Werner) (01/10/86)
> The major pharmacological action of aspirin is inhibition of various > prostagladins, resulting in: Actually the direct action of Aspirin is two-fold. For the first 15 minutes, it is Acetysalicylic Acid and it irreversibly inhibits an enzyme called Cyclooxygenase - the first step in Prostaglandin synthesis. For the rest of the time it is in the body as Salicylic Acid, and it inhibits the 2nd step on the pathway to Leukotrienes (which are involved in imflammation). As it turns out, the built up precursor continues to inhibit cyclooxygenase and prevent prostaglandin production. This dual action, incidentally, is why Aspirin, unlike Tylenol, is both an analgesic and an anti-imflammatory, and the irreversible part (in platelets) is why one Aspirin a day can prevent 2nd heart attacks. (Data is not in for 1st ones yet.) The end effects have been previously described by Lippman -- Craig Werner !philabs!aecom!werner "...if that's the hand you use, well, nevermind..."
kort@hounx.UUCP (B.KORT) (01/12/86)
Aspirin will also keep your cut flowers fresh. Just crumble up a tablet and dissolve it in the water. --Barry Kort
larry@kitty.UUCP (Larry Lippman) (01/13/86)
> > The major pharmacological action of aspirin is inhibition of various > > prostagladins, resulting in: > ... list of effects ... > > Not listed was another: aspirin sensitizes the inner ear to nerve > damage and deafness. If you take lots of aspirin, don't go to loud > places!! The length of time you need to be exposed and the loudness > to which you must be exposed to cause deafness are reduced. > Why? I don't know. The effect of aspirin is that of producing "ringing" in the ears, which is properly called tinnitus (not to be confused with tinea cruris :-) ). Aspirin - and other drugs like quinine, streptomycin, neomycin - cause tinnitus by irritating (and injuring) hair cells and nerve cells in the spiral ganglion of Corti in the inner ear. I believe that tinnitus caused by aspirin and other drugs generally disappears following discontinuance of the drug - unless excessive dosages were used which caused irreversible nerve cell injury. However, having this type of tinnitus should not make the ear more susceptible to damage from loud sound. ==> Larry Lippman @ Recognition Research Corp., Clarence, New York <== ==> UUCP {decvax|dual|rocksanne|rocksvax|watmath}!sunybcs!kitty!larry <== ==> VOICE 716/741-9185 {rice|shell}!baylor!/ <== ==> FAX 716/741-9635 {G1, G2, G3 modes} duke!ethos!/ <== ==> seismo!/ <== ==> "Have you hugged your cat today?" ihnp4!/ <==
larry@kitty.UUCP (Larry Lippman) (01/15/86)
> > The major pharmacological action of aspirin is inhibition of various > > prostagladins, resulting in: > > Actually the direct action of Aspirin is two-fold. For the first 15 > minutes, it is Acetysalicylic Acid and irreversibly inhibits an enzyme called > Cyclooxygenase - the first step in Prostaglandin synthesis. ^^^^^^^^^^^^^^ Is cyclooxygenase the same as prostaglandin synthetase? That actually is the enzyme responsible for prostaglandin synthesis from arachidonic acid? I'll feel better if it's the same. My formal education in biochemistry stopped 15 years ago, and I am constantly frustrated by changing biochemical nomenclature when I get involved in clinical instrumentation projects. ==> Larry Lippman @ Recognition Research Corp., Clarence, New York <== ==> UUCP {decvax|dual|rocksanne|rocksvax|watmath}!sunybcs!kitty!larry <== ==> VOICE 716/741-9185 {rice|shell}!baylor!/ <== ==> FAX 716/741-9635 {G1, G2, G3 modes} duke!ethos!/ <== ==> seismo!/ <== ==> "Have you hugged your cat today?" ihnp4!/ <==
ems@amdahl.UUCP (ems) (01/15/86)
In article <704@kitty.UUCP>, larry@kitty.UUCP (Larry Lippman) writes: > > > The major pharmacological action of aspirin is inhibition of various > > > prostagladins, resulting in: > > ... list of effects ... > > > > Not listed was another: aspirin sensitizes the inner ear to nerve > > damage and deafness. If you take lots of aspirin, don't go to loud > > places!! The length of time you need to be exposed and the loudness > > to which you must be exposed to cause deafness are reduced. > > Why? I don't know. > > The effect of aspirin is that of producing "ringing" in the ears, > which is properly called tinnitus (not to be confused with tinea cruris :-) ). > Aspirin - and other drugs like quinine, streptomycin, neomycin - cause tinnitus > by irritating (and injuring) hair cells and nerve cells in the spiral ganglion > of Corti in the inner ear. > I believe that tinnitus caused by aspirin and other drugs generally > disappears following discontinuance of the drug - unless excessive dosages > were used which caused irreversible nerve cell injury. However, having this > type of tinnitus should not make the ear more susceptible to damage from loud > sound. The tinnitus may or may not be related to the increased susceptiblity of the inner ear to damage. I cannot speak to that. It is true, however, that aspirin *DOES* increase the susceptiblity of the inner ear to damage by *high sound levels*. (Source? My M.D. when warning me about things that might further damage my already reduced hearing...). -- E. Michael Smith ...!{hplabs,ihnp4,amd,nsc}!amdahl!ems This is the obligatory disclaimer of everything.
werner@aecom.UUCP (Craig Werner) (01/23/86)
> > Cyclooxygenase - the first step in Prostaglandin synthesis. > ^^^^^^^^^^^^^^ > Is cyclooxygenase the same as prostaglandin synthetase? That actually > is the enzyme responsible for prostaglandin synthesis from arachidonic acid? > I'll feel better if it's the same. My formal education in biochemistry > stopped 15 years ago, and I am constantly frustrated by changing biochemical > nomenclature when I get involved in clinical instrumentation projects. >==> Larry Lippman @ Recognition Research Corp., Clarence, New York <== No, cyclooxygenase is the first step, from Arachodonic Acid, to PG-G and PG-H, prostaglandin synthetases are the second step enzymes, from PG-G/H to the active ones, PG-E and PG-F, etc.. Of course, some people refer to all of them are Prostaglandin Synthetase, life can be confusing sometimes. -- Craig Werner !philabs!aecom!werner "Never attribute to malice what can be adequately explained by stupidity."