[net.med] Aluminum and Alzheimers Disease

eugenez@azure.UUCP (Eugene Zinter) (11/22/83)

        SUBJECT: Aluminum and Alzheimer's Disease

In the SEP/OCT 1983 issue of "American Health"  there  appears  an  article
named "Alzheimer's & Aluminum:  An Element of Suspicion" on pages 48-54.

What follows is taken from  that  article.   Things  in  quotes  are  taken
directly from the article.  Things in [brackets] are supplied by me.


        "... widespread use of the metal [aluminum] started barely 50 years
ago."

        "It may take decades for aluminum to build up to levels  implicated
in  nerve  damage.  And that's how long aluminum use has really been on the
rise."

        "Doubts about this long-trusted metal first arose several years ago
in  a  special  corner  of  medicine:  lifesaving dialysis centers treating
patients whose kidneys had failed.  Several times a  week,  the  substitute
kidneys  filtered  body  wastes  from  their blood stream.  But some of the
patients started going mad.  At first, the symptoms  appeared  only  during
dialysis---trouble with talking, confusion and muscle spasms.  ...  Sliding
swiftly downhill, patients became helpless, demented, bedridden  and  died.
Doctors called the disease dialysis dementia."

        "... Dr. Allen C. Alfrey, professor of medicine at  the  University
of  Colorado  and  chief  of  Denver  VA  Hospital's  kidney  division  ...
[discovered that] Autopsy  analysis  of  the  brains  of  dialysis-dementia
victoms furnished a strategic clue:  high concentrations of aluminum in the
brain cells."

        "It didn't take long to figure out  where  the  aluminum  might  be
coming from.  Large amounts of tap water go into the dialysis solution that
flushes wastes out of a patient's blood stream.  Many  municipalities  rely
on  aluminum  for removing impurities from their water supply.  The varying
metallic content of  water  in  different  locals  would  account  for  the
hit-or-miss  occurrence  of  the  dementia.  In addition, dialysis patients
routinely swallowed huge amounts of aluminum in  antacids  to  prevent  the
accumulation  of  phosphorus  in  their  blood,  a  common  complication of
dialysis."

       [THOUGHT:  It's hard for me to believe that, at ANY time,
                  TAP water would be used for such a purpose!!!
                  How could they believe that ANY tap water would
                  be safe for such a thing as flushing wastes out
                  of the blood?]


        "But everyone agrees on one thing:  The light, bright metal has  no
business in the brain."

        "There is no known human need for aluminum."

        "... only about 12% to 25% of the aluminum we consume seems  to  be
absorbed  into  the  body,  estimates  Dr. Armand Lione, head of Associated
Pharmacologists and Toxicologists  in  Washington,  DC.   A  typical  daily
intake  may  be  22  milligrams of aluminum, though some people may get 100
times that."

    [NOTE:  That means some people are ingesting as much as 2.2 GRAMS of
            ALUMINUM PER DAY!!!!]

        "However, brain aluminum concentrations are about  four  [4]  times
higher  than  normal  in patients with Alzheimer's disease, even in regions
where all diets  are  high  in  aluminum.   In  addition  to  the  telltale
aluminum,  these  patients'  brain  cells have become structurally damaged.
Scientists characteristically  find  two  kinds  of  lesions:  plaques  and
tangles.   Tangles  are clumps of filaments that form within the nerve cell
body.  A plaque is a hard knot of debris marking the site of  a  burned-out
nerve  cell ending.  It short-circuits pathways of communication from nerve
cell to nerve cell that is essential for all human activity."

        "Many of the disordered cells in Alzheimer's disease either  branch
out from or are located in what proves to be a critical place---the brain's
nucleus basilis.  Researchers believe this  region  serves  as  a  cerebral
activator,  keeping  higher  brain levels from falling asleep, for example.
The region also turns out to be  a  rich  source  of  the  neurotransmitter
acetylcholine.    This  substance,  studies  now  show,  is  important  for
brain-cell processing of recent memory."

        "The evidence  is  tantalizing:   three  nervous  system  disorders
marked   by   destructive  cell  changes  and,  within  those  very  cells,
concentrations of aluminum where no aluminum ought to be.  But the evidence
is also almost completely circumstancial."

        "A bit of evidence that aluminum is directly toxic to  brain  cells
comes  from  animal  studies  conducted  by  Dr.  Donald R. C. McLachlan, a
professor of physiology and medicine at the University of Toronto.  In  one
set  of  studies, he injected aluminum directly into cats' brains.  Result:
behavioral changes similar to some of the symptoms of Alzheimer's disease."

        "Neurofibrillar tangles appeared within the nerve cells, to, though
they  were  not exactly like the tangles seen in the human version. ... Dr.
Leopold Liss, a  professor  of  pathology  and  psychiatry  at  Ohio  State
University,  fed aluminum to rabbits, thus more closely duplicating the way
people get an excess of the metal.  Result:  again neurofibrillar  tangles,
though not identical to those seen in human Alzheimer's victims."

        "... McLachlan is now testing ways to get the metal  out  of  brain
cells.  He gives intramuscular doses of a chelating agent, desferrioxamine,
twice daily.  This iron compound binds with aluminum and escorts it out  of
the body.  He hopes it will stop the disease from progressing."

        "Another approach is to give the  chelating  agent  ethylenediamine
tetra-acetic  acid (EDTA) intravenously.  But this therapy requires careful
monitoring in a hospital and is hazardous to the kidneys."

[However aluminum gets in (there's some controversy on  how  it  does  it's
dirty  work)  much  of can be kept out by simply NOT ingesting those foods,
etc.  that contain aluminum.]

        "... many municipal water-treatment systems add  aluminum  to  help
remove  solid  particles  such as plant debris.  Aluminum attaches to these
impurities and sinks them to the bottom,  leaving  the  water  attractively
clear.  But, inevitably, some of the metal remains in the water supply."

        "Aluminum is also a common additive in food and some medicines.  We
use  sodium  aluminum  phospate,  a  leavening  agent,  in household baking
powder, self-rising flour, cake  mix,  pancake  batter  and  frozen  dough.
Other  aluminum-containing  additives emulsify processed cheese, especially
the individually wrapped slices, so it melts easily."


        "A SINGLE SLICE OF PROCESSED CHEESE MAY CONTAIN  50  MILLIGRAMS  OF
ALUMINUM  OR  MORE. [capitals supplied by me---I wonder how Velveeta scores
here?]"


        "And aluminum's anti-caking properties make it useful  in  nondairy
creamers, table salt and other powdered foods."

        "Most over-the-counter indigestion remedies (one notable  exception
is  Tums,  which  depends  on  calcium  carbonate) contain large amounts of
aluminum hydroxide to  soothe  unsettled  stomaches.   Similarly,  buffered
aspirins often use aluminum compounds to counteract aspirin's irritation of
the stomach lining.  Read the label on your  antiperspirant  or  deodorant,
and  you're  likely  to find aluminum.  Check hemorrhoid preperations, too.
Some have up to 50% aluminum hydroxide."

        "And then there's the kitchen: pots, pans, cans and foils.  When we
cook  or  store  highly  acidic,  alkaline  or  salty  foods like tomatoes,
sauerkraut, citrus fruits and carbonated  drinks  in  aluminum  containers,
some of the metal leaches out into the food."

        "Here's the rub.  Originally, everyone thought  aluminum  was  safe
because  it  wasn't  absorbed by the body.  Whatever else we learn from the
Alzheimer's generation, we have discovered that  aluminum  can  damage  the
brain and that a lot of it gets into our bodies."


[So there you have it, another substance that I bet you  didn't  even  know
you  were  ingesting!   Or  if you did, you probably thought it couldn't be
very much!!!  I wonder how many substances  that  WE  humans  are  actually
ingesting that we aren't really aware of---and how long we take to discover
it---tragically, many times too late.  For a person who  is  interested  in
optimum  health,  I  think that these recent articles on caffeine, smoking,
formaldehyde, chemical additives to foods such as ice  cream,  etc.  SHOULD
prompt  us to take on more RESPONSIBILITY in finding out WHAT we are REALLY
eating.  To become more educated as  to  what  is  actually  IN  our  food.
Instead  of depending on "big brother" or "the scientists" or (you-pick-it)
on making sure everything is "safe" for us.  After all,  these  people  are
only human.]

[I make it a personal policy that if there is ANY doubt in  my  mind  about
the safety of a substance, then I do the simple thing:

        I DON'T USE IT!!!  THAT IS, I DON'T EAT IT, DRINK IT, BREATHE IT,
                           RUB IT ON MY SKIN, ETC.  

			   And  if that's not feasable (like polluted air), 
			   I MINIMIZE it's USE ANY WAY I CAN.

			   For instance, with aluminum, I might not be able
			   to QUIT using it 100%, but I bet I can reduce the
			   amount that gets into my body by 90% to 95%.
			   However, had I not been AWARE of the problem,
			   I could be heading towards Alzheimer's disease
			   without knowing what I could have done to prevent
			   it.
			   Doing that should be far safer than the usual dodge
			   (said with an all knowing smile):  

			     'Why worry about it---there's so many other
			     things that are poisoning you and you're
			     going to die anyway.  ENJOY LIFE NOW!'

			   ... Tell that to the Alzheimer Patients.   
			       They would do anything to NOT have this
			       disease.


With MY  approach, there  is NO worry  (stress)  about  what it  will do to 
you---and you don't risk  experiencing the 10 or 50 year later side effects
either.]

                                                ECZ





































4                         Mon 21-Nov-83 11:55 AM